| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunocytochemistry; mouse; 1:500; loading ...; fig 6e
| Hansen J, Kaiser F, Klausen C, Stüven B, Chong R, Bönigk W, et al. Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium. elife. 2020;9: pubmed publisher |
- immunocytochemistry; human; 1:500; loading ...; fig 10a
| Viol L, Hata S, Pastor Peidro A, Neuner A, Murke F, Wuchter P, et al. Nek2 kinase displaces distal appendages from the mother centriole prior to mitosis. J Cell Biol. 2020;219: pubmed publisher |
- immunocytochemistry; mouse; 1:200; loading ...; fig 1a
- immunohistochemistry; mouse; 1:200; loading ...; fig 2d
| Martin Hurtado A, Martin Morales R, Robledinos Antón N, Blanco R, Palacios Blanco I, Lastres Becker I, et al. NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling. Sci Rep. 2019;9:13896 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 1a
- western blot; human; loading ...; fig s1c
| Molinari E, Ramsbottom S, Srivastava S, Booth P, Alkanderi S, McLafferty S, et al. Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts. Sci Rep. 2019;9:10828 pubmed publisher |
- immunocytochemistry; mouse; 1:1000; loading ...; fig 1a
| Engelke M, Waas B, Kearns S, Suber A, Boss A, Allen B, et al. Acute Inhibition of Heterotrimeric Kinesin-2 Function Reveals Mechanisms of Intraflagellar Transport in Mammalian Cilia. Curr Biol. 2019;: pubmed publisher |
- immunocytochemistry; mouse; loading ...; fig s3b
| Ignarski M, Rill C, Kaiser R, Kaldirim M, Neuhaus R, Esmaillie R, et al. The RNA-Protein Interactome of Differentiated Kidney Tubular Epithelial Cells. J Am Soc Nephrol. 2019;30:564-576 pubmed publisher |
- immunocytochemistry; human; 1:200; loading ...; fig 7d
| Huang N, Zhang D, Li F, Chai P, Wang S, Teng J, et al. M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole. Nat Commun. 2018;9:4511 pubmed publisher |
- western blot; mouse; loading ...; fig s5b
| Moye A, Singh R, Kimler V, Dilan T, Munezero D, Saravanan T, et al. ARL2BP, a protein linked to retinitis pigmentosa, is needed for normal photoreceptor cilia doublets and outer segment structure. Mol Biol Cell. 2018;29:1590-1598 pubmed publisher |
- immunohistochemistry; human; 1:500; loading ...; fig 5a
| Mönnich M, Borgeskov L, Breslin L, Jakobsen L, Rogowski M, Doğanlı C, et al. CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium. Cell Rep. 2018;22:2584-2592 pubmed publisher |
- immunocytochemistry; mouse; loading ...; fig 3e
| Toriyama M, Toriyama M, Wallingford J, Finnell R. Folate-dependent methylation of septins governs ciliogenesis during neural tube closure. FASEB J. 2017;31:3622-3635 pubmed publisher |
- immunohistochemistry; human; 1:100; loading ...; fig 3b,4a
| Grzelak C, Sigglekow N, Tirnitz Parker J, Hamson E, Warren A, Maneck B, et al. Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease. PLoS ONE. 2017;12:e0171480 pubmed publisher |
- immunocytochemistry; mouse; fig 4D
| Hong C, Hamilton B. Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function. PLoS Genet. 2016;12:e1006357 pubmed publisher |
- immunocytochemistry; rat; 1:250; fig s5
| Doobin D, Kemal S, Dantas T, Vallee R. Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages. Nat Commun. 2016;7:12551 pubmed publisher |
- immunocytochemistry; human; 1:600; loading ...; fig 1a
| Ghossoub R, Lindbæk L, Molla Herman A, Schmitt A, Christensen S, Benmerah A. Morphological and Functional Characterization of the Ciliary Pocket by Electron and Fluorescence Microscopy. Methods Mol Biol. 2016;1454:35-51 pubmed publisher |
- immunocytochemistry; human; 1:200; loading ...; fig 2A
| Kim M, Froese C, Xie H, Trimble W. Immunofluorescent staining of septins in primary cilia. Methods Cell Biol. 2016;136:269-83 pubmed publisher |
- immunocytochemistry; human; 1:150; loading ...; fig 6a
- western blot; human; 1:1000; loading ...; fig 4b
| Zhang W, Taylor S, Nevarez L, Lachman R, Nickerson D, Bamshad M, et al. IFT52 mutations destabilize anterograde complex assembly, disrupt ciliogenesis and result in short rib polydactyly syndrome. Hum Mol Genet. 2016;25:4012-4020 pubmed publisher |
- immunohistochemistry - frozen section; human; 1:100
| Wang L, Hou S, Han Y. Hedgehog signaling promotes basal progenitor expansion and the growth and folding of the neocortex. Nat Neurosci. 2016;19:888-96 pubmed publisher |
- immunohistochemistry; human; 1:500; loading ...; fig s9
| Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen T, Texier Y, et al. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun. 2016;7:11491 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 1d
| Sánchez A, Urrego D, Pardo L. Cyclic expression of the voltage-gated potassium channel KV10.1 promotes disassembly of the primary cilium. EMBO Rep. 2016;17:708-23 pubmed publisher |
- immunohistochemistry; mouse; 1:1000; tbl 1
| May Simera H. Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea. J Vis Exp. 2016;:53559 pubmed publisher |
- immunohistochemistry; human; 1:3000; fig 4
| Hoang Minh L, Deleyrolle L, Siebzehnrubl D, Ugartemendia G, Futch H, Griffith B, et al. Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis. Oncotarget. 2016;7:7029-43 pubmed publisher |
- immunocytochemistry; human; 1:400; fig 2
- immunocytochemistry; mouse; 1:400; fig s3
- western blot; mouse; 1:1000; fig s3
| Slaats G, Isabella C, Kroes H, Dempsey J, Gremmels H, Monroe G, et al. MKS1 regulates ciliary INPP5E levels in Joubert syndrome. J Med Genet. 2016;53:62-72 pubmed publisher |
| Yamazoe T, Nagai T, Umeda S, Sugaya Y, Mizuno K. Roles of TOG and jelly-roll domains of centrosomal protein CEP104 in its functions in cilium elongation and Hedgehog signaling. J Biol Chem. 2020;: pubmed publisher |
| Yoshida S, Aoki K, Fujiwara K, Nakakura T, Kawamura A, Yamada K, et al. The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis. elife. 2020;9: pubmed publisher |
| Findakly S, Choudhury A, Daggubati V, Pekmezci M, Lang U, Raleigh D. Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals. Acta Neuropathol Commun. 2020;8:114 pubmed publisher |
| Gerakopoulos V, Ngo P, Tsiokas L. Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway. Life Sci Alliance. 2020;3: pubmed publisher |
| Van Bergen N, Ahmed S, Collins F, Cowley M, Vetro A, Dale R, et al. Mutations in the exocyst component EXOC2 cause severe defects in human brain development. J Exp Med. 2020;217: pubmed publisher |
| Bonucci M, Kuperwasser N, Barbe S, Koka V, De Villeneuve D, Zhang C, et al. mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division. Nat Commun. 2020;11:3200 pubmed publisher |
| Bangs F, Miller P, O Neill E. Ciliogenesis and Hedgehog signalling are suppressed downstream of KRAS during acinar-ductal metaplasia in mouse. Dis Model Mech. 2020;13: pubmed publisher |
| Su S, Begum S, Ezratty E. An IFT20 mechano-trafficking axis is required for integrin recycling, focal adhesion dynamics and polarized cell migration. Mol Biol Cell. 2020;:mbcE20040232 pubmed publisher |
| Mc Fie M, Koneva L, Collins I, Coveney C, Clube A, Chanalaris A, et al. Ciliary proteins specify the cell inflammatory response by tuning NFκB signalling, independently of primary cilia. J Cell Sci. 2020;133: pubmed publisher |
| Toro Tapia G, Das R. Primary cilium remodeling mediates a cell signaling switch in differentiating neurons. Sci Adv. 2020;6:eabb0601 pubmed publisher |
| Desai P, Stuck M, Lv B, Pazour G. Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling. J Cell Biol. 2020;219: pubmed publisher |
| Yukimoto H, Miyamoto T, Kiyono T, Wang S, Matsuura S, Mizoguchi A, et al. A novel CDK-independent function of p27Kip1 in preciliary vesicle trafficking during ciliogenesis. Biochem Biophys Res Commun. 2020;527:716-722 pubmed publisher |
| Miyamoto T, Hosoba K, Itabashi T, Iwane A, Akutsu S, Ochiai H, et al. Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome. EMBO J. 2020;39:e103499 pubmed publisher |
| Yan H, Chen C, Chen H, Hong H, Huang Y, Ling K, et al. TALPID3 and ANKRD26 selectively orchestrate FBF1 localization and cilia gating. Nat Commun. 2020;11:2196 pubmed publisher |
| Kim Y, Lee J, Seppala M, Cobourne M, Kim S. Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration. Nat Commun. 2020;11:1994 pubmed publisher |
| Venugopal N, Ghosh A, Gala H, Aloysius A, Vyas N, Dhawan J. The primary cilium dampens proliferative signaling and represses a G2/M transcriptional network in quiescent myoblasts. BMC Mol Cell Biol. 2020;21:25 pubmed publisher |
| Zhang C, Li C, Siu G, Luo X, Yu S. Distinct Roles of TRAPPC8 and TRAPPC12 in Ciliogenesis via Their Interactions With OFD1. Front Cell Dev Biol. 2020;8:148 pubmed publisher |
| Wang W, Allard B, Pottorf T, Wang H, Vivian J, Tran P. Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis. FASEB J. 2020;34:6369-6381 pubmed publisher |
| Gigante E, Taylor M, Ivanova A, Kahn R, Caspary T. ARL13B regulates Sonic hedgehog signaling from outside primary cilia. elife. 2020;9: pubmed publisher |
| Iaconis D, Crina C, Brillante S, Indrieri A, Morleo M, Franco B. The HOPS complex subunit VPS39 controls ciliogenesis through autophagy. Hum Mol Genet. 2020;29:1018-1029 pubmed publisher |
| Liu P, Dodson M, Fang D, Chapman E, Zhang D. NRF2 negatively regulates primary ciliogenesis and hedgehog signaling. PLoS Biol. 2020;18:e3000620 pubmed publisher |
| Boukhalfa A, Nascimbeni A, Ramel D, Dupont N, Hirsch E, Gayral S, et al. PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress. Nat Commun. 2020;11:294 pubmed publisher |
| Bowie E, Goetz S. TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons. elife. 2020;9: pubmed publisher |
| Gilet J, Ivanova E, Trofimova D, Rudolf G, Meziane H, Broix L, et al. Conditional switching of KIF2A mutation provides new insights into cortical malformations pathogeny. Hum Mol Genet. 2020;: pubmed publisher |
| Li Z, Zhao W, Wang G, Gu N, Sun F. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Biosci Rep. 2020;40: pubmed publisher |
| Goldsmith T, Sakib S, Webster D, Carlson D, Van Der Hoorn F, Dobrinski I. A reduction of primary cilia but not hedgehog signaling disrupts morphogenesis in testicular organoids. Cell Tissue Res. 2020;: pubmed publisher |
| Ki S, Kim J, Won S, Oh S, Lee I, Bae Y, et al. CEP41-mediated ciliary tubulin glutamylation drives angiogenesis through AURKA-dependent deciliation. EMBO Rep. 2020;21:e48290 pubmed publisher |
| Belgacemi R, Luczka E, Ancel J, Diabasana Z, Perotin J, Germain A, et al. Airway epithelial cell differentiation relies on deficient Hedgehog signalling in COPD. EBioMedicine. 2020;51:102572 pubmed publisher |
| Shohayeb B, Ho U, Yeap Y, Parton R, Millard S, Xu Z, et al. The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development. Hum Mol Genet. 2020;29:248-263 pubmed publisher |
| Pizon V, Gaudin N, Poteau M, Cifuentes Diaz C, Demdou R, Heyer V, et al. hVFL3/CCDC61 is a component of mother centriole subdistal appendages required for centrosome cohesion and positioning. Biol Cell. 2020;112:22-37 pubmed publisher |
| Brydon E, Bronstein R, Buskin A, Lako M, Pierce E, Fernandez Godino R. AAV-Mediated Gene Augmentation Therapy Restores Critical Functions in Mutant PRPF31+/- iPSC-Derived RPE Cells. Mol Ther Methods Clin Dev. 2019;15:392-402 pubmed publisher |
| Flynn M, Whitton L, Donohoe G, Morrison C, Morris D. Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function. Hum Mol Genet. 2019;: pubmed publisher |
| Kullmann J, Meyer S, Pipicelli F, Kyrousi C, Schneider F, Bartels N, et al. Profilin1-Dependent F-Actin Assembly Controls Division of Apical Radial Glia and Neocortex Development. Cereb Cortex. 2019;: pubmed publisher |
| Pruski M, Hu L, Yang C, Wang Y, Zhang J, Zhang L, et al. Roles for IFT172 and Primary Cilia in Cell Migration, Cell Division, and Neocortex Development. Front Cell Dev Biol. 2019;7:287 pubmed publisher |
| Portal C, Rompolas P, Lwigale P, Iomini C. Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse. elife. 2019;8: pubmed publisher |
| Bae J, Kang G, Min S, Jo D, Jung Y, Kim K, et al. Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson's disease model. Cell Death Dis. 2019;10:952 pubmed publisher |
| Wang Y, Hussein A, Somasundaram L, Sankar R, Detraux D, Mathieu J, et al. microRNAs Regulating Human and Mouse Naïve Pluripotency. Int J Mol Sci. 2019;20: pubmed publisher |
| Hilgendorf K, Johnson C, Mezger A, Rice S, Norris A, Demeter J, et al. Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis. Cell. 2019;179:1289-1305.e21 pubmed publisher |
| Martínez Hernández R, Serrano Somavilla A, Ramos Levi A, Sampedro Nuñez M, Lens Pardo A, Muñoz de Nova J, et al. Integrated miRNA and mRNA expression profiling identifies novel targets and pathological mechanisms in autoimmune thyroid diseases. EBioMedicine. 2019;: pubmed publisher |
| Spiombi E, Angrisani A, Fonte S, De Feudis G, Fabretti F, Cucchi D, et al. KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2. Oncogenesis. 2019;8:64 pubmed publisher |
| White C, Jayasekara W, Picard D, Chen J, Watkins D, Cain J, et al. A Sexually Dimorphic Role for STAT3 in Sonic Hedgehog Medulloblastoma. Cancers (Basel). 2019;11: pubmed publisher |
| Conkar D, Bayraktar H, Firat Karalar E. Centrosomal and ciliary targeting of CCDC66 requires cooperative action of centriolar satellites, microtubules and molecular motors. Sci Rep. 2019;9:14250 pubmed publisher |
| Gerondopoulos A, Strutt H, Stevenson N, Sobajima T, Levine T, Stephens D, et al. Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex. Curr Biol. 2019;29:3323-3330.e8 pubmed publisher |
| Khouj E, Prosser S, Tada H, Chong W, Liao J, Sugasawa K, et al. Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair. J Cell Sci. 2019;132: pubmed publisher |
| Kim M, Mun H, Sung C, Cho E, Jeon H, Chun S, et al. Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening. Nat Commun. 2019;10:3991 pubmed publisher |
| Nozaki S, Castro Araya R, Katoh Y, Nakayama K. Requirement of IFT-B-BBSome complex interaction in export of GPR161 from cilia. Biol Open. 2019;8: pubmed publisher |
| Wang G, Lou H, Salit J, Leopold P, Driscoll S, Schymeinsky J, et al. Characterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity. Respir Res. 2019;20:196 pubmed publisher |
| Ordóñez A, Fernández B, Fdez E, Romo Lozano M, Madero Pérez J, Lobbestael E, et al. RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits. Hum Mol Genet. 2019;: pubmed publisher |
| Cassidy H, Slyne J, Higgins M, Radford R, Conlon P, Watson A, et al. Neutrophil gelatinase-associated lipocalin (NGAL) is localised to the primary cilium in renal tubular epithelial cells - A novel source of urinary biomarkers of renal injury. Biochim Biophys Acta Mol Basis Dis. 2019;1865:165532 pubmed publisher |
| Ritter A, Kreis N, Roth S, Friemel A, Jennewein L, Eichbaum C, et al. Restoration of primary cilia in obese adipose-derived mesenchymal stem cells by inhibiting Aurora A or extracellular signal-regulated kinase. Stem Cell Res Ther. 2019;10:255 pubmed publisher |
| Frikstad K, Molinari E, Thoresen M, Ramsbottom S, Hughes F, Letteboer S, et al. A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling. Cell Rep. 2019;28:1907-1922.e6 pubmed publisher |
| Uzquiano A, Cifuentes Diaz C, Jabali A, Romero D, Houllier A, Dingli F, et al. Mutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary Cilia. Cell Rep. 2019;28:1596-1611.e10 pubmed publisher |
| Park S, Yoo H, Seol J, Rhee K. HDAC3 and HDAC8 are required for cilia assembly and elongation. Biol Open. 2019;8: pubmed publisher |
| Mirvis M, Siemers K, Nelson W, Stearns T. Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding. PLoS Biol. 2019;17:e3000381 pubmed publisher |
| Barrell W, Griffin J, Harvey J, Danovi D, Beales P, Grigoriadis A, et al. Induction of Neural Crest Stem Cells From Bardet-Biedl Syndrome Patient Derived hiPSCs. Front Mol Neurosci. 2019;12:139 pubmed publisher |
| Oh Y, Wang E, Gailey C, Brautigan D, Allen B, Fu Z. Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis. Cells. 2019;8: pubmed publisher |
| Chiticariu E, Regamey A, Huber M, Hohl D. CENPV is a CYLD-interacting molecule regulating ciliary acetylated α-tubulin. J Invest Dermatol. 2019;: pubmed publisher |
| King C, A A Quadros A, Chazeau A, Saarloos I, van der Graaf A, Verhage M, et al. Fbxo41 Promotes Disassembly of Neuronal Primary Cilia. Sci Rep. 2019;9:8179 pubmed publisher |
| Jeong B, Kim T, Kim D, Shin W, Lee J, Kim N, et al. Spastin Contributes to Neural Development through the Regulation of Microtubule Dynamics in the Primary Cilia of Neural Stem Cells. Neuroscience. 2019;: pubmed publisher |
| Bodle J, Hamouda M, Cai S, Williams R, Bernacki S, Loboa E. Primary Cilia Exhibit Mechanosensitivity to Cyclic Tensile Strain and Lineage-Dependent Expression in Adipose-Derived Stem Cells. Sci Rep. 2019;9:8009 pubmed publisher |
| Cheong A, Degani R, Tremblay K, Mager J. A null allele of Dnaaf2 displays embryonic lethality and mimics human ciliary dyskinesia. Hum Mol Genet. 2019;: pubmed publisher |
| Fokin Artem I, Zhapparova Olga N, Burakov Anton V, Nadezhdina Elena S. Centrosome-derived microtubule radial array, PCM-1 protein, and primary cilia formation. Protoplasma. 2019;: pubmed publisher |
| Dupont M, Humbert C, Huber C, Siour Q, Guerrera I, Jung V, et al. Human IFT52 mutations uncover a novel role for the protein in microtubule dynamics and centrosome cohesion. Hum Mol Genet. 2019;: pubmed publisher |
| Miki D, Kobayashi Y, Okada T, Miyamoto T, Takei N, Sekino Y, et al. Characterization of Functional Primary Cilia in Human Induced Pluripotent Stem Cell-Derived Neurons. Neurochem Res. 2019;44:1736-1744 pubmed publisher |
| Wang C, Tsai P, Chen T, Tsai H, Kuo P, Su M. Elevated miR-200a and miR-141 inhibit endocrine gland-derived vascular endothelial growth factor expression and ciliogenesis in preeclampsia. J Physiol. 2019;597:3069-3083 pubmed publisher |
| Wheway G, Nazlamova L, Turner D, Cross S. 661W Photoreceptor Cell Line as a Cell Model for Studying Retinal Ciliopathies. Front Genet. 2019;10:308 pubmed publisher |
| Hong H, Joo K, Park S, Seo J, Kim M, Shin E, et al. Extraciliary roles of the ciliopathy protein JBTS17 in mitosis and neurogenesis. Ann Neurol. 2019;86:99-115 pubmed publisher |
| Tsai J, Hsu W, Liu J, Chang C, Tang T. CEP120 interacts with C2CD3 and Talpid3 and is required for centriole appendage assembly and ciliogenesis. Sci Rep. 2019;9:6037 pubmed publisher |
| Bhattarai S, Begum S, Popow R, Ezratty E. The ciliary GTPase Arl3 maintains tissue architecture by directing planar spindle orientation during epidermal morphogenesis. Development. 2019;146: pubmed publisher |
| Fu S, Thompson C, Ali A, Wang W, Chapple J, Mitchison H, et al. Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation. Osteoarthritis Cartilage. 2019;27:1064-1074 pubmed publisher |
| Lodge E, Santambrogio A, Russell J, Xekouki P, Jacques T, Johnson R, et al. Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade. elife. 2019;8: pubmed publisher |
| Kane M, Diamonstein C, Hauser N, Deeken J, Niederhuber J, Vilboux T. Endosomal trafficking defects in patient cells with KIAA1109 biallelic variants. Genes Dis. 2019;6:56-67 pubmed publisher |
| Lim J, Nair S, Shyamasundar S, Chua P, Muniasamy U, Matsumoto K, et al. Silencing Y-box binding protein-1 inhibits triple-negative breast cancer cell invasiveness via regulation of MMP1 and beta-catenin expression. Cancer Lett. 2019;452:119-131 pubmed publisher |
| Kiseleva A, Korobeynikov V, Nikonova A, Zhang P, Makhov P, Deneka A, et al. Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs. Clin Cancer Res. 2019;: pubmed publisher |
| Kluth O, Stadion M, Gottmann P, Aga H, Jähnert M, Scherneck S, et al. Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans. Cell Rep. 2019;26:3027-3036.e3 pubmed publisher |
| Mao H, Tang Z, Li H, Sun B, Tan M, Fan S, et al. Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1. Protein Cell. 2019;: pubmed publisher |
| Bae J, Choi H, Shin D, Na H, Park N, Kim J, et al. Fine particulate matter (PM2.5) inhibits ciliogenesis by increasing SPRR3 expression via c-Jun activation in RPE cells and skin keratinocytes. Sci Rep. 2019;9:3994 pubmed publisher |
| Izumi H, Li Y, Shibaki M, Mori D, Yasunami M, Sato S, et al. Recycling endosomal CD133 functions as an inhibitor of autophagy at the pericentrosomal region. Sci Rep. 2019;9:2236 pubmed publisher |
| Kunova Bosakova M, Nita A, Gregor T, Varecha M, Gudernová I, Fafilek B, et al. Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase. Proc Natl Acad Sci U S A. 2019;: pubmed publisher |
| Maerz L, Burkhalter M, Schilpp C, Wittekindt O, Frick M, Philipp M. Pharmacological cholesterol depletion disturbs ciliogenesis and ciliary function in developing zebrafish. Commun Biol. 2019;2:31 pubmed publisher |
| Tang T, Zhang Y, Wang Y, Cai Z, Lu Z, Li L, et al. HDAC1 and HDAC2 Regulate Intermediate Progenitor Positioning to Safeguard Neocortical Development. Neuron. 2019;101:1117-1133.e5 pubmed publisher |
| Shim J, Territo P, Simpson S, Watson J, Jiang L, Riley A, et al. Hydrocephalus in a rat model of Meckel Gruber syndrome with a TMEM67 mutation. Sci Rep. 2019;9:1069 pubmed publisher |
| Lee J, Yi S, Chang J, Kim J, Sul H, Park K, et al. Loss of Primary Cilia Results in the Development of Cancer in the Murine Thyroid Gland. Mol Cells. 2019;42:113-122 pubmed publisher |
| Verschuren E, Hoenderop J, Peters D, Arjona F, Bindels R. Tubular flow activates magnesium transport in the distal convoluted tubule. FASEB J. 2019;33:5034-5044 pubmed publisher |
| Capowski E, Samimi K, Mayerl S, Phillips M, Pinilla I, Howden S, et al. Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines. Development. 2019;146: pubmed publisher |
| Singer D, Thamm K, Zhuang H, Karbanova J, Gao Y, Walker J, et al. Prominin-1 controls stem cell activation by orchestrating ciliary dynamics. EMBO J. 2019;38: pubmed publisher |
| Chong Y, Lim T, Fu Y, Shin E, Tergaonkar V, Han W. Indian Hedgehog links obesity to development of hepatocellular carcinoma. Oncogene. 2019;38:2206-2222 pubmed publisher |
| Patnaik S, Kretschmer V, Brücker L, Schneider S, Volz A, Oancea Castillo L, et al. Bardet-Biedl Syndrome proteins regulate cilia disassembly during tissue maturation. Cell Mol Life Sci. 2019;76:757-775 pubmed publisher |
| Chen T, Lien W, Cheng H, Kuan T, Sheu S, Wang C. Chloroquine inhibits human retina pigmented epithelial cell growth and microtubule nucleation by downregulating p150glued. J Cell Physiol. 2019;234:10445-10457 pubmed publisher |
| Massa F, Tammaro R, Prado M, Cesana M, Lee B, Finley D, et al. The deubiquitinating enzyme Usp14 controls ciliogenesis and Hedgehog signaling. Hum Mol Genet. 2019;28:764-777 pubmed publisher |
| Kong M, Bak S, Han K, Kim J, Park J, Park K. Fragmentation of kidney epithelial cell primary cilia occurs by cisplatin and these cilia fragments are excreted into the urine. Redox Biol. 2019;20:38-45 pubmed publisher |
| Ikeuchi Y, Kogiso H, Hosogi S, Tanaka S, Shimamoto C, Matsumura H, et al. Carbocisteine stimulated an increase in ciliary bend angle via a decrease in [Cl-]i in mouse airway cilia. Pflugers Arch. 2019;471:365-380 pubmed publisher |
| Shivanna M, Anand M, Chakrabarti S, Khanna H. Ocular Ciliopathies: Genetic and Mechanistic Insights into Developing Therapies. Curr Med Chem. 2019;26:3120-3131 pubmed publisher |
| Vuong L, Iomini C, Balmer S, Esposito D, Aaronson S, Mlodzik M. Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling. Nat Commun. 2018;9:5304 pubmed publisher |
| Tu H, Qin X, Liu Z, Song Z, Hu H, Zhang Y, et al. Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis. Nat Commun. 2018;9:5277 pubmed publisher |
| Ford M, Yeyati P, Mali G, Keighren M, Waddell S, Mjoseng H, et al. A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice. Dev Cell. 2018;47:509-523.e5 pubmed publisher |
| Ramsbottom S, Molinari E, Srivastava S, Silberman F, Henry C, Alkanderi S, et al. Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model. Proc Natl Acad Sci U S A. 2018;115:12489-12494 pubmed publisher |
| Hoang Minh L, Dutra Clarke M, Breunig J, Sarkisian M. Glioma cell proliferation is enhanced in the presence of tumor-derived cilia vesicles. Cilia. 2018;7:6 pubmed publisher |
| Wang Q, Taschner M, Ganzinger K, Kelley C, Villasenor A, Heymann M, et al. Membrane association and remodeling by intraflagellar transport protein IFT172. Nat Commun. 2018;9:4684 pubmed publisher |
| Nagai T, Mukoyama S, Kagiwada H, Goshima N, Mizuno K. Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation. J Cell Sci. 2018;131: pubmed publisher |
| Vuolo L, Stevenson N, Heesom K, Stephens D. Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function. elife. 2018;7: pubmed publisher |
| Buskin A, Zhu L, Chichagova V, Basu B, Mozaffari Jovin S, Dolan D, et al. Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa. Nat Commun. 2018;9:4234 pubmed publisher |
| Sánchez Danés A, Larsimont J, Liagre M, Muñoz Couselo E, Lapouge G, Brisebarre A, et al. A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy. Nature. 2018;562:434-438 pubmed publisher |
| Alkanderi S, Molinari E, Shaheen R, Elmaghloob Y, Stephen L, Sammut V, et al. ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition. Am J Hum Genet. 2018;103:612-620 pubmed publisher |
| Wang L, Failler M, Fu W, Dynlacht B. A distal centriolar protein network controls organelle maturation and asymmetry. Nat Commun. 2018;9:3938 pubmed publisher |
| Stephen L, Elmaghloob Y, McIlwraith M, Yelland T, Castro Sánchez P, Roda Navarro P, et al. The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK. Dev Cell. 2018;47:122-132.e4 pubmed publisher |
| Kurtulmus B, Yuan C, Schuy J, Neuner A, Hata S, Kalamakis G, et al. LRRC45 contributes to early steps of axoneme extension. J Cell Sci. 2018;131: pubmed publisher |
| He K, Ma X, Xu T, Li Y, Hodge A, Zhang Q, et al. Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules. Nat Commun. 2018;9:3310 pubmed publisher |
| de Bruijn S, Verbakel S, de Vrieze E, Kremer H, Cremers F, Hoyng C, et al. Homozygous variants in KIAA1549, encoding a ciliary protein, are associated with autosomal recessive retinitis pigmentosa. J Med Genet. 2018;55:705-712 pubmed publisher |
| Abdelhamed Z, Ryan T, Fuller M, Coulson Gilmer C, Abdelmottaleb D, Wang T, et al. Characterization of Primary Cilia in Normal Fallopian Tube Epithelium and Serous Tubal Intraepithelial Carcinoma. Int J Gynecol Cancer. 2018;28:1535-1544 pubmed publisher |
| Zingg D, Debbache J, Peña Hernández R, Antunes A, Schaefer S, Cheng P, et al. EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation. Cancer Cell. 2018;34:69-84.e14 pubmed publisher |
| Dafinger C, Rinschen M, Borgal L, Ehrenberg C, Basten S, Franke M, et al. Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus. Exp Mol Med. 2018;50:75 pubmed publisher |
| Park S, Lim J, Ramakrishina S, Kim S, Kim W, Lee J, et al. Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination. Neuron. 2018;99:83-97.e7 pubmed publisher |
| Ohta S, Schoenwolf G. Dorsoventral differences in cAMP levels and correlated changes in the subcellular distribution of the PKA catalytic domain, provide further evidence that PKA signaling coordinates dorsoventral patterning of the otocyst. Dev Growth Differ. 2018;60:431-441 pubmed publisher |
| Coveney C, Collins I, Mc Fie M, Chanalaris A, Yamamoto K, Wann A. Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP-1-mediated endocytosis. FASEB J. 2018;:fj201800334 pubmed publisher |
| Jenks A, Vyse S, Wong J, Kostaras E, Keller D, Burgoyne T, et al. Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer. Cell Rep. 2018;23:3042-3055 pubmed publisher |
| Barny I, Perrault I, Michel C, Soussan M, Goudin N, Rio M, et al. Basal exon skipping and nonsense-associated altered splicing allows bypassing complete CEP290 loss-of-function in individuals with unusually mild retinal disease. Hum Mol Genet. 2018;: pubmed publisher |
| Liu Z, Lee J, Son M, Lim J, Dutta R, Maharjan Y, et al. Ciliogenesis is reciprocally regulated by PPARA and NR1H4/FXR through controlling autophagy in vitro and in vivo. Autophagy. 2018;14:1011-1027 pubmed publisher |
| Lee J, Yi S, Won M, Song Y, Yi H, Park Y, et al. Loss-of-function of IFT88 determines metabolic phenotypes in thyroid cancer. Oncogene. 2018;37:4455-4474 pubmed publisher |
| Wang B, Zhang Y, Dong H, Gong S, Wei B, Luo M, et al. Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice. Cell Death Dis. 2018;9:520 pubmed publisher |
| Takei R, Katoh Y, Nakayama K. Robust interaction of IFT70 with IFT52-IFT88 in the IFT-B complex is required for ciliogenesis. Biol Open. 2018;7: pubmed publisher |
| Wiegering A, Dildrop R, Kalfhues L, Spychala A, Kuschel S, Lier J, et al. Cell type-specific regulation of ciliary transition zone assembly in vertebrates. EMBO J. 2018;37: pubmed publisher |
| Maharjan Y, Lee J, Kwak S, Lim H, Dutta R, Liu Z, et al. Autophagy alteration prevents primary cilium disassembly in RPE1 cells. Biochem Biophys Res Commun. 2018;500:242-248 pubmed publisher |
| Johnson M, Sun X, Kodani A, Borges Monroy R, Girskis K, Ryu S, et al. Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size. Nature. 2018;556:370-375 pubmed publisher |
| Stevenson N, Bergen D, Xu A, Wyatt E, Henry F, McCaughey J, et al. Regulator of calcineurin-2 is a centriolar protein with a role in cilia length control. J Cell Sci. 2018;131: pubmed publisher |
| Beyer T, Bolz S, Junger K, Horn N, Moniruzzaman M, Wissinger Y, et al. CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement. Mol Cell Proteomics. 2018;17:1285-1294 pubmed publisher |
| Revenkova E, Liu Q, Gusella G, Iomini C. The Joubert syndrome protein ARL13B binds tubulin to maintain uniform distribution of proteins along the ciliary membrane. J Cell Sci. 2018;131: pubmed publisher |
| Shannon M, Fame R, Chau K, Dani N, Calicchio M, GELEOC G, et al. Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors. Am J Pathol. 2018;188:1334-1344 pubmed publisher |
| Tavano S, Taverna E, Kalebic N, Haffner C, Namba T, Dahl A, et al. Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7. Neuron. 2018;97:1299-1314.e8 pubmed publisher |
| Vion A, Alt S, Klaus Bergmann A, Szymborska A, Zheng T, Perovic T, et al. Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression. J Cell Biol. 2018;217:1651-1665 pubmed publisher |
| Jeong A, Ka H, Han S, Lee S, Lee E, Soh S, et al. Oncoprotein CIP2A promotes the disassembly of primary cilia and inhibits glycolytic metabolism. EMBO Rep. 2018;19: pubmed publisher |
| Sipos E, Komoly S, Acs P. Quantitative Comparison of Primary Cilia Marker Expression and Length in the Mouse Brain. J Mol Neurosci. 2018;64:397-409 pubmed publisher |
| Mohammed S, Arjona F, Verschuren E, Bakey Z, Alkema W, van Hijum S, et al. Primary cilia-regulated transcriptome in the renal collecting duct. FASEB J. 2018;32:3653-3668 pubmed publisher |
| Ogungbenro Y, Tena T, Gaboriau D, Lalor P, Dockery P, Philipp M, et al. Centrobin controls primary ciliogenesis in vertebrates. J Cell Biol. 2018;217:1205-1215 pubmed publisher |
| Canning P, Park K, Goncalves J, Li C, Howard C, Sharpe T, et al. CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function. Cell Rep. 2018;22:885-894 pubmed publisher |
| Bozal Basterra L, Martín Ruiz I, Pirone L, Liang Y, Sigurðsson J, Gonzalez Santamarta M, et al. Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome. Am J Hum Genet. 2018;102:249-265 pubmed publisher |
| Kunova Bosakova M, Varecha M, Hampl M, Durán I, Nita A, Buchtová M, et al. Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies. Hum Mol Genet. 2018;27:1093-1105 pubmed publisher |
| Han S, Jung J, Im S, Lee S, Jang B, Park K, et al. Deficiency of primary cilia in kidney epithelial cells induces epithelial to mesenchymal transition. Biochem Biophys Res Commun. 2018;496:450-454 pubmed publisher |
| Fernández Barrera J, Bernabé Rubio M, Casares Arias J, Rangel L, Fernández Martín L, Correas I, et al. The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression. J Cell Biol. 2018;217:929-944 pubmed publisher |
| May Simera H, Wan Q, Jha B, Hartford J, Khristov V, Dejene R, et al. Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells. Cell Rep. 2018;22:189-205 pubmed publisher |
| Kim Y, Osborn D, Lee J, Araki M, Araki K, Mohun T, et al. WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome. EMBO Rep. 2018;19:269-289 pubmed publisher |
| Hartill V, van de Hoek G, Patel M, Little R, Watson C, Berry I, et al. DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport. Hum Mol Genet. 2018;27:529-545 pubmed publisher |
| Takahashi K, Nagai T, Chiba S, Nakayama K, Mizuno K. Glucose deprivation induces primary cilium formation through mTORC1 inactivation. J Cell Sci. 2018;131: pubmed publisher |
| Ryan R, Failler M, Reilly M, Garfa Traoré M, Delous M, Filhol E, et al. Functional characterization of tektin-1 in motile cilia and evidence for TEKT1 as a new candidate gene for motile ciliopathies. Hum Mol Genet. 2018;27:266-282 pubmed publisher |
| Broix L, Asselin L, Silva C, Ivanova E, Tilly P, Gilet J, et al. Ciliogenesis and cell cycle alterations contribute to KIF2A-related malformations of cortical development. Hum Mol Genet. 2018;27:224-238 pubmed publisher |
| Lee S, Joo K, Jung E, Hong H, Seo J, Kim J. Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1. FASEB J. 2018;32:957-968 pubmed publisher |
| Wang Q, Cobo Stark P, Patel V, Somlo S, Han P, Igarashi P. Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease. Kidney Int. 2018;93:403-415 pubmed publisher |
| Martin L, Kaci N, Estibals V, Goudin N, Garfa Traoré M, Benoist Lasselin C, et al. Constitutively-active FGFR3 disrupts primary cilium length and IFT20 trafficking in various chondrocyte models of achondroplasia. Hum Mol Genet. 2018;27:1-13 pubmed publisher |
| Sigg M, Menchen T, Lee C, Johnson J, Jungnickel M, Choksi S, et al. Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways. Dev Cell. 2017;43:744-762.e11 pubmed publisher |
| Rafiullah R, Long A, Ivanova A, Ali H, Berkel S, Mustafa G, et al. A novel homozygous ARL13B variant in patients with Joubert syndrome impairs its guanine nucleotide-exchange factor activity. Eur J Hum Genet. 2017;25:1324-1334 pubmed publisher |
| Bizzotto S, Uzquiano A, Dingli F, Ershov D, Houllier A, Arras G, et al. Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex. Sci Rep. 2017;7:17308 pubmed publisher |
| Taulet N, Vitre B, Anguille C, Douanier A, Rocancourt M, Taschner M, et al. IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning. Nat Commun. 2017;8:1928 pubmed publisher |
| Hanke Gogokhia C, Wu Z, Sharif A, Yazigi H, Frederick J, Baehr W. The guanine nucleotide exchange factor Arf-like protein 13b is essential for assembly of the mouse photoreceptor transition zone and outer segment. J Biol Chem. 2017;292:21442-21456 pubmed publisher |
| Kazatskaya A, Kuhns S, Lambacher N, Kennedy J, Brear A, McManus G, et al. Primary Cilium Formation and Ciliary Protein Trafficking Is Regulated by the Atypical MAP Kinase MAPK15 in Caenorhabditis elegans and Human Cells. Genetics. 2017;207:1423-1440 pubmed publisher |
| Taniguchi K, Shao Y, Townshend R, Cortez C, Harris C, Meshinchi S, et al. An apicosome initiates self-organizing morphogenesis of human pluripotent stem cells. J Cell Biol. 2017;216:3981-3990 pubmed publisher |
| Srivastava S, Ramsbottom S, Molinari E, Alkanderi S, Filby A, White K, et al. A human patient-derived cellular model of Joubert syndrome reveals ciliary defects which can be rescued with targeted therapies. Hum Mol Genet. 2017;26:4657-4667 pubmed publisher |
| Schmitz F, Burtscher I, Stauber M, Gossler A, Lickert H. A novel Cre-inducible knock-in ARL13B-tRFP fusion cilium reporter. Genesis. 2017;55: pubmed publisher |
| Schock E, Brugmann S. Neural crest cells utilize primary cilia to regulate ventral forebrain morphogenesis via Hedgehog-dependent regulation of oriented cell division. Dev Biol. 2017;431:168-178 pubmed publisher |
| Thompson C, Plant J, Wann A, Bishop C, Novak P, Mitchison H, et al. Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling. Eur Cell Mater. 2017;34:128-141 pubmed publisher |
| Baek H, Shin H, Kim J, Shin N, Kim S, Yi M, et al. Primary cilia modulate TLR4-mediated inflammatory responses in hippocampal neurons. J Neuroinflammation. 2017;14:189 pubmed publisher |
| Windpassinger C, Piard J, Bonnard C, Alfadhel M, Lim S, Bisteau X, et al. CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays. Am J Hum Genet. 2017;101:391-403 pubmed publisher |
| Prosseda P, Luo N, Wang B, Alvarado J, Hu Y, Sun Y. Loss of OCRL increases ciliary PI(4,5)P2 in Lowe oculocerebrorenal syndrome. J Cell Sci. 2017;130:3447-3454 pubmed publisher |
| Roy K, Jerman S, Jozsef L, McNamara T, Onyekaba G, Sun Z, et al. Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation. J Biol Chem. 2017;292:17703-17717 pubmed publisher |
| Nagai T, Mizuno K. Jasplakinolide induces primary cilium formation through cell rounding and YAP inactivation. PLoS ONE. 2017;12:e0183030 pubmed publisher |
| Vestergaard M, Grubb S, Koefoed K, Anderson Jenkins Z, Grunnet Lauridsen K, Calloe K, et al. Human Embryonic Stem Cell-Derived Cardiomyocytes Self-Arrange with Areas of Different Subtypes During Differentiation. Stem Cells Dev. 2017;26:1566-1577 pubmed publisher |
| Kohli P, Höhne M, Jüngst C, Bertsch S, Ebert L, Schauss A, et al. The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia. EMBO Rep. 2017;18:1521-1535 pubmed publisher |
| Kopinke D, Roberson E, Reiter J. Ciliary Hedgehog Signaling Restricts Injury-Induced Adipogenesis. Cell. 2017;170:340-351.e12 pubmed publisher |
| Shimada H, Lu Q, Insinna Kettenhofen C, Nagashima K, English M, Semler E, et al. In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations. Cell Rep. 2017;20:384-396 pubmed publisher |
| Giddens M, Wong J, Schroeder J, Farrow E, Smith B, Owino S, et al. GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant. Neurobiol Dis. 2017;106:181-190 pubmed publisher |
| Kanie T, Abbott K, Mooney N, Plowey E, Demeter J, JACKSON P. The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base. Dev Cell. 2017;42:22-36.e12 pubmed publisher |
| Lancaster M, Corsini N, Wolfinger S, Gustafson E, Phillips A, Burkard T, et al. Guided self-organization and cortical plate formation in human brain organoids. Nat Biotechnol. 2017;35:659-666 pubmed publisher |
| Lu H, Galeano M, Ott E, Kaeslin G, Kausalya P, Kramer C, et al. Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease. Nat Genet. 2017;49:1025-1034 pubmed publisher |
| Stayner C, Poole C, McGlashan S, Pilanthananond M, Brauning R, Markie D, et al. An ovine hepatorenal fibrocystic model of a Meckel-like syndrome associated with dysmorphic primary cilia and TMEM67 mutations. Sci Rep. 2017;7:1601 pubmed publisher |
| Rakotomamonjy J, Brunner M, Jüschke C, Zang K, Huang E, Reichardt L, et al. Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia. Neural Dev. 2017;12:7 pubmed publisher |
| Trempus C, Song W, Lazrak A, Yu Z, Creighton J, Young B, et al. A novel role for primary cilia in airway remodeling. Am J Physiol Lung Cell Mol Physiol. 2017;313:L328-L338 pubmed publisher |
| Gabriel E, Gopalakrishnan J. Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders. J Vis Exp. 2017;: pubmed publisher |
| Schwarz N, Lane A, Jovanovic K, Parfitt D, Aguilà M, Thompson C, et al. Arl3 and RP2 regulate the trafficking of ciliary tip kinesins. Hum Mol Genet. 2017;26:2480-2492 pubmed publisher |
| Nguyen T, Hull S, Roepman R, van den Born L, Oud M, de Vrieze E, et al. Missense mutations in the WD40 domain of AHI1 cause non-syndromic retinitis pigmentosa. J Med Genet. 2017;54:624-632 pubmed publisher |
| Durán I, Taylor S, Zhang W, Martin J, Qureshi F, Jacques S, et al. Mutations in IFT-A satellite core component genes IFT43 and IFT121 produce short rib polydactyly syndrome with distinctive campomelia. Cilia. 2017;6:7 pubmed publisher |
| Kane M, Davids M, Bond M, Adams C, Grout M, Phelps I, et al. Abnormal glycosylation in Joubert syndrome type 10. Cilia. 2017;6:2 pubmed publisher |
| Millington G, Elliott K, Chang Y, Chang C, Dlugosz A, Brugmann S. Cilia-dependent GLI processing in neural crest cells is required for tongue development. Dev Biol. 2017;424:124-137 pubmed publisher |
| Yeyati P, Schiller R, Mali G, Kasioulis I, Kawamura A, Adams I, et al. KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability. J Cell Biol. 2017;216:999-1013 pubmed publisher |
| Stephen J, Vilboux T, Mian L, Kuptanon C, Sinclair C, Yildirimli D, et al. Mutations in KIAA0753 cause Joubert syndrome associated with growth hormone deficiency. Hum Genet. 2017;136:399-408 pubmed publisher |
| Katoh Y, Michisaka S, Nozaki S, Funabashi T, Hirano T, Takei R, et al. Practical method for targeted disruption of cilia-related genes by using CRISPR/Cas9-mediated, homology-independent knock-in system. Mol Biol Cell. 2017;28:898-906 pubmed publisher |
| Thorpe S, Gambassi S, Thompson C, Chandrakumar C, Santucci A, Knight M. Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria. J Cell Physiol. 2017;232:2407-2417 pubmed publisher |
| Schou K, Mogensen J, Morthorst S, Nielsen B, Aleliunaite A, Serra Marques A, et al. KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling. Nat Commun. 2017;8:14177 pubmed publisher |
| Gabriel E, Ramani A, Karow U, Gottardo M, Natarajan K, Gooi L, et al. Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids. Cell Stem Cell. 2017;20:397-406.e5 pubmed publisher |
| Zhao L, Arsenault M, Ng E, Longmuss E, Chau T, Hartwig S, et al. SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice. Dev Biol. 2017;423:46-56 pubmed publisher |
| Flanagan A, Stavenschi E, Basavaraju S, Gaboriau D, Hoey D, Morrison C. Centriole splitting caused by loss of the centrosomal linker protein C-NAP1 reduces centriolar satellite density and impedes centrosome amplification. Mol Biol Cell. 2017;28:736-745 pubmed publisher |
| Phua S, Chiba S, Suzuki M, Su E, Roberson E, Pusapati G, et al. Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision. Cell. 2017;168:264-279.e15 pubmed publisher |
| Li S, O Neill S, Zhang Y, Holtzman M, Takemaru K, Korach K, et al. Estrogen receptor α is required for oviductal transport of embryos. FASEB J. 2017;31:1595-1607 pubmed publisher |
| Funabashi T, Katoh Y, Michisaka S, Terada M, Sugawa M, Nakayama K. Ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46-IFT56 as well as on its nuclear localization signal. Mol Biol Cell. 2017;28:624-633 pubmed publisher |
| Kobayashi T, Nakazono K, Tokuda M, Mashima Y, Dynlacht B, Itoh H. HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma. EMBO Rep. 2017;18:334-343 pubmed publisher |
| Choi H, Shin J, Kim E, Park S, Bae I, Jo Y, et al. Primary Cilia Negatively Regulate Melanogenesis in Melanocytes and Pigmentation in a Human Skin Model. PLoS ONE. 2016;11:e0168025 pubmed publisher |
| Nozaki S, Katoh Y, Terada M, Michisaka S, Funabashi T, Takahashi S, et al. Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E. J Cell Sci. 2017;130:563-576 pubmed publisher |
| Dores C, Alpaugh W, Su L, Biernaskie J, Dobrinski I. Primary cilia on porcine testicular somatic cells and their role in hedgehog signaling and tubular morphogenesis in vitro. Cell Tissue Res. 2017;368:215-223 pubmed publisher |
| Lee J, Yi S, Kang Y, Chang J, Kim J, Sul H, et al. Defective ciliogenesis in thyroid hürthle cell tumors is associated with increased autophagy. Oncotarget. 2016;7:79117-79130 pubmed publisher |
| Fu W, Wang L, Kim S, Li J, Dynlacht B. Role for the IFT-A Complex in Selective Transport to the Primary Cilium. Cell Rep. 2016;17:1505-1517 pubmed publisher |
| Chang C, Chang Y, Millington G, Brugmann S. Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline. PLoS Genet. 2016;12:e1006351 pubmed publisher |
| Giridhar P, Bell S, Sridharan A, Rajavelu P, Kitzmiller J, Na C, et al. Airway Epithelial KIF3A Regulates Th2 Responses to Aeroallergens. J Immunol. 2016;197:4228-4239 pubmed |
| May Simera H, Gumerson J, Gao C, Campos M, Cologna S, Beyer T, et al. Loss of MACF1 Abolishes Ciliogenesis and Disrupts Apicobasal Polarity Establishment in the Retina. Cell Rep. 2016;17:1399-1413 pubmed publisher |
| Wang C, Tsai H, Syu J, Chen T, Su M. Primary Cilium-Regulated EG-VEGF Signaling Facilitates Trophoblast Invasion. J Cell Physiol. 2017;232:1467-1477 pubmed publisher |
| Chen H, Kaya K, Dong L, Swaroop A. Three-dimensional retinal organoids from mouse pluripotent stem cells mimic in vivo development with enhanced stratification and rod photoreceptor differentiation. Mol Vis. 2016;22:1077-1094 pubmed |
| Durán I, Taylor S, Zhang W, Martin J, Forlenza K, Spiro R, et al. Destabilization of the IFT-B cilia core complex due to mutations in IFT81 causes a Spectrum of Short-Rib Polydactyly Syndrome. Sci Rep. 2016;6:34232 pubmed publisher |
| Wang B, Zheng Y, Shi H, Du X, Zhang Y, Wei B, et al. Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice. Genes Brain Behav. 2017;16:296-307 pubmed publisher |
| Kim M, Suh Y, Oh J, Lee B, Kim J, Jang S. KIF3A binds to β-arrestin for suppressing Wnt/β-catenin signalling independently of primary cilia in lung cancer. Sci Rep. 2016;6:32770 pubmed publisher |
| Ramos R, Toia A, Pasternack D, Dotzler T, Cuoco J, Esposito A, et al. Neuroanatomical characterization of the cellular and axonal architecture of subcortical band heterotopia in the BXD29-Tlr4lps-2J/J mouse cortex. Neuroscience. 2016;337:48-65 pubmed publisher |
| Song P, Dudinsky L, Fogerty J, Gaivin R, Perkins B. Arl13b Interacts With Vangl2 to Regulate Cilia and Photoreceptor Outer Segment Length in Zebrafish. Invest Ophthalmol Vis Sci. 2016;57:4517-26 pubmed publisher |
| Caspary T, Marazziti D, Berbari N. Methods for Visualization of Neuronal Cilia. Methods Mol Biol. 2016;1454:203-14 pubmed publisher |
| Verdier P, Morthorst S, Pedersen L. Targeting of ASH Domain-Containing Proteins to the Centrosome. Methods Mol Biol. 2016;1454:15-33 pubmed publisher |
| Li P, Lee E, Du F, Gordon R, Yuelling L, Liu Y, et al. Nestin Mediates Hedgehog Pathway Tumorigenesis. Cancer Res. 2016;76:5573-83 pubmed publisher |
| Dutta N, Seo S. RPGR, a prenylated retinal ciliopathy protein, is targeted to cilia in a prenylation- and PDE6D-dependent manner. Biol Open. 2016;5:1283-9 pubmed publisher |
| Paige Taylor S, Kunova Bosakova M, Varecha M, Balek L, Bárta T, Trantirek L, et al. An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome. Hum Mol Genet. 2016;25:3998-4011 pubmed publisher |
| Lee S, Lee M, Choi T, Hong H, Seo J, Kim C, et al. MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment. Sci Rep. 2016;6:27284 pubmed publisher |
| Parker A, Le M, Smith T, Hoang Minh L, Atkinson E, Ugartemendia G, et al. Neonatal seizures induced by pentylenetetrazol or kainic acid disrupt primary cilia growth on developing mouse cortical neurons. Exp Neurol. 2016;282:119-27 pubmed publisher |
| Li Y, Tian X, Ma M, Jerman S, Kong S, Somlo S, et al. Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney Cysts. J Am Soc Nephrol. 2016;27:3628-3638 pubmed |
| Parfitt D, Lane A, Ramsden C, Carr A, Munro P, Jovanovic K, et al. Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups. Cell Stem Cell. 2016;18:769-81 pubmed publisher |
| Oud M, Bonnard C, Mans D, Altunoglu U, Tohari S, Ng A, et al. A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndrome. Cilia. 2016;5:8 pubmed publisher |
| Li L, Grausam K, Wang J, Lun M, Ohli J, Lidov H, et al. Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells. Nat Cell Biol. 2016;18:418-30 pubmed publisher |
| Yadav S, Sharma N, Liu C, Dong L, Li T, Swaroop A. Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis. Development. 2016;143:1491-501 pubmed publisher |
| Di Pietro C, Marazziti D, La Sala G, Abbaszadeh Z, Golini E, Matteoni R, et al. Primary Cilia in the Murine Cerebellum and in Mutant Models of Medulloblastoma. Cell Mol Neurobiol. 2017;37:145-154 pubmed publisher |
| Gabriel E, Wason A, Ramani A, Gooi L, Keller P, Pozniakovsky A, et al. CPAP promotes timely cilium disassembly to maintain neural progenitor pool. EMBO J. 2016;35:803-19 pubmed publisher |
| Casey J, Brennan K, Scheidel N, McGettigan P, Lavin P, Carter S, et al. Recessive NEK9 mutation causes a lethal skeletal dysplasia with evidence of cell cycle and ciliary defects. Hum Mol Genet. 2016;25:1824-35 pubmed publisher |
| Dummer A, Poelma C, DeRuiter M, Goumans M, Hierck B. Measuring the primary cilium length: improved method for unbiased high-throughput analysis. Cilia. 2016;5:7 pubmed publisher |
| Hanke Gogokhia C, Wu Z, Gerstner C, Frederick J, Zhang H, Baehr W. Arf-like Protein 3 (ARL3) Regulates Protein Trafficking and Ciliogenesis in Mouse Photoreceptors. J Biol Chem. 2016;291:7142-55 pubmed publisher |
| Dinsmore C, Reiter J. Endothelial primary cilia inhibit atherosclerosis. EMBO Rep. 2016;17:156-66 pubmed publisher |
| Zhang C, Zhang W, Lu Y, Yan X, Yan X, Zhu X, et al. NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1. Cell Res. 2016;26:239-53 pubmed publisher |
| Kurtulmus B, Wang W, Ruppert T, Neuner A, Cerikan B, Viol L, et al. WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis. J Cell Sci. 2016;129:621-36 pubmed publisher |
| Lambacher N, Bruel A, van Dam T, Szymanska K, Slaats G, Kuhns S, et al. TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome. Nat Cell Biol. 2016;18:122-31 pubmed publisher |
| Seixas C, Choi S, Polgar N, Umberger N, East M, Zuo X, et al. Arl13b and the exocyst interact synergistically in ciliogenesis. Mol Biol Cell. 2016;27:308-20 pubmed publisher |
| Yee L, Garcia Gonzalo F, Bowie R, Li C, Kennedy J, Ashrafi K, et al. Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling. PLoS Genet. 2015;11:e1005627 pubmed publisher |
| Thompson C, Wiles A, Poole C, Knight M. Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling. FASEB J. 2016;30:716-26 pubmed publisher |
| Bizet A, Becker Heck A, Ryan R, Weber K, Filhol E, Krug P, et al. Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization. Nat Commun. 2015;6:8666 pubmed publisher |
| Lokaj M, Kösling S, Koerner C, Lange S, van Beersum S, van Reeuwijk J, et al. The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function. Structure. 2015;23:2122-32 pubmed publisher |
| Singh J, Wen X, Scales S. The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels. J Biol Chem. 2015;290:29663-75 pubmed publisher |
| Joiner A, Green W, McIntyre J, Allen B, Schwob J, Martens J. Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium. J Neurosci. 2015;35:13761-72 pubmed publisher |
| Jiang S, Du J, Kong Q, Li C, Li Y, Sun H, et al. A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation. PLoS ONE. 2015;10:e0139830 pubmed publisher |
| Lim Y, McGlashan S, Cooling M, Long D. Culture and detection of primary cilia in endothelial cell models. Cilia. 2015;4:11 pubmed publisher |
| Malicdan M, Vilboux T, Stephen J, Maglic D, Mian L, Konzman D, et al. Mutations in human homologue of chicken talpid3 gene (KIAA0586) cause a hybrid ciliopathy with overlapping features of Jeune and Joubert syndromes. J Med Genet. 2015;52:830-9 pubmed publisher |
| Nielsen B, Malinda R, Schmid F, Pedersen S, Christensen S, Pedersen L. PDGFRβ and oncogenic mutant PDGFRα D842V promote disassembly of primary cilia through a PLCγ- and AURKA-dependent mechanism. J Cell Sci. 2015;128:3543-9 pubmed publisher |
| Majumder S, Cash A, Fisk H. Non-Overlapping Distributions and Functions of the VDAC Family in Ciliogenesis. Cells. 2015;4:331-53 pubmed publisher |
| Datta P, Allamargot C, Hudson J, Andersen E, Bhattarai S, Drack A, et al. Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome. Proc Natl Acad Sci U S A. 2015;112:E4400-9 pubmed publisher |
| Wheway G, Schmidts M, Mans D, Szymanska K, Nguyen T, Racher H, et al. An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes. Nat Cell Biol. 2015;17:1074-1087 pubmed publisher |
| Lim Y, Tang B. A role for Rab23 in the trafficking of Kif17 to the primary cilium. J Cell Sci. 2015;128:2996-3008 pubmed publisher |
| Taylor S, Dantas T, Durán I, Wu S, Lachman R, Nelson S, et al. Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome. Nat Commun. 2015;6:7092 pubmed publisher |
| Rao K, Li L, Anand M, Khanna H. Ablation of retinal ciliopathy protein RPGR results in altered photoreceptor ciliary composition. Sci Rep. 2015;5:11137 pubmed publisher |
| Nygaard M, Almstrup K, Lindbæk L, Christensen S, Svingen T. Cell context-specific expression of primary cilia in the human testis and ciliary coordination of Hedgehog signalling in mouse Leydig cells. Sci Rep. 2015;5:10364 pubmed publisher |
| Hong H, Kim J, Kim J. Myosin heavy chain 10 (MYH10) is required for centriole migration during the biogenesis of primary cilia. Biochem Biophys Res Commun. 2015;461:180-5 pubmed publisher |
| Paridaen J, Huttner W, Wilsch Bräuninger M. Analysis of primary cilia in the developing mouse brain. Methods Cell Biol. 2015;127:93-129 pubmed publisher |
| Hoshi M, Wang J, Jain S, Mahjoub M. Imaging centrosomes and cilia in the mouse kidney. Methods Cell Biol. 2015;127:1-17 pubmed publisher |
| Chen T, Syu J, Han T, Cheng H, Lu F, Wang C. Cell Cycle-Dependent Localization of Dynactin Subunit p150 glued at Centrosome. J Cell Biochem. 2015;116:2049-60 pubmed publisher |
| Prosser S, Morrison C. Centrin2 regulates CP110 removal in primary cilium formation. J Cell Biol. 2015;208:693-701 pubmed publisher |
| Miyamoto T, Hosoba K, Ochiai H, Royba E, Izumi H, Sakuma T, et al. The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation. Cell Rep. 2015;10:664-673 pubmed publisher |
| Snedecor E, Sung C, Moncayo A, Rothstein B, Mockler D, Tonnesen M, et al. Loss of primary cilia in melanoma cells is likely independent of proliferation and cell cycle progression. J Invest Dermatol. 2015;135:1456-1458 pubmed publisher |
| Carpenter B, Barry R, Verhey K, Allen B. The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function. J Cell Sci. 2015;128:1034-50 pubmed publisher |
| Gainullin V, Hopp K, Ward C, Hommerding C, Harris P. Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner. J Clin Invest. 2015;125:607-20 pubmed publisher |
| Lu H, Toh M, Narasimhan V, Thamilselvam S, Choksi S, Roy S. A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation. Dev Biol. 2015;397:225-36 pubmed publisher |
