This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
JAK2
catalog :
17670-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunoprecipitation
citations: 31
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 4b
Xiang S, Chen K, Xu L, Wang T, Guo C. Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway. Drug Des Devel Ther. 2020;14:129-143 pubmed publisher
Song X, Yang W, Wu C, Han Y, Lu Y. USP9X promotes the proliferation, invasion and metastasis of liver cancer cells through regulating the JAK2/STAT3 signaling. Oncol Lett. 2020;20:2897-2905 pubmed publisher
Li Y, Zhai P, Zheng Y, Zhang J, Kellum J, Peng Z. Csf2 Attenuated Sepsis-Induced Acute Kidney Injury by Promoting Alternative Macrophage Transition. Front Immunol. 2020;11:1415 pubmed publisher
Zhang J, Sun Z, Lin N, Lu W, Huang X, Weng J, et al. Fucoidan from Fucus vesiculosus attenuates doxorubicin-induced acute cardiotoxicity by regulating JAK2/STAT3-mediated apoptosis and autophagy. Biomed Pharmacother. 2020;130:110534 pubmed publisher
Dong X, Wu D, Zhang Y, Jia L, Pan X, Sun J, et al. Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway. Antioxidants (Basel). 2020;9: pubmed publisher
Ren S, Xing Y, Wang C, Jiang F, Liu G, Li Z, et al. Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway. Int J Biochem Cell Biol. 2020;125:105777 pubmed publisher
Kang N, Cao S, Jiang B, Zhang Q, Donkor P, Zhu Y, et al. Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells. Toxicol In Vitro. 2020;67:104885 pubmed publisher
Zhang J, Zhu S, Tan Q, Cheng D, Dai Q, Yang Z, et al. Combination therapy with ropivacaine-loaded liposomes and nutrient deprivation for simultaneous cancer therapy and cancer pain relief. Theranostics. 2020;10:4885-4899 pubmed publisher
Wang W, Hu X, Xia Z, Liu Z, Zhong Z, Lu Z, et al. Mild Hypothermia Attenuates Hepatic Ischemia-Reperfusion Injury through Regulating the JAK2/STAT3-CPT1a-Dependent Fatty Acid β-Oxidation. Oxid Med Cell Longev. 2020;2020:5849794 pubmed publisher
Chen M, Li Y, Xiao L, Dai G, Lu P, Wang Y, et al. AQP1 modulates tendon stem/progenitor cells senescence during tendon aging. Cell Death Dis. 2020;11:193 pubmed publisher
Xiong G, Deng Y, Liao X, Zhang J, Cheng B, Cao Z, et al. Graphene oxide nanoparticles induce hepatic dysfunction through the regulation of innate immune signaling in zebrafish (Danio rerio). Nanotoxicology. 2020;14:667-682 pubmed publisher
Zhang S, Zhou L, Zhang M, Wang Y, Wang M, Du J, et al. Berberine Maintains the Neutrophil N1 Phenotype to Reverse Cancer Cell Resistance to Doxorubicin. Front Pharmacol. 2019;10:1658 pubmed publisher
Guo X, Yan Z, Zhang G, Wang X, Pan Y, Huang M. STIP1 Regulates Proliferation and Migration of Lung Adenocarcinoma Through JAK2/STAT3 Signaling Pathway. Cancer Manag Res. 2019;11:10061-10072 pubmed publisher
Zhang Y, Zhou L, Zhang Z, Xu Q, Han X, Zhao Y, et al. Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5. Environ Sci Pollut Res Int. 2019;: pubmed publisher
Zhang Y, Wang S, Zhao T, Yang L, Guo S, Shi Y, et al. Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells. Ecotoxicol Environ Saf. 2019;184:109611 pubmed publisher
Zhu D, Yan Q, Li Y, Liu J, Liu H, Jiang Z. Effect of Konjac Mannan Oligosaccharides on Glucose Homeostasis via the Improvement of Insulin and Leptin Resistance In Vitro and In Vivo. Nutrients. 2019;11: pubmed publisher
Li P, Huang T, Zou Q, Liu D, Wang Y, Tan X, et al. FGFR2 Promotes Expression of PD-L1 in Colorectal Cancer via the JAK/STAT3 Signaling Pathway. J Immunol. 2019;202:3065-3075 pubmed publisher
Zhu Y, Meng Y, Zhao Y, Zhu J, Xu H, Zhang E, et al. Toxicological exploration of peptide-based cationic liposomes in siRNA delivery. Colloids Surf B Biointerfaces. 2019;179:66-76 pubmed publisher
Chen B, Yang L, Chen J, Chen Y, Zhang L, Wang L, et al. Inhibition of Connexin43 hemichannels with Gap19 protects cerebral ischemia/reperfusion injury via the JAK2/STAT3 pathway in mice. Brain Res Bull. 2019;146:124-135 pubmed publisher
Fang X, Liu Y, Lu J, Hong H, Yuan J, Zhang Y, et al. Protocatechuic aldehyde protects against isoproterenol-induced cardiac hypertrophy via inhibition of the JAK2/STAT3 signaling pathway. Naunyn Schmiedebergs Arch Pharmacol. 2018;391:1373-1385 pubmed publisher
Li M, Gao J, Li D, Yin Y. CEP55 Promotes Cell Motility via JAK2?STAT3?MMPs Cascade in Hepatocellular Carcinoma. Cells. 2018;7: pubmed publisher
Song Y, Gao L, Tang Z, Li H, Sun B, Chu P, et al. Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo. J Cell Physiol. 2018;234:777-788 pubmed publisher
Pan H, Fu C, Huang L, Jiang Y, Deng X, Guo J, et al. Anti-Obesity Effect of Chitosan Oligosaccharide Capsules (COSCs) in Obese Rats by Ameliorating Leptin Resistance and Adipogenesis. Mar Drugs. 2018;16: pubmed publisher
Xie L, Zeng Y, Dai Z, He W, Ke H, Lin Q, et al. Chemical and genetic inhibition of STAT3 sensitizes hepatocellular carcinoma cells to sorafenib induced cell death. Int J Biol Sci. 2018;14:577-585 pubmed publisher
Jing Y, Wu M, Zhang D, Chen D, Yang M, Mei S, et al. Triptolide delays disease progression in an adult rat model of polycystic kidney disease through the JAK2-STAT3 pathway. Am J Physiol Renal Physiol. 2018;315:F479-F486 pubmed publisher
Chen S, Wang Z, Wan S, Huang H, Liang H. Effect of modified Xiaochaihu decoction?containing serum on HepG2.2.15 cells via the JAK2/STAT3 signaling pathway. Mol Med Rep. 2017;16:7416-7422 pubmed publisher
Song Y, Kong L, Sun B, Gao L, Chu P, Ahsan A, et al. Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells. Cell Biol Int. 2017;41:1367-1378 pubmed publisher
Xiao J, Gong Y, Chen Y, Yu D, Wang X, Zhang X, et al. IL-6 promotes epithelial-to-mesenchymal transition of human peritoneal mesothelial cells possibly through the JAK2/STAT3 signaling pathway. Am J Physiol Renal Physiol. 2017;313:F310-F318 pubmed publisher
Li H, Lu Y, Pang Y, Li M, Cheng X, Chen J. Propofol enhances the cisplatin-induced apoptosis on cervical cancer cells via EGFR/JAK2/STAT3 pathway. Biomed Pharmacother. 2017;86:324-333 pubmed publisher
Cao N, Ma X, Guo Z, Zheng Y, Geng S, Meng M, et al. Oral kanglaite injection (KLTI) attenuates the lung cancer-promoting effect of high-fat diet (HFD)-induced obesity. Oncotarget. 2016;7:61093-61106 pubmed publisher
Huang C, Lei K, Tsang N. Paper-based microreactor array for rapid screening of cell signaling cascades. Lab Chip. 2016;16:2911-20 pubmed publisher
product information
CatalogNo :
17670-1-AP
AntigenName :
JAK2
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
Janus kinase 2 (a protein tyrosine kinase)
Immunogen :
Fusion Protein
Species :
human, mouse, rat, zebrafish
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
JAK 2, JAK2, Janus kinase 2, JTK10, Tyrosine protein kinase JAK2
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC039695
Category :
Apoptosis;Binding Proteins;Cell Cycle;Cytoskeleton/Scaffold Proteins;Development;Membrane Proteins;Metabolism;Signal transduction;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IHC 1:200 ; IP 1:300 ; WB 1:600 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.