This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
PTCH1 antibody - KD/KO Validated
catalog :
17520-1-AP
quantity :
150 ul
price :
USD299
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry
citations: 16
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 2b
Deng Q, Li P, Che M, Liu J, Biswas S, Ma G, et al. Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin. elife. 2019;8: pubmed publisher
McCurdy E, Chung K, Benitez Agosto C, Hengst U. Promotion of Axon Growth by the Secreted End of a Transcription Factor. Cell Rep. 2019;29:363-377.e5 pubmed publisher
Edens B, Vissers C, Su J, Arumugam S, Xu Z, Shi H, et al. FMRP Modulates Neural Differentiation through m6A-Dependent mRNA Nuclear Export. Cell Rep. 2019;28:845-854.e5 pubmed publisher
Zhu R, Gires O, Zhu L, Liu J, Li J, Yang H, et al. TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling. Nat Commun. 2019;10:2863 pubmed publisher
Kleene R, Loers G, Jakovcevski I, Mishra B, Schachner M. Histone H1 improves regeneration after mouse spinal cord injury and changes shape and gene expression of cultured astrocytes. Restor Neurol Neurosci. 2019;37:291-313 pubmed publisher
Song L, Chen X, Wang P, Gao S, Qu C, Liu L. Effects of baicalein on pancreatic cancer stem cells via modulation of sonic Hedgehog pathway. Acta Biochim Biophys Sin (Shanghai). 2018;50:586-596 pubmed publisher
Song K, Zheng G, Zhao Y. Liver kinase B1 suppresses growth of lung cancer cells through sonic hedgehog signaling pathway. Cell Biol Int. 2018;42:994-1005 pubmed publisher
Wan X, Kong Z, Chu K, Yi C, Hu J, Qin R, et al. Co-expression analysis revealed PTCH1-3'UTR promoted cell migration and invasion by activating miR-101-3p/SLC39A6 axis in non-small cell lung cancer: implicating the novel function of PTCH1. Oncotarget. 2018;9:4798-4813 pubmed publisher
Zhuang H, Cao G, Kou C, Liu T. CCL2/CCR2 axis induces hepatocellular carcinoma invasion and epithelial-mesenchymal transition in vitro through activation of the Hedgehog pathway. Oncol Rep. 2018;39:21-30 pubmed publisher
Matsumoto K, Shimo T, Kurio N, Okui T, Ibaragi S, Kunisada Y, et al. Low-intensity pulsed ultrasound stimulation promotes osteoblast differentiation through hedgehog signaling. J Cell Biochem. 2018;119:4352-4360 pubmed publisher
Yan B, Zhang Z, Jin D, Cai C, Jia C, Liu W, et al. mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation. Nat Commun. 2016;7:11151 pubmed publisher
Shimo T, Matsumoto K, Takabatake K, Aoyama E, Takebe Y, Ibaragi S, et al. The Role of Sonic Hedgehog Signaling in Osteoclastogenesis and Jaw Bone Destruction. PLoS ONE. 2016;11:e0151731 pubmed publisher
Pang P, Shimo T, Takada H, Matsumoto K, Yoshioka N, Ibaragi S, et al. Expression pattern of sonic hedgehog signaling and calcitonin gene-related peptide in the socket healing process after tooth extraction. Biochem Biophys Res Commun. 2015;467:21-6 pubmed publisher
Trnski D, Sabol M, Gojević A, Martinić M, Ozretic P, Musani V, et al. GSK3? and Gli3 play a role in activation of Hedgehog-Gli pathway in human colon cancer - Targeting GSK3? downregulates the signaling pathway and reduces cell proliferation. Biochim Biophys Acta. 2015;1852:2574-84 pubmed publisher
Zhang L, Zhou Y, Cheng C, Cui H, Cheng L, Kong P, et al. Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma. Am J Hum Genet. 2015;96:597-611 pubmed publisher
Gurung B, Hua X, Runske M, Bennett B, LiVolsi V, Roses R, et al. PTCH 1 staining of pancreatic neuroendocrine tumor (PNET) samples from patients with and without multiple endocrine neoplasia (MEN-1) syndrome reveals a potential therapeutic target. Cancer Biol Ther. 2015;16:219-24 pubmed publisher
product information
CatalogNo :
17520-1-AP
Product name :
PTCH1 antibody - KD/KO Validated
Product Type :
Primary
Host :
Rabbit
Species :
human, mouse
Clonlity :
Polyclonal
Package :
150 ul
PriceInUS :
USD299
Application :
WB, IHC, IF, ELISA
IsConjugated :
Unconjugated
IsoType :
IgG
Full Name :
patched homolog 1 (Drosophila)
Immunogen :
Peptide
Antigen Species :
human
Synonyms :
HPE7, NBCCS, Patched, patched homolog 1 (Drosophila), Patched1, Protein patched homolog 1, PTC, PTC1, PTCH, PTCH1, PTCH11
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Category :
Binding Proteins;Membrane Proteins;Neurology;
20ul trial size available :
20ul trial size available
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.