This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
IFT140
catalog :
17460-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 33
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:50; loading ...; fig 3C
Kim M, Froese C, Xie H, Trimble W. Immunofluorescent staining of septins in primary cilia. Methods Cell Biol. 2016;136:269-83 pubmed publisher
Yoshida S, Aoki K, Fujiwara K, Nakakura T, Kawamura A, Yamada K, et al. The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis. elife. 2020;9: pubmed publisher
Yu F, Li T, Sui Y, Chen Q, Yang S, Yang J, et al. O-GlcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis. Protein Cell. 2020;: pubmed publisher
Yan H, Chen C, Chen H, Hong H, Huang Y, Ling K, et al. TALPID3 and ANKRD26 selectively orchestrate FBF1 localization and cilia gating. Nat Commun. 2020;11:2196 pubmed publisher
Ni X, Wang J, Lv M, Liu C, Zhong Y, Tian S, et al. A novel homozygous mutation in WDR19 induces disorganization of microtubules in sperm flagella and nonsyndromic asthenoteratospermia. J Assist Reprod Genet. 2020;37:1431-1439 pubmed publisher
Ran J, Liu M, Feng J, Li H, Ma H, Song T, et al. ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia. Dev Cell. 2020;53:287-299.e5 pubmed publisher
Wang W, Allard B, Pottorf T, Wang H, Vivian J, Tran P. Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis. FASEB J. 2020;34:6369-6381 pubmed publisher
Lv M, Liu W, Chi W, Ni X, Wang J, Cheng H, et al. Homozygous mutations in DZIP1 can induce asthenoteratospermia with severe MMAF. J Med Genet. 2020;57:445-453 pubmed publisher
Nozaki S, Castro Araya R, Katoh Y, Nakayama K. Requirement of IFT-B-BBSome complex interaction in export of GPR161 from cilia. Biol Open. 2019;8: pubmed publisher
Wang X, Sha Y, Wang W, Cui Y, Chen J, Yan W, et al. Novel IFT140 variants cause spermatogenic dysfunction in humans. Mol Genet Genomic Med. 2019;7:e920 pubmed publisher
Tao D, Xue H, Zhang C, Li G, Sun Y. The Role of IFT140 in Osteogenesis of Adult Mice Long Bone. J Histochem Cytochem. 2019;:22155419847188 pubmed publisher
Liu W, He X, Yang S, Zouari R, Wang J, Wu H, et al. Bi-allelic Mutations in TTC21A Induce Asthenoteratospermia in Humans and Mice. Am J Hum Genet. 2019;104:738-748 pubmed publisher
Vuong L, Iomini C, Balmer S, Esposito D, Aaronson S, Mlodzik M. Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling. Nat Commun. 2018;9:5304 pubmed publisher
Bowie E, Norris R, Anderson K, Goetz S. Spinocerebellar ataxia type 11-associated alleles of Ttbk2 dominantly interfere with ciliogenesis and cilium stability. PLoS Genet. 2018;14:e1007844 pubmed publisher
Oud M, Latour B, Bakey Z, Letteboer S, Lugtenberg D, Wu K, et al. Cellular ciliary phenotyping indicates pathogenicity of novel variants in IFT140 and confirms a Mainzer-Saldino syndrome diagnosis. Cilia. 2018;7:1 pubmed publisher
Vuolo L, Stevenson N, Heesom K, Stephens D. Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function. elife. 2018;7: pubmed publisher
Wang L, Failler M, Fu W, Dynlacht B. A distal centriolar protein network controls organelle maturation and asymmetry. Nat Commun. 2018;9:3938 pubmed publisher
Funabashi T, Katoh Y, Okazaki M, Sugawa M, Nakayama K. Interaction of heterotrimeric kinesin-II with IFT-B-connecting tetramer is crucial for ciliogenesis. J Cell Biol. 2018;217:2867-2876 pubmed publisher
Forbes T, Howden S, Lawlor K, Phipson B, Maksimovic J, Hale L, et al. Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms. Am J Hum Genet. 2018;102:816-831 pubmed publisher
Takei R, Katoh Y, Nakayama K. Robust interaction of IFT70 with IFT52-IFT88 in the IFT-B complex is required for ciliogenesis. Biol Open. 2018;7: pubmed publisher
Silva L, Jacobs D, Allard B, Fields T, Sharma M, Wallace D, et al. Inhibition of Hedgehog signaling suppresses proliferation and microcyst formation of human Autosomal Dominant Polycystic Kidney Disease cells. Sci Rep. 2018;8:4985 pubmed publisher
Ye F, Nager A, Nachury M. BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone. J Cell Biol. 2018;217:1847-1868 pubmed publisher
Li G, Liu M, Zhang S, Wan H, Zhang Q, Yue R, et al. Essential Role of IFT140 in Promoting Dentinogenesis. J Dent Res. 2018;97:423-431 pubmed publisher
Taulet N, Vitre B, Anguille C, Douanier A, Rocancourt M, Taschner M, et al. IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning. Nat Commun. 2017;8:1928 pubmed publisher
Shimada H, Lu Q, Insinna Kettenhofen C, Nagashima K, English M, Semler E, et al. In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations. Cell Rep. 2017;20:384-396 pubmed publisher
Kanie T, Abbott K, Mooney N, Plowey E, Demeter J, JACKSON P. The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base. Dev Cell. 2017;42:22-36.e12 pubmed publisher
Phua S, Chiba S, Suzuki M, Su E, Roberson E, Pusapati G, et al. Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision. Cell. 2017;168:264-279.e15 pubmed publisher
Nozaki S, Katoh Y, Terada M, Michisaka S, Funabashi T, Takahashi S, et al. Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E. J Cell Sci. 2017;130:563-576 pubmed publisher
Fu W, Wang L, Kim S, Li J, Dynlacht B. Role for the IFT-A Complex in Selective Transport to the Primary Cilium. Cell Rep. 2016;17:1505-1517 pubmed publisher
Garcia Gonzalo F, Phua S, Roberson E, Garcia G, Abedin M, Schurmans S, et al. Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling. Dev Cell. 2015;34:400-409 pubmed publisher
Siller S, Burke M, Li F, Takemaru K. Chibby functions to preserve normal ciliary morphology through the regulation of intraflagellar transport in airway ciliated cells. Cell Cycle. 2015;14:3163-72 pubmed publisher
Ran J, Yang Y, Li D, Liu M, Zhou J. Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly. Sci Rep. 2015;5:12917 pubmed publisher
Xu Y, Cao J, Huang S, Feng D, Zhang W, Zhu X, et al. Characterization of tetratricopeptide repeat-containing proteins critical for cilia formation and function. PLoS ONE. 2015;10:e0124378 pubmed publisher
product information
CatalogNo :
17460-1-AP
AntigenName :
IFT140
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
intraflagellar transport 140 homolog (Chlamydomonas)
Immunogen :
Recombinant Protein
Species :
human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, CoIP, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
c305C8.4, c380F5.1, gs114, IFT140, KIAA0590, WDTC2
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC035577
Category :
Cytoskeleton/Scaffold Proteins;Membrane Proteins;Miscellaneous;Signal transduction;Transport/Trafficking;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IHC 1:200 ; IP 1:300 ; WB 1:300 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.