| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; human; fig 1a
| Otera H, Miyata N, Kuge O, Mihara K. Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling. J Cell Biol. 2016;212:531-44 pubmed publisher |
- western blot knockout validation; mouse; loading ...; fig s4a
| Toyama E, Herzig S, Courchet J, Lewis T, Losón O, Hellberg K, et al. Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress. Science. 2016;351:275-281 pubmed publisher |
- western blot; human; loading ...; fig 3g
| Hammerschmidt P, Ostkotte D, Nolte H, Gerl M, Jais A, Brunner H, et al. CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity. Cell. 2019;177:1536-1552.e23 pubmed publisher |
- immunocytochemistry; rat; fig 5g
| Rangaraju V, Lauterbach M, Schuman E. Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity. Cell. 2019;176:73-84.e15 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 6e
| Velázquez Villegas L, Perino A, Lemos V, Zietak M, Nomura M, Pols T, et al. TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue. Nat Commun. 2018;9:245 pubmed publisher |
- western blot; mouse; loading ...; fig 4a
- western blot; human; loading ...; fig 1a
| Zhao F, Wang W, Wang C, Siedlak S, Fujioka H, Tang B, et al. Mfn2 protects dopaminergic neurons exposed to paraquat both in vitro and in vivo: Implications for idiopathic Parkinson's disease. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1359-1370 pubmed publisher |
- western blot; human; loading ...; fig sf1
| Lee J, Westrate L, Wu H, Page C, Voeltz G. Multiple dynamin family members collaborate to drive mitochondrial division. Nature. 2016;540:139-143 pubmed publisher |
- western blot; mouse; loading ...; fig 4b
| Franco A, Kitsis R, Fleischer J, Gavathiotis E, Kornfeld O, Gong G, et al. Correcting mitochondrial fusion by manipulating mitofusin conformations. Nature. 2016;540:74-79 pubmed publisher |
- western blot; mouse; 1:500; fig 6
| Bal N, Maurya S, Singh S, Wehrens X, Periasamy M. Increased Reliance on Muscle-based Thermogenesis upon Acute Minimization of Brown Adipose Tissue Function. J Biol Chem. 2016;291:17247-57 pubmed publisher |
- western blot; mouse; fig s2
| Korwitz A, Merkwirth C, Richter Dennerlein R, Tröder S, Sprenger H, Quirós P, et al. Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol. 2016;212:157-66 pubmed publisher |
| Ma D, Zheng B, Liu H, Zhao Y, Liu X, Zhang X, et al. Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission. PLoS Biol. 2020;18:e3000808 pubmed publisher |
| Mou J, Xu J, Wang Z, Wang C, Yang X, Wang X, et al. Effects of photoperiod on morphology and function in testis and epididymis of Cricetulus barabensis. J Cell Physiol. 2020;: pubmed publisher |
| Moyzis A, Lally N, Liang W, Leon L, Najor R, Orogo A, et al. Mcl-1-mediated mitochondrial fission protects against stress but impairs cardiac adaptation to exercise. J Mol Cell Cardiol. 2020;146:109-120 pubmed publisher |
| Jing X, Du T, Yang X, Zhang W, Wang G, Liu X, et al. Desferoxamine protects against glucocorticoid-induced osteonecrosis of the femoral head via activating HIF-1α expression. J Cell Physiol. 2020;: pubmed publisher |
| Wang Z, Xu J, Mou J, Kong X, Wu M, Xue H, et al. Photoperiod Affects Harderian Gland Morphology and Secretion in Female Cricetulus barabensis: Autophagy, Apoptosis, and Mitochondria. Front Physiol. 2020;11:408 pubmed publisher |
| Zhang W, Zhang H, Yao W, Li L, Niu P, Huo Y, et al. Morphometric, Hemodynamic, and Multi-Omics Analyses in Heart Failure Rats with Preserved Ejection Fraction. Int J Mol Sci. 2020;21: pubmed publisher |
| Ahn Y, Sabouny R, Villa B, Yee N, Mychasiuk R, Uddin G, et al. Aberrant Mitochondrial Morphology and Function in the BTBR Mouse Model of Autism Is Improved by Two Weeks of Ketogenic Diet. Int J Mol Sci. 2020;21: pubmed publisher |
| Nagashima S, Tábara L, Tilokani L, Paupe V, Anand H, Pogson J, et al. Golgi-derived PI(4)P-containing vesicles drive late steps of mitochondrial division. Science. 2020;367:1366-1371 pubmed publisher |
| Tokuyama T, Hirai A, Shiiba I, Ito N, Matsuno K, Takeda K, et al. Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease Patients. Biomolecules. 2020;10: pubmed publisher |
| Guo J, Ren R, Yao X, Ye Y, Sun K, Lin J, et al. PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission. Aging (Albany NY). 2020;12:3976-3992 pubmed publisher |
| Lee Y, Nam Y, Shin K, Yoon S, Park W, Joung J, et al. Androgen-induced expression of DRP1 regulates mitochondrial metabolic reprogramming in prostate cancer. Cancer Lett. 2020;471:72-87 pubmed publisher |
| Heo J, Harper N, Paulo J, Li M, Xu Q, Coughlin M, et al. Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy. Sci Adv. 2019;5:eaay4624 pubmed publisher |
| Ma Y, Du M, Yang F, Mai Z, Zhang C, Qu W, et al. Quantifying the inhibitory effect of Bcl-xl on the action of Mff using live-cell fluorescence imaging. FEBS Open Bio. 2019;9:2041-2051 pubmed publisher |
| Seo J, Agarwal E, Chae Y, Lee Y, Garlick D, Storaci A, et al. Mitochondrial fission factor is a novel Myc-dependent regulator of mitochondrial permeability in cancer. EBioMedicine. 2019;48:353-363 pubmed publisher |
| Nagashima S, Takeda K, Ohno N, Ishido S, Aoki M, Saitoh Y, et al. MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress. Life Sci Alliance. 2019;2: pubmed publisher |
| Yedida G, Milani M, Cohen G, Varadarajan S. Apogossypol-mediated reorganisation of the endoplasmic reticulum antagonises mitochondrial fission and apoptosis. Cell Death Dis. 2019;10:521 pubmed publisher |
| Zeng Y, Pan Q, Wang X, Li D, Lin Y, Man F, et al. Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells. Oxid Med Cell Longev. 2019;2019:4508762 pubmed publisher |
| Zhao Y, Sun X, Hu D, Prosdocimo D, Hoppel C, Jain M, et al. ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects. Nat Commun. 2019;10:1371 pubmed publisher |
| D Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, et al. The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging. Mol Cell. 2019;73:775-787.e10 pubmed publisher |
| Wang Z, Jiang S, Cao J, Liu K, Xu S, Arfat Y, et al. Novel findings on ultrastructural protection of skeletal muscle fibers during hibernation of Daurian ground squirrels: Mitochondria, nuclei, cytoskeleton, glycogen. J Cell Physiol. 2019;234:13318-13331 pubmed publisher |
| Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Tani H, Mito T, et al. Acquired Expression of Mutant Mitofusin 2 Causes Progressive Neurodegeneration and Abnormal Behavior. J Neurosci. 2019;39:1588-1604 pubmed publisher |
| Chen C, Wang H, Huang C, Huang C, Lim W, Tu I, et al. Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder. Proc Natl Acad Sci U S A. 2019;116:566-574 pubmed publisher |
| Zhong X, Cui P, Cai Y, Wang L, He X, Long P, et al. Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells. Cell Metab. 2019;29:979-992.e4 pubmed publisher |
| Sprenger H, Wani G, Hesseling A, König T, Patron M, MacVicar T, et al. Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol Med. 2019;11: pubmed publisher |
| Wang D, Kinoshita C, Kinoshita Y, Sopher B, Uo T, Lee R, et al. Neuronal susceptibility to beta-amyloid toxicity and ischemic injury involves histone deacetylase-2 regulation of endophilin-B1. Brain Pathol. 2019;29:164-175 pubmed publisher |
| Nasca A, Nardecchia F, Commone A, Semeraro M, Legati A, Garavaglia B, et al. Clinical and Biochemical Features in a Patient With Mitochondrial Fission Factor Gene Alteration. Front Genet. 2018;9:625 pubmed publisher |
| Bao F, Shi H, Gao M, Yang L, Zhou L, Zhao Q, et al. Polybrene induces neural degeneration by bidirectional Ca2+ influx-dependent mitochondrial and ER-mitochondrial dynamics. Cell Death Dis. 2018;9:966 pubmed publisher |
| Lee J, Pappalardo Z, Chopra D, Hennings T, Vaughn I, Lan C, et al. A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission. Endocrinology. 2018;159:3321-3330 pubmed publisher |
| Lin H, Chung Y, Cheng C, Ouyang C, Fu Y, Kuo C, et al. Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis. Autophagy. 2018;14:1481-1498 pubmed publisher |
| Jian F, Chen D, Chen L, Yan C, Lu B, Zhu Y, et al. Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology. Cell Rep. 2018;23:2989-3005 pubmed publisher |
| Chakrabarti R, Ji W, Stan R, de Juan Sanz J, Ryan T, Higgs H. INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division. J Cell Biol. 2018;217:251-268 pubmed publisher |
| Ji W, Chakrabarti R, Fan X, Schoenfeld L, Strack S, Higgs H. Receptor-mediated Drp1 oligomerization on endoplasmic reticulum. J Cell Biol. 2017;216:4123-4139 pubmed publisher |
| Helle S, Feng Q, Aebersold M, Hirt L, Grüter R, Vahid A, et al. Mechanical force induces mitochondrial fission. elife. 2017;6: pubmed publisher |
| Xu Z, Jin X, Pan T, Liu T, Wan N, Li S. Antagonistic effects of selenium on cadmium-induced apoptosis by restoring the mitochondrial dynamic equilibrium and energy metabolism in chicken spleens. Oncotarget. 2017;8:52629-52641 pubmed publisher |
| Liu X, Wang W, Song G, Wei X, Zeng Y, Han P, et al. Astragaloside IV ameliorates diabetic nephropathy by modulating the mitochondrial quality control network. PLoS ONE. 2017;12:e0182558 pubmed publisher |
| Oanh N, Park Y, Cho H. Mitochondria elongation is mediated through SIRT1-mediated MFN1 stabilization. Cell Signal. 2017;38:67-75 pubmed publisher |
| Ban T, Ishihara T, Kohno H, Saita S, Ichimura A, Maenaka K, et al. Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin. Nat Cell Biol. 2017;19:856-863 pubmed publisher |
| Sabouny R, Fraunberger E, Geoffrion M, Ng A, Baird S, Screaton R, et al. The Keap1-Nrf2 Stress Response Pathway Promotes Mitochondrial Hyperfusion Through Degradation of the Mitochondrial Fission Protein Drp1. Antioxid Redox Signal. 2017;27:1447-1459 pubmed publisher |
| Wang L, Zhang T, Wang L, Cai Y, Zhong X, He X, et al. Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission. EMBO J. 2017;36:1330-1347 pubmed publisher |
| Guo C, Wilkinson K, Evans A, Rubin P, Henley J. SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death. Sci Rep. 2017;7:43811 pubmed publisher |
| Casinelli G, LaRosa J, Sharma M, Cherok E, Banerjee S, Branca M, et al. N-Myc overexpression increases cisplatin resistance in neuroblastoma via deregulation of mitochondrial dynamics. Cell Death Discov. 2016;2:16082 pubmed publisher |
| Lu Y, Wang R, Dong Y, Tucker D, Zhao N, Ahmed M, et al. Low-level laser therapy for beta amyloid toxicity in rat hippocampus. Neurobiol Aging. 2017;49:165-182 pubmed publisher |
| Jugé R, Breugnot J, Da Silva C, Bordes S, Closs B, Aouacheria A. Quantification and Characterization of UVB-Induced Mitochondrial Fragmentation in Normal Primary Human Keratinocytes. Sci Rep. 2016;6:35065 pubmed publisher |
| Kulkarni S, Joffraud M, Boutant M, Ratajczak J, Gao A, Maclachlan C, et al. Mfn1 Deficiency in the Liver Protects Against Diet-Induced Insulin Resistance and Enhances the Hypoglycemic Effect of Metformin. Diabetes. 2016;65:3552-3560 pubmed |
| Wu W, Lin C, Wu K, Jiang L, Wang X, Li W, et al. FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions. EMBO J. 2016;35:1368-84 pubmed publisher |
| Liu S, Gao Y, Zhang C, Li H, Pan S, Wang X, et al. SAMM50 Affects Mitochondrial Morphology through the Association of Drp1 in Mammalian Cells. FEBS Lett. 2016;590:1313-23 pubmed publisher |
| Sharoar M, Shi Q, Ge Y, He W, Hu X, Perry G, et al. Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease. Mol Psychiatry. 2016;21:1263-71 pubmed publisher |
| Xu S, Cherok E, Das S, Li S, Roelofs B, Ge S, et al. Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein. Mol Biol Cell. 2016;27:349-59 pubmed publisher |
| Zhang Z, Liu L, Wu S, Xing D. Drp1, Mff, Fis1, and MiD51 are coordinated to mediate mitochondrial fission during UV irradiation-induced apoptosis. FASEB J. 2016;30:466-76 pubmed publisher |
| Ban Ishihara R, Tomohiro Takamiya S, Tani M, Baudier J, Ishihara N, Kuge O. COX assembly factor ccdc56 regulates mitochondrial morphology by affecting mitochondrial recruitment of Drp1. FEBS Lett. 2015;589:3126-32 pubmed publisher |
| Li H, Ruan Y, Zhang K, Jian F, Hu C, Miao L, et al. Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization. Cell Death Differ. 2016;23:380-92 pubmed publisher |
| Gao J, Qin S, Jiang C. Parkin-induced ubiquitination of Mff promotes its association with p62/SQSTM1 during mitochondrial depolarization. Acta Biochim Biophys Sin (Shanghai). 2015;47:522-9 pubmed publisher |
| Ducommun S, Deak M, Sumpton D, Ford R, Núñez Galindo A, Kussmann M, et al. Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: identification of mitochondrial fission factor as a new AMPK substrate. Cell Signal. 2015;27:978-88 pubmed publisher |
| Li S, Xu S, Roelofs B, Boyman L, Lederer W, Sesaki H, et al. Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission. J Cell Biol. 2015;208:109-23 pubmed publisher |
| Ishihara T, Ban Ishihara R, Maeda M, Matsunaga Y, Ichimura A, Kyogoku S, et al. Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development. Mol Cell Biol. 2015;35:211-23 pubmed publisher |
