| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; loading ...; fig 5a
| Zhu B, Ren C, Du K, Zhu H, Ai Y, Kang F, et al. Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways. Biochem Pharmacol. 2019;170:113642 pubmed publisher |
- western blot; human; 1:4000; loading ...; fig 2a
| Wang K, Zhu T, Zhao R. Filamin A regulates EGFR/ERK/Akt signaling and affects colorectal cancer cell growth and migration. Mol Med Rep. 2019;20:3671-3678 pubmed publisher |
- western blot; human; loading ...; fig 6e
| Zeng C, Xing W, Liu Y. Identification of UGP2 as a progression marker that promotes cell growth and motility in human glioma. J Cell Biochem. 2019;120:12489-12499 pubmed publisher |
- western blot; mouse; 1:3000; loading ...; fig 8b
- western blot; human; 1:3000; loading ...; fig 8a
| Zhang S, Liu W, Yang Y, Sun K, Li S, Xu H, et al. Tmem30a Deficiency in endothelial cells impairs cell proliferation and angiogenesis. J Cell Sci. 2019;: pubmed publisher |
- western blot; human; 1:5000; fig 7
| Wu X, Liu W, Duan Z, Gao Y, Li S, Wang K, et al. The Involvement of Protease Nexin-1 (PN1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration. Sci Rep. 2016;6:30563 pubmed publisher |
- western blot; human; 1:1000; fig 5
| Dong F, Ling Q, Ye D, Zhang Z, Shu J, Chen G, et al. TCF7L2 involvement in estradiol- and progesterone-modulated islet and hepatic glucose homeostasis. Sci Rep. 2016;6:24859 pubmed publisher |
| Wang P, Wang X, Tang Q, Chen H, Zhang Q, Jiang H, et al. Functionalized graphene oxide against U251 glioma cells and its molecular mechanism. Mater Sci Eng C Mater Biol Appl. 2020;116:111187 pubmed publisher |
| Xu T, Xu L, Meng P, Ma X, Yang X, Zhou Y, et al. Angptl7 promotes insulin resistance and type 2 diabetes mellitus by multiple mechanisms including SOCS3-mediated IRS1 degradation. FASEB J. 2020;: pubmed publisher |
| Hu Z, Wang H, Fu Y, Ma K, Ma X, Wang J. Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways. Nutr Cancer. 2020;:1-12 pubmed publisher |
| Zhu X, Mao Y, Guo M, Yu H, Hao L, Hua Q, et al. Enhancement of anti-acne effect of Scutellaria baicalensis extract by fermentation with symbiotic fungus Penicillium decumbens. J Biosci Bioeng. 2020;: pubmed publisher |
| Yu Z, Yang L, Deng S, Liang M. Daidzein ameliorates LPS-induced hepatocyte injury by inhibiting inflammation and oxidative stress. Eur J Pharmacol. 2020;885:173399 pubmed publisher |
| Kong F, Li N, Tu T, Tao Y, Bi Y, Yuan D, et al. Hepatitis B virus core protein promotes the expression of neuraminidase 1 to facilitate hepatocarcinogenesis. Lab Invest. 2020;: pubmed publisher |
| Wu L, Liu X, Huang Y, Lu C, Zhou J, Ren P, et al. Antidepressant-like Effect of Merazin Hydrate Depends on NO/ERK by Suppressing Its Downstream NF-κB or Nonactivating CREB/BDNF in Mouse Hippocampus. ACS Chem Neurosci. 2020;11:2472-2481 pubmed publisher |
| Liu J, Hu Y, Feng Y, Jiang Y, Guo Y, Liu Y, et al. BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer. J Exp Clin Cancer Res. 2020;39:123 pubmed publisher |
| Zhou X, Liu Z, Ying K, Wang H, Liu P, Ji X, et al. WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling. Oxid Med Cell Longev. 2020;2020:7950457 pubmed publisher |
| Du Q, Zhang C, Li W, Mu Y, Xu Y, Lowe S, et al. Gan Shen Fu Fang ameliorates liver fibrosis in vitro and in vivo by inhibiting the inflammatory response and extracellular signal-regulated kinase phosphorylation. World J Gastroenterol. 2020;26:2810-2820 pubmed publisher |
| Liu Y, Tsai J, Weng Y, Hsu F. Regorafenib suppresses epidermal growth factor receptor signaling-modulated progression of colorectal cancer. Biomed Pharmacother. 2020;128:110319 pubmed publisher |
| Li P, Ding L, Cao S, Feng X, Zhang Q, Chen Y, et al. Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells. J Ethnopharmacol. 2020;259:113015 pubmed publisher |
| Hu C, Xia H, Bai S, Zhao J, Edwards H, Li X, et al. CUDC-907, a novel dual PI3K and HDAC inhibitor, in prostate cancer: Antitumour activity and molecular mechanism of action. J Cell Mol Med. 2020;: pubmed publisher |
| Wang X, Guo R, Ma L, Ding Q, Meng J, Chen Y, et al. Antiprolactinoma Effect of Hordenine by Inhibiting MAPK Signaling Pathway Activation in Rats. Evid Based Complement Alternat Med. 2020;2020:3107290 pubmed publisher |
| Liu X, Zhou C, Li Y, Deng Y, Lu W, Li J. Upregulation of circ-0000745 in acute lymphoblastic leukemia enhanced cell proliferation by activating ERK pathway. Gene. 2020;751:144726 pubmed publisher |
| Pang H, Wang N, Chai J, Wang X, Zhang Y, Bi Z, et al. Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury. Eur J Med Chem. 2020;197:112314 pubmed publisher |
| Jiang F, Chen Y, Ren S, Li Z, Sun K, Xing Y, et al. Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1‑AKT/ERK‑Snail signaling pathway. Int J Oncol. 2020;57:183-196 pubmed publisher |
| Wang H, Cai J, Du S, Wei W, Shen X. LAMC2 modulates the acidity of microenvironments to promote invasion and migration of pancreatic cancer cells via regulating AKT-dependent NHE1 activity. Exp Cell Res. 2020;391:111984 pubmed publisher |
| Liu Q, Yang C, Wang S, Shi D, Wei C, Song J, et al. Wnt5a-induced M2 polarization of tumor-associated macrophages via IL-10 promotes colorectal cancer progression. Cell Commun Signal. 2020;18:51 pubmed publisher |
| Qin W, Feng S, Sun Y, Jiang G. MiR-96-5p promotes breast cancer migration by activating MEK/ERK signaling. J Gene Med. 2020;22:e3188 pubmed publisher |
| Zong J, Jiang J, Shi P, Liu J, Wang W, Li B, et al. Fatty acid extracts facilitate cutaneous wound healing through activating AKT, ERK, and TGF-β/Smad3 signaling and promoting angiogenesis. Am J Transl Res. 2020;12:478-492 pubmed |
| Yu Z, Jiang X, Zhao R, Qin J, Luo C, Ren Y, et al. Effect of KIF22 on promoting proliferation and migration of gastric cancer cells via MAPK-ERK pathways. Chin Med J (Engl). 2020;133:919-928 pubmed publisher |
| Song J, Liu L, Lv L, Hu S, Tariq A, Wang W, et al. Fluid shear stress induces Runx-2 expression via upregulation of PIEZO1 in MC3T3-E1 cells. Cell Biol Int. 2020;44:1491-1502 pubmed publisher |
| Yuan C, Dai C, Li Z, Zheng L, Zhao M, Dong S. Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage. Neurochem Res. 2020;45:1500-1509 pubmed publisher |
| Du S, Wang H, Cai J, Ren R, Zhang W, Wei W, et al. Apolipoprotein E2 modulates cell cycle function to promote proliferation in pancreatic cancer cells via regulation of the c-Myc-p21Waf1 signalling pathway. Biochem Cell Biol. 2020;98:191-202 pubmed publisher |
| Zhu Y, Zhu C, Yang H, Deng J, Fan D. Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice. Pharmacol Res. 2020;155:104746 pubmed publisher |
| Liu Q, Song J, Pan Y, Shi D, Yang C, Wang S, et al. Wnt5a/CaMKII/ERK/CCL2 axis is required for tumor-associated macrophages to promote colorectal cancer progression. Int J Biol Sci. 2020;16:1023-1034 pubmed publisher |
| Chen Q, Yu W, Zhang H, Zhang S, Fang J, Wu F, et al. PBX3 Promotes Tumor Growth and Angiogenesis via Activation of AT1R/VEGFR2 Pathway in Papillary Thyroid Carcinoma. Biomed Res Int. 2020;2020:8954513 pubmed publisher |
| Zheng P, Li L. FANCI Cooperates with IMPDH2 to Promote Lung Adenocarcinoma Tumor Growth via a MEK/ERK/MMPs Pathway. Onco Targets Ther. 2020;13:451-463 pubmed publisher |
| Lv S, Ju C, Peng J, Liang M, Zhu F, Wang C, et al. 25-Hydroxycholesterol protects against myocardial ischemia-reperfusion injury via inhibiting PARP activity. Int J Biol Sci. 2020;16:298-308 pubmed publisher |
| Xu D, Liu J, Ma H, Guo W, Wang J, Kan X, et al. Schisandrin A protects against lipopolysaccharide-induced mastitis through activating Nrf2 signaling pathway and inducing autophagy. Int Immunopharmacol. 2020;78:105983 pubmed publisher |
| Li L, Jiang H, Wei X, Geng D, He M, Du H. Bu Shen Zhu Yun Decoction Improves Endometrial Receptivity via VEGFR-2-Mediated Angiogenesis. Evid Based Complement Alternat Med. 2019;2019:3949824 pubmed publisher |
| Wang L, Huang W, Zhan J. Grape Seed Proanthocyanidins Induce Autophagy and Modulate Survivin in HepG2 Cells and Inhibit Xenograft Tumor Growth in Vivo. Nutrients. 2019;11: pubmed publisher |
| Yang J, Liu J, Sheng M, Zhang X, Liu M. Programmed cell death protein 1 promotes hepatitis B virus transmission through the regulation of ERK1/2-mediated trophoblasts differentiation. Arch Gynecol Obstet. 2019;: pubmed publisher |
| Yu H, Li M, Li Y, Lei B, Xin Yuan -, Xing X, et al. Benzoylaconitine inhibits production of IL-6 and IL-8 via MAPK, Akt, NF-κB signaling in IL-1β-induced human synovial cells. Biol Pharm Bull. 2019;: pubmed publisher |
| Liu K, Lu R, Zhao Q, Du J, Li Y, Zheng M, et al. Association and clinicopathologic significance of p38MAPK-ERK-JNK-CDC25C with polyploid giant cancer cell formation. Med Oncol. 2019;37:6 pubmed publisher |
| Xu W, Li J, Tian H, Wang R, Feng Y, Tang J, et al. MicroRNA‑186‑5p mediates osteoblastic differentiation and cell viability by targeting CXCL13 in non‑traumatic osteonecrosis. Mol Med Rep. 2019;20:4594-4602 pubmed publisher |
| Lu H, Feng Y, Hu Y, Guo Y, Liu Y, Mao Q, et al. Spondin 2 promotes the proliferation, migration and invasion of gastric cancer cells. J Cell Mol Med. 2019;: pubmed publisher |
| Li G, Wang G, Wang S, Sun M, Wen Z. Isorhamnetin attenuates Streptococcus suis virulence by inhibiting the inflammatory response. Antonie Van Leeuwenhoek. 2019;: pubmed publisher |
| Gao L, Dou Z, Ren W, Li S, Liang X, Zhi K. CircCDR1as upregulates autophagy under hypoxia to promote tumor cell survival via AKT/ERK½/mTOR signaling pathways in oral squamous cell carcinomas. Cell Death Dis. 2019;10:745 pubmed publisher |
| Ma Q, Gu J, Wang B, Feng J, Yang L, Kang X, et al. PlGF signaling and macrophage repolarization contribute to the anti-neoplastic effect of metformin. Eur J Pharmacol. 2019;863:172696 pubmed publisher |
| Lin F, Yang D, Huang Y, Zhao Y, Ye J, Xiao M. The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice. Mar Drugs. 2019;17: pubmed publisher |
| Zhang C, Wu Q, Huang H, Chen X, Huang T, Li W, et al. Caveolin-1 promotes Rfng expression via Erk-Jnk-p38 signaling pathway in mouse hepatocarcinoma cells. J Physiol Biochem. 2019;: pubmed publisher |
| Hu W, Chang G, Zhang M, Li Y, Yin L, Huang Y, et al. MicroRNA-125a-3p affects smooth muscle cell function in vascular stenosis. J Mol Cell Cardiol. 2019;136:85-94 pubmed publisher |
| Xu Q, Long Q, Zhu D, Fu D, Zhang B, Han L, et al. Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression. Aging Cell. 2019;18:e13027 pubmed publisher |
| Kang Y, Ding L, Dai H, Wang F, Zhou H, Gao Q, et al. Intermedin in Paraventricular Nucleus Attenuates Ang II-Induced Sympathoexcitation through the Inhibition of NADPH Oxidase-Dependent ROS Generation in Obese Rats with Hypertension. Int J Mol Sci. 2019;20: pubmed publisher |
| Liu N, Huang X, Liu S, Lu Y. EXT1, Regulated by MiR-665, Promotes Cell Apoptosis via ERK1/2 Signaling Pathway in Acute Lymphoblastic Leukemia. Med Sci Monit. 2019;25:6491-6503 pubmed publisher |
| Ma J, Zhao S, Qiao X, Knight T, Edwards H, Polin L, et al. Inhibition of Bcl-2 Synergistically Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia. Clin Cancer Res. 2019;: pubmed publisher |
| Zhang C, Huang H, Zhang J, Wu Q, Chen X, Huang T, et al. Caveolin-1 promotes invasion and metastasis by upregulating Pofut1 expression in mouse hepatocellular carcinoma. Cell Death Dis. 2019;10:477 pubmed publisher |
| Shi A, Heinayati A, Bao D, Liu H, Ding X, Tong X, et al. Small molecule inhibitor of TGF-β signaling enables robust osteogenesis of autologous GMSCs to successfully repair minipig severe maxillofacial bone defects. Stem Cell Res Ther. 2019;10:172 pubmed publisher |
| Wang G, Xu B, Shi F, Du M, Li Y, Yu T, et al. Protective Effect of Methane-Rich Saline on Acetic Acid-Induced Ulcerative Colitis via Blocking the TLR4/NF-κB/MAPK Pathway and Promoting IL-10/JAK1/STAT3-Mediated Anti-inflammatory Response. Oxid Med Cell Longev. 2019;2019:7850324 pubmed publisher |
| Wu X, Chen L, Zeb F, Huang Y, An J, Ren J, et al. Regulation of circadian rhythms by NEAT1 mediated TMAO-induced endothelial proliferation: A protective role of asparagus extract. Exp Cell Res. 2019;: pubmed publisher |
| Yang H, Liu J, Shang H, Lin S, Zhao J, Lin J. Qingjie Fuzheng granules inhibit colorectal cancer cell growth by the PI3K/AKT and ERK pathways. World J Gastrointest Oncol. 2019;11:377-392 pubmed publisher |
| Wu Y, Su T, Dai G, Su J, Liu C. Flaccidoxide-13-Acetate-Induced Apoptosis in Human Bladder Cancer Cells is through Activation of p38/JNK, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress Regulated Pathway. Mar Drugs. 2019;17: pubmed publisher |
| Yang F, Lin Z, Huang T, Chen T, Cui J, Li M, et al. Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway. Sci Rep. 2019;9:6991 pubmed publisher |
| Jin H, Liu P, Kong L, Fei X, Gao Y, Wu T, et al. Identification of RE1-Silencing Transcription Factor as a Promoter of Metastasis in Pancreatic Cancer. Front Oncol. 2019;9:291 pubmed publisher |
| Chen H, Liu J, Wang H, Cheng Q, Zhou C, Chen X, et al. Inhibition of RNA-Binding Protein Musashi-1 Suppresses Malignant Properties and Reverses Paclitaxel Resistance in Ovarian Carcinoma. J Cancer. 2019;10:1580-1592 pubmed publisher |
| Yin J, Yang K, Zhou C, Xu P, Xiao W, Yang H. Aryl hydrocarbon receptor activation alleviates dextran sodium sulfate-induced colitis through enhancing the differentiation of goblet cells. Biochem Biophys Res Commun. 2019;514:180-186 pubmed publisher |
| Jia Y, Peng Y, Zhao Y, Cheng X, Zhou Y, Chai C, et al. Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs. J Agric Food Chem. 2019;: pubmed publisher |
| Chen J, Li D, Chen Y, Tao H, Pu Z, Zhang J, et al. Elucidating dosage-effect relationship of different efficacy of rhubarb in constipation model rats by factor analysis. J Ethnopharmacol. 2019;238:111868 pubmed publisher |
| Ren D, Zhao Y, Zheng Q, Alim A, Yang X. Immunomodulatory effects of an acidic polysaccharide fraction from herbal Gynostemma pentaphyllum tea in RAW264.7 cells. Food Funct. 2019;10:2186-2197 pubmed publisher |
| Guo Y, Guo C, Ha W, Ding Z. Carnosine improves diabetic retinopathy via the MAPK/ERK pathway. Exp Ther Med. 2019;17:2641-2647 pubmed publisher |
| Sun C, Nie J, Zheng Z, Zhao J, Wu L, Zhu Y, et al. Renoprotective effect of scutellarin on cisplatin-induced renal injury in mice: Impact on inflammation, apoptosis, and autophagy. Biomed Pharmacother. 2019;112:108647 pubmed publisher |
| Chen L, Liu D, Wang Y, Liu X, Han S, Zhang K, et al. Treatment with MQA, a Derivative of Caffeoylquinic Acid, Provides Neuroprotective Effects against Cerebral Ischemia Through Suppression of the p38 Pathway and Oxidative Stress in Rats. J Mol Neurosci. 2019;67:604-612 pubmed publisher |
| Li G, Shen X, Wei Y, Si X, Deng X, Wang J. Quercetin reduces Streptococcus suis virulence by inhibiting suilysin activity and inflammation. Int Immunopharmacol. 2019;69:71-78 pubmed publisher |
| Luo H, Han Y, Liu J, Zhang Y. Identification of microRNAs in granulosa cells from patients with different levels of ovarian reserve function and the potential regulatory function of miR-23a in granulosa cell apoptosis. Gene. 2019;686:250-260 pubmed publisher |
| Yuan C, Guo X, Zhou Q, Du F, Jiang W, Zhou X, et al. OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice. Biochim Biophys Acta Mol Basis Dis. 2019;1865:161-180 pubmed publisher |
| Sun J, Ren X, Kang Y, Dai H, Ding L, Tong N, et al. Intermedin in Paraventricular Nucleus Attenuates Sympathoexcitation and Decreases TLR4-Mediated Sympathetic Activation via Adrenomedullin Receptors in Rats with Obesity-Related Hypertension. Neurosci Bull. 2019;35:34-46 pubmed publisher |
| Xiao K, Yang K, Wang J, Sun P, Huang H, Khaliq H, et al. Transcriptional Study Revealed That Boron Supplementation May Alter the Immune-Related Genes Through MAPK Signaling in Ostrich Chick Thymus. Biol Trace Elem Res. 2019;189:209-223 pubmed publisher |
| Yin B, Hou X, Lu M. Astragaloside IV attenuates myocardial ischemia/reperfusion injury in rats via inhibition of calcium-sensing receptor-mediated apoptotic signaling pathways. Acta Pharmacol Sin. 2019;40:599-607 pubmed publisher |
| Liang S, Lv Z, Zhang J, Wang Y, Dong Y, Wang Z, et al. Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes. Front Pharmacol. 2018;9:1378 pubmed publisher |
| Li H, Zhang M, Linghu E, Zhou F, Herman J, Hu L, et al. Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma. Clin Epigenetics. 2018;10:137 pubmed publisher |
| Zhou T, Ma Y, Tang J, Guo F, Dong M, Wei Q. Modulation of IGF1R Signaling Pathway by GIGYF1 in High Glucose-Induced SHSY-5Y Cells. DNA Cell Biol. 2018;: pubmed publisher |
| Chen T, Zhu H, Wang Y, Zhao P, Chen J, Sun J, et al. Apoptosis of bone marrow mesenchymal stromal/stem cells via the MAPK and endoplasmic reticulum stress signaling pathways. Am J Transl Res. 2018;10:2555-2566 pubmed |
| Tang Y, Huang W, Song Q, Zheng X, He R, Liu J. Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4/NF-κB and MAPK Signaling. Evid Based Complement Alternat Med. 2018;2018:3063145 pubmed publisher |
| Zhao L, Li D, Liu N, Liu L, Zhang Z, Gao C, et al. Correlation of TGN-020 with the analgesic effects via ERK pathway activation after chronic constriction injury. Mol Pain. 2018;14:1744806918796057 pubmed publisher |
| Walana W, Wang J, Yabasin I, Ntim M, Kampo S, Al Azab M, et al. IL-8 analogue CXCL8 (3-72) K11R/G31P, modulates LPS-induced inflammation via AKT1-NF-kβ and ERK1/2-AP-1 pathways in THP-1 monocytes. Hum Immunol. 2018;79:809-816 pubmed publisher |
| Li X, Wu J, Zhang X, Chen W. Glutathione reductase-mediated thiol oxidative stress suppresses metastasis of murine melanoma cells. Free Radic Biol Med. 2018;129:256-267 pubmed publisher |
| He J, Lu X, Wei T, Dong Y, Cai Z, Tang L, et al. Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages. Int J Mol Sci. 2018;19: pubmed publisher |
| Zhang T, Qu N, Sun G, Zhang L, Wang Y, Mu X, et al. NRG1 regulates redox homeostasis via NRF2 in papillary thyroid cancer. Int J Oncol. 2018;53:685-693 pubmed publisher |
| Wang S, Xu M, Li X, Su X, Xiao X, Keating A, et al. Exosomes released by hepatocarcinoma cells endow adipocytes with tumor-promoting properties. J Hematol Oncol. 2018;11:82 pubmed publisher |
| Xiang L, Xu X, Zhang S, Cai D, Dai X. Cold atmospheric plasma conveys selectivity on triple negative breast cancer cells both in vitro and in vivo. Free Radic Biol Med. 2018;124:205-213 pubmed publisher |
| Lin J, Cao S, Wang Y, Hu Y, Liu H, Li J, et al. Long non-coding RNA UBE2CP3 enhances HCC cell secretion of VEGFA and promotes angiogenesis by activating ERK1/2/HIF-1α/VEGFA signalling in hepatocellular carcinoma. J Exp Clin Cancer Res. 2018;37:113 pubmed publisher |
| Zhang J, Zhang Q, Chen X, Liu Y, Xue J, Dahan A, et al. Revealing Synergistic Mechanism of Multiple Components in Gandi Capsule for Diabetic Nephropathy Therapeutics by Network Pharmacology. Evid Based Complement Alternat Med. 2018;2018:6503126 pubmed publisher |
| Cheng Y, Zhao P, Wu S, Yang T, Chen Y, Zhang X, et al. Cisplatin and curcumin co-loaded nano-liposomes for the treatment of hepatocellular carcinoma. Int J Pharm. 2018;545:261-273 pubmed publisher |
| Wang L, Wei W, Zhang X, Liu D, Zeng K, Tu P. An Integrated Proteomics and Bioinformatics Approach Reveals the Anti-inflammatory Mechanism of Carnosic Acid. Front Pharmacol. 2018;9:370 pubmed publisher |
| Jin X, Li F, Liu B, Zheng X, Li H, Ye F, et al. Different mitochondrial fragmentation after irradiation with X-rays and carbon ions in HeLa cells and its influence on cellular apoptosis. Biochem Biophys Res Commun. 2018;500:958-965 pubmed publisher |
| Zhang J, Liu L, Wang J, Ren B, Zhang L, Li W. Formononetin, an isoflavone from Astragalus membranaceus inhibits proliferation and metastasis of ovarian cancer cells. J Ethnopharmacol. 2018;221:91-99 pubmed publisher |
| Fang Y, Liu G, Xie C, Qian K, Lei X, Liu Q, et al. Pharmacological inhibition of TRPV4 channel suppresses malignant biological behavior of hepatocellular carcinoma via modulation of ERK signaling pathway. Biomed Pharmacother. 2018;101:910-919 pubmed publisher |
| Liu H, Liu Q, Hua L, Pan J. Inhibition of transient receptor potential melastatin 8 alleviates airway inflammation and remodeling in a murine model of asthma with cold air stimulus. Acta Biochim Biophys Sin (Shanghai). 2018;50:499-506 pubmed publisher |
| Liu Y, Wang T, Liu X, Wen Y, Xu T, Yu X, et al. Overexpression of zinc-α2-glycoprotein suppressed seizures and seizure-related neuroflammation in pentylenetetrazol-kindled rats. J Neuroinflammation. 2018;15:92 pubmed publisher |
| Jin B, Jin H. Oxymatrine attenuates lipopolysaccharide-induced acute lung injury by activating the epithelial sodium channel and suppressing the JNK signaling pathway. Exp Anim. 2018;67:337-347 pubmed publisher |
| Liu J, Jiang G, Mao P, Zhang J, Zhang L, Liu L, et al. Down-regulation of GADD45A enhances chemosensitivity in melanoma. Sci Rep. 2018;8:4111 pubmed publisher |
| He J, Li J, Liu H, Yang Z, Zhou F, Wei T, et al. Scandoside Exerts Anti-Inflammatory Effect Via Suppressing NF-?B and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages. Int J Mol Sci. 2018;19: pubmed publisher |
| Wang Y, Gao H, Wu T, Wang Z, Song F, Chen A, et al. Pseudolaric acid B induced autophagy, but not apoptosis, in MRC5 human fibroblast cells. Oncol Lett. 2018;15:863-870 pubmed publisher |
| Roe A, Qi X. Drp1 phosphorylation by MAPK1 causes mitochondrial dysfunction in cell culture model of Huntington's disease. Biochem Biophys Res Commun. 2018;496:706-711 pubmed publisher |
| Li H, Fu X, Gao Y, Li X, Shen Y, Wang W. Small interfering RNA-mediated silencing of G-protein-coupled receptor 137 inhibits growth of osteosarcoma cells. J Bone Oncol. 2018;11:17-22 pubmed publisher |
| Zhang S, Xiao J, Chai Y, Hong Z, Liu Z, Yuan R, et al. Speckle-Type POZ Protein Down-Regulates Matrix Metalloproteinase 2 Expression via Sp1/PI3K/Akt Signaling Pathway in Colorectal Cancer. Dig Dis Sci. 2018;63:395-402 pubmed publisher |
| Su Y, Li X, Ma J, Zhao J, Liu S, Wang G, et al. Targeting PI3K, mTOR, ERK, and Bcl-2 signaling network shows superior antileukemic activity against AML ex vivo. Biochem Pharmacol. 2018;148:13-26 pubmed publisher |
| Sun D, Liu Y, Wang H, Deng F, Zhang Y, Zhao S, et al. Novel decellularized liver matrix-alginate hybrid gel beads for the 3D culture of hepatocellular carcinoma cells. Int J Biol Macromol. 2018;109:1154-1163 pubmed publisher |
| Zeng G, Wang Z, Zhao L, Fan J, Tan N. NF-κB and JNK mediated apoptosis and G0/G1 arrest of HeLa cells induced by rubiarbonol G, an arborinane-type triterpenoid from Rubia yunnanensis. J Ethnopharmacol. 2018;220:220-227 pubmed publisher |
| Zhao P, Chang R, Liu N, Wang J, Zhou R, Qi X, et al. Neuroprotective Effect of Oxysophocarpine by Modulation of MAPK Pathway in Rat Hippocampal Neurons Subject to Oxygen-Glucose Deprivation and Reperfusion. Cell Mol Neurobiol. 2018;38:529-540 pubmed publisher |
| Yan Z, Feng J, Peng J, Lai Z, Zhang L, Jin Y, et al. Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways. Oncol Lett. 2017;14:7923-7930 pubmed publisher |
| Su J, Xie C, Fan Y, Cheng W, Hu Y, Huang Q, et al. Interleukin-25 enhances the capacity of mesenchymal stem cells to induce intestinal epithelial cell regeneration. Am J Transl Res. 2017;9:5320-5331 pubmed |
| Xu S, Niu P, Chen K, Xia Y, Yu Q, Liu N, et al. The liver protection of propylene glycol alginate sodium sulfate preconditioning against ischemia reperfusion injury: focusing MAPK pathway activity. Sci Rep. 2017;7:15175 pubmed publisher |
| Liu J, Wang L, Du Y, Liu S. An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress. Adv Sci (Weinh). 2017;4:1700089 pubmed publisher |
| Yin L, Qi Y, Xu Y, Xu L, Han X, Tao X, et al. Dioscin Inhibits HSC-T6 Cell Migration via Adjusting SDC-4 Expression: Insights from iTRAQ-Based Quantitative Proteomics. Front Pharmacol. 2017;8:665 pubmed publisher |
| Fan L, Xiong Y, Fu Z, Xu D, Wang L, Chen Y, et al. Polyaniline promotes peripheral nerve regeneration by enhancement of the brain?derived neurotrophic factor and ciliary neurotrophic factor expression and activation of the ERK1/2/MAPK signaling pathway. Mol Med Rep. 2017;16:7534-7540 pubmed publisher |
| Hou L, Gu W, Zhu H, Yao W, Wang W, Meng Q. Spiroplasma eriocheiris induces mouse 3T6-Swiss albino cell apoptosis that associated with the infection mechanism. Mol Immunol. 2017;91:75-85 pubmed publisher |
| Han Y, Luo H, Wang H, Cai J, Zhang Y. SIRT1 induces resistance to apoptosis in human granulosa cells by activating the ERK pathway and inhibiting NF-?B signaling with anti-inflammatory functions. Apoptosis. 2017;22:1260-1272 pubmed publisher |
| Chen H, Luo C, Liang J, Zhang Z, Lin G, Wu J, et al. Anti-inflammatory activity of coptisine free base in mice through inhibition of NF-?B and MAPK signaling pathways. Eur J Pharmacol. 2017;811:222-231 pubmed publisher |
| Ning C, Liang M, Liu S, Wang G, Edwards H, Xia Y, et al. Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer. Oncotarget. 2017;8:44295-44311 pubmed publisher |
| Yamaguchi M, Saito S, Nishiyama R, Nakamura M, Todoroki K, Toyo oka T, et al. Caffeine Suppresses the Activation of Hepatic Stellate Cells cAMP-Independently by Antagonizing Adenosine Receptors. Biol Pharm Bull. 2017;40:658-664 pubmed publisher |
| Yang Y, Gong X, Huang L, Wang Z, Wan R, Zhang P, et al. Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice. Oncotarget. 2017;8:30723-30733 pubmed publisher |
| Xie X, Zhao N, Xu Q, Yang X, Xia W, Chen Q, et al. Relaxin attenuates aristolochic acid induced human tubular epithelial cell apoptosis in vitro by activation of the PI3K/Akt signaling pathway. Apoptosis. 2017;22:769-776 pubmed publisher |
| Wei W, Sun Z, Shen C, Song H, Zhang X, Qiu Z, et al. Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer. Theranostics. 2017;7:987-1001 pubmed publisher |
| Zhao X, Zhao G, Shi Z, Zhou C, Chen Y, Hu B, et al. Low-intensity pulsed ultrasound (LIPUS) prevents periprosthetic inflammatory loosening through FBXL2-TRAF6 ubiquitination pathway. Sci Rep. 2017;7:45779 pubmed publisher |
| Jiang Z, Song F, Li Y, Xue D, Zhao N, Zhang J, et al. Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways. Oxid Med Cell Longev. 2017;2017:6175841 pubmed publisher |
| Liu Y, Tang Q, Shao S, Chen Y, Chen W, Xu X. Lyophilized Powder of Catalpol and Puerarin Protected Cerebral Vessels from Ischemia by Its Anti-apoptosis on Endothelial Cells. Int J Biol Sci. 2017;13:327-338 pubmed publisher |
| Chen X, Luo Y, Huang Z, Jia G, Liu G, Zhao H. Akirin2 regulates proliferation and differentiation of porcine skeletal muscle satellite cells via ERK1/2 and NFATc1 signaling pathways. Sci Rep. 2017;7:45156 pubmed publisher |
| Gong X, Yang Y, Huang L, Zhang Q, Wan R, Zhang P, et al. Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice. Int Immunopharmacol. 2017;46:124-132 pubmed publisher |
| Ren D, Lin D, Alim A, Zheng Q, Yang X. Chemical characterization of a novel polysaccharide ASKP-1 from Artemisia sphaerocephala Krasch seed and its macrophage activation via MAPK, PI3k/Akt and NF-?B signaling pathways in RAW264.7 cells. Food Funct. 2017;8:1299-1312 pubmed publisher |
| Fu J, Xia X, Liu Z, Wang Y, Wang Y, Shi Q, et al. The acute exposure of tetrachloro-p-benzoquinone (a.k.a. chloranil) triggers inflammation and neurological dysfunction via Toll-like receptor 4 signaling: The protective role of melatonin preconditioning. Toxicology. 2017;381:39-50 pubmed publisher |
| Yin K, Zhu R, Wang S, Zhao R. Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells. Stem Cells Dev. 2017;26:762-775 pubmed publisher |
| Peng U, Wang Z, Pei S, Ou Y, Hu P, Liu W, et al. ACY-1215 accelerates vemurafenib induced cell death of BRAF-mutant melanoma cells via induction of ER stress and inhibition of ERK activation. Oncol Rep. 2017;37:1270-1276 pubmed publisher |
| Wang D, Wang D, Wang N, Long Z, Ren X. Long Non-Coding RNA BANCR Promotes Endometrial Cancer Cell Proliferation and Invasion by Regulating MMP2 and MMP1 via ERK/MAPK Signaling Pathway. Cell Physiol Biochem. 2016;40:644-656 pubmed |
| Yi X, Zhang Y, Zhong C, Zhong X, Xiao F. The role of STIM1 in the Cr(vi)-induced [Ca2+]i increase and cell injury in L-02 hepatocytes. Metallomics. 2016;8:1273-1282 pubmed |
| Li Y, Jiang Z, Xue D, Deng G, Li M, Liu X, et al. Mycoplasma ovipneumoniae induces sheep airway epithelial cell apoptosis through an ERK signalling-mediated mitochondria pathway. BMC Microbiol. 2016;16:222 pubmed |
| Xin B, He X, Wang J, Cai J, Wei W, Zhang T, et al. Nerve growth factor regulates CD133 function to promote tumor cell migration and invasion via activating ERK1/2 signaling in pancreatic cancer. Pancreatology. 2016;16:1005-1014 pubmed publisher |
| Hu Y, Tao X, Han X, Xu L, Yin L, Qi Y, et al. Dioscin attenuates gastric ischemia/reperfusion injury through the down-regulation of PKC/ERK1/2 signaling via PKC? and PKC?2 inhibition. Chem Biol Interact. 2016;258:234-44 pubmed publisher |
| Xu D, Wang H, Zheng W, Gao Y, Wang M, Zhang Y, et al. Charaterization and immunomodulatory activities of polysaccharide isolated from Pleurotus eryngii. Int J Biol Macromol. 2016;92:30-36 pubmed publisher |
| Liu X, Ren K, Suo R, Xiong S, Zhang Q, Mo Z, et al. ApoA-I induces S1P release from endothelial cells through ABCA1 and SR-BI in a positive feedback manner. J Physiol Biochem. 2016;72:657-667 pubmed |
| Huang C, Lei K, Tsang N. Paper-based microreactor array for rapid screening of cell signaling cascades. Lab Chip. 2016;16:2911-20 pubmed publisher |
| Zhang L, Liu L, He X, Shen Y, Liu X, Wei J, et al. CHIP promotes thyroid cancer proliferation via activation of the MAPK and AKT pathways. Biochem Biophys Res Commun. 2016;477:356-62 pubmed publisher |
| Wang Z, Hu P, Tang F, Lian H, Chen X, Zhang Y, et al. HDAC6 promotes cell proliferation and confers resistance to temozolomide in glioblastoma. Cancer Lett. 2016;379:134-42 pubmed publisher |
| Wang Z, Tang F, Hu P, Wang Y, Gong J, Sun S, et al. HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma. Oncol Rep. 2016;36:589-97 pubmed publisher |
| Liu X, Zou C, Yu C, Xie R, Sui M, Mu S, et al. Original Research: Atorvastatin prevents rat cardiomyocyte hypertrophy induced by parathyroid hormone 1-34 associated with the Ras-ERK signaling. Exp Biol Med (Maywood). 2016;241:1745-50 pubmed publisher |
| Wang Z, Hu P, Tang F, Xie C. HDAC6-mediated EGFR stabilization and activation restrict cell response to sorafenib in non-small cell lung cancer cells. Med Oncol. 2016;33:50 pubmed publisher |
| Wang D, Wang M, Jiang N, Zhang Y, Bian X, Wang X, et al. Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer. Oncotarget. 2016;7:13153-66 pubmed publisher |
| Tong Q, Tao T, Xie L, Lu H. ELISA-PLA: A novel hybrid platform for the rapid, highly sensitive and specific quantification of proteins and post-translational modifications. Biosens Bioelectron. 2016;80:385-391 pubmed publisher |
| He X, Wang J, Wei W, Shi M, Xin B, Zhang T, et al. Hypoxia regulates ABCG2 activity through the activivation of ERK1/2/HIF-1α and contributes to chemoresistance in pancreatic cancer cells. Cancer Biol Ther. 2016;17:188-98 pubmed publisher |
| Wang N, Cao Y, Zhu Y. Netrin-1 prevents the development of cardiac hypertrophy and heart failure. Mol Med Rep. 2016;13:2175-81 pubmed publisher |
| Li Z, Yang S, Yin P, Chang T, Shi L, Fang L, et al. Activated estrogen receptor-mitogen-activated protein kinases cross talk confer acquired resistance to lapatinib. Thorac Cancer. 2015;6:695-703 pubmed publisher |
| Zhang Q, Zhuang J, Deng Y, Zhao X, Tang B, Yao D, et al. GOLPH3 is a potential therapeutic target and a prognostic indicator of poor survival in bladder cancer treated by cystectomy. Oncotarget. 2015;6:32177-92 pubmed publisher |
| Morgan J, Shanderson R, Boyd N, Cacan E, Greer S. The class II transactivator (CIITA) is regulated by post-translational modification cross-talk between ERK1/2 phosphorylation, mono-ubiquitination and Lys63 ubiquitination. Biosci Rep. 2015;35: pubmed publisher |
| Chen K, He H, Xie Y, Zhao L, Zhao S, Wan X, et al. miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis. Sci Rep. 2015;5:11909 pubmed publisher |
| Mu X, Ma J, Zhang Z, Zhou H, Xu S, Qin Y, et al. Famitinib enhances nasopharyngeal cancer cell radiosensitivity by attenuating radiation-induced phosphorylation of platelet-derived growth factor receptor and c-kit and inhibiting microvessel formation. Int J Radiat Biol. 2015;91:771-6 pubmed publisher |
| Xie Y, Cui D, Sui L, Xu Y, Zhang N, Ma Y, et al. Induction of forkhead box M1 (FoxM1) by EGF through ERK signaling pathway promotes trophoblast cell invasion. Cell Tissue Res. 2015;362:421-30 pubmed publisher |
| Su C, Xia X, Shi Q, Song X, Fu J, Xiao C, et al. Neohesperidin Dihydrochalcone versus CClâ‚„-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation. J Agric Food Chem. 2015;63:5468-75 pubmed publisher |
| Huang P, Li C, Fu T, Zhao D, Yi Z, Lu Q, et al. Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice. Behav Brain Res. 2015;288:1-10 pubmed publisher |
| Shan X, Aziz F, Tian L, Wang X, Yan Q, Liu J. Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/LeY expression. Int J Oncol. 2015;46:1667-76 pubmed publisher |
