This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
MRPS18B
catalog :
16139-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 23
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:2000; loading ...; fig 1b
Richter U, Ng K, Suomi F, Marttinen P, Turunen T, Jackson C, et al. Mitochondrial stress response triggered by defects in protein synthesis quality control. Life Sci Alliance. 2019;2: pubmed publisher
  • western blot; human; loading ...; fig 2
Rozanska A, Richter Dennerlein R, Rorbach J, Gao F, Lewis R, Chrzanowska Lightowlers Z, et al. The human RNA-binding protein RBFA promotes the maturation of the mitochondrial ribosome. Biochem J. 2017;474:2145-2158 pubmed publisher
  • western blot; human; loading ...; fig 1c
Richter Dennerlein R, Oeljeklaus S, Lorenzi I, Ronsör C, Bareth B, Schendzielorz A, et al. Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein. Cell. 2016;167:471-483.e10 pubmed publisher
  • western blot; human; fig 4
Nouws J, Goswami A, Bestwick M, McCann B, Surovtseva Y, Shadel G. Mitochondrial Ribosomal Protein L12 Is Required for POLRMT Stability and Exists as Two Forms Generated by Alternative Proteolysis during Import. J Biol Chem. 2016;291:989-97 pubmed publisher
Reyes A, Favia P, Vidoni S, Petruzzella V, Zeviani M. RCC1L (WBSCR16) isoforms coordinate mitochondrial ribosome assembly through their interaction with GTPases. PLoS Genet. 2020;16:e1008923 pubmed publisher
Bruni F, Proctor Kent Y, Lightowlers R, Chrzanowska Lightowlers Z. Messenger RNA delivery to mitoribosomes - hints from a bacterial toxin. FEBS J. 2020;: pubmed publisher
Nandi S, Liang G, Sindhava V, Angireddy R, Basu A, Banerjee S, et al. YY1 control of mitochondrial-related genes does not account for regulation of immunoglobulin class switch recombination in mice. Eur J Immunol. 2020;50:822-838 pubmed publisher
Reyes A, Rusecka J, Tonska K, Zeviani M. RNase H1 Regulates Mitochondrial Transcription and Translation via the Degradation of 7S RNA. Front Genet. 2019;10:1393 pubmed publisher
Wang C, Richter Dennerlein R, Pacheu Grau D, Liu F, Zhu Y, Dennerlein S, et al. MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex. EMBO Rep. 2019;:e48833 pubmed publisher
Van Haute L, Hendrick A, D Souza A, Powell C, Rebelo Guiomar P, Harbour M, et al. METTL15 introduces N4-methylcytidine into human mitochondrial 12S rRNA and is required for mitoribosome biogenesis. Nucleic Acids Res. 2019;47:10267-10281 pubmed publisher
Pulman J, Ruzzenente B, Bianchi L, Rio M, Boddaert N, Munnich A, et al. Mutations in the MRPS28 gene encoding the small mitoribosomal subunit protein bS1m in a patient with intrauterine growth retardation, craniofacial dysmorphism and multisystemic involvement. Hum Mol Genet. 2019;28:1445-1462 pubmed publisher
Jackson C, Huemer M, Bolognini R, Martin F, Szinnai G, Donner B, et al. A variant in MRPS14 (uS14m) causes perinatal hypertrophic cardiomyopathy with neonatal lactic acidosis, growth retardation, dysmorphic features and neurological involvement. Hum Mol Genet. 2019;28:639-649 pubmed publisher
Ruzzenente B, Assouline Z, Barcia G, Rio M, Boddaert N, Munnich A, et al. Inhibition of mitochondrial translation in fibroblasts from a patient expressing the KARS p.(Pro228Leu) variant and presenting with sensorineural deafness, developmental delay, and lactic acidosis. Hum Mutat. 2018;39:2047-2059 pubmed publisher
Lavdovskaia E, Kolander E, Steube E, Mai M, Urlaub H, Richter Dennerlein R. The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis. Nucleic Acids Res. 2018;46:8471-8482 pubmed publisher
Zurita Rendón O, Shoubridge E. LONP1 Is Required for Maturation of a Subset of Mitochondrial Proteins, and Its Loss Elicits an Integrated Stress Response. Mol Cell Biol. 2018;38: pubmed publisher
Mushtaq M, Jensen L, Davidsson S, Grygoruk O, Andrén O, Kashuba V, et al. The MRPS18-2 protein levels correlate with prostate tumor progression and it induces CXCR4-dependent migration of cancer cells. Sci Rep. 2018;8:2268 pubmed publisher
Lake N, Webb B, Stroud D, Richman T, Ruzzenente B, Compton A, et al. Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome. Am J Hum Genet. 2017;101:239-254 pubmed publisher
Antonicka H, Choquet K, Lin Z, Gingras A, Kleinman C, Shoubridge E. A pseudouridine synthase module is essential for mitochondrial protein synthesis and cell viability. EMBO Rep. 2017;18:28-38 pubmed publisher
Akman G, Desai R, Bailey L, Yasukawa T, Dalla Rosa I, Durigon R, et al. Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria. Proc Natl Acad Sci U S A. 2016;113:E4276-85 pubmed publisher
Mints M, Mushtaq M, Iurchenko N, Kovalevska L, Stip M, Budnikova D, et al. Mitochondrial ribosomal protein S18-2 is highly expressed in endometrial cancers along with free E2F1. Oncotarget. 2016;7:22150-8 pubmed publisher
Richter U, Lahtinen T, Marttinen P, Suomi F, Battersby B. Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness. J Cell Biol. 2015;211:373-89 pubmed publisher
Zhang X, Gao X, Coots R, Conn C, Liu B, Qian S. Translational control of the cytosolic stress response by mitochondrial ribosomal protein L18. Nat Struct Mol Biol. 2015;22:404-10 pubmed publisher
Antonicka H, Shoubridge E. Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis. Cell Rep. 2015;10:920-932 pubmed publisher
product information
CatalogNo :
16139-1-AP
AntigenName :
MRPS18B
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
mitochondrial ribosomal protein S18B
Immunogen :
Recombinant Protein
Species :
human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, CoIP, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
C6orf14, HSPC183, HumanS18a, MRP S18 2, MRP S18 b, MRPS18 2, Mrps18 b, MRPS18B, PTD017, S18amt, S18mt b
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC005373
Category :
Cytoskeleton/Scaffold Proteins;Metabolism;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
AppTiter :
IF 1:50 ; IHC 1:200 ; IP 1:1000 ; WB 1:800 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.