This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
Piezo1 (extracellular domain)
catalog :
15939-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, western blot knockout validation
citations: 21
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 2e
Sun W, Chi S, Li Y, Ling S, Tan Y, Xu Y, et al. The mechanosensitive Piezo1 channel is required for bone formation. elife. 2019;8: pubmed publisher
  • western blot; mouse; 1:100; loading ...; fig 1a
MacKay C, Leo M, Fernández Peña C, Hasan R, Yin W, Mata Daboin A, et al. Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure. elife. 2020;9: pubmed publisher
  • immunocytochemistry; mouse; 1:100; loading ...; fig 3b
  • western blot; mouse; 1:500; loading ...; fig e6b
SEGEL M, Neumann B, Hill M, Weber I, Viscomi C, Zhao C, et al. Niche stiffness underlies the ageing of central nervous system progenitor cells. Nature. 2019;573:130-134 pubmed publisher
  • immunohistochemistry; mouse; 1:250; loading ...; fig 7h
Tao H, Zhu M, Lau K, Whitley O, Samani M, Xiao X, et al. Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch. Nat Commun. 2019;10:1703 pubmed publisher
  • immunocytochemistry; human; fig 5c
  • western blot; human; fig 5f
Chen X, Wanggou S, Bodalia A, Zhu M, Dong W, Fan J, et al. A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression. Neuron. 2018;100:799-815.e7 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 6b
Ilkan Z, Wright J, Goodall A, Gibbins J, Jones C, Mahaut Smith M. Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line. J Biol Chem. 2017;292:9204-9217 pubmed publisher
Sugisawa E, Takayama Y, Takemura N, Kondo T, Hatakeyama S, Kumagai Y, et al. RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis. Cell. 2020;: pubmed publisher
Mousawi F, Peng H, Li J, Sreenivasan P, Roger S, Zhao H, et al. Chemical activation of the Piezo1 channel drives mesenchymal stem cell migration via inducing ATP release and activation of P2 receptor purinergic signalling. Stem Cells. 2019;: pubmed publisher
Saleh A, Marhuenda E, Fabre C, Hassani Z, Weille J, Boukhaddaoui H, et al. A novel 3D nanofibre scaffold conserves the plasticity of glioblastoma stem cell invasion by regulating galectin-3 and integrin-β1 expression. Sci Rep. 2019;9:14612 pubmed publisher
Caulier A, Jankovsky N, Demont Y, Ouled Haddou H, Demagny J, Guitton C, et al. PIEZO1 activation delays erythroid differentiation of normal and Hereditary Xerocytosis-derived human progenitors. Haematologica. 2019;: pubmed publisher
Zhong M, Wu W, Kang H, Hong Z, Xiong S, Gao X, et al. Alveolar Stretch Activation of Endothelial Piezo1 Protects Adherens Junctions and Lung Vascular Barrier. Am J Respir Cell Mol Biol. 2019;: pubmed publisher
Han Y, Liu C, Zhang D, Men H, Huo L, Geng Q, et al. Mechanosensitive ion channel Piezo1 promotes prostate cancer development through the activation of the Akt/mTOR pathway and acceleration of cell cycle. Int J Oncol. 2019;: pubmed publisher
Forget A, Gianni Barrera R, Uccelli A, Sarem M, Kohler E, Fogli B, et al. Mechanically Defined Microenvironment Promotes Stabilization of Microvasculature, Which Correlates with the Enrichment of a Novel Piezo-1+ Population of Circulating CD11b+ /CD115+ Monocytes. Adv Mater. 2019;31:e1808050 pubmed publisher
Lhomme A, Gilbert G, Pele T, Deweirdt J, Henrion D, Baudrimont I, et al. Stretch-activated Piezo1 Channel in Endothelial Cells Relaxes Mouse Intrapulmonary Arteries. Am J Respir Cell Mol Biol. 2019;60:650-658 pubmed publisher
Kang H, Hong Z, Zhong M, Klomp J, Bayless K, Mehta D, et al. Piezo1 mediates angiogenesis through activation of MT1-MMP signaling. Am J Physiol Cell Physiol. 2019;316:C92-C103 pubmed publisher
Albarrán Juárez J, Iring A, Wang S, Joseph S, Grimm M, Strilic B, et al. Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation. J Exp Med. 2018;215:2655-2672 pubmed publisher
Zhang J, Zhou Y, Huang T, Wu F, Liu L, Kwan J, et al. PIEZO1 functions as a potential oncogene by promoting cell proliferation and migration in gastric carcinogenesis. Mol Carcinog. 2018;57:1144-1155 pubmed publisher
Liang J, Huang B, Yuan G, Chen Y, Liang F, Zeng H, et al. Stretch-activated channel Piezo1 is up-regulated in failure heart and cardiomyocyte stimulated by AngII. Am J Transl Res. 2017;9:2945-2955 pubmed
Gudipaty S, Lindblom J, Loftus P, Redd M, Edes K, Davey C, et al. Mechanical stretch triggers rapid epithelial cell division through Piezo1. Nature. 2017;543:118-121 pubmed publisher
Wang S, Chennupati R, Kaur H, Iring A, Wettschureck N, Offermanns S. Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. J Clin Invest. 2016;126:4527-4536 pubmed publisher
Fotiou E, Martin Almedina S, Simpson M, Lin S, Gordon K, Brice G, et al. Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis. Nat Commun. 2015;6:8085 pubmed publisher
product information
CatalogNo :
15939-1-AP
AntigenName :
Piezo1 (extracellular domain)
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
family with sequence similarity 38, member A
Immunogen :
Recombinant Protein
Species :
dog, human, mouse, zebrafish
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IHC, IF, FC, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
FAM38A, KIAA0233, Mib, PIEZO1
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC008073
Category :
Cytoskeleton/Scaffold Proteins;Disease Related;Membrane Proteins;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:50 ; IHC 1:200 ; WB 1:400 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.