PKM2-specific | Proteintech Group 15822-1-AP product information

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product summary

company name :

Proteintech Group

product type :

antibody

product name :

PKM2-specific

catalog :

15822-1-AP

quantity :

150UL

price :

299 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation

citations: 46

Reference
Chen D, Wang Y, Lu R, Jiang X, Chen X, Meng N, et al. E3 ligase ZFP91 inhibits Hepatocellular Carcinoma Metabolism Reprogramming by regulating PKM splicing. Theranostics. 2020;10:8558-8572 pubmed publisher
Wang C, Li Y, Yan S, Wang H, Shao X, Xiao M, et al. Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2. Nat Commun. 2020;11:3162 pubmed publisher
Gao Z, Dlamini M, Ge H, Jiang L, Geng C, Li Q, et al. ATF4-mediated autophagy-dependent glycolysis plays an important role in attenuating apoptosis induced by Cr (VI) in A549 cells. Toxicol Lett. 2020;331:178-187 pubmed publisher
Jiang Y, Gu Y, Xu H, Tian X, Zhang X, Xu X, et al. Bromide impairs the circadian clock and glycolytic homeostasis via disruption of autophagy in rat H9C2 cardiomyocytes. BMC Mol Cell Biol. 2020;21:44 pubmed publisher
Dong D, Dong Y, Fu J, Lu S, Yuan C, Xia M, et al. Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells. Life Sci. 2020;255:117846 pubmed publisher
Zhang C, Gou X, He W, Yang H, Yin H. A glycolysis-based 4-mRNA signature correlates with the prognosis and cell cycle process in patients with bladder cancer. Cancer Cell Int. 2020;20:177 pubmed publisher
Zhang Z, Su H, Ahmed R, Zheng Y, Jin X. Critical biomarkers for myocardial damage by fine particulate matter: Focused on PPARα-regulated energy metabolism. Environ Pollut. 2020;264:114659 pubmed publisher
Hua Q, Mi B, Xu F, Wen J, Zhao L, Liu J, et al. Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis. Theranostics. 2020;10:4762-4778 pubmed publisher
Chen L, Peng J, Wang Y, Jiang H, Wang W, Dai J, et al. Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway. Am J Transl Res. 2020;12:428-446 pubmed
Yuan Q, Yu H, Chen J, Song X, Sun L. Antitumor Effect of miR-1294/Pyruvate Kinase M2 Signaling Cascade in Osteosarcoma Cells. Onco Targets Ther. 2020;13:1637-1647 pubmed publisher
Li M, Shao J, Guo Z, Jin C, Wang L, Wang F, et al. Novel mitochondrion-targeting copper(II) complex induces HK2 malfunction and inhibits glycolysis via Drp1-mediating mitophagy in HCC. J Cell Mol Med. 2020;24:3091-3107 pubmed publisher
Gassaway B, Cardone R, Padyana A, Petersen M, Judd E, Hayes S, et al. Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production. Cell Rep. 2019;29:3394-3404.e9 pubmed publisher
Chai X, Le Y, Wang J, Mei C, Feng J, Zhao H, et al. Carpesium abrotanoides (L.) Root as a Potential Source of Natural Anticancer Compounds: Targeting Glucose Metabolism and PKM2/HIF-1α Axis of Breast Cancer Cells. J Food Sci. 2019;84:3825-3832 pubmed publisher
Chu X, Xiang M, Feng L, Liu H, Zhou C. Prolyl hydroxylase 3 involvement in lung cancer progression under hypoxic conditions: association with hypoxia-inducible factor-1α and pyruvate kinase M2. J Thorac Dis. 2019;11:3941-3950 pubmed publisher
Zhang W, Shao W, Dong Z, Zhang S, Liu C, Chen S. Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ. Cell Death Dis. 2019;10:404 pubmed publisher
Chen M, Sheng X, Qin Y, Zhu S, Wu Q, Jia L, et al. TBC1D8 Amplification Drives Tumorigenesis through Metabolism Reprogramming in Ovarian Cancer. Theranostics. 2019;9:676-690 pubmed publisher
Ma R, Liu Q, Zheng S, Liu T, Tan D, Lu X. PKM2-regulated STAT3 promotes esophageal squamous cell carcinoma progression via TGF-β1-induced EMT. J Cell Biochem. 2019;: pubmed publisher
Wang F, Jia Y, Li M, Wang L, Shao J, Guo Q, et al. Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells. Cell Commun Signal. 2019;17:11 pubmed publisher
Ye M, Pang N, Wan T, Huang Y, Wei T, Jiang X, et al. Oxidized Vitamin C (DHA) Overcomes Resistance to EGFR-targeted Therapy of Lung Cancer through Disturbing Energy Homeostasis. J Cancer. 2019;10:757-764 pubmed publisher
Liu B, Wang T, Li L, Zhang L, Liu Y, Feng J, et al. Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer. Acta Pharmacol Sin. 2019;40:530-538 pubmed publisher
Xiong P, Tian L, Dunham Snary K, Chen K, Mewburn J, Neuber Hess M, et al. Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities. Front Cardiovasc Med. 2018;5:195 pubmed publisher
Meng Q, Xu J, Liang C, Liu J, Hua J, Zhang Y, et al. GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation. Cell Death Dis. 2018;9:1187 pubmed publisher
Liu B, Jin J, Zhang Z, Zuo L, Jiang M, Xie C. Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2-AMPK-PGC1α signaling pathway. Biochem Cell Biol. 2018;:1-9 pubmed publisher
Yang P, Ding G, Liu W, Fu R, Sajid A, Li Z. Tannic acid directly targets pyruvate kinase isoenzyme M2 to attenuate colon cancer cell proliferation. Food Funct. 2018;9:5547-5559 pubmed publisher
Zhang X, Li Y, Ma Y, Yang L, Wang T, Meng X, et al. Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress. J Exp Clin Cancer Res. 2018;37:216 pubmed publisher
Li W, Qiu Y, Hao J, Zhao C, Deng X, Shu G. Dauricine upregulates the chemosensitivity of hepatocellular carcinoma cells: Role of repressing glycolysis via miR-199a:HK2/PKM2 modulation. Food Chem Toxicol. 2018;121:156-165 pubmed publisher
Chen J, Yu Y, Chen X, He Y, Hu Q, Li H, et al. MiR-139-5p is associated with poor prognosis and regulates glycolysis by repressing PKM2 in gallbladder carcinoma. Cell Prolif. 2018;51:e12510 pubmed publisher
Fan L, Huang C, Li J, Gao T, Lin Z, Yao T. Long non‑coding RNA urothelial cancer associated 1 regulates radioresistance via the hexokinase 2/glycolytic pathway in cervical cancer. Int J Mol Med. 2018;42:2247-2259 pubmed publisher
Yan B, Cheng L, Jiang Z, Chen K, Zhou C, Sun L, et al. Resveratrol Inhibits ROS-Promoted Activation and Glycolysis of Pancreatic Stellate Cells via Suppression of miR-21. Oxid Med Cell Longev. 2018;2018:1346958 pubmed publisher
Xing Y, Li M, Tao L, Ruan L, Hong W, Chen C, et al. Anti-Cancer Effects of Emodin on HepG2 Cells as Revealed by 1H NMR Based Metabolic Profiling. J Proteome Res. 2018;17:1943-1952 pubmed publisher
Wu L, Cao K, Ni Z, Li W, Chen Z, Cheng H, et al. Effects of Dahuang zhechong pill on doxorubicin-resistant SMMC-7721 xenografts in mice. J Ethnopharmacol. 2018;222:71-78 pubmed publisher
Gao L, Wang K, Zhang N, Li J, Qin X, Wang X. 1H Nuclear Magnetic Resonance Based Metabolomics Approach Reveals the Metabolic Mechanism of (-)-5-Hydroxy-equol against Hepatocellular Carcinoma Cells in Vitro. J Proteome Res. 2018;17:1833-1843 pubmed publisher
Kobierzycki C, Piotrowska A, Latkowski K, Zabel M, Nowak Markwitz E, Spaczynski M, et al. Correlation of Pyruvate Kinase M2 Expression with Clinicopathological Data in Ovarian Cancer. Anticancer Res. 2018;38:295-300 pubmed
Konno M, Ishii H, Koseki J, Tanuma N, Nishida N, Kawamoto K, et al. Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells. Regen Ther. 2015;1:63-71 pubmed publisher
Jing C, Qu X, Li Z, Wu C, Zhao M, Wang Y, et al. EGFRwt/vIII-PKM2-?-catenin cascade affects proliferation and chemo-sensitivity in head and neck squamous cell carcinoma. Am J Cancer Res. 2017;7:2491-2502 pubmed
Huang J, Chen M, Chen D, Gao X, Zhu S, Huang H, et al. A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth. Mol Cell. 2017;68:171-184.e6 pubmed publisher
Wu L, Zhao J, Cai H, Wang J, Chen Z, Li W, et al. Dahuang Zhechong Pill Combined with Doxorubicin Induces Cell Death through Regulating Energy Metabolism in Human Hepatocellular Carcinoma Cells. Evid Based Complement Alternat Med. 2017;2017:6279576 pubmed publisher
Horiuchi Y, Nakatsu D, Kano F, Murata M. Pyruvate kinase M1 interacts with A-Raf and inhibits endoplasmic reticulum stress-induced apoptosis by activating MEK1/ERK pathway in mouse insulinoma cells. Cell Signal. 2017;38:212-222 pubmed publisher
Lian X, Zhao J, Wu X, Zhang Y, Li Q, Lin S, et al. The changes in glucose metabolism and cell proliferation in the kidneys of polycystic kidney disease mini-pig models. Biochem Biophys Res Commun. 2017;488:374-381 pubmed publisher
Huang P, Zhao X, Xiao W, Dong Y, Hu G. 18F-fluorodeoxyglucose uptake predicts PKM2 expression in lung adenocarcinoma. Oncotarget. 2017;8:39618-39626 pubmed publisher
Wu H, Li Z, Wang Y, Yang P, Li Z, Li H, et al. MiR-106b-mediated Mfn2 suppression is critical for PKM2 induced mitochondrial fusion. Am J Cancer Res. 2016;6:2221-2234 pubmed
Lu W, Cao Y, Zhang Y, Li S, Gao J, Wang X, et al. Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer. Sci Rep. 2016;6:26351 pubmed publisher
Konno M, Koseki J, Kawamoto K, Nishida N, Matsui H, Dewi D, et al. Embryonic MicroRNA-369 Controls Metabolic Splicing Factors and Urges Cellular Reprograming. PLoS ONE. 2015;10:e0132789 pubmed publisher
Cautain B, de Pedro N, Schulz C, Pascual J, Sousa T, Martin J, et al. Identification of the Lipodepsipeptide MDN-0066, a Novel Inhibitor of VHL/HIF Pathway Produced by a New Pseudomonas Species. PLoS ONE. 2015;10:e0125221 pubmed publisher
Nakatsu D, Horiuchi Y, Kano F, Noguchi Y, Sugawara T, Takamoto I, et al. L-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2. Proc Natl Acad Sci U S A. 2015;112:E1067-76 pubmed publisher
Yang H, Kim T, Song S, Menon L, Jiang X, Huang W, et al. A small subunit processome protein promotes cancer by altering translation. Oncogene. 2015;34:4471-81 pubmed publisher

product information

CatalogNo :

15822-1-AP

AntigenName :

PKM2-specific

Package :

150UL

Price :

299 USD

Exsists20ul :

20ul trial size available

FullName :

PKM pyruvate kinase, muscle

Immunogen :

Peptide

Species :

human, mouse, rat

Host :

Rabbit

IsConjugated :

Unconjugated

AntigenSpecies :

human

Application :

WB, IP, IHC, IF, CoIP, chIP, ELISA

Clonlity :

Polyclonal

IsoType :

IgG

Synonyms :

CTHBP, OIP 3, OIP3, Opa interacting protein 3, p58, PK2, PK3, PKM, PKM2, PK-M2, PKM2 pyruvate kinase, muscle, Pyruvate kinase 2/3, Pyruvate kinase isozymes M1/M2, Pyruvate kinase muscle isozyme, TCB, THBP1, Tumor M2 PK

PrimaryOrSecondary :

Primary

AntibodyBuffer :

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

GenBankNo :

NM_002654

Category :

Binding Proteins;Cytoskeleton/Scaffold Proteins;Disease Related;Metabolism;

PurifyMethod :

Antigen affinity purification

NewAb :

False

IsSellable :

True

Feature :

siRNA

AppTiter :

IF 1:25 ; IHC 1:200 ; IP 1:300 ; WB 1:2000 ;