PKM1-specific | Proteintech Group 15821-1-AP product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Proteintech Group

product type :

antibody

product name :

PKM1-specific

catalog :

15821-1-AP

quantity :

150UL

price :

299 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 23

Reference
Wang C, Li Y, Yan S, Wang H, Shao X, Xiao M, et al. Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2. Nat Commun. 2020;11:3162 pubmed publisher
Sun X, Yao L, Liang H, Wang D, He Y, Wei Y, et al. Intestinal epithelial PKM2 serves as a safeguard against experimental colitis via activating β-catenin signaling. Mucosal Immunol. 2019;12:1280-1290 pubmed publisher
Zhao R, Li L, Yang J, Niu Q, Wang H, Qin X, et al. Overexpression of Pyruvate Kinase M2 in Tumor Tissues Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma. Pathol Oncol Res. 2019;: pubmed publisher
Xiong P, Tian L, Dunham Snary K, Chen K, Mewburn J, Neuber Hess M, et al. Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities. Front Cardiovasc Med. 2018;5:195 pubmed publisher
Ma B, Chen J, Mu Y, Xue B, Zhao A, Wang D, et al. Proteomic analysis of rat serum revealed the effects of chronic sleep deprivation on metabolic, cardiovascular and nervous system. PLoS ONE. 2018;13:e0199237 pubmed publisher
Huang D, Chen J, Yang L, Ouyang Q, Li J, Lao L, et al. NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death. Nat Immunol. 2018;19:1112-1125 pubmed publisher
Jiang H, Zhang S, Song T, Guan X, Zhang R, Chen X. Trichostatin a Protects Dendritic Cells Against Oxygen-Glucose Deprivation via the SRSF3/PKM2/Glycolytic Pathway. Front Pharmacol. 2018;9:612 pubmed publisher
Williams A, Khadka V, Tang M, Avelar A, Schunke K, Menor M, et al. HIF1 mediates a switch in pyruvate kinase isoforms after myocardial infarction. Physiol Genomics. 2018;50:479-494 pubmed publisher
Hilander T, Zhou X, Konovalova S, Zhang F, Euro L, Chilov D, et al. Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria. Nucleic Acids Res. 2018;46:849-860 pubmed publisher
Qin S, Yang D, Chen K, Li H, Zhang L, Li Y, et al. Pkm2 can enhance pluripotency in ESCs and promote somatic cell reprogramming to iPSCs. Oncotarget. 2017;8:84276-84284 pubmed publisher
Horiuchi Y, Nakatsu D, Kano F, Murata M. Pyruvate kinase M1 interacts with A-Raf and inhibits endoplasmic reticulum stress-induced apoptosis by activating MEK1/ERK pathway in mouse insulinoma cells. Cell Signal. 2017;38:212-222 pubmed publisher
Wei L, Dai Y, Zhou Y, He Z, Yao J, Zhao L, et al. Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression. Cell Death Dis. 2017;8:e2944 pubmed publisher
Xu Y, Chu L, Yuan S, Yang Y, Yang Y, Xu B, et al. RGD-modified oncolytic adenovirus-harboring shPKM2 exhibits a potent cytotoxic effect in pancreatic cancer via autophagy inhibition and apoptosis promotion. Cell Death Dis. 2017;8:e2835 pubmed publisher
Wei Y, Wang D, Jin F, Bian Z, Li L, Liang H, et al. Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23. Nat Commun. 2017;8:14041 pubmed publisher
Lu W, Cao Y, Zhang Y, Li S, Gao J, Wang X, et al. Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer. Sci Rep. 2016;6:26351 pubmed publisher
de Andrade Barreto E, de Souza Santos P, Bergmann A, de Oliveira I, Wernersbach Pinto L, Blanco T, et al. Alterations in glucose metabolism proteins responsible for the Warburg effect in esophageal squamous cell carcinoma. Exp Mol Pathol. 2016;101:66-73 pubmed publisher
Dong K, Ni H, Wu M, Tang Z, Halim M, Shi D. ROS-mediated glucose metabolic reprogram induces insulin resistance in type 2 diabetes. Biochem Biophys Res Commun. 2016;476:204-211 pubmed publisher
Mukherjee J, Ohba S, See W, Phillips J, Molinaro A, Pieper R. PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells. Int J Cancer. 2016;139:99-111 pubmed publisher
Casson R, Wood J, Han G, Kittipassorn T, Peet D, Chidlow G. M-Type Pyruvate Kinase Isoforms and Lactate Dehydrogenase A in the Mammalian Retina: Metabolic Implications. Invest Ophthalmol Vis Sci. 2016;57:66-80 pubmed publisher
Santi A, Caselli A, Ranaldi F, Paoli P, Mugnaioni C, Michelucci E, et al. Cancer associated fibroblasts transfer lipids and proteins to cancer cells through cargo vesicles supporting tumor growth. Biochim Biophys Acta. 2015;1853:3211-23 pubmed publisher
Konno M, Koseki J, Kawamoto K, Nishida N, Matsui H, Dewi D, et al. Embryonic MicroRNA-369 Controls Metabolic Splicing Factors and Urges Cellular Reprograming. PLoS ONE. 2015;10:e0132789 pubmed publisher
Nakatsu D, Horiuchi Y, Kano F, Noguchi Y, Sugawara T, Takamoto I, et al. L-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2. Proc Natl Acad Sci U S A. 2015;112:E1067-76 pubmed publisher
Yang H, Kim T, Song S, Menon L, Jiang X, Huang W, et al. A small subunit processome protein promotes cancer by altering translation. Oncogene. 2015;34:4471-81 pubmed publisher

product information

CatalogNo :

15821-1-AP

AntigenName :

PKM1-specific

Package :

150UL

Price :

299 USD

Exsists20ul :

20ul trial size available

FullName :

PKM pyruvate kinase, muscle

Immunogen :

Peptide

Species :

human, monkey, mouse, rat

Host :

Rabbit

IsConjugated :

Unconjugated

AntigenSpecies :

human

Application :

WB, IP, IHC, IF, ELISA

Clonlity :

Polyclonal

IsoType :

IgG

Synonyms :

CTHBP, OIP 3, OIP3, Opa interacting protein 3, p58, PK2, PK3, PKM, PKM1, PK-M1, PKM1 pyruvate kinase, muscle, Pyruvate kinase 2/3, Pyruvate kinase isozymes M1/M2, Pyruvate kinase muscle isozyme, TCB, THBP1, Tumor M2 PK

PrimaryOrSecondary :

Primary

AntibodyBuffer :

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

GenBankNo :

NM_182470

Category :

Binding Proteins;Cytoskeleton/Scaffold Proteins;Disease Related;Metabolism;

PurifyMethod :

Antigen affinity purification

NewAb :

False

IsSellable :

True

Feature :

siRNA

AppTiter :

IHC 1:200 ; IP 1:1000 ; WB 1:2000 ;