This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
Fibronectin
catalog :
15613-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, zebrafish
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section
citations: 169
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 3b
Sundararaman A, Fukushima Y, Norman J, Uemura A, Mellor H. RhoJ Regulates α5β1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis. Curr Biol. 2020;30:2146-2155.e5 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 1b, 5f
Jiang Z, Tang Y, Song H, Yang M, Li B, Ni C. miRNA‑342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6. Int J Mol Med. 2020;45:45-52 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5b
Esfahani M, Lee L, Jeon Y, Flynn R, Stehr H, Hui A, et al. Functional significance of U2AF1 S34F mutations in lung adenocarcinomas. Nat Commun. 2019;10:5712 pubmed publisher
  • western blot; rat; loading ...; fig 3b
  • immunohistochemistry; mouse; loading ...; fig 1d
  • western blot; mouse; loading ...; fig 1g
Chen Z, Sun X, Chen Q, Lan T, Huang K, Xiao H, et al. Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked Nox4 polyubiquitination and degradation via the inhibition of Smurf1 expression. Br J Pharmacol. 2019;: pubmed publisher
  • western blot; mouse; loading ...; fig 1g
Feng F, Wang Z, Li R, Wu Q, Gu C, Xu Y, et al. Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2. Biomed Pharmacother. 2019;112:108669 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 5a, 5b, 5c
  • western blot; human; 1:500; loading ...; fig 4a, 4b, 4c
Xin H, Wang C, Liu Z. miR-196a-5p promotes metastasis of colorectal cancer via targeting IκBα. BMC Cancer. 2019;19:30 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:20; loading ...; fig 8a
  • western blot; zebrafish ; 1:500; loading ...; fig s10a
Han S, Liu X, Xie S, Gao M, Liu F, Yu S, et al. Knockout of ush2a gene in zebrafish causes hearing impairment and late onset rod-cone dystrophy. Hum Genet. 2018;137:779-794 pubmed publisher
  • immunoprecipitation; human; fig s3
  • immunohistochemistry; human
  • western blot; human; fig s2
Ren S, Wang J, Chen T, Li H, Wan Y, Peng N, et al. Hepatitis B Virus Stimulated Fibronectin Facilitates Viral Maintenance and Replication through Two Distinct Mechanisms. PLoS ONE. 2016;11:e0152721 pubmed publisher
Miao K, Pan T, Mou Y, Zhang L, Xiong W, Xu Y, et al. Scutellarein inhibits BLM-mediated pulmonary fibrosis by affecting fibroblast differentiation, proliferation, and apoptosis. Ther Adv Chronic Dis. 2020;11:2040622320940185 pubmed publisher
Ye C, Xiong W, Lei C, Tang H, Su H, Yi F, et al. MAD2B contributes to parietal epithelial cell activation and crescentic glomerulonephritis via Skp2. Am J Physiol Renal Physiol. 2020;: pubmed publisher
Chen Z, Sun X, Li X, Xu Z, Yang Y, Lin Z, et al. Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway. Acta Pharmacol Sin. 2020;: pubmed publisher
Yang K, Fan B, Zhao Q, Ji Y, Liu P, Gao S, et al. Hirudin Ameliorates Renal Interstitial Fibrosis via Regulating TGF-β1/Smad and NF-κB Signaling in UUO Rat Model. Evid Based Complement Alternat Med. 2020;2020:7291075 pubmed publisher
Li J, Liu J, Yue W, Xu K, Cai W, Cui F, et al. Andrographolide attenuates epithelial-mesenchymal transition induced by TGF-β1 in alveolar epithelial cells. J Cell Mol Med. 2020;: pubmed publisher
Wu L, Wang Q, Guo F, Ma X, Wang J, Zhao Y, et al. Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress. J Cell Physiol. 2020;: pubmed publisher
Xu D, Chen P, Zheng P, Yin F, Cheng Q, Zhou Z, et al. KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion kidney injury. Acta Pharmacol Sin. 2020;: pubmed publisher
Jin M, Gao D, Wang R, Sik A, Liu K. Possible involvement of TGF‑β‑SMAD‑mediated epithelial‑mesenchymal transition in pro‑metastatic property of PAX6. Oncol Rep. 2020;44:555-564 pubmed publisher
Ndibalema A, Kabuye D, Wen S, Li L, Li X, Fan Q. Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha. Diabetes Metab Syndr Obes. 2020;13:1953-1967 pubmed publisher
Liu D, Zhang H, Cui M, Chen C, Feng Y. Hsa-miR-425-5p promotes tumor growth and metastasis by activating the CTNND1-mediated β-catenin pathway and EMT in colorectal cancer. Cell Cycle. 2020;19:1917-1927 pubmed publisher
Li Y, Liu Y, Wang K, Huang Y, Han W, Xiong J, et al. Klotho is regulated by transcription factor Sp1 in renal tubular epithelial cells. BMC Mol Cell Biol. 2020;21:45 pubmed publisher
Yuan Q, Xu T, Chen Y, Qu W, Sun D, Liu X, et al. MiR-185-5p ameliorates endoplasmic reticulum stress and renal fibrosis by downregulation of ATF6. Lab Invest. 2020;: pubmed publisher
Feng M, Fang F, Fang T, Jiao H, You S, Wang X, et al. Sox13 promotes hepatocellular carcinoma metastasis by transcriptionally activating Twist1. Lab Invest. 2020;: pubmed publisher
Chen D, Li L, Wang Y, Xu R, Peng S, Zhou L, et al. Ischemia-reperfusion injury of brain induces endothelial-mesenchymal transition and vascular fibrosis via activating let-7i/TGF-βR1 double-negative feedback loop. FASEB J. 2020;34:7178-7191 pubmed publisher
Xu B, Wang C, Wang Y, Chen S, Wu J, Zhu W, et al. miR-143 inhibits renal cell carcinoma cells metastatic potential by suppressing ABL2. Kaohsiung J Med Sci. 2020;: pubmed publisher
Hu Y, Yu J, Wang Q, Zhang L, Chen X, Cao Y, et al. Tartrate-Resistant Acid Phosphatase 5/ACP5 Interacts with p53 to Control the Expression of SMAD3 in Lung Adenocarcinoma. Mol Ther Oncolytics. 2020;16:272-288 pubmed publisher
He J, Jiang Y, Wang Y, Tian X, Sun S. Micro-vesicles from mesenchymal stem cells over-expressing miR-34a inhibit transforming growth factor-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells in vitro. Chin Med J (Engl). 2020;133:800-807 pubmed publisher
Zeng K, Chen X, Xu M, Liu X, Li C, Xu X, et al. LRIG3 represses cell motility by inhibiting slug via inactivating ERK signaling in human colorectal cancer. IUBMB Life. 2020;72:1393-1403 pubmed publisher
Wang D, Hao C, Zhang L, Zhang J, Liu S, Li Y, et al. Exosomal miR-125a-5p derived from silica-exposed macrophages induces fibroblast transdifferentiation. Ecotoxicol Environ Saf. 2020;192:110253 pubmed publisher
Zhou Z, Ni J, Li J, Huo C, Miao N, Yin F, et al. RIG-I aggravates interstitial fibrosis via c-Myc-mediated fibroblast activation in UUO mice. J Mol Med (Berl). 2020;98:527-540 pubmed publisher
Ma T, Liang Y, Li Y, Song X, Zhang N, Li X, et al. LncRNA LINP1 confers tamoxifen resistance and negatively regulated by ER signaling in breast cancer. Cell Signal. 2020;68:109536 pubmed publisher
Su H, Ye C, Lei C, Tang H, Zeng J, Yi F, et al. Subcellular trafficking of tubular MDM2 implicates in acute kidney injury to chronic kidney disease transition during multiple low-dose cisplatin exposure. FASEB J. 2020;34:1620-1636 pubmed publisher
Ouyang F, Liu X, Liu G, Qiu H, He Y, Hu H, et al. Long non-coding RNA RNF7 promotes the cardiac fibrosis in rat model via miR-543/THBS1 axis and TGFβ1 activation. Aging (Albany NY). 2020;12:996-1010 pubmed publisher
Liu S, Zhao M, Zhou Y, Li L, Wang C, Yuan Y, et al. A self-assembling peptide hydrogel-based drug co-delivery platform to improve tissue repair after ischemia-reperfusion injury. Acta Biomater. 2020;103:102-114 pubmed publisher
Yang X, Yan H, Jiang N, Yu Z, Yuan J, Ni Z, et al. IL-6 trans-signaling drives a STAT3-dependent pathway that leads to structural alterations of the peritoneal membrane. Am J Physiol Renal Physiol. 2020;318:F338-F353 pubmed publisher
Xiao H, Sun X, Liu R, Chen Z, Lin Z, Yang Y, et al. Gentiopicroside activates the bile acid receptor Gpbar1 (TGR5) to repress NF-kappaB pathway and ameliorate diabetic nephropathy. Pharmacol Res. 2020;151:104559 pubmed publisher
Guan R, Wang J, Cai Z, Li Z, Wang L, Li Y, et al. Hydrogen sulfide attenuates cigarette smoke-induced airway remodeling by upregulating SIRT1 signaling pathway. Redox Biol. 2020;28:101356 pubmed publisher
Yang X, Wang H, Tu Y, Li Y, Zou Y, Li G, et al. WNT1-inducible signaling protein-1 mediates TGF-β1-induced renal fibrosis in tubular epithelial cells and unilateral ureteral obstruction mouse models via autophagy. J Cell Physiol. 2020;235:2009-2022 pubmed publisher
Wang K, Wei H, Zhan J, Liang X, Zhang C, Liu Y, et al. GSPE alleviates renal fibrosis by inhibiting the activation of C3/ HMGB1/ TGF-β1 pathway. Chem Biol Interact. 2019;316:108926 pubmed publisher
Rao N, Wang X, Xie J, Li J, Zhai Y, Li X, et al. Stem Cells from Human Exfoliated Deciduous Teeth Ameliorate Diabetic Nephropathy In Vivo and In Vitro by Inhibiting Advanced Glycation End Product-Activated Epithelial-Mesenchymal Transition. Stem Cells Int. 2019;2019:2751475 pubmed publisher
Ma T, Xu L, Lu L, Cao X, Li X, Li L, et al. Ursolic Acid Treatment Alleviates Diabetic Kidney Injury By Regulating The ARAP1/AT1R Signaling Pathway. Diabetes Metab Syndr Obes. 2019;12:2597-2608 pubmed publisher
Li H, Cui X, Hu Q, Chen X, Zhou P. CLK3 Is A Direct Target Of miR-144 And Contributes To Aggressive Progression In Hepatocellular Carcinoma. Onco Targets Ther. 2019;12:9201-9213 pubmed publisher
Geng X, Ma A, He J, Wang L, Jia Y, Shao G, et al. Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways. Acta Pharmacol Sin. 2019;: pubmed publisher
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Wang Y, Li C, Gu J, Chen C, Duanmu J, Miao J, et al. Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signalling. J Cell Mol Med. 2019;: pubmed publisher
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Wu J, Lu K, Zhu M, Xie X, Ding Y, Shao X, et al. miR-485 suppresses inflammation and proliferation of mesangial cells in an in vitro model of diabetic nephropathy by targeting NOX5. Biochem Biophys Res Commun. 2019;: pubmed publisher
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Feng X, Yang R, Tian Y, Miao X, Guo H, Gao F, et al. HMGB1 protein promotes glomerular mesangial matrix deposition via TLR2 in lupus nephritis. J Cell Physiol. 2019;: pubmed publisher
Huang F, Wang Q, Guo F, Zhao Y, Ji L, An T, et al. FoxO1-mediated inhibition of STAT1 alleviates tubulointerstitial fibrosis and tubule apoptosis in diabetic kidney disease. EBioMedicine. 2019;48:491-504 pubmed publisher
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Zhang C, Zhu X, Li L, Ma T, Shi M, Yang Y, et al. A small molecule inhibitor MCC950 ameliorates kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome activation. Diabetes Metab Syndr Obes. 2019;12:1297-1309 pubmed publisher
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Ge Y, Wang J, Wu D, Zhou Y, Qiu S, Chen J, et al. lncRNA NR_038323 Suppresses Renal Fibrosis in Diabetic Nephropathy by Targeting the miR-324-3p/DUSP1 Axis. Mol Ther Nucleic Acids. 2019;17:741-753 pubmed publisher
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Huang F, Zhao Y, Wang Q, Hillebrands J, van den Born J, Ji L, et al. Dapagliflozin Attenuates Renal Tubulointerstitial Fibrosis Associated With Type 1 Diabetes by Regulating STAT1/TGFβ1 Signaling. Front Endocrinol (Lausanne). 2019;10:441 pubmed publisher
Chang J, Gao F, Chu H, Lou L, Wang H, Chen Y. miR-363-3p inhibits migration, invasion, and epithelial-mesenchymal transition by targeting NEDD9 and SOX4 in non-small-cell lung cancer. J Cell Physiol. 2019;: pubmed publisher
Qiu Y, Zhou J, Zhang H, Zhou H, Tang H, Lei C, et al. Rhodojaponin II attenuates kidney injury by regulating TGF-β1/Smad pathway in mice with adriamycin nephropathy. J Ethnopharmacol. 2019;243:112078 pubmed publisher
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Wang L, Zhang P, Li X, Zhang Y, Zhan Q, Wang C. Low-molecular-weight fucoidan attenuates bleomycin-induced pulmonary fibrosis: possible role in inhibiting TGF-β1-induced epithelial-mesenchymal transition through ERK pathway. Am J Transl Res. 2019;11:2590-2602 pubmed
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Ji L, Wang Q, Huang F, An T, Guo F, Zhao Y, et al. FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX. Oxid Med Cell Longev. 2019;2019:3286928 pubmed publisher
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Hwang S, Song J, Kim Y, Lim J, Kim M, Kim E, et al. Inhibition of lymphatic proliferation by the selective VEGFR-3 inhibitor SAR131675 ameliorates diabetic nephropathy in db/db mice. Cell Death Dis. 2019;10:219 pubmed publisher
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Gu L, Wang Y, Yang G, Tilyek A, Zhang C, Li S, et al. Ribes diacanthum Pall (RDP) ameliorates UUO-induced renal fibrosis via both canonical and non-canonical TGF-β signaling pathways in mice. J Ethnopharmacol. 2019;231:302-310 pubmed publisher
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Li X, Li C, Tang Y, Huang Y, Cheng Q, Huang X, et al. NMDA receptor activation inhibits the antifibrotic effect of BM-MSCs on bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2018;315:L404-L421 pubmed publisher
Li A, Peng R, Sun Y, Liu H, Peng H, Zhang Z. LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1? signaling. Cell Death Dis. 2018;9:461 pubmed publisher
Li X, Yu T, Shan H, Jiang H, Sun J, Zhao X, et al. lncRNA PFAL promotes lung fibrosis through CTGF by competitively binding miR-18a. FASEB J. 2018;32:5285-5297 pubmed publisher
Sun J, Chang T, Li M, Sun L, Yan X, Yang Z, et al. SNAI1, an endothelial-mesenchymal transition transcription factor, promotes the early phase of ocular neovascularization. Angiogenesis. 2018;21:635-652 pubmed publisher
Zhao X, Sun J, Su W, Shan H, Zhang B, Wang Y, et al. Melatonin Protects against Lung Fibrosis by Regulating the Hippo/YAP Pathway. Int J Mol Sci. 2018;19: pubmed publisher
He F, You R, Ye C, Lei C, Tang H, Su H, et al. Inhibition of SIRT2 Alleviates Fibroblast Activation and Renal Tubulointerstitial Fibrosis via MDM2. Cell Physiol Biochem. 2018;46:451-460 pubmed publisher
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Wang Q, Yang X, Xu Y, Shen Z, Cheng H, Cheng F, et al. RhoA/Rho-kinase triggers epithelial-mesenchymal transition in mesothelial cells and contributes to the pathogenesis of dialysis-related peritoneal fibrosis. Oncotarget. 2018;9:14397-14412 pubmed publisher
Graupp M, Rinner B, Frisch M, Weiss G, Fuchs J, Sundl M, et al. Towards an in vitro fibrogenesis model of human vocal fold scarring. Eur Arch Otorhinolaryngol. 2018;275:1211-1218 pubmed publisher
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product information
CatalogNo :
15613-1-AP
AntigenName :
Fibronectin
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
fibronectin 1
Immunogen :
Recombinant Protein
Species :
human, mouse, porcine, rat, swine
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
CIG, Cold insoluble globulin, ED B, Fibronectin, fibronectin 1, FINC, FN, FN1, FNZ, GFND, GFND2, LETS, MSF
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC005858
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Disease Related;Membrane Proteins;Signal transduction;Stem Cells;Transport/Trafficking;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:50 ; IP 1:300 ; WB 1:1000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.