This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
RNASEH1
catalog :
15606-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunocytochemistry, immunoprecipitation
citations: 15
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; loading ...; fig s6b
  • western blot; human; 1:500; loading ...; fig 4h
Chiang H, Zhang X, Li J, Zhao X, Chen J, Wang H, et al. BRCA1-associated R-loop affects transcription and differentiation in breast luminal epithelial cells. Nucleic Acids Res. 2019;47:5086-5099 pubmed publisher
  • immunocytochemistry; human; 1:250; fig 4
Abraham K, Chan J, Salvi J, Ho B, Hall A, Vidya E, et al. Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybrids. Nucleic Acids Res. 2016;44:8870-8884 pubmed
Zhang C, Chen L, Peng D, Jiang A, He Y, Zeng Y, et al. METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation. Mol Cell. 2020;: pubmed publisher
Pan X, Chen Y, Biju B, Ahmed N, Kong J, Goldenberg M, et al. FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops. Sci Rep. 2019;9:19110 pubmed publisher
Deasy S, Uehara R, Vodnala S, Yang H, Dass R, Hu Y, et al. Aicardi-Goutières syndrome gene Rnaseh2c is a metastasis susceptibility gene in breast cancer. PLoS Genet. 2019;15:e1008020 pubmed publisher
Tumini E, Herrera Moyano E, San Martín Alonso M, Barroso S, Galmarini C, Aguilera A. The Antitumor Drugs Trabectedin and Lurbinectedin Induce Transcription-Dependent Replication Stress and Genome Instability. Mol Cancer Res. 2019;17:773-782 pubmed publisher
Bhatia V, Valdés Sánchez L, Rodríguez Martínez D, Bhattacharya S. Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice. F1000Res. 2018;7:1233 pubmed publisher
Almeida R, Fernández Justel J, Santa María C, Cadoret J, Cano Aroca L, Lombraña R, et al. Chromatin conformation regulates the coordination between DNA replication and transcription. Nat Commun. 2018;9:1590 pubmed publisher
Gorthi A, Romero J, Loranc E, Cao L, Lawrence L, Goodale E, et al. EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma. Nature. 2018;555:387-391 pubmed publisher
Michelini F, Pitchiaya S, Vitelli V, Sharma S, Gioia U, Pessina F, et al. Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks. Nat Cell Biol. 2017;19:1400-1411 pubmed publisher
Zhang X, Chiang H, Wang Y, Zhang C, Smith S, Zhao X, et al. Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis. Nat Commun. 2017;8:15908 pubmed publisher
Hill S, Mordes D, Cameron L, Neuberg D, Landini S, Eggan K, et al. Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage. Proc Natl Acad Sci U S A. 2016;113:E7701-E7709 pubmed
Kasuya T, Hori S, Watanabe A, Nakajima M, Gahara Y, Rokushima M, et al. Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides. Sci Rep. 2016;6:30377 pubmed publisher
García Rubio M, Pérez Calero C, Barroso S, Tumini E, Herrera Moyano E, Rosado I, et al. The Fanconi Anemia Pathway Protects Genome Integrity from R-loops. PLoS Genet. 2015;11:e1005674 pubmed publisher
Hori S, Yamamoto T, Obika S. XRN2 is required for the degradation of target RNAs by RNase H1-dependent antisense oligonucleotides. Biochem Biophys Res Commun. 2015;464:506-11 pubmed publisher
product information
CatalogNo :
15606-1-AP
AntigenName :
RNASEH1
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
ribonuclease H1
Immunogen :
Recombinant Protein
Species :
human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
H1RNA, Ribonuclease H type II, ribonuclease H1, RNase H1, RNASEH1, RNH1
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC002973
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Metabolism;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:50 ; IP 1:500 ; WB 1:1200 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.