LONP1 | Proteintech Group 15440-1-AP product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Proteintech Group

product type :

antibody

product name :

LONP1

catalog :

15440-1-AP

quantity :

150UL

price :

299 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 24

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:3000; loading ...; fig 2a	Zhou Q, Zhu L, Qiu W, Liu Y, Yang F, Chen W, et al. Nicotinamide Riboside Enhances Mitochondrial Proteostasis and Adult Neurogenesis through Activation of Mitochondrial Unfolded Protein Response Signaling in the Brain of ALS SOD1G93A Mice. Int J Biol Sci. 2020;16:284-297 pubmed publisher
immunohistochemistry - paraffin section; human; loading ...; fig 1c immunocytochemistry; human; fig 3a western blot; human; fig 2e	Di K, Lomeli N, Wood S, Vanderwal C, Bota D. Mitochondrial Lon is over-expressed in high-grade gliomas, and mediates hypoxic adaptation: potential role of Lon as a therapeutic target in glioma. Oncotarget. 2016;7:77457-77467 pubmed publisher
	Perez M, Ivanyuk D, Panagiotakopoulou V, Di Napoli G, Kalb S, Brunetti D, et al. Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids. Mol Psychiatry. 2020;: pubmed publisher
	Jiang D, Cui H, Xie N, Banerjee S, Liu R, Dai H, et al. ATF4 Mediates Mitochondrial Unfolded Protein Response (UPRmt) in Alveolar Epithelial Cells. Am J Respir Cell Mol Biol. 2020;: pubmed publisher
	Alegre Cortés E, Muriel González A, Canales Cortés S, Uribe Carretero E, Martínez Chacón G, Aiastui A, et al. Toxicity of Necrostatin-1 in Parkinson's Disease Models. Antioxidants (Basel). 2020;9: pubmed publisher
	Zhou H, Yuan D, Gao W, Tian J, Sun H, Yu S, et al. Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia. IUBMB Life. 2020;72:1659-1679 pubmed publisher
	Shen Y, Ding M, Xie Z, Liu X, Yang H, Jin S, et al. Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice. Front Cell Neurosci. 2019;13:568 pubmed publisher
	Rudler D, Hughes L, Perks K, Richman T, Kuznetsova I, Ermer J, et al. Fidelity of translation initiation is required for coordinated respiratory complex assembly. Sci Adv. 2019;5:eaay2118 pubmed publisher
	Ferreira N, Perks K, Rossetti G, Rudler D, Hughes L, Ermer J, et al. Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation. EMBO J. 2019;38:e102155 pubmed publisher
	Kim J, Park H, Choi S, Kong M, Kang T. TRPC6-Mediated ERK1/2 Activation Increases Dentate Granule Cell Resistance to Status Epilepticus Via Regulating Lon Protease-1 Expression and Mitochondrial Dynamics. Cells. 2019;8: pubmed publisher
	Kim J, Park H, Choi S, Kong M, Kang T. CDDO-Me Selectively Attenuates CA1 Neuronal Death Induced by Status Epilepticus via Facilitating Mitochondrial Fission Independent of LONP1. Cells. 2019;8: pubmed publisher
	Yang X, Li Y, Zheng L, He X, Luo Y, Huang K, et al. Glucose-regulated protein 75 in foodborne disease models induces renal tubular necrosis. Food Chem Toxicol. 2019;133:110720 pubmed publisher
	Wang P, Deng J, Dong J, Liu J, Bigio E, Mesulam M, et al. TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response. PLoS Genet. 2019;15:e1007947 pubmed publisher
	Hu D, Sun X, Liao X, Zhang X, Zarabi S, Schimmer A, et al. Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity. Acta Neuropathol. 2019;137:939-960 pubmed publisher
	Fu Z, Liu F, Liu C, Jin B, Jiang Y, Tang M, et al. Mutant huntingtin inhibits the mitochondrial unfolded protein response by impairing ABCB10 mRNA stability. Biochim Biophys Acta Mol Basis Dis. 2019;1865:1428-1435 pubmed publisher
	Yakhine Diop S, Niso Santano M, Rodríguez Arribas M, Gómez Sánchez R, Martínez Chacón G, Uribe Carretero E, et al. Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson's Disease Patients. Mol Neurobiol. 2019;56:2466-2481 pubmed publisher
	Iida R, Ueki M, Yasuda T. Knockout of Mpv17-Like Protein (M-LPH) Gene in Human Hepatoma Cells Results in Impairment of mtDNA Integrity through Reduction of TFAM, OGG1, and LIG3 at the Protein Levels. Oxid Med Cell Longev. 2018;2018:6956414 pubmed publisher
	Jian F, Chen D, Chen L, Yan C, Lu B, Zhu Y, et al. Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology. Cell Rep. 2018;23:2989-3005 pubmed publisher
	Wu F, Li S, Zhang N, Huang W, Li X, Wang M, et al. Hispidulin alleviates high-glucose-induced podocyte injury by regulating protective autophagy. Biomed Pharmacother. 2018;104:307-314 pubmed publisher
	Yang X, Wang H, Huang C, He X, Xu W, Luo Y, et al. Zinc enhances the cellular energy supply to improve cell motility and restore impaired energetic metabolism in a toxic environment induced by OTA. Sci Rep. 2017;7:14669 pubmed publisher
	Polo M, Alegre F, Moragrega A, Gibellini L, Marti Rodrigo A, Blas García A, et al. Lon protease: a novel mitochondrial matrix protein in the interconnection between drug-induced mitochondrial dysfunction and endoplasmic reticulum stress. Br J Pharmacol. 2017;174:4409-4429 pubmed publisher
	Pryde K, Taanman J, Schapira A. A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria. Cell Rep. 2016;17:2522-2531 pubmed publisher
	Rang Z, Yang G, Wang Y, Cui F. miR-542-3p suppresses invasion and metastasis by targeting the proto-oncogene serine/threonine protein kinase, PIM1, in melanoma. Biochem Biophys Res Commun. 2016;474:315-320 pubmed publisher
	Kil I, Ryu K, Lee S, Kim J, Chu S, Kim J, et al. Circadian Oscillation of Sulfiredoxin in the Mitochondria. Mol Cell. 2015;59:651-63 pubmed publisher

product information

CatalogNo :

15440-1-AP

AntigenName :

LONP1

Package :

150UL

Price :

299 USD

Exsists20ul :

20ul trial size available

FullName :

lon peptidase 1, mitochondrial

Immunogen :

Recombinant Protein

Species :

human, mouse, rat

Host :

Rabbit

IsConjugated :

Unconjugated

AntigenSpecies :

human

Application :

WB, IP, IHC, IF, ELISA

Clonlity :

Polyclonal

IsoType :

IgG

Synonyms :

hLON, LON, lon peptidase 1, mitochondrial, Lon protease like protein, LonHS, LONP, LONP1, PIM1, PRSS15, Serine protease 15

PrimaryOrSecondary :

Primary

AntibodyBuffer :

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

GenBankNo :

BC000235

Category :

Binding Proteins;Cytoskeleton/Scaffold Proteins;Metabolism;

PurifyMethod :

Antigen affinity purification

NewAb :

False

IsSellable :

True

Feature :

siRNA

AppTiter :

IF 1:50 ; IHC 1:200 ; IP 1:1000 ; WB 1:2000 ;