This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
TIM22
catalog :
14927-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, brewer's yeast
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 14
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig e6a
Hoshino A, Wang W, Wada S, McDermott Roe C, Evans C, Gosis B, et al. The ADP/ATP translocase drives mitophagy independent of nucleotide exchange. Nature. 2019;575:375-379 pubmed publisher
  • western blot; human; 1:1000; fig s6
Guo W, Liu W, Chen Z, Gu Y, Peng S, Shen L, et al. Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis. Nat Commun. 2017;8:2168 pubmed publisher
  • western blot; brewer's yeast; fig 1
Wrobel L, Sokol A, Chojnacka M, Chacinska A. The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly. Sci Rep. 2016;6:27484 pubmed publisher
Singh R, Jeyaraju D, Voisin V, Hurren R, Xu C, Hawley J, et al. Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal. Cell Stem Cell. 2020;26:926-937.e10 pubmed publisher
Gomkale R, Cruz Zaragoza L, Suppanz I, Guiard B, Montoya J, Callegari S, et al. Defining the Substrate Spectrum of the TIM22 Complex Identifies Pyruvate Carrier Subunits as Unconventional Cargos. Curr Biol. 2020;30:1119-1127.e5 pubmed publisher
Wei X, Du M, Xie J, Luo T, Zhou Y, Zhang K, et al. Mutations in TOMM70 lead to multi-OXPHOS deficiencies and cause severe anemia, lactic acidosis, and developmental delay. J Hum Genet. 2020;65:231-240 pubmed publisher
Busch J, Cipullo M, Atanassov I, Bratic A, Silva Ramos E, Schondorf T, et al. MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition. Cell Rep. 2019;29:1728-1738.e9 pubmed publisher
HU Z, Qu G, Yu X, Jiang H, Teng X, Ding L, et al. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. Cell Metab. 2019;: pubmed publisher
Liu Y, Wang X, Coyne L, Yang Y, Qi Y, Middleton F, et al. Mitochondrial carrier protein overloading and misfolding induce aggresomes and proteostatic adaptations in the cytosol. Mol Biol Cell. 2019;30:1272-1284 pubmed publisher
Mohanraj K, Wasilewski M, Benincá C, Cysewski D, Poznanski J, Sakowska P, et al. Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7. EMBO Mol Med. 2019;11: pubmed publisher
Pacheu Grau D, Callegari S, Emperador S, Thompson K, Aich A, Topol S, et al. Mutations of the mitochondrial carrier translocase channel subunit TIM22 cause early-onset mitochondrial myopathy. Hum Mol Genet. 2018;27:4135-4144 pubmed publisher
Vukotic M, Nolte H, König T, Saita S, Ananjew M, Kruger M, et al. Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria. Mol Cell. 2017;67:471-483.e7 pubmed publisher
Callegari S, Richter F, Chojnacka K, Jans D, Lorenzi I, Pacheu Grau D, et al. TIM29 is a subunit of the human carrier translocase required for protein transport. FEBS Lett. 2016;590:4147-4158 pubmed publisher
Li H, Zhang L, Zhu X, Shang J, Chen X, Zhu Y, et al. Analysis of EV71 infection progression using triple-SILAC-based proteomics approach. Proteomics. 2015;15:3629-43 pubmed publisher
product information
CatalogNo :
14927-1-AP
AntigenName :
TIM22
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
translocase of inner mitochondrial membrane 22 homolog (yeast)
Immunogen :
Recombinant Protein
Species :
human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
Testis expressed sequence 4, TEX4, TIM22, TIMM22
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC002324
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Membrane Proteins;Transport/Trafficking;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:50 ; IHC 1:50 ; IP 1:1000 ; WB 1:1000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.