This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
UCHL1/PGP9.5
catalog :
14730-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, western blot knockout validation, immunohistochemistry knockout validation
citations: 26
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry knockout validation; mouse; 1:1000; fig 1
  • western blot knockout validation; mouse; 1:2000; fig 1
Genç B, Jara J, Schultz M, Manuel M, Stanford M, Gautam M, et al. Absence of UCHL 1 function leads to selective motor neuropathy. Ann Clin Transl Neurol. 2016;3:331-45 pubmed publisher
Lei Q, Yi T, Li H, Yan Z, Lv Z, Li G, et al. Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78). Sci Rep. 2020;10:10604 pubmed publisher
Fang Y, Li F, Qi C, Mao X, Xu Y, Zhao Z, et al. Plakoglobin is involved in cytoskeletal rearrangement of podocytes under the regulation of UCH-L1. Biochem Biophys Res Commun. 2020;529:112-118 pubmed publisher
Zhang M, Jin F, Zhu Y, Qi F. Peripheral FGFR1 Regulates Myofascial Pain in Rats via the PI3K/AKT Pathway. Neuroscience. 2020;436:1-10 pubmed publisher
Liu J, Zhu Z, Liu Y, Wei L, Li B, Mao F, et al. MDM2 inhibition-mediated autophagy contributes to the pro-apoptotic effect of berberine in p53-null leukemic cells. Life Sci. 2020;242:117228 pubmed publisher
Bi H, Zhang Y, Yang J, Shu Q, Yang X, Yan X, et al. Inhibition of UCHL1 by LDN-57444 attenuates Ang II-Induced atrial fibrillation in mice. Hypertens Res. 2019;: pubmed publisher
França C, Riggers R, Muschler J, Widbiller M, Lococo P, Diogenes A, et al. 3D-Imaging of Whole Neuronal and Vascular Networks of the Human Dental Pulp via CLARITY and Light Sheet Microscopy. Sci Rep. 2019;9:10860 pubmed publisher
Ding X, Wang H, Qian X, Han X, Yang L, Cao Y, et al. Panicle-Shaped Sympathetic Architecture in the Spleen Parenchyma Modulates Antibacterial Innate Immunity. Cell Rep. 2019;27:3799-3807.e3 pubmed publisher
Bu J, Qiao X, He Y, Liu J. Colonic electrical stimulation improves colonic transit in rotenone-induced Parkinson's disease model through affecting enteric neurons. Life Sci. 2019;:116581 pubmed publisher
Sun D, Stopka Farooqui U, Barry S, Aksoy E, Parsonage G, Vossenkamper A, et al. Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation. Cell Rep. 2019;27:1461-1471.e4 pubmed publisher
Hinder L, Sas K, O Brien P, Backus C, Kayampilly P, Hayes J, et al. Mitochondrial uncoupling has no effect on microvascular complications in type 2 diabetes. Sci Rep. 2019;9:881 pubmed publisher
Roa Coria J, Pineda Farias J, Barragán Iglesias P, Quiñonez Bastidas G, Zúñiga Romero Á, Huerta Cruz J, et al. Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats. BMC Neurosci. 2019;20:1 pubmed publisher
Li L, Li J, Zuo Y, Dang D, Frost J, Yang Q. Activation of KCNQ Channels Prevents Paclitaxel-Induced Peripheral Neuropathy and Associated Neuropathic Pain. J Pain. 2019;20:528-539 pubmed publisher
Sun T, Li D, Hu S, Huang L, Sun H, Yang S, et al. Aging-dependent decrease in the numbers of enteric neurons, interstitial cells of Cajal and expression of connexin43 in various regions of gastrointestinal tract. Aging (Albany NY). 2018;10:3851-3865 pubmed publisher
Yang W, Sung K, Zhou F, Xu W, Rissman R, Ding J, et al. Targeted Mutation (R100W) of the Gene Encoding NGF Leads to Deficits in the Peripheral Sensory Nervous System. Front Aging Neurosci. 2018;10:373 pubmed publisher
O Brien P, Hinder L, Rumora A, Hayes J, Dauch J, Backus C, et al. Juvenile murine models of prediabetes and type 2 diabetes develop neuropathy. Dis Model Mech. 2018;11: pubmed publisher
Pace M, Xu G, Fromholt S, Howard J, Crosby K, Giasson B, et al. Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease. Acta Neuropathol. 2018;136:919-938 pubmed publisher
Wen Y, Wu Q, Shi Q, Xie Y, Dan W, Chen Y, et al. UCH-L1 inhibition aggravates mossy fiber sprouting in the pentylenetetrazole kindling model. Biochem Biophys Res Commun. 2018;503:2312-2318 pubmed publisher
Child K, Herrick D, Schwob J, Holbrook E, Jang W. The Neuroregenerative Capacity of Olfactory Stem Cells Is Not Limitless: Implications for Aging. J Neurosci. 2018;38:6806-6824 pubmed publisher
Park S, Eber M, Tsuzuki S, Booker M, Sunil A, Widner D, et al. Adeno-associated virus serotype rh10 is a useful gene transfer vector for sensory nerves that innervate bone in immunodeficient mice. Sci Rep. 2017;7:17428 pubmed publisher
Lin B, Coleman J, Peterson J, Zunitch M, Jang W, Herrick D, et al. Injury Induces Endogenous Reprogramming and Dedifferentiation of Neuronal Progenitors to Multipotency. Cell Stem Cell. 2017;21:761-774.e5 pubmed publisher
Jiang H, Ding X, Cao Y, Wang H, Zeng W. Dense Intra-adipose Sympathetic Arborizations Are Essential for Cold-Induced Beiging of Mouse White Adipose Tissue. Cell Metab. 2017;26:686-692.e3 pubmed publisher
Xiao X, Feng Y, Du B, Sun H, Ding Y, Qi J. Antibody incubation at 37°C improves fluorescent immunolabeling in free-floating thick tissue sections. Biotechniques. 2017;62:115-122 pubmed publisher
Liu L, Yu J, Li L, Zhang B, Liu L, Wu C, et al. Alpha7 nicotinic acetylcholine receptor is required for amyloid pathology in brain endothelial cells induced by Glycoprotein 120, methamphetamine and nicotine. Sci Rep. 2017;7:40467 pubmed publisher
Genç B, Lagrimas A, Kuru P, Hess R, Tu M, Menichella D, et al. Visualization of Sensory Neurons and Their Projections in an Upper Motor Neuron Reporter Line. PLoS ONE. 2015;10:e0132815 pubmed publisher
Jara J, Genç B, Cox G, Bohn M, Roos R, Macklis J, et al. Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function. Cereb Cortex. 2015;25:4259-72 pubmed publisher
product information
CatalogNo :
14730-1-AP
AntigenName :
UCHL1/PGP9.5
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Immunogen :
Recombinant Protein
Species :
human, monkey, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, CoIP, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
Neuron cytoplasmic protein 9.5, PARK5, PGP 9.5, PGP9.5, Ubiquitin thioesterase L1, Uch L1, UCHL1, UCH-L1
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC000332
Category :
Binding Proteins;Cell Cycle;Cytoskeleton/Scaffold Proteins;Disease Related;Metabolism;Neurology;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:50 ; IHC 1:200 ; IP 1:2000 ; WB 1:4000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.