This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
ASNS
catalog :
14681-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 17
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; fig 5
Krall A, Xu S, Graeber T, Braas D, Christofk H. Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. Nat Commun. 2016;7:11457 pubmed publisher
Recouvreux M, Moldenhauer M, Galenkamp K, Jung M, James B, Zhang Y, et al. Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer. J Exp Med. 2020;217: pubmed publisher
Tan J, Wang H, Yang J, Liu Q, Li C, Wang Y, et al. JMJD2B-induced amino acid alterations enhance the survival of colorectal cancer cells under glucose-deprivation via autophagy. Theranostics. 2020;10:5763-5777 pubmed publisher
Deng L, Yao P, Li L, Ji F, Zhao S, Xu C, et al. p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival. Nat Commun. 2020;11:1755 pubmed publisher
Williams R, Guarecuco R, Gates L, Barrows D, Passarelli M, Carey B, et al. ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase. Cell Metab. 2020;31:852-861.e6 pubmed publisher
Jiang J, Srivastava S, Seim G, Pavlova N, King B, Zou L, et al. Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion. J Biol Chem. 2019;294:18674-18684 pubmed publisher
Yang X, Zhang X, Jing Y, Ding L, Fu Y, Wang S, et al. Amino acids signatures of distance-related surgical margins of oral squamous cell carcinoma. EBioMedicine. 2019;48:81-91 pubmed publisher
Lee C, Griffiths S, Digard P, Pham N, Auer M, Haas J, et al. Asparagine Deprivation Causes a Reversible Inhibition of Human Cytomegalovirus Acute Virus Replication. MBio. 2019;10: pubmed publisher
Lukey M, Cluntun A, Katt W, Lin M, Druso J, Ramachandran S, et al. Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer. Cell Rep. 2019;29:76-88.e7 pubmed publisher
Li H, Ning S, Ghandi M, Kryukov G, Gopal S, Deik A, et al. The landscape of cancer cell line metabolism. Nat Med. 2019;25:850-860 pubmed publisher
Pant A, Cao S, Yang Z. Asparagine Is a Critical Limiting Metabolite for Vaccinia Virus Protein Synthesis during Glutamine Deprivation. J Virol. 2019;93: pubmed publisher
Cheng C, Qi Y, Wang Y, Chi K, Chung Y, Ouyang C, et al. Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction. Commun Biol. 2018;1:178 pubmed publisher
Lin H, Chung Y, Cheng C, Ouyang C, Fu Y, Kuo C, et al. Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis. Autophagy. 2018;14:1481-1498 pubmed publisher
Kremer J, Prudner B, Lange S, Bean G, Schultze M, Brashears C, et al. Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers. Cell Rep. 2017;18:991-1004 pubmed publisher
Xu Y, Lv F, Zhu X, Wu Y, Shen X. Loss of asparagine synthetase suppresses the growth of human lung cancer cells by arresting cell cycle at G0/G1 phase. Cancer Gene Ther. 2016;23:287-94 pubmed publisher
Dhillon H, Mamidi S, McClean P, Reindl K. Transcriptome Analysis of Piperlongumine-Treated Human Pancreatic Cancer Cells Reveals Involvement of Oxidative Stress and Endoplasmic Reticulum Stress Pathways. J Med Food. 2016;19:578-85 pubmed publisher
Li H, Zhou F, Du W, Dou J, Xu Y, Gao W, et al. Knockdown of asparagine synthetase by RNAi suppresses cell growth in human melanoma cells and epidermoid carcinoma cells. Biotechnol Appl Biochem. 2016;63:328-33 pubmed publisher
product information
CatalogNo :
14681-1-AP
AntigenName :
ASNS
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
asparagine synthetase
Immunogen :
Recombinant Protein
Species :
human
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
ASNS, asparagine synthetase, TS11
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC014621
Category :
Binding Proteins;Metabolism;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:100 ; IHC 1:200 ; IP 1:500 ; WB 1:1000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.