This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
PPP1R15B
catalog :
14634-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 13
Reference
Kastan J, Dobrikova E, Bryant J, Gromeier M. CReP mediates selective translation initiation at the endoplasmic reticulum. Sci Adv. 2020;6:eaba0745 pubmed publisher
Krzyzosiak A, Sigurdardottir A, Luh L, Carrara M, Das I, Schneider K, et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018;174:1216-1228.e19 pubmed publisher
Xu X, Krumm C, So J, Bare C, Holman C, Gromada J, et al. Preemptive Activation of the Integrated Stress Response Protects Mice From Diet-Induced Obesity and Insulin Resistance by Fibroblast Growth Factor 21 Induction. Hepatology. 2018;68:2167-2181 pubmed publisher
Hülsmann J, Kravic B, Weith M, Gstaiger M, Aebersold R, Collins B, et al. AP-SWATH Reveals Direct Involvement of VCP/p97 in Integrated Stress Response Signaling Through Facilitating CReP/PPP1R15B Degradation. Mol Cell Proteomics. 2018;17:1295-1307 pubmed publisher
Shelkovnikova T, Dimasi P, Kukharsky M, An H, Quintiero A, Schirmer C, et al. Chronically stressed or stress-preconditioned neurons fail to maintain stress granule assembly. Cell Death Dis. 2017;8:e2788 pubmed publisher
Young S, Shao Y, Bidwell J, Wek R. Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 Expression. J Biol Chem. 2016;291:13780-8 pubmed publisher
de Gassart A, Bujisic B, Zaffalon L, Decosterd L, Di Micco A, Frera G, et al. An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response. Proc Natl Acad Sci U S A. 2016;113:E117-26 pubmed publisher
Young S, Willy J, Wu C, Sachs M, Wek R. Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response. J Biol Chem. 2015;290:28257-71 pubmed publisher
Friend K, Brooks H, Propson N, Thomson J, Kimble J. Embryonic Stem Cell Growth Factors Regulate eIF2α Phosphorylation. PLoS ONE. 2015;10:e0139076 pubmed publisher
Kernohan K, Tétreault M, Liwak Muir U, Geraghty M, Qin W, Venkateswaran S, et al. Homozygous mutation in the eukaryotic translation initiation factor 2alpha phosphatase gene, PPP1R15B, is associated with severe microcephaly, short stature and intellectual disability. Hum Mol Genet. 2015;24:6293-300 pubmed publisher
Loveless T, Topacio B, Vashisht A, Galaang S, Ulrich K, Young B, et al. DNA Damage Regulates Translation through β-TRCP Targeting of CReP. PLoS Genet. 2015;11:e1005292 pubmed publisher
So J, Cho S, Min S, Kimball S, Lee A. IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis. Mol Cell Biol. 2015;35:2761-70 pubmed publisher
Wu H, Wei L, Fan F, Ji S, Zhang S, Geng J, et al. Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis. Nat Commun. 2015;6:6239 pubmed publisher
product information
CatalogNo :
14634-1-AP
AntigenName :
PPP1R15B
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
protein phosphatase 1, regulatory (inhibitor) subunit 15B
Immunogen :
Recombinant Protein
Species :
human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, CoIP, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
CREP, PPP1R15B
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC065280
Category :
Apoptosis;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:50 ; IHC 1:100 ; IP 1:1000 ; WB 1:1000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.