| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; loading ...; fig 3a
- western blot knockout validation; mouse; loading ...; fig 2b
| Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, et al. HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains. PLoS Pathog. 2017;13:e1006162 pubmed publisher |
- western blot knockout validation; human; loading ...; fig 2f
| Yang Y, Yang C, Chan W, Wang Z, Deibel K, Pomerantz J. Molecular Determinants of Scaffold-induced Linear Ubiquitinylation of B Cell Lymphoma/Leukemia 10 (Bcl10) during T Cell Receptor and Oncogenic Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling. J Biol Chem. 2016;291:25921-25936 pubmed |
- immunoprecipitation; mouse; loading ...; fig 3c
- western blot; mouse; loading ...; fig 2e
| Peltzer N, Darding M, Montinaro A, Dráber P, Draberova H, Kupka S, et al. LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis. Nature. 2018;557:112-117 pubmed publisher |
- western blot; human; loading ...; fig s1d
| Strickson S, Emmerich C, Goh E, Zhang J, Kelsall I, MacArtney T, et al. Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling. Proc Natl Acad Sci U S A. 2017;114:E3481-E3489 pubmed publisher |
- western blot; mouse; loading ...; fig 6d
- western blot; human; loading ...; fig 2c
| Lafont E, Kantari Mimoun C, Dráber P, De Miguel D, Hartwig T, Reichert M, et al. The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. EMBO J. 2017;36:1147-1166 pubmed publisher |
- western blot; human; 1:1000; fig s15
| Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, et al. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 2016;7:12547 pubmed publisher |
- western blot; human; fig 1
| Kupka S, De Miguel D, Dráber P, Martino L, Surinova S, Rittinger K, et al. SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes. Cell Rep. 2016;16:2271-80 pubmed publisher |
- western blot; mouse; fig 6
| Damgaard R, Walker J, Marco Casanova P, Morgan N, Titheradge H, Elliott P, et al. The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Cell. 2016;166:1215-1230.e20 pubmed publisher |
| Smith H, Jamal K, Dayal J, Tenev T, Kyula Currie J, Guppy N, et al. RIPK1-mediated immunogenic cell death promotes anti-tumour immunity against soft-tissue sarcoma. EMBO Mol Med. 2020;12:e10979 pubmed publisher |
| Douglas T, Saleh M. Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation. J Biol Chem. 2020;295:5216-5228 pubmed publisher |
| Yamanaka S, Sato Y, Oikawa D, Goto E, Fukai S, Tokunaga F, et al. Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling. Biochem Biophys Res Commun. 2019;: pubmed publisher |
| Douglas T, Saleh M. Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death. Cell Rep. 2019;29:3652-3663.e5 pubmed publisher |
| Dondelinger Y, Delanghe T, Priem D, Wynosky Dolfi M, Sorobetea D, Rojas Rivera D, et al. Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation. Nat Commun. 2019;10:1729 pubmed publisher |
| Sun S, Li F, Liu Y, Qu H, Wong S, Zeng L, et al. A novel inhibitor of nuclear factor kappa-B kinase subunit gamma mutation identified in an incontinentia pigmenti patient with syndromic tooth agenesis. Arch Oral Biol. 2019;101:100-107 pubmed publisher |
| Lee I, Lim J, Cho H, Kim E, Kim Y, Oh H, et al. MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity. Mol Cell. 2019;73:1138-1149.e6 pubmed publisher |
| Moerke C, Jaco I, Dewitz C, Müller T, Jacobsen A, Gautheron J, et al. The anticonvulsive Phenhydan® suppresses extrinsic cell death. Cell Death Differ. 2018;: pubmed publisher |
| Taraborrelli L, Peltzer N, Montinaro A, Kupka S, Rieser E, Hartwig T, et al. LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L. Nat Commun. 2018;9:3910 pubmed publisher |
| MacDuff D, Baldridge M, Qaqish A, Nice T, Darbandi A, Hartley V, et al. HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection. J Virol. 2018;92: pubmed publisher |
| Wang Y, Shan B, Liang Y, Wei H, Yuan J. Parkin regulates NF-?B by mediating site-specific ubiquitination of RIPK1. Cell Death Dis. 2018;9:732 pubmed publisher |
| Heger K, Wickliffe K, Ndoja A, Zhang J, Murthy A, Dugger D, et al. OTULIN limits cell death and inflammation by deubiquitinating LUBAC. Nature. 2018;559:120-124 pubmed publisher |
| Annibaldi A, Wicky John S, Vanden Berghe T, Swatek K, Ruan J, Liccardi G, et al. Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2. Mol Cell. 2018;69:566-580.e5 pubmed publisher |
| Dziedzic S, Su Z, Jean Barrett V, Najafov A, Mookhtiar A, Amin P, et al. ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC. Nat Cell Biol. 2018;20:58-68 pubmed publisher |
| Peuhu E, Salomaa S, De Franceschi N, Potter C, Sundberg J, Pouwels J. Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice. PLoS ONE. 2017;12:e0186628 pubmed publisher |
| Weber A, Elliott P, Pinto Fernandez A, Bonham S, Kessler B, Komander D, et al. A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN. Cell Chem Biol. 2017;24:1299-1313.e7 pubmed publisher |
| Boege Y, Malehmir M, Healy M, Bettermann K, Lorentzen A, Vucur M, et al. A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development. Cancer Cell. 2017;32:342-359.e10 pubmed publisher |
| Khan M, Salomaa S, Jacquemet G, Butt U, Miihkinen M, Deguchi T, et al. The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex. J Cell Sci. 2017;130:3094-3107 pubmed publisher |
| Wei R, Xu L, Liu J, Li Y, Zhang P, Shan B, et al. SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination. Genes Dev. 2017;31:1162-1176 pubmed publisher |
| Jaco I, Annibaldi A, Lalaoui N, Wilson R, Tenev T, Laurien L, et al. MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death. Mol Cell. 2017;66:698-710.e5 pubmed publisher |
| Goto E, Tokunaga F. Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP. Biochem Biophys Res Commun. 2017;485:152-159 pubmed publisher |
| Peuhu E, Kaukonen R, Lerche M, Saari M, Guzman C, Rantakari P, et al. SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland. EMBO J. 2017;36:165-182 pubmed publisher |
| Zinngrebe J, Rieser E, Taraborrelli L, Peltzer N, Hartwig T, Ren H, et al. --LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation. J Exp Med. 2016;213:2671-2689 pubmed |
| Elliott P, Leske D, Hrdinka M, Bagola K, Fiil B, McLaughlin S, et al. SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling. Mol Cell. 2016;63:990-1005 pubmed publisher |
| Schlicher L, Wissler M, Preiss F, Brauns Schubert P, Jakob C, Dumit V, et al. SPATA2 promotes CYLD activity and regulates TNF-induced NF-?B signaling and cell death. EMBO Rep. 2016;17:1485-1497 pubmed |
| Hrdinka M, Fiil B, Zucca M, Leske D, Bagola K, Yabal M, et al. CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling. Cell Rep. 2016;14:2846-58 pubmed publisher |
| Nastase M, Zeng Brouwers J, Frey H, Hsieh L, Poluzzi C, Beckmann J, et al. An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis. Am J Pathol. 2016;186:1206-20 pubmed publisher |
| Dráber P, Kupka S, Reichert M, Draberova H, Lafont E, De Miguel D, et al. LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes. Cell Rep. 2015;13:2258-72 pubmed publisher |
| Douglas T, Champagne C, Morizot A, Lapointe J, Saleh M. The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice. J Immunol. 2015;195:2365-73 pubmed publisher |
| de Almagro M, Goncharov T, Newton K, Vucic D. Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination. Cell Death Dis. 2015;6:e1800 pubmed publisher |
| Boisson B, Laplantine E, Dobbs K, Cobat A, Tarantino N, Hazen M, et al. Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia. J Exp Med. 2015;212:939-51 pubmed publisher |
