This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
LC3
catalog :
14600-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 159
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 5b
Xiang S, Chen K, Xu L, Wang T, Guo C. Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway. Drug Des Devel Ther. 2020;14:129-143 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2e
Zhou Q, Zhu L, Qiu W, Liu Y, Yang F, Chen W, et al. Nicotinamide Riboside Enhances Mitochondrial Proteostasis and Adult Neurogenesis through Activation of Mitochondrial Unfolded Protein Response Signaling in the Brain of ALS SOD1G93A Mice. Int J Biol Sci. 2020;16:284-297 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 8d
  • western blot; human; 1:5000; fig 8d
Gao L, Wang Z, Lu D, Huang J, Liu J, Hong L. Paeonol induces cytoprotective autophagy via blocking the Akt/mTOR pathway in ovarian cancer cells. Cell Death Dis. 2019;10:609 pubmed publisher
  • western blot; human; fig 3d
Park S, Choi Y, Jung N, Kim J, Oh S, Yu Y, et al. Autophagy induction in the skeletal myogenic differentiation of human tonsil-derived mesenchymal stem cells. Int J Mol Med. 2017;39:831-840 pubmed publisher
Zheng T, Chen K, Zhang X, Feng H, Shi Y, Liu L, et al. Knockdown of TXNDC9 induces apoptosis and autophagy in glioma and mediates cell differentiation by p53 activation. Aging (Albany NY). 2020;12:18649-18659 pubmed publisher
Jin C, Miao X, Zhong Y, Han J, Liu Q, Zhu J, et al. The renoprotective effect of diosgenin on aristolochic acid I-induced renal injury in rats: impact on apoptosis, mitochondrial dynamics and autophagy. Food Funct. 2020;: pubmed publisher
Li Z, Cheng J, Liu J. Baicalin Protects Human OA Chondrocytes Against IL-1β-Induced Apoptosis and ECM Degradation by Activating Autophagy via MiR-766-3p/AIFM1 Axis. Drug Des Devel Ther. 2020;14:2645-2655 pubmed publisher
Liu Z, Ye S, Zhong X, Wang W, Lai C, Yang W, et al. Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy. Mol Med Rep. 2020;22:2373-2385 pubmed publisher
Lu J, Lu J, Chen Y, Feng Z, Liu S, Guan S. 3-Chloro-1, 2-propanediol inhibits autophagic flux by impairment of lysosomal function in HepG2 cells. Food Chem Toxicol. 2020;144:111575 pubmed publisher
Xu Z, Feng J, Li Y, Guan D, Chen H, Zhai X, et al. The vicious cycle between ferritinophagy and ROS production triggered EMT inhibition of gastric cancer cells was through p53/AKT/mTor pathway. Chem Biol Interact. 2020;328:109196 pubmed publisher
Yang Y, Liao Y, Gui Y, Zhao L, Guo L. GL-V9 reverses adriamycin resistance in hepatocellular carcinoma cells by affecting JNK2-related autophagy. Chin J Nat Med. 2020;18:491-499 pubmed publisher
Liu J, Hu Y, Feng Y, Jiang Y, Guo Y, Liu Y, et al. BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer. J Exp Clin Cancer Res. 2020;39:123 pubmed publisher
Wang L, Xu X, Liu T, Wang J, Shen J, Guo M, et al. 1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42), a novel ALK inhibitor, induces apoptosis and protective autophagy in H2228 cells. J Pharm Pharmacol. 2020;72:1370-1382 pubmed publisher
Wu B, Jiang M, Liu X, Huang C, Gu Z, Cao Y. Evaluation of toxicity of halloysite nanotubes and multi-walled carbon nanotubes to endothelial cells in vitro and blood vessels in vivo. Nanotoxicology. 2020;:1-22 pubmed publisher
Xu J, Zhang M, Lin X, Wang Y, He X. A steroidal saponin isolated from Allium chinense simultaneously induces apoptosis and autophagy by modulating the PI3K/Akt/mTOR signaling pathway in human gastric adenocarcinoma. Steroids. 2020;161:108672 pubmed publisher
Reimann L, Schwäble A, Fricke A, Mühlhäuser W, Leber Y, Lohanadan K, et al. Phosphoproteomics identifies dual-site phosphorylation in an extended basophilic motif regulating FILIP1-mediated degradation of filamin-C. Commun Biol. 2020;3:253 pubmed publisher
You L, Chen J, Liu W, Xiang Q, Luo Z, Wang W, et al. Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation. Virulence. 2020;11:537-553 pubmed publisher
Huang Y, Wang Y, Meng S, Chen Z, Kong H, Pan T, et al. Autophagy Contributes to Host Immunity and Protection against Zika Virus Infection via Type I IFN Signaling. Mediators Inflamm. 2020;2020:9527147 pubmed publisher
Ma J, Qi J, Li S, Zhang C, Wang H, Shao L, et al. Desloratadine, a Novel Antigrowth Reagent for Bladder Cancer. Technol Cancer Res Treat. 2020;19:1533033820926591 pubmed publisher
Jiang W, Zhao W, Ye F, Huang S, Wu Y, Chen H, et al. Inhibiting PKCβ2 protects HK-2 cells against meglumine diatrizoate and AGEs-induced apoptosis and autophagy. Ann Transl Med. 2020;8:293 pubmed publisher
Ji J, Wu L, Feng J, Mo W, Wu J, Yu Q, et al. Cafestol preconditioning attenuates apoptosis and autophagy during hepatic ischemia-reperfusion injury by inhibiting ERK/PPARγ pathway. Int Immunopharmacol. 2020;84:106529 pubmed publisher
Chen H, Liang F, Gu P, Xu B, Xu H, Wang W, et al. Exosomes derived from mesenchymal stem cells repair a Parkinson's disease model by inducing autophagy. Cell Death Dis. 2020;11:288 pubmed publisher
Li S, Hao M, Li B, Chen M, Chen J, Tang J, et al. CACNA1H downregulation induces skeletal muscle atrophy involving endoplasmic reticulum stress activation and autophagy flux blockade. Cell Death Dis. 2020;11:279 pubmed publisher
Dai L, Yu Q, Zhou S, Bao Y, Zhong J, Shen L, et al. Effect of combination of curcumin and GLUT-1 AS-ODN on radiosensitivity of laryngeal carcinoma through regulating autophagy. Head Neck. 2020;42:2287-2297 pubmed publisher
Yao X, Jiang H, Gao Q, Li Y, Xu Y, Kim N. Melatonin alleviates defects induced by zearalenone during porcine embryo development. Theriogenology. 2020;151:66-73 pubmed publisher
Xie X, Chen C, Xu C, Lin J, Cao L, Chen G, et al. The Class III PI3K/Beclin-1 Autophagic Pathway Participates in the mmLDL-Induced Upregulation of ETA Receptor in Mouse Mesenteric Arteries. Adv Pharmacol Pharm Sci. 2020;2020:5070436 pubmed publisher
Sun Y, Lu F, Yu X, Wang B, Chen J, Lu F, et al. Exogenous H2S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice. Aging Dis. 2020;11:269-285 pubmed publisher
Feng J, Li C, Xu R, Li Y, Hou Q, Feng R, et al. DpdtC-Induced EMT Inhibition in MGC-803 Cells Was Partly through Ferritinophagy-Mediated ROS/p53 Pathway. Oxid Med Cell Longev. 2020;2020:9762390 pubmed publisher
Hu Y, Chen H, Zhang L, Lin X, Li X, Zhuang H, et al. The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses. Autophagy. 2020;:1-15 pubmed publisher
Gu L, Li Q, Liu H, Lu X, Zhu M. Long Noncoding RNA TUG1 Promotes Autophagy-Associated Paclitaxel Resistance by Sponging miR-29b-3p in Ovarian Cancer Cells. Onco Targets Ther. 2020;13:2007-2019 pubmed publisher
Sun X, Wang D, Zhang T, Lu X, Duan F, Ju L, et al. Eugenol Attenuates Cerebral Ischemia-Reperfusion Injury by Enhancing Autophagy via AMPK-mTOR-P70S6K Pathway. Front Pharmacol. 2020;11:84 pubmed publisher
Tan Y, Yin L, Sun Z, Shao S, Chen W, Man X, et al. Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro. Int J Biol Macromol. 2020;153:349-356 pubmed publisher
Wang N, Xu F, Lu S, Zhang N, Sun Y. Septin4 as an autophagy modulator regulates Angiotensin-II mediated VSMCs proliferation and migration. Biochem Biophys Res Commun. 2020;525:272-279 pubmed publisher
Liang C, Feng Z, Manthari R, Wang C, Han Y, Fu W, et al. Arsenic induces dysfunctional autophagy via dual regulation of mTOR pathway and Beclin1-Vps34/PI3K complex in MLTC-1 cells. J Hazard Mater. 2020;391:122227 pubmed publisher
Shang Y, Wang Q, Li J, Zhao Q, Huang X, Dong H, et al. The Acetone Indigo Red Dehydrating Agent IF203 Induces HepG2 Cell Death Through Cell Cycle Arrest, Autophagy and Apoptosis. Onco Targets Ther. 2020;13:473-486 pubmed publisher
Yu M, Zeng M, Pan Z, Wu F, Guo L, He G. Discovery of novel akt1 inhibitor induces autophagy associated death in hepatocellular carcinoma cells. Eur J Med Chem. 2020;189:112076 pubmed publisher
Liu Y, Fan D. The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K. Nutrients. 2020;12: pubmed publisher
Xu J, Deng Y, Wang Y, Sun X, Chen S, Fu G. SPAG5-AS1 inhibited autophagy and aggravated apoptosis of podocytes via SPAG5/AKT/mTOR pathway. Cell Prolif. 2020;53:e12738 pubmed publisher
Hu Z, Pan Y, Cheng A, Zhang X, Wang M, Chen S, et al. Autophagy Promotes Duck Tembusu Virus Replication by Suppressing p62/SQSTM1-Mediated Innate Immune Responses In Vitro. Vaccines (Basel). 2020;8: pubmed publisher
Wang M, Yang C, Jin Y, Wan C, Qian W, Xing F, et al. Baicalin Inhibits Coxsackievirus B3 Replication by Reducing Cellular Lipid Synthesis. Am J Chin Med. 2020;:1-18 pubmed publisher
Liu Q, Zhao M, Chen W, Xu K, Huang F, Qu J, et al. Mainstream cigarette smoke induces autophagy and promotes apoptosis in oral mucosal epithelial cells. Arch Oral Biol. 2020;111:104646 pubmed publisher
Rosencrans W, Walsh Z, Houerbi N, Blum A, Belew M, Liu C, et al. Cells deficient for Krüppel-like factor 4 exhibit mitochondrial dysfunction and impaired mitophagy. Eur J Cell Biol. 2020;99:151061 pubmed publisher
Baldini F, Portincasa P, Grasselli E, Damonte G, Salis A, Bonomo M, et al. Aquaporin-9 is involved in the lipid-lowering activity of the nutraceutical silybin on hepatocytes through modulation of autophagy and lipid droplets composition. Biochim Biophys Acta Mol Cell Biol Lipids. 2020;1865:158586 pubmed publisher
Hu L, Wang J, Chen X, Yan Y. Lanosterol modulates proteostasis via dissolving cytosolic sequestosomes/aggresome-like induced structures. Biochim Biophys Acta Mol Cell Res. 2020;1867:118617 pubmed publisher
Zhang W, Zhu T, Chen L, Luo W, Chao J. MCP-1 mediates ischemia-reperfusion-induced cardiomyocyte apoptosis via MCPIP1 and CaSR. Am J Physiol Heart Circ Physiol. 2020;318:H59-H71 pubmed publisher
Tang Y, Zhang Y, Liu S, Sun Z, Wang C, Li L, et al. 14-3-3ζ binds to and stabilizes phospho-beclin 1S295 and induces autophagy in hepatocellular carcinoma cells. J Cell Mol Med. 2020;24:954-964 pubmed publisher
Li X, Ma R, Li Q, Li S, Zhang H, Xie J, et al. Transmembrane Protein 39A Promotes the Replication of Encephalomyocarditis Virus via Autophagy Pathway. Front Microbiol. 2019;10:2680 pubmed publisher
Ma K, Guo J, Wang G, Ni Q, Liu X. Toll-Like Receptor 2-Mediated Autophagy Promotes Microglial Cell Death by Modulating the Microglial M1/M2 Phenotype. Inflammation. 2019;: pubmed publisher
Wang L, Huang W, Zhan J. Grape Seed Proanthocyanidins Induce Autophagy and Modulate Survivin in HepG2 Cells and Inhibit Xenograft Tumor Growth in Vivo. Nutrients. 2019;11: pubmed publisher
Wu X, Jia R, Wang M, Chen S, Liu M, Zhu D, et al. Downregulation of microRNA-30a-5p contributes to the replication of duck enteritis virus by regulating Beclin-1-mediated autophagy. Virol J. 2019;16:144 pubmed publisher
Wang H, Peng X, Huang Y, Xiao Y, Wang Z, Zhan L. Propofol Attenuates Hypoxia/Reoxygenation-Induced Apoptosis and Autophagy in HK-2 Cells by Inhibiting JNK Activation. Yonsei Med J. 2019;60:1195-1202 pubmed publisher
Xiao Y, Wei R, Yuan Z, Lan X, Kuang J, Hu D, et al. Rutin suppresses FNDC1 expression in bone marrow mesenchymal stem cells to inhibit postmenopausal osteoporosis. Am J Transl Res. 2019;11:6680-6690 pubmed
Kuang M, Li L, Li C, Wang G. Protective effects of UFL1 against endoplasmic reticulum stress-induced autophagy in bovine mammary epithelial cells. Cell Stress Chaperones. 2019;24:1115-1125 pubmed publisher
Wang D, Guo H, Yang H, Wang D, Gao P, Wei W. Pterostilbene, An Active Constituent of Blueberries, Suppresses Proliferation Potential of Human Cholangiocarcinoma via Enhancing the Autophagic Flux. Front Pharmacol. 2019;10:1238 pubmed publisher
Guo X, Shi Y, Du P, Wang J, Han Y, Sun B, et al. HMGB1/TLR4 promotes apoptosis and reduces autophagy of hippocampal neurons in diabetes combined with OSA. Life Sci. 2019;239:117020 pubmed publisher
Liu J, Hu Y, Feng Y, Guo Y, Liu Y, Yang J, et al. Rafoxanide promotes apoptosis and autophagy of gastric cancer cells by suppressing PI3K /Akt/mTOR pathway. Exp Cell Res. 2019;385:111691 pubmed publisher
Nazarinia D, Aboutaleb N, Gholamzadeh R, Nasseri Maleki S, Mokhtari B, Nikougoftar M. Conditioned medium obtained from human amniotic mesenchymal stem cells attenuates focal cerebral ischemia/reperfusion injury in rats by targeting mTOR pathway. J Chem Neuroanat. 2019;102:101707 pubmed publisher
Peng F, Zhang N, Wang C, Wang X, Huang W, Peng C, et al. Aconitine induces cardiomyocyte damage by mitigating BNIP3-dependent mitophagy and the TNFα-NLRP3 signalling axis. Cell Prolif. 2019;:e12701 pubmed publisher
Wang N, Yang B, Muhetaer G, Wang S, Zheng Y, Lu J, et al. XIAOPI formula promotes breast cancer chemosensitivity via inhibiting CXCL1/HMGB1-mediated autophagy. Biomed Pharmacother. 2019;120:109519 pubmed publisher
Chan K, Wong E, Wong I, Cheung C, Wong O, Ngan H, et al. Overexpression of iASPP is required for autophagy in response to oxidative stress in choriocarcinoma. BMC Cancer. 2019;19:953 pubmed publisher
Pian L, Huang X, Zhao M, Zhang Y, Qin C, Zhang J, et al. Leucine-rich repeat and sterile alpha motif containing 1 promotes the oncogenic growth of human hepatocellular carcinoma cells. Cancer Cell Int. 2019;19:255 pubmed publisher
Bu T, Wang C, Jin H, Meng Q, Huo X, Sun H, et al. Organic anion transporters and PI3K-AKT-mTOR pathway mediate the synergistic anticancer effect of pemetrexed and rhein. J Cell Physiol. 2019;: pubmed publisher
Wang R, Liu H, Shao Y, Wang K, Yin S, Qiu Y, et al. Sophoridine Inhibits Human Colorectal Cancer Progression via Targeting MAPKAPK2. Mol Cancer Res. 2019;17:2469-2479 pubmed publisher
Huo T, Jia Y, Yin C, Luo X, Zhao J, Wang Z, et al. Iron dysregulation in vascular dementia: Focused on the AMPK/autophagy pathway. Brain Res Bull. 2019;153:305-313 pubmed publisher
Xu B, Lang L, Li S, Yuan J, Wang J, Yang H, et al. Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure. Animals (Basel). 2019;9: pubmed publisher
Liu N, Feng J, Lu X, Yao Z, Liu Q, Lv Y, et al. Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways. Mediators Inflamm. 2019;2019:6175091 pubmed publisher
Ma Z, Zhang J, Xu X, Qu Y, Dong H, Dang J, et al. LncRNA expression profile during autophagy and Malat1 function in macrophages. PLoS ONE. 2019;14:e0221104 pubmed publisher
Wang F, Lei X, Zhao Y, Yu Q, Li Q, Zhao H, et al. Protective role of thymoquinone in sepsis-induced liver injury in BALB/c mice. Exp Ther Med. 2019;18:1985-1992 pubmed publisher
Wei W, Lu M, Lan X, Liu N, Wang H, Du J, et al. Neuroprotective effect of Verbascoside on hypoxic-ischemic brain damage in neonatal rat. Neurosci Lett. 2019;711:134415 pubmed publisher
Cali C, Patino M, Tai Y, Ho W, McLean C, Morris C, et al. C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy. Acta Neuropathol. 2019;: pubmed publisher
Zhang X, Bu H, Jiang Y, Sun G, Jiang R, Huang X, et al. The antidepressant effects of apigenin are associated with the promotion of autophagy via the mTOR/AMPK/ULK1 pathway. Mol Med Rep. 2019;20:2867-2874 pubmed publisher
Sun Y, Li C, Feng J, Li Y, Zhai X, Zhang L, et al. Ferritinophagic Flux Activation in CT26 Cells Contributed to EMT Inhibition Induced by a Novel Iron Chelator, DpdtpA. Oxid Med Cell Longev. 2019;2019:8753413 pubmed publisher
Wang W, Wu L, Li J, Ji J, Chen K, Yu Q, et al. Alleviation of Hepatic Ischemia Reperfusion Injury by Oleanolic Acid Pretreating via Reducing HMGB1 Release and Inhibiting Apoptosis and Autophagy. Mediators Inflamm. 2019;2019:3240713 pubmed publisher
Wang H, Zhong P, Sun L. Exogenous hydrogen sulfide mitigates NLRP3 inflammasome-mediated inflammation through promoting autophagy via the AMPK-mTOR pathway. Biol Open. 2019;8: pubmed publisher
Fan Y, Li N, Liu C, Dong H, Hu X. Excessive Methionine Supplementation Exacerbates the Development of Abdominal Aortic Aneurysm in Rats. J Vasc Res. 2019;:1-11 pubmed publisher
Shang Y, Wang Q, Wu B, Zhao Q, Li J, Huang X, et al. Platelet-Membrane-Camouflaged Black Phosphorus Quantum Dots Enhance Anticancer Effect Mediated by Apoptosis and Autophagy. ACS Appl Mater Interfaces. 2019;11:28254-28266 pubmed publisher
Li P, Ma R, Dong L, Liu L, Zhou G, Tian Z, et al. Autophagy impairment contributes to PBDE-47-induced developmental neurotoxicity and its relationship with apoptosis. Theranostics. 2019;9:4375-4390 pubmed publisher
Ye J, Xue M, Liu Y, Zhu S, Li Y, Liu X, et al. Diosbulbin B-Induced Mitochondria-Dependent Apoptosis in L-02 Hepatocytes is Regulated by Reactive Oxygen Species-Mediated Autophagy. Front Pharmacol. 2019;10:676 pubmed publisher
Zhong W, Shi X, Yuan H, Bu H, Wu L, Wang R. Effects of Exercise Training on the Autophagy-Related Muscular Proteins Expression in Ovariectomized Rats. Front Physiol. 2019;10:735 pubmed publisher
Zhong Y, Zheng Q, Sun C, Zhang Z, Han K, Jia N. Orientin Improves Cognition by Enhancing Autophagosome Clearance in an Alzheimer's Mouse Model. J Mol Neurosci. 2019;69:246-253 pubmed publisher
Xu W, Yang R, Zheng H, Yu W, Zheng X, Li B, et al. PGC-1α acts as an mediator of Sirtuin2 to protect annulus fibrosus from apoptosis induced by oxidative stress through restraining mitophagy. Int J Biol Macromol. 2019;136:1007-1017 pubmed publisher
Liu T, Zong S, Luo P, Yanji Q, Yingying W, Peiyu D, et al. Enhancing autophagy by down-regulating GSK-3β alleviates cisplatin-induced ototoxicity in vivo and in vitro. Toxicol Lett. 2019;: pubmed publisher
Li N, Guo X, Liu L, Wang L, Cheng R. Molecular mechanism of miR-204 regulates proliferation, apoptosis and autophagy of cervical cancer cells by targeting ATF2. Artif Cells Nanomed Biotechnol. 2019;47:2529-2535 pubmed publisher
Cui C, Li Z, Wu D. The long non-coding RNA H19 induces hypoxia/reoxygenation injury by up-regulating autophagy in the hepatoma carcinoma cells. Biol Res. 2019;52:32 pubmed publisher
Ma S, Miao H, Luo Y, Sun Y, Tian X, Wang F, et al. FePt/GO Nanosheets Suppress Proliferation, Enhance Radiosensitization and Induce Autophagy of Human Non-Small Cell Lung Cancer Cells. Int J Biol Sci. 2019;15:999-1009 pubmed publisher
Zhou G, Tang S, Yang L, Niu Q, Chen J, Xia T, et al. Effects of long-term fluoride exposure on cognitive ability and the underlying mechanisms: Role of autophagy and its association with apoptosis. Toxicol Appl Pharmacol. 2019;:114608 pubmed publisher
Zhu J, Li J, Wang X, Feng X, Li Y. Nonstructural Protein NP1 of Human Bocavirus 1 suppresses the growth of A549 cell by promoting autophagy. New Microbiol. 2019;42:161-165 pubmed
Wu X, Ansari A, Pang X, Li H, Zhang Z, Luo Y, et al. Visfatin Plays a Significant Role in Alleviating Lipopolysaccharide-Induced Apoptosis and Autophagy Through PI3K/AKT Signaling Pathway During Acute Lung Injury in Mice. Arch Immunol Ther Exp (Warsz). 2019;: pubmed publisher
Barot S, Abo Ali E, Zhou D, Palaguachi C, Dukhande V. Inhibition of glycogen catabolism induces intrinsic apoptosis and augments multikinase inhibitors in hepatocellular carcinoma cells. Exp Cell Res. 2019;: pubmed publisher
Liu P, Li Y, Yang W, Liu D, Ji X, Chi T, et al. Prevention of Huntington's Disease-Like Behavioral Deficits in R6/1 Mouse by Tolfenamic Acid Is Associated with Decreases in Mutant Huntingtin and Oxidative Stress. Oxid Med Cell Longev. 2019;2019:4032428 pubmed publisher
Chen C, Jiang L, Zhang M, Pan X, Peng C, Huang W, et al. Isodunnianol alleviates doxorubicin-induced myocardial injury by activating protective autophagy. Food Funct. 2019;10:2651-2657 pubmed publisher
Zhou Q, Wang L, Chen H, Xu B, Xu W, Sheng Y, et al. 2,3',4,4',5-Pentachlorobiphenyl induced autophagy of the thyrocytes via DAPK2/PKD/VPS34 pathway. Arch Toxicol. 2019;: pubmed publisher
Li R, Du J, Yao Y, Yao G, Wang X. Adiponectin inhibits high glucose-induced angiogenesis via inhibiting autophagy in RF/6A cells. J Cell Physiol. 2019;: pubmed publisher
Xu G, Wang X, Yu H, Wang C, Liu Y, Zhao R, et al. Beclin 1, LC3, and p62 expression in paraquat-induced pulmonary fibrosis. Hum Exp Toxicol. 2019;38:794-802 pubmed publisher
Yin F, Yan J, Zhao Y, Guo K, Zhang Z, Li A, et al. Bone marrow mesenchymal stem cells repair Cr (VI)- injured kidney by regulating mitochondria-mediated apoptosis and mitophagy mediated via the MAPK signaling pathway. Ecotoxicol Environ Saf. 2019;176:234-241 pubmed publisher
Wu J, Kuang L, Chen C, Yang J, Zeng W, Li T, et al. miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis. Biomaterials. 2019;206:87-100 pubmed publisher
Du W, Wang N, Li F, Jia K, An J, Liu Y, et al. STAT3 phosphorylation mediates high glucose-impaired cell autophagy in an HDAC1-dependent and -independent manner in Schwann cells of diabetic peripheral neuropathy. FASEB J. 2019;:fj201900127R pubmed publisher
Yu Q, Wu L, Liu T, Li S, Feng J, Mao Y, et al. Protective effects of levo-tetrahydropalmatine on hepatic ischemia/reperfusion injury are mediated by inhibition of the ERK/NF-κB pathway. Int Immunopharmacol. 2019;70:435-445 pubmed publisher
Zhang Q, Meng X, Qin G, Xue X, Dang N. Lyn Kinase Promotes the Proliferation of Malignant Melanoma Cells through Inhibition of Apoptosis and Autophagy via the PI3K/Akt Signaling Pathway. J Cancer. 2019;10:1197-1208 pubmed publisher
Xia Y, Zhang G, Han C, Ma K, Guo X, Wan F, et al. Microglia as modulators of exosomal alpha-synuclein transmission. Cell Death Dis. 2019;10:174 pubmed publisher
Ma L, Liu Y, Zhao X, Li P, Jin Q. Rapamycin attenuates articular cartilage degeneration by inhibiting β-catenin in a murine model of osteoarthritis. Connect Tissue Res. 2019;:1-11 pubmed publisher
Li L, Li L, Zhou X, Yu Y, Li Z, Zuo D, et al. Silver nanoparticles induce protective autophagy via Ca2+/CaMKKβ/AMPK/mTOR pathway in SH-SY5Y cells and rat brains. Nanotoxicology. 2019;13:369-391 pubmed publisher
Nian F, Li L, Cheng C, Wu P, Lin Y, Tang C, et al. Rab18 Collaborates with Rab7 to Modulate Lysosomal and Autophagy Activities in the Nervous System: an Overlapping Mechanism for Warburg Micro Syndrome and Charcot-Marie-Tooth Neuropathy Type 2B. Mol Neurobiol. 2019;: pubmed publisher
Mao Z, Han X, Chen D, Xu Y, Xu L, Yin L, et al. Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage. Br J Pharmacol. 2019;176:919-937 pubmed publisher
Ho W, Tai Y, Chang J, Liang J, Tyan S, Chen S, et al. The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy. Autophagy. 2019;15:827-842 pubmed publisher
Ren Z, Xiao W, Zeng Y, Liu M, Li G, Tang Z, et al. Fibroblast growth factor-21 alleviates hypoxia/reoxygenation injury in H9c2 cardiomyocytes by promoting autophagic flux. Int J Mol Med. 2019;43:1321-1330 pubmed publisher
Zhao Q, Niu Q, Chen J, Xia T, Zhou G, Li P, et al. Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: mechanisms of action in vitro and associations with cognition in rats and children. Arch Toxicol. 2019;93:709-726 pubmed publisher
Wu X, Zhang J, Ma C, Li W, Zeng J, Wang Y, et al. A role for Wnt/β-catenin signalling in suppressing Bacillus Calmette-Guerin-induced macrophage autophagy. Microb Pathog. 2019;127:277-287 pubmed publisher
Hasnat M, Yuan Z, Naveed M, Khan A, Raza F, Xu D, et al. Drp1-associated mitochondrial dysfunction and mitochondrial autophagy: a novel mechanism in triptolide-induced hepatotoxicity. Cell Biol Toxicol. 2019;35:267-280 pubmed publisher
Zhang W, He B, Wu Y, Qiao J, Peng Z. Melatonin protects against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice. Life Sci. 2019;217:8-15 pubmed publisher
Li J, Li B, Cheng Y, Meng Q, Wei L, Li W, et al. The synergistic effect of NOD2 and TLR4 on the activation of autophagy in human submandibular gland inflammation. J Oral Pathol Med. 2019;48:87-95 pubmed publisher
Zhang Z, Zhang M, Liu H, Yin W. AZD9291 promotes autophagy and inhibits PI3K/Akt pathway in NSCLC cancer cells. J Cell Biochem. 2019;120:756-767 pubmed publisher
Liu T, Xu L, Wang C, Chen K, Xia Y, Li J, et al. Alleviation of hepatic fibrosis and autophagy via inhibition of transforming growth factor-β1/Smads pathway through shikonin. J Gastroenterol Hepatol. 2019;34:263-276 pubmed publisher
Sun R, Fan Y, Liang X, Gong T, Wang Q, Liu H, et al. Rapamycin and FTY720 Alleviate Atherosclerosis by Cross Talk of Macrophage Polarization and Autophagy. Biomed Res Int. 2018;2018:1010248 pubmed publisher
Yu Q, Liu T, Li S, Feng J, Wu L, Wang W, et al. The Protective Effects of Levo-Tetrahydropalmatine on ConA-Induced Liver Injury Are via TRAF6/JNK Signaling. Mediators Inflamm. 2018;2018:4032484 pubmed publisher
Deng J, Feng J, Liu T, Lu X, Wang W, Liu N, et al. Beraprost sodium preconditioning prevents inflammation, apoptosis, and autophagy during hepatic ischemia-reperfusion injury in mice via the P38 and JNK pathways. Drug Des Devel Ther. 2018;12:4067-4082 pubmed publisher
Hsiao C, Chang C, Ibrahim R, Lin I, Wang C, Wang W, et al. Gli2 modulates cell cycle re-entry through autophagy-mediated regulation of the length of primary cilia. J Cell Sci. 2018;131: pubmed publisher
Chen T, Huang B, Shi X, Gao L, Huang C. Mutant UBQLN2P497H in motor neurons leads to ALS-like phenotypes and defective autophagy in rats. Acta Neuropathol Commun. 2018;6:122 pubmed publisher
Wu Y, Li Y, Wu B, Tan C, He X, Xu B, et al. β-Arrestin2 Inhibits Expression of Inflammatory Cytokines in BEAS-2B Lung Epithelial Cells Treated with Cigarette Smoke Condensate via Inhibition of Autophagy. Cell Physiol Biochem. 2018;50:1270-1285 pubmed publisher
Wu J, Li L, Wang S, Pang X, Wu J, Sheng S, et al. Autophagy is positively associated with the accumulation of myeloid‑derived suppressor cells in 4‑nitroquinoline‑1‑oxide‑induced oral cancer. Oncol Rep. 2018;40:3381-3391 pubmed publisher
Wu Y, Li Y, Wang B, He X, Li Y, Wu B, et al. Role of p62/SQSTM1 in lipopolysaccharide (LPS)-induced mucus hypersecretion in bronchial epithelial cells. Life Sci. 2018;211:270-278 pubmed publisher
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product information
CatalogNo :
14600-1-AP
AntigenName :
LC3
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
microtubule-associated protein 1 light chain 3 beta
Immunogen :
Recombinant Protein
Species :
cow, duck, goat, human, monkey, mouse, rabbit, rat, swine, zebrafish
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, FC, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
LC3, LC3B, LC3-II, MAP1A/1BLC3, MAP1A/MAP1B LC3 B, MAP1A/MAP1B light chain 3 B, MAP1ALC3, MAP1LC3B
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC067797
Category :
Apoptosis;Autophagy;Binding Proteins;Cytoskeleton/Scaffold Proteins;Membrane Proteins;Metabolism;Neurology;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
AppTiter :
FC 1:0 ; IF 1:400 ; IHC 1:600 ; IP 1:1000 ; WB 1:2500 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.