This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
p70(S6K)
catalog :
14485-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
citations: 56
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:2000; loading ...; fig 3a
Gao H, Zhang J, Ren X. PD-L1 regulates tumorigenesis and autophagy of ovarian cancer by activating mTORC signaling. Biosci Rep. 2019;39: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6a
Yue G, Chen C, Bai L, Wang G, Huang Y, Wang Y, et al. Knockdown of long noncoding RNA DLEU1 suppresses the progression of renal cell carcinoma by downregulating the Akt pathway. Mol Med Rep. 2019;20:4551-4557 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6c
Dou N, Yu S, Ye X, Yang D, Li Y, Gao Y. Aberrant overexpression of ADAR1 promotes gastric cancer progression by activating mTOR/p70S6K signaling. Oncotarget. 2016;7:86161-86173 pubmed publisher
Chen N, Mu L, Yang Z, Du C, Wu M, Song S, et al. Carbohydrate response element-binding protein regulates lipid metabolism via mTOR complex1 in diabetic nephropathy. J Cell Physiol. 2020;: pubmed publisher
Liu J, Shangguan Y, Sun J, Cong W, Xie Y. BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways. Biomed Pharmacother. 2020;129:110414 pubmed publisher
An Y, Zhang J, Cheng X, Li B, Tian Y, Zhang X, et al. miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6. Cancer Cell Int. 2020;20:237 pubmed publisher
Ponsford A, Ryan T, Raimondi A, Cocucci E, Wycislo S, Fröhlich F, et al. Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor. Autophagy. 2020;:1-19 pubmed publisher
Ma J, Qi J, Li S, Zhang C, Wang H, Shao L, et al. Desloratadine, a Novel Antigrowth Reagent for Bladder Cancer. Technol Cancer Res Treat. 2020;19:1533033820926591 pubmed publisher
Yang Z, Li J, Chen W, Kong F. Oncogenic gene RGC-32 is a direct target of miR-26b and facilitates tongue squamous cell carcinoma aggressiveness through EMT and PI3K/AKT signalling. Cell Biochem Funct. 2020;: pubmed publisher
Zhang J, Zhu S, Tan Q, Cheng D, Dai Q, Yang Z, et al. Combination therapy with ropivacaine-loaded liposomes and nutrient deprivation for simultaneous cancer therapy and cancer pain relief. Theranostics. 2020;10:4885-4899 pubmed publisher
Jing X, Chen Y, Chen Y, Shi G, Lv S, Cheng N, et al. Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion. Cancer Manag Res. 2020;12:2185-2194 pubmed publisher
Sun X, Yang S, Song W. Prazosin inhibits the proliferation and survival of acute myeloid leukaemia cells through down-regulating TNS1. Biomed Pharmacother. 2020;124:109731 pubmed publisher
Zhang C, Wang B, Wang X, Sheng X, Cui Y. Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1). Cancer Cell Int. 2019;19:339 pubmed publisher
Wang J, Li L, Wang J, Song L, Tan N, Wang Z. Natural Naphthohydroquinone Dimer Rubioncolin C Exerts Anti-Tumor Activity by Inducing Apoptotic and Autophagic Cell Death and Inhibiting the NF-κB and Akt/mTOR/P70S6K Pathway in Human Cancer Cells. Cells. 2019;8: pubmed publisher
Li Z, Hu Y, Zeng Q, Wang H, Yan J, Li H, et al. Circular RNA MYLK promotes hepatocellular carcinoma progression by increasing Rab23 expression by sponging miR-362-3p. Cancer Cell Int. 2019;19:211 pubmed publisher
Li L, Yu S, Wu Q, Dou N, Li Y, Gao Y. KLF4-Mediated CDH3 Upregulation Suppresses Human Hepatoma Cell Growth and Migration via GSK-3β Signaling. Int J Biol Sci. 2019;15:953-961 pubmed publisher
Xu S, Ma H, Bo Y, Shao M. The oncogenic role of CB2 in the progression of non-small-cell lung cancer. Biomed Pharmacother. 2019;117:109080 pubmed publisher
Bian X, Bai Y, Su X, Zhao G, Sun G, Li D. Knockdown of periostin attenuates 5/6 nephrectomy-induced intrarenal renin-angiotensin system activation, fibrosis, and inflammation in rats. J Cell Physiol. 2019;234:22857-22873 pubmed publisher
Zheng R, Huang S, Zhu J, Lin W, Xu H, Zheng X. Leucine attenuates muscle atrophy and autophagosome formation by activating PI3K/AKT/mTOR signaling pathway in rotator cuff tears. Cell Tissue Res. 2019;: pubmed publisher
Li Q, Zeng Y, Jiang Q, Wu C, Zhou J. Role of mTOR signaling in the regulation of high glucose-induced podocyte injury. Exp Ther Med. 2019;17:2495-2502 pubmed publisher
Sun Z, Liu J. mTOR-S6K1 pathway mediates cytoophidium assembly. J Genet Genomics. 2019;46:65-74 pubmed publisher
Wang Q, Shi W. UNBS5162 inhibits SKOV3 ovarian cancer cell proliferation by regulating the PI3K/AKT signalling pathway. Oncol Lett. 2019;17:2976-2982 pubmed publisher
Lan Y, Sullivan P, Hu F. SMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis. Autophagy. 2019;15:871-885 pubmed publisher
Zhao B, Hu T. JTC-801 inhibits the proliferation and metastasis of the Hep G2 hepatoblastoma cell line by regulating the phosphatidylinositol 3-kinase/protein kinase B signalling pathway. Oncol Lett. 2019;17:1939-1945 pubmed publisher
Liang H, Mokrani A, Chisomo Kasiya H, Ji K, Ge X, Ren M, et al. Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala. Fish Physiol Biochem. 2019;45:719-732 pubmed publisher
Zhang X, Liu J, Gu Y, Sun C, Qu F. Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs. Cell Biol Int. 2019;43:158-166 pubmed publisher
Li Q, Ma R, Zhang M. XRCC1 rs1799782 (C194T) polymorphism correlated with tumor metastasis and molecular subtypes in breast cancer. Onco Targets Ther. 2018;11:8435-8444 pubmed publisher
Qiao J, Wang W, Zhang Y. Aclidinium inhibits proliferation and metastasis of ovarian cancer SKOV3 cells via downregulating PI3K/AKT/mTOR signaling pathway. Oncol Lett. 2018;16:6417-6422 pubmed publisher
Huang T, Liu D, Wang Y, Li P, Sun L, Xiong H, et al. FGFR2 Promotes Gastric Cancer Progression by Inhibiting the Expression of Thrombospondin4 via PI3K-Akt-Mtor Pathway. Cell Physiol Biochem. 2018;50:1332-1345 pubmed publisher
Tian T, Sun J, Wang J, Liu Y, Liu H. Isoliquiritigenin inhibits cell proliferation and migration through the PI3K/AKT signaling pathway in A549 lung cancer cells. Oncol Lett. 2018;16:6133-6139 pubmed publisher
Yin Y, Zhou L, Zhan R, Zhang Q, Li M. Identification of WDR12 as a novel oncogene involved in hepatocellular carcinoma propagation. Cancer Manag Res. 2018;10:3985-3993 pubmed publisher
Wang S, Xue X, Wang R, Li X, Li Q, Wang Y, et al. CircZNF609 promotes breast cancer cell growth, migration, and invasion by elevating p70S6K1 via sponging miR-145-5p. Cancer Manag Res. 2018;10:3881-3890 pubmed publisher
Jin J, Hu K, Ye M, Wu D, He Q. Rapamycin Reduces Podocyte Apoptosis and is Involved in Autophagy and mTOR/ P70S6K/4EBP1 Signaling. Cell Physiol Biochem. 2018;48:765-772 pubmed publisher
Zhang H, Han B, Lu H, Zhao Y, Chen X, Meng Q, et al. USP22 promotes resistance to EGFR-TKIs by preventing ubiquitination-mediated EGFR degradation in EGFR-mutant lung adenocarcinoma. Cancer Lett. 2018;433:186-198 pubmed publisher
Chen S, Wang L, Sun K, Liu Y, Guan X, Zong Z, et al. LncRNA PCGEM1 Induces Ovarian Carcinoma Tumorigenesis and Progression Through RhoA Pathway. Cell Physiol Biochem. 2018;47:1578-1588 pubmed publisher
Wu Z, Zhu Q, Zhang Y, Yin Y, Kang D, Cao R, et al. EGFR‑associated pathways involved in traditional Chinese medicine (TCM)‑1‑induced cell growth inhibition, autophagy and apoptosis in prostate cancer. Mol Med Rep. 2018;17:7875-7885 pubmed publisher
Zhang S, Wang Y. Telmisartan inhibits NSCLC A549 cell proliferation and migration by regulating the PI3K/AKT signaling pathway. Oncol Lett. 2018;15:5859-5864 pubmed publisher
Wu Z, Zhu Q, Yin Y, Kang D, Cao R, Tian Q, et al. Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer. Cancer Med. 2018;7:1546-1559 pubmed publisher
Li C, Zhang J, Xu H, Chang M, Lv C, Xue W, et al. Retigabine ameliorates acute stress-induced impairment of spatial memory retrieval through regulating USP2 signaling pathways in hippocampal CA1 area. Neuropharmacology. 2018;135:151-162 pubmed publisher
Zhang L, Liu W, Wang Q, Li Q, Wang H, Wang J, et al. New Drug Candidate Targeting the 4A1 Orphan Nuclear Receptor for Medullary Thyroid Cancer Therapy. Molecules. 2018;23: pubmed publisher
Chen L, Xue Y, Zheng J, Liu X, Liu J, Chen J, et al. MiR-429 Regulated by Endothelial Monocyte Activating Polypeptide-II (EMAP-II) Influences Blood-Tumor Barrier Permeability by Inhibiting the Expressions of ZO-1, Occludin and Claudin-5. Front Mol Neurosci. 2018;11:35 pubmed publisher
Tian T, Qiu R, Qiu X. SNHG1 promotes cell proliferation by acting as a sponge of miR-145 in colorectal cancer. Oncotarget. 2018;9:2128-2139 pubmed publisher
Chen S, Wang L, Sun K, Xiu Y, Zong Z, Chen X, et al. The role of the long non-coding RNA TDRG1 in epithelial ovarian carcinoma tumorigenesis and progression through miR-93/RhoC pathway. Mol Carcinog. 2018;57:225-234 pubmed publisher
Li M, Jin C, Xu M, Zhou L, Li D, Yin Y. Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling. Cell Commun Signal. 2017;15:52 pubmed publisher
Song L, Wang Z, Wang Y, Guo D, Yang J, Chen L, et al. Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells. Molecules. 2017;22: pubmed publisher
Zhang Y, Huang Y, Huang T, Pang W, Zhu J, LIU Y, et al. The Mammalian Target of Rapamycin and DNA methyltransferase 1 axis mediates vascular endothelial dysfunction in response to disturbed flow. Sci Rep. 2017;7:14996 pubmed publisher
Sun K, Wu D, Chen S, Zhao Y, Zong Z. LncRNA MEG3 inhibit endometrial carcinoma tumorigenesis and progression through PI3K pathway. Apoptosis. 2017;22:1543-1552 pubmed publisher
Liu Y, Zong Z, Guan X, Wang L, Zhao Y. The role of long non-coding RNA PCA3 in epithelial ovarian carcinoma tumorigenesis and progression. Gene. 2017;633:42-47 pubmed publisher
Wu D, Chen X, Sun K, Wang L, Chen S, Zhao Y. Role of the lncRNA ABHD11-AS1 in the tumorigenesis and progression of epithelial ovarian cancer through targeted regulation of RhoC. Mol Cancer. 2017;16:138 pubmed publisher
Wang L, Sun K, Wu D, Xiu Y, Chen X, Chen S, et al. DLEU1 contributes to ovarian carcinoma tumourigenesis and development by interacting with miR-490-3p and altering CDK1 expression. J Cell Mol Med. 2017;21:3055-3065 pubmed publisher
Cui X, Long C, Zhu J, Tian J. Protective Effects of Fluvastatin on Reproductive Function in Obese Male Rats Induced by High-Fat Diet through Enhanced Signaling of mTOR. Cell Physiol Biochem. 2017;41:598-608 pubmed publisher
Zhao L, Zheng X. MicroRNA-490 inhibits tumorigenesis and progression in breast cancer. Onco Targets Ther. 2016;9:4505-16 pubmed publisher
Yu X, Jin D, Yu A, Sun J, Chen X, Yang Z. p65 down-regulates DEPTOR expression in response to LPS stimulation in hepatocytes. Gene. 2016;589:12-19 pubmed publisher
Li L, Sun H, Liu X, Gao S, Jiang H, Hu X, et al. Down-Regulation of NDUFB9 Promotes Breast Cancer Cell Proliferation, Metastasis by Mediating Mitochondrial Metabolism. PLoS ONE. 2015;10:e0144441 pubmed publisher
Zhang Q, Zhuang J, Deng Y, Zhao X, Tang B, Yao D, et al. GOLPH3 is a potential therapeutic target and a prognostic indicator of poor survival in bladder cancer treated by cystectomy. Oncotarget. 2015;6:32177-92 pubmed publisher
Bai Y, Xuan B, Liu H, Zhong J, Yu D, Qian Z. Tuberous Sclerosis Complex Protein 2-Independent Activation of mTORC1 by Human Cytomegalovirus pUL38. J Virol. 2015;89:7625-35 pubmed publisher
product information
CatalogNo :
14485-1-AP
AntigenName :
p70(S6K)
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
ribosomal protein S6 kinase, 70kDa, polypeptide 1
Immunogen :
Recombinant Protein
Species :
blunt snout bream, human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, FC, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
p70 alpha, p70 ribosomal S6 kinase alpha, p70 S6 kinase alpha, p70 S6K 1, p70 S6K alpha, p70 S6KA, p70(S6K) alpha, p70S6K, P70S6K1, PS6K, Ribosomal protein S6 kinase I, RPS6KB1, S6K, S6K beta 1, S6K1, STK14A
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC053365
Category :
Binding Proteins;Cell Cycle;Cytoskeleton/Scaffold Proteins;Development;Disease Related;Membrane Proteins;Metabolism;Neurology;Signal transduction;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
FC 1:0 ; IF 1:25 ; IHC 1:200 ; IP 1:1000 ; WB 1:4000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.