This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
smooth muscle actin
catalog :
14395-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
citations: 204
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig s4c
Chen Z, Sun X, Chen Q, Lan T, Huang K, Xiao H, et al. Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked Nox4 polyubiquitination and degradation via the inhibition of Smurf1 expression. Br J Pharmacol. 2019;: pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 3b
Yang Y, Chen S, Tao L, Gan S, Luo H, Xu Y, et al. Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro. Med Sci Monit. 2019;25:5375-5388 pubmed publisher
  • western blot; mouse; fig 3
Wu W, Zhao L, Yang P, Zhou W, Li B, Moorhead J, et al. Inflammatory Stress Sensitizes the Liver to Atorvastatin-Induced Injury in ApoE-/- Mice. PLoS ONE. 2016;11:e0159512 pubmed publisher
  • western blot; human; fig 2
Chen X, Kong X, Liu D, Gao P, Zhang Y, Li P, et al. In vitro differentiation of endometrial regenerative cells into smooth muscle cells: ? potential approach for the management of pelvic organ prolapse. Int J Mol Med. 2016;38:95-104 pubmed publisher
  • western blot; mouse; fig 2
Zhang Q, Gao M, Zhang Y, Song Y, Cheng H, Zhou R. The germline-enriched Ppp1r36 promotes autophagy. Sci Rep. 2016;6:24609 pubmed publisher
  • immunocytochemistry; rat; 1:100; fig 1g
Liu J, Han Z, Han Z, He Z. Mesenchymal stem cell-conditioned media suppresses inflammation-associated overproliferation of pulmonary artery smooth muscle cells in a rat model of pulmonary hypertension. Exp Ther Med. 2016;11:467-475 pubmed
Sun B, Wang X, Liu X, Wang L, Ren F, Wang X, et al. Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease. Antioxidants (Basel). 2020;9: pubmed publisher
Wu L, Wang Q, Guo F, Ma X, Wang J, Zhao Y, et al. Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress. J Cell Physiol. 2020;: pubmed publisher
Yang G, Zheng B, Qin Y, Zhou J, Yang Z, Zhang X, et al. Salvia miltiorrhiza-derived miRNAs suppress vascular remodeling through regulating OTUD7B/KLF4/NMHC IIA axis. Theranostics. 2020;10:7787-7811 pubmed publisher
Xu J, Zhang Y, You S, Guo Y, Chen S, Chang Y, et al. Paired box 9 regulates VSMC phenotypic transformation, proliferation, and migration via sonic hedgehog. Life Sci. 2020;257:118053 pubmed publisher
Zhang Y, You S, Tian Y, Lu S, Cao L, Sun Y, et al. WWP2 regulates SIRT1-STAT3 acetylation and phosphorylation involved in hypertensive angiopathy. J Cell Mol Med. 2020;: pubmed publisher
Lei Q, Yi T, Li H, Yan Z, Lv Z, Li G, et al. Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78). Sci Rep. 2020;10:10604 pubmed publisher
Lin X, Li Y, Zhang X, Wei Y, Wen S, Lu Z, et al. Tormentic acid inhibits hepatic stellate cells activation via blocking PI3K/Akt/mTOR and NF-κB signalling pathways. Cell Biochem Funct. 2020;: pubmed publisher
Guan G, Wei N, Song T, Zhao C, Sun Y, Pan R, et al. miR-448-3p alleviates diabetic vascular dysfunction by inhibiting endothelial-mesenchymal transition through DPP-4 dysregulation. J Cell Physiol. 2020;: pubmed publisher
Du Y, Xiao H, Wan J, Wang X, Li T, Zheng S, et al. Atorvastatin attenuates TGF‑β1‑induced fibrogenesis by inhibiting Smad3 and MAPK signaling in human ventricular fibroblasts. Int J Mol Med. 2020;46:633-640 pubmed publisher
Zhao Q, Zhang C, Xiang R, Wu L, Li L. CTRP15 derived from cardiac myocytes attenuates TGFβ1-induced fibrotic response in cardiac fibroblasts. Cardiovasc Drugs Ther. 2020;34:591-604 pubmed publisher
Wang H, Wei Z, Li H, Guan Y, Han Z, Wang H, et al. MiR-377-3p inhibits atherosclerosis-associated vascular smooth muscle cell proliferation and migration via targeting neuropilin2. Biosci Rep. 2020;40: pubmed publisher
Peng L, Yu M, Yang M, Liu P, Zhou H, Huang W, et al. Icotinib Attenuates Monocrotaline-Induced Pulmonary Hypertension by Preventing Pulmonary Arterial Smooth Muscle Cell Dysfunction. Am J Hypertens. 2020;33:775-783 pubmed publisher
Cai R, Wang P, Zhao X, Lu X, Deng R, Wang X, et al. LTBP1 promotes esophageal squamous cell carcinoma progression through epithelial-mesenchymal transition and cancer-associated fibroblasts transformation. J Transl Med. 2020;18:139 pubmed publisher
Zhong L, Ding W, Zeng Q, He B, Zhang H, Wang L, et al. Sodium Tanshinone IIA Sulfonate Attenuates Erectile Dysfunction in Rats with Hyperlipidemia. Oxid Med Cell Longev. 2020;2020:7286958 pubmed publisher
Zhu J, Shao M, Guo F, Ren J, Tang Z, Geng J, et al. Downregulation of lysyl oxidase in venous malformations: Association with vascular destabilization and sclerotherapy. J Dermatol. 2020;47:518-526 pubmed publisher
Zhou S, Zhou Y, Yu J, Du Y, Tan Y, Ke Y, et al. Ophiocordyceps lanpingensis polysaccharides attenuate pulmonary fibrosis in mice. Biomed Pharmacother. 2020;126:110058 pubmed publisher
Liu F, Shang Y. Sirtuin 6 attenuates epithelial-mesenchymal transition by suppressing the TGF-β1/Smad3 pathway and c-Jun in asthma models. Int Immunopharmacol. 2020;82:106333 pubmed publisher
Zhao J, Jiang Y, Sun X, Liu X, Liu F, Song M, et al. The mechanism and role of intracellular α-ketoglutarate reduction in hepatic stellate cell activation. Biosci Rep. 2020;40: pubmed publisher
Wang D, Hao C, Zhang L, Zhang J, Liu S, Li Y, et al. Exosomal miR-125a-5p derived from silica-exposed macrophages induces fibroblast transdifferentiation. Ecotoxicol Environ Saf. 2020;192:110253 pubmed publisher
Zhang N, Zhang Y, You S, Tian Y, Lu S, Cao L, et al. Septin4 Prevents PDGF-BB-induced HAVSMC Phenotypic Transformation, Proliferation and Migration by Promoting SIRT1-STAT3 Deacetylation and Dephosphorylation. Int J Biol Sci. 2020;16:708-718 pubmed publisher
Wang J, Cui Y, Xing K, Luan J, Han J. Generation and characterization of a human iPSC line derived from congenital clubfoot amniotic fluid cells. Stem Cell Res. 2020;43:101712 pubmed publisher
Sun L, Qu L, Brigstock D, Li H, Li Y, Gao R. Biological and Proteomic Characteristics of an Immortalized Human Pancreatic Stellate Cell Line. Int J Med Sci. 2020;17:137-144 pubmed publisher
Zhang N, Zhang Y, Wu B, You S, Sun Y. Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury. Redox Biol. 2020;30:101419 pubmed publisher
Xia H, Cao D, Yang F, Yang W, Li W, Liu P, et al. Jiawei Yanghe decoction ameliorates cartilage degradation in vitro and vivo via Wnt/β-catenin signaling pathway. Biomed Pharmacother. 2020;122:109708 pubmed publisher
Tian C, Gao F, Li X, Li Z. Icariside II attenuates eosinophils-induced airway inflammation and remodeling via inactivation of NF-κB and STAT3 in an asthma mouse model. Exp Mol Pathol. 2020;113:104373 pubmed publisher
Wang L, Yu P, Zhou B, Song J, Li Z, Zhang M, et al. Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function. Nat Cell Biol. 2020;22:108-119 pubmed publisher
Su H, Ye C, Lei C, Tang H, Zeng J, Yi F, et al. Subcellular trafficking of tubular MDM2 implicates in acute kidney injury to chronic kidney disease transition during multiple low-dose cisplatin exposure. FASEB J. 2020;34:1620-1636 pubmed publisher
Ouyang F, Liu X, Liu G, Qiu H, He Y, Hu H, et al. Long non-coding RNA RNF7 promotes the cardiac fibrosis in rat model via miR-543/THBS1 axis and TGFβ1 activation. Aging (Albany NY). 2020;12:996-1010 pubmed publisher
Hashimoto R, Lanier G, Dhagia V, Joshi S, Jordan A, Waddell I, et al. Pluripotent hematopoietic stem cells augment α-adrenergic receptor-mediated contraction of pulmonary artery and contribute to the pathogenesis of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2020;318:L386-L401 pubmed publisher
Weng C, Li Q, Chen K, Xu C, Deng M, Li T, et al. Bleomycin induces epithelial-to-mesenchymal transition via bFGF/PI3K/ESRP1 signaling in pulmonary fibrosis. Biosci Rep. 2020;40: pubmed publisher
Fu S, Li Y, Wu Y, Yue Y, Yang D. Icariside II improves myocardial fibrosis in spontaneously hypertensive rats by inhibiting collagen synthesis. J Pharm Pharmacol. 2020;72:227-235 pubmed publisher
Liu Y, Chen S, Liu J, Jin Y, Yu S, An R. Telmisartan inhibits oxalate and calcium oxalate crystal-induced epithelial-mesenchymal transformation via PPAR-γ-AKT/STAT3/p38 MAPK-Snail pathway. Life Sci. 2020;241:117108 pubmed publisher
Wu H, Chen G, Wang J, Deng M, Yuan F, Gong J. TIM-4 interference in Kupffer cells against CCL4-induced liver fibrosis by mediating Akt1/Mitophagy signalling pathway. Cell Prolif. 2020;53:e12731 pubmed publisher
Shao Q, Jiang C, Xia Y, Zhao M, Zhang Q, Jin B, et al. Dioscin ameliorates peritoneal fibrosis by inhibiting epithelial-to-mesenchymal transition of human peritoneal mesothelial cells via the TLR4/MyD88/NF-κB signaling pathway. Int J Clin Exp Pathol. 2019;12:867-875 pubmed
Sun Y, Hei M, Fang Z, Tang Z, Wang B, Hu N. High-Mobility Group Box 1 Contributes to Cerebral Cortex Injury in a Neonatal Hypoxic-Ischemic Rat Model by Regulating the Phenotypic Polarization of Microglia. Front Cell Neurosci. 2019;13:506 pubmed publisher
Zeng Q, He S, Zhong L, Wang L, Cheng F, Zhang H, et al. [Exogenous hydrogen sulfide improves erectile dysfunction by inhibiting apoptosis of corpus cavernosum smooth muscle cells in rats with cavernous nerve injury]. Nan Fang Yi Ke Da Xue Xue Bao. 2019;39:1329-1336 pubmed publisher
Dongdong Z, Jin Y, Yang T, Yang Q, Wu B, Chen Y, et al. Antiproliferative and Immunoregulatory Effects of Azelaic Acid Against Acute Myeloid Leukemia via the Activation of Notch Signaling Pathway. Front Pharmacol. 2019;10:1396 pubmed publisher
Li Z, Chen D, Jia Y, Feng Y, Wang C, Tong Y, et al. Methane-Rich Saline Counteracts Cholestasis-Induced Liver Damage via Regulating the TLR4/NF-κB/NLRP3 Inflammasome Pathway. Oxid Med Cell Longev. 2019;2019:6565283 pubmed publisher
Luo Y, Yang P, Li Z, Luo Y, Shen J, Li R, et al. Liraglutide Improves Non-Alcoholic Fatty Liver Disease In Diabetic Mice By Modulating Inflammatory Signaling Pathways. Drug Des Devel Ther. 2019;13:4065-4074 pubmed publisher
Guan X, Zong Z, Liu Y, Chen S, Wang L, Zhao Y. circPUM1 Promotes Tumorigenesis and Progression of Ovarian Cancer by Sponging miR-615-5p and miR-6753-5p. Mol Ther Nucleic Acids. 2019;18:882-892 pubmed publisher
Wang Y, Li C, Gu J, Chen C, Duanmu J, Miao J, et al. Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signalling. J Cell Mol Med. 2019;: pubmed publisher
Che H, Wang Y, Li Y, Lv J, Li H, Liu Y, et al. Inhibition of microRNA-150-5p alleviates cardiac inflammation and fibrosis via targeting Smad7 in high glucose-treated cardiac fibroblasts. J Cell Physiol. 2019;: pubmed publisher
Du H, Zhao Q, Zang H, Chang C, Li X. Artemisinin attenuates the development of atherosclerotic lesions by the regulation of vascular smooth muscle cell phenotype switching. Life Sci. 2019;237:116943 pubmed publisher
Hoca M, Becer E, Kabadayı H, Yücecan S, Vatansever H. The Effect of Resveratrol and Quercetin on Epithelial-Mesenchymal Transition in Pancreatic Cancer Stem Cell. Nutr Cancer. 2019;:1-12 pubmed publisher
Xu G, Zhang B, Ye J, Cao S, Shi J, Zhao Y, et al. Exosomal miRNA-139 in cancer-associated fibroblasts inhibits gastric cancer progression by repressing MMP11 expression. Int J Biol Sci. 2019;15:2320-2329 pubmed publisher
Gu W, Yuan Y, Wang L, Yang H, Li S, Tang Z, et al. Long non-coding RNA TUG1 promotes airway remodelling by suppressing the miR-145-5p/DUSP6 axis in cigarette smoke-induced COPD. J Cell Mol Med. 2019;23:7200-7209 pubmed publisher
Zhang H, Yu J, Sun H, Zhao Y, Wang J, Zhang J, et al. Effects of ubiquitin-proteasome inhibitor on the expression levels of TNF-α and TGF-β1 in mice with viral myocarditis. Exp Ther Med. 2019;18:2799-2804 pubmed publisher
Xu B, Lang L, Li S, Yuan J, Wang J, Yang H, et al. Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure. Animals (Basel). 2019;9: pubmed publisher
Wei W, Li X, Xu M. Inhibition of vascular neointima hyperplasia by FGF21 associated with FGFR1/Syk/NLRP3 inflammasome pathway in diabetic mice. Atherosclerosis. 2019;289:132-142 pubmed publisher
Dias H, de Oliveira J, Donadio M, Kimura S. Fructose-1,6-bisphosphate prevents pulmonary fibrosis by regulating extracellular matrix deposition and inducing phenotype reversal of lung myofibroblasts. PLoS ONE. 2019;14:e0222202 pubmed publisher
Li T, Tan X, Zhu S, Zhong W, Huang B, Sun J, et al. SPARC induces phenotypic modulation of human brain vascular smooth muscle cells via AMPK/mTOR-mediated autophagy. Neurosci Lett. 2019;712:134485 pubmed publisher
Zhai X, Wang W, Dou D, Ma Y, Gang D, Jiang Z, et al. A novel technique to prepare a single cell suspension of isolated quiescent human hepatic stellate cells. Sci Rep. 2019;9:12757 pubmed publisher
Liu N, Feng J, Lu X, Yao Z, Liu Q, Lv Y, et al. Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways. Mediators Inflamm. 2019;2019:6175091 pubmed publisher
He X, Jiang H, Gao F, Liang S, Wei M, Chen L. Indoxyl sulfate-induced calcification of vascular smooth muscle cells via the PI3K/Akt/NF-κB signaling pathway. Microsc Res Tech. 2019;: pubmed publisher
Li T, Zha L, Luo H, Li S, Zhao L, He J, et al. Galectin-3 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension. Aging Dis. 2019;10:731-745 pubmed publisher
Fan J, Wang Q, Zhang Z, Sun L. Curcumin mitigates the epithelial-to-mesenchymal transition in biliary epithelial cells through upregulating CD109 expression. Drug Dev Res. 2019;: pubmed publisher
Xu F, Si X, Du J, Xu F, Yang A, Zhang C, et al. Downregulating SynCAM and MPP6 expression is associated with ovarian cancer progression. Oncol Lett. 2019;18:2477-2483 pubmed publisher
Zhang R, Qi F, Shao S, Li G, Feng Y. Human colorectal cancer-derived carcinoma associated fibroblasts promote CD44-mediated adhesion of colorectal cancer cells to endothelial cells by secretion of HGF. Cancer Cell Int. 2019;19:192 pubmed publisher
Su M, Tian F, Ouyang B, Wu X, Guo F, Chen H, et al. Bufei Qingyu Granules Inhibit the Development of Systemic Sclerosis via Notch-1/Jagged-2 Signaling Pathway. Evid Based Complement Alternat Med. 2019;2019:6709278 pubmed publisher
Li Q, Liu B, Breitkopf Heinlein K, Weng H, Jiang Q, Dong P, et al. Adenovirus‑mediated overexpression of bone morphogenetic protein‑9 promotes methionine choline deficiency‑induced non‑alcoholic steatohepatitis in non‑obese mice. Mol Med Rep. 2019;20:2743-2753 pubmed publisher
Song G, Zhang Y, Yu S, Lv W, Guan Z, Sun M, et al. Chrysophanol attenuates airway inflammation and remodeling through nuclear factor-kappa B signaling pathway in asthma. Phytother Res. 2019;: pubmed publisher
Yang P, Liang Y, Luo Y, Li Z, Wen Y, Shen J, et al. Liraglutide ameliorates nonalcoholic fatty liver disease in diabetic mice via the IRS2/PI3K/Akt signaling pathway. Diabetes Metab Syndr Obes. 2019;12:1013-1021 pubmed publisher
Suga T, Yamaguchi H, Ogura J, Shoji S, Maekawa M, Mano N. Altered bile acid composition and disposition in a mouse model of non-alcoholic steatohepatitis. Toxicol Appl Pharmacol. 2019;379:114664 pubmed publisher
Jiang R, Liao Y, Yang F, Cheng Y, Dai X, Chao J. SPIO nanoparticle-labeled bone marrow mesenchymal stem cells inhibit pulmonary EndoMT induced by SiO2. Exp Cell Res. 2019;:111492 pubmed publisher
Zhang Y, Zhang X, Wei Q, Leng S, Li C, Han B, et al. Activation of Sigma-1 Receptor Enhanced Pericyte Survival via the Interplay Between Apoptosis and Autophagy: Implications for Blood-Brain Barrier Integrity in Stroke. Transl Stroke Res. 2019;: pubmed publisher
Yang F, Chen E, Yang Y, Han F, Han S, Wu G, et al. The Akt/FoxO/p27Kip1 axis contributes to the anti-proliferation of pentoxifylline in hypertrophic scars. J Cell Mol Med. 2019;23:6164-6172 pubmed publisher
Wu Q, Hong J, Wang Z, Hu J, Chen R, Hu Z, et al. Abnormal Ribosome Biogenesis Partly Induced p53-Dependent Aortic Medial Smooth Muscle Cell Apoptosis and Oxidative Stress. Oxid Med Cell Longev. 2019;2019:7064319 pubmed publisher
Wang Y, Chu Y, Ren X, Xiang H, Xi Y, Ma X, et al. Epidural adipose tissue-derived mesenchymal stem cell activation induced by lung cancer cells promotes malignancy and EMT of lung cancer. Stem Cell Res Ther. 2019;10:168 pubmed publisher
Liu Y, Shen P, Zhou Y, Tang L, Chai H. c‑Jun N‑terminal kinase/transforming growth factor‑β/Smad3 pathway: Is it associated with endoplasmic reticulum stress‑mediated renal interstitial fibrosis?. Mol Med Rep. 2019;20:755-762 pubmed publisher
Yuan H, Xu J, Xu X, Gao T, Wang Y, Fan Y, et al. Calhex231 Alleviates High Glucose-Induced Myocardial Fibrosis via Inhibiting Itch-Ubiquitin Proteasome Pathway in Vitro. Biol Pharm Bull. 2019;42:1337-1344 pubmed publisher
Dalghi M, Clayton D, Ruiz W, Al Bataineh M, Satlin L, Kleyman T, et al. Expression and distribution of PIEZO1 in the mouse urinary tract. Am J Physiol Renal Physiol. 2019;317:F303-F321 pubmed publisher
Bian X, Bai Y, Su X, Zhao G, Sun G, Li D. Knockdown of periostin attenuates 5/6 nephrectomy-induced intrarenal renin-angiotensin system activation, fibrosis, and inflammation in rats. J Cell Physiol. 2019;234:22857-22873 pubmed publisher
Sun X, Huang X, Zhu X, Liu L, Mo S, Wang H, et al. HBOA ameliorates CCl4-incuded liver fibrosis through inhibiting TGF-β1/Smads, NF-κB and ERK signaling pathways. Biomed Pharmacother. 2019;115:108901 pubmed publisher
Sun Z, Liu Y, Yu F, Xu Y, Yanli L, Liu N. Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline. Biomed Pharmacother. 2019;115:108933 pubmed publisher
Tang H, Chu Y, Huang Z, Cai J, Wang Z. The metastatic phenotype shift towards myofibroblast of adipose-derived mesenchymal stem cells promotes ovarian cancer progression. Carcinogenesis. 2019;: pubmed publisher
Liu W, Song J, Du X, Zhou Y, Li Y, Li R, et al. AKR1B10 (Aldo-keto reductase family 1 B10) promotes brain metastasis of lung cancer cells in a multi-organ microfluidic chip model. Acta Biomater. 2019;91:195-208 pubmed publisher
Yang C, Li X, Zhang B, Fu S, Li S, Shen J, et al. The Mechanism of Rap1 Regulates N-cadherin to Control Neuronal Migration. J Mol Neurosci. 2019;: pubmed publisher
Xu G, Wang X, Yu H, Wang C, Liu Y, Zhao R, et al. Beclin 1, LC3, and p62 expression in paraquat-induced pulmonary fibrosis. Hum Exp Toxicol. 2019;38:794-802 pubmed publisher
Choi S, Oh S, Kang S, Kang S, Kim J, Lee H, et al. NAB 2-Expressing Cancer-Associated Fibroblast Promotes HNSCC Progression. Cancers (Basel). 2019;11: pubmed publisher
Yin J, Xia W, Wu M, Zhang Y, Huang S, Zhang A, et al. Inhibition of mitochondrial complex I activity attenuates neointimal hyperplasia by inhibiting smooth muscle cell proliferation and migration. Chem Biol Interact. 2019;304:73-82 pubmed publisher
Tao W, Sun W, Zhu H, Zhang J. miR-205-5p suppresses pulmonary vascular smooth muscle cell proliferation by targeting MICAL2-mediated Erk1/2 signaling. Microvasc Res. 2019;124:43-50 pubmed publisher
Li K, Du Q, Wang H, Sun H. Death-associated protein kinase 3 deficiency alleviates vascular calcification via AMPK-mediated inhibition of endoplasmic reticulum stress. Eur J Pharmacol. 2019;852:90-98 pubmed publisher
Feng H, Wang J, Yu B, Cong X, Zhang W, Li L, et al. Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α Inhibits Vascular Calcification Through Sirtuin 3-Mediated Reduction of Mitochondrial Oxidative Stress. Antioxid Redox Signal. 2019;31:75-91 pubmed publisher
Jiang R, Zhou Z, Liao Y, Yang F, Cheng Y, Huang J, et al. The emerging roles of a novel CCCH-type zinc finger protein, ZC3H4, in silica-induced epithelial to mesenchymal transition. Toxicol Lett. 2019;307:26-40 pubmed publisher
Zhao X, Wei S, Li Z, Lin C, Zhu Z, Sun D, et al. Autophagic flux blockage in alveolar epithelial cells is essential in silica nanoparticle-induced pulmonary fibrosis. Cell Death Dis. 2019;10:127 pubmed publisher
Fan Z, Li L, Li X, Zhang M, Dou M, Zhao J, et al. Anti-senescence role of heterozygous fumarate hydratase gene knockout in rat lung fibroblasts in vitro. Aging (Albany NY). 2019;11:573-589 pubmed publisher
Wang M, Li H, Zhao Y, Lv C, Zhou G. Rhynchophylline attenuates allergic bronchial asthma by inhibiting transforming growth factor-β1-mediated Smad and mitogen-activated protein kinase signaling transductions in vivo and in vitro. Exp Ther Med. 2019;17:251-259 pubmed publisher
Kluge M, Namkoong E, Khakipoor S, Park K, Roussa E. Differential regulation of vacuolar H+ -ATPase subunits by transforming growth factor-β1 in salivary ducts. J Cell Physiol. 2019;: pubmed publisher
Ruan W, Pan R, Shen X, Nie Y, Wu Y. CDH11 promotes liver fibrosis via activation of hepatic stellate cells. Biochem Biophys Res Commun. 2019;508:543-549 pubmed publisher
Hong J, Hu Z, Wu Q, Tang C, Hu J, Chen R, et al. The deregulation of STIM1 and store operative calcium entry impaired aortic smooth muscle cells contractility in aortic medial degeneration. Biosci Rep. 2019;39: pubmed publisher
Jiang Z, Yang H, Zhang X, Wang Z, Rong R, Wang X. Histone deacetylase-1 as a prognostic factor and mediator of gastric cancer progression by enhancing glycolysis. Hum Pathol. 2019;85:194-201 pubmed publisher
He C, Wang M, Yan Z, Zhang S, Liu H. Isolation and culture of vascular smooth muscle cells from rat placenta. J Cell Physiol. 2019;234:7675-7682 pubmed publisher
Sun A, Lai Z, Zhao M, Mu L, Hu X. Native nanodiscs from blood inhibit pulmonary fibrosis. Biomaterials. 2019;192:51-61 pubmed publisher
Gu L, Wang Y, Yang G, Tilyek A, Zhang C, Li S, et al. Ribes diacanthum Pall (RDP) ameliorates UUO-induced renal fibrosis via both canonical and non-canonical TGF-β signaling pathways in mice. J Ethnopharmacol. 2019;231:302-310 pubmed publisher
Pan J, Zhu S, Huang J, Liang J, Zhang D, Zhao X, et al. Monitoring the Process of Endostar-Induced Tumor Vascular Normalization by Non-contrast Intravoxel Incoherent Motion Diffusion-Weighted MRI. Front Oncol. 2018;8:524 pubmed publisher
Zhu J, Wang R, Xu T, Zhang S, Zhao Y, Li Z, et al. Salvianolic Acid A Attenuates Endoplasmic Reticulum Stress and Protects Against Cholestasis-Induced Liver Fibrosis via the SIRT1/HSF1 Pathway. Front Pharmacol. 2018;9:1277 pubmed publisher
Song S, Qiu D, Luo F, Wei J, Wu M, Wu H, et al. Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells. J Mol Endocrinol. 2018;61:101-113 pubmed publisher
Zhao Z, Shen W, Zhu H, Lin L, Jiang G, Zhu Y, et al. Zoledronate inhibits fibroblasts' proliferation and activation via targeting TGF-β signaling pathway. Drug Des Devel Ther. 2018;12:3021-3031 pubmed publisher
Zhu P, Wu J, Wang Y, Zhu X, Lu T, Liu B, et al. LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis. Nat Cell Biol. 2018;20:1134-1144 pubmed publisher
Pan F, Li W, Yang W, Yang X, Liu S, Li X, et al. Anterior gradient 2 as a supervisory marker for tumor vessel normalization induced by anti-angiogenic treatment. Oncol Lett. 2018;16:3083-3091 pubmed publisher
Zhang C, Liu X, Sun H, Meng X, Bao Y, Zhang H, et al. Octreotide attenuates hepatic fibrosis and hepatic stellate cells proliferation and activation by inhibiting Wnt/β-catenin signaling pathway, c-Myc and cyclin D1. Int Immunopharmacol. 2018;63:183-190 pubmed publisher
Ning C, Gao X, Wang C, Kong Y, Liu Z, Sun H, et al. Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro. Regul Toxicol Pharmacol. 2018;98:58-68 pubmed publisher
Liu Z, Zhang Z, Huang M, Sun X, Liu B, Guo Q, et al. Taurocholic acid is an active promoting factor, not just a biomarker of progression of liver cirrhosis: evidence from a human metabolomic study and in vitro experiments. BMC Gastroenterol. 2018;18:112 pubmed publisher
Li H, Li Q, Zhang X, Zheng X, Zhang Q, Hao Z. Thymosin β4 suppresses CCl4 -induced murine hepatic fibrosis by down-regulating transforming growth factor β receptor-II. J Gene Med. 2018;20:e3043 pubmed publisher
Feng J, Chen K, Xia Y, Wu L, Li J, Li S, et al. Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways. Drug Des Devel Ther. 2018;12:1837-1853 pubmed publisher
Liu L, Li Y, Wang Z, Ding F, Cheng Z, Xu Q, et al. Rab7 empowers renal tubular epithelial cells with autophagy-mediated protection against albumin-induced injury. Exp Cell Res. 2018;370:198-207 pubmed publisher
Liu Z, Zhu P, Zhang L, Xiong B, Tao J, Guan W, et al. Autophagy inhibition attenuates the induction of anti-inflammatory effect of catalpol in liver fibrosis. Biomed Pharmacother. 2018;103:1262-1271 pubmed publisher
Zhang W, Sha Y, Wei K, Wu C, Ding D, Yang Y, et al. Rotenone ameliorates chronic renal injury caused by acute ischemia/reperfusion. Oncotarget. 2018;9:24199-24208 pubmed publisher
Zhuo C, Wu X, Li J, Hu D, Jian J, Chen C, et al. Chemokine (C-X-C motif) ligand 1 is associated with tumor progression and poor prognosis in patients with colorectal cancer. Biosci Rep. 2018;38: pubmed publisher
Li X, Li C, Tang Y, Huang Y, Cheng Q, Huang X, et al. NMDA receptor activation inhibits the antifibrotic effect of BM-MSCs on bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2018;315:L404-L421 pubmed publisher
Gao X, Wang C, Ning C, Liu K, Wang X, Liu Z, et al. Hepatoprotection of auraptene from peels of citrus fruits against thioacetamide-induced hepatic fibrosis in mice by activating farnesoid X receptor. Food Funct. 2018;9:2684-2694 pubmed publisher
He F, You R, Ye C, Lei C, Tang H, Su H, et al. Inhibition of SIRT2 Alleviates Fibroblast Activation and Renal Tubulointerstitial Fibrosis via MDM2. Cell Physiol Biochem. 2018;46:451-460 pubmed publisher
Xu J, Wang J, Cheng Y, Li X, He M, Zhu J, et al. Glucagon-Like Peptide-1 Mediates the Protective Effect of the Dipeptidyl Peptidase IV Inhibitor on Renal Fibrosis via Reducing the Phenotypic Conversion of Renal Microvascular Cells in Monocrotaline-Treated Rats. Biomed Res Int. 2018;2018:1864107 pubmed publisher
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product information
CatalogNo :
14395-1-AP
AntigenName :
smooth muscle actin
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
actin, alpha 2, smooth muscle, aorta
Immunogen :
Recombinant Protein
Species :
human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, FC, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
a SMA, AAT6, ACTA2, ACTA2 Smooth muscle Actin, Actin, aortic smooth muscle, Actin, aortic smooth muscle Actin, ACTSA, ACTVS, Alpha actin 2, Alpha SMA, a-SMA, α SMA
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC017554
Category :
Binding Proteins;Cell Cycle;Cytoskeleton/Scaffold Proteins;IVD;Transport/Trafficking;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
AppTiter :
FC 1:0 ; IF 1:50 ; IHC 1:3000 ; IP 1:1000 ; WB 1:6000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.