| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunoprecipitation; human; loading ...; fig 7a
- immunocytochemistry; rat; loading ...; fig 6e
- western blot; rat; loading ...; fig 5e
- immunohistochemistry; mouse; loading ...; fig 6a
| Chen Z, Sun X, Chen Q, Lan T, Huang K, Xiao H, et al. Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked Nox4 polyubiquitination and degradation via the inhibition of Smurf1 expression. Br J Pharmacol. 2019;: pubmed publisher |
- western blot; human; loading ...; fig 3i
| Zhang H, Wang J, Wang Y, Gao C, Gu Y, Huang J, et al. Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats. Oxid Med Cell Longev. 2019;2019:2853534 pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig 4b
| Zhou J, Ge L, Jia C, Zheng X, Cui H, Zong R, et al. ROS-mediated Different Homeostasis of Murine Corneal Epithelial Progenitor Cell Line under Oxidative Stress. Sci Rep. 2016;6:36481 pubmed publisher |
| Chen Z, Sun X, Li X, Xu Z, Yang Y, Lin Z, et al. Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway. Acta Pharmacol Sin. 2020;: pubmed publisher |
| Chen N, Mu L, Yang Z, Du C, Wu M, Song S, et al. Carbohydrate response element-binding protein regulates lipid metabolism via mTOR complex1 in diabetic nephropathy. J Cell Physiol. 2020;: pubmed publisher |
| Dong X, Wu D, Zhang Y, Jia L, Pan X, Sun J, et al. Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway. Antioxidants (Basel). 2020;9: pubmed publisher |
| Zhou B, Qiu Y, Wu N, Chen A, Zhou H, Chen Q, et al. FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway. Oxid Med Cell Longev. 2020;2020:6384803 pubmed publisher |
| Tan X, Li T, Zhu S, Zhong W, Li F, Wang Y. Induction of SPARC on Oxidative Stress, Inflammatory Phenotype Transformation, and Apoptosis of Human Brain Smooth Muscle Cells Via TGF-β1-NOX4 Pathway. J Mol Neurosci. 2020;: pubmed publisher |
| Zhu Y, Zhu C, Yang H, Deng J, Fan D. Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice. Pharmacol Res. 2020;155:104746 pubmed publisher |
| Cao L, Li X, XU R, Yao K, Yang W, Zhu H, et al. DUOX2, a common modulator in preventive effects of monoamine-based antidepressants on water immersion restraint stress- and indomethacin- induced gastric mucosal damage. Eur J Pharmacol. 2020;876:173058 pubmed publisher |
| Li C, Sun X, Li A, Mo M, Zhao Z. S-Allylmercaptocysteine attenuates Bleomycin-induced pulmonary fibrosis in mice via suppressing TGF-β1/Smad and oxidative stress pathways. Int Immunopharmacol. 2020;79:106110 pubmed publisher |
| Zhang Q, Zhao S, Zheng W, Fu H, Wu T, Hu F. Plumbagin attenuated oxygen-glucose deprivation/reoxygenation-induced injury in human SH-SY5Y cells by inhibiting NOX4-derived ROS-activated NLRP3 inflammasome. Biosci Biotechnol Biochem. 2020;84:134-142 pubmed publisher |
| Zhang Q, Wang Z, Miao L, Wang Y, Chang L, Guo W, et al. Neuroprotective Effect of SCM-198 through Stabilizing Endothelial Cell Function. Oxid Med Cell Longev. 2019;2019:7850154 pubmed publisher |
| Zhang Z, He J, Zhao Y, Chen H, Tan N. Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ. Acta Pharmacol Sin. 2019;: pubmed publisher |
| Guo Y, You Y, Lv D, Yan J, Shang F, Wang X, et al. Inducible nitric oxide synthase contributes to insulin resistance and cardiac dysfunction after burn injury in mice. Life Sci. 2019;239:116912 pubmed publisher |
| Muthuramalingam K, Cho M, Kim Y. Cellular senescence and EMT crosstalk in bleomycin-induced pathogenesis of pulmonary fibrosis-an in vitro analysis. Cell Biol Int. 2019;: pubmed publisher |
| Zhang J, Cai W, Fan Z, Yang C, Wang W, Xiong M, et al. MicroRNA-24 inhibits the oxidative stress induced by vascular injury by activating the Nrf2/Ho-1 signaling pathway. Atherosclerosis. 2019;290:9-18 pubmed publisher |
| Balta E, Hardt R, Liang J, Kirchgessner H, Orlik C, Jahraus B, et al. Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells. Nat Commun. 2019;10:4073 pubmed publisher |
| Yang Q, Wang C, Jin Y, Ma X, Xie T, Wang J, et al. Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis. Pharmacol Res. 2019;148:104414 pubmed publisher |
| Cui C, Xu P, Li G, Qiao Y, Han W, Geng C, et al. Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: Role of renin-angiotensin system. Redox Biol. 2019;26:101295 pubmed publisher |
| Xue M, Li T, Wang Y, Chang Y, Cheng Y, Lu Y, et al. Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice. Clin Sci (Lond). 2019;133:1705-1720 pubmed publisher |
| Lin J, Fang L, Li H, Li Z, Lyu L, Wang H, et al. Astragaloside IV alleviates doxorubicin induced cardiomyopathy by inhibiting NADPH oxidase derived oxidative stress. Eur J Pharmacol. 2019;:172490 pubmed publisher |
| Gao W, Wang W, Zhang J, Deng P, Hu J, Yang J, et al. Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice. Metab Brain Dis. 2019;: pubmed publisher |
| Yamaleyeva L, Brosnihan K, Elsangeedy E, McGee C, Shi S, Caudell D, et al. Systemic Outcomes of (Pyr1)-Apelin-13 Infusion at Mid-Late Pregnancy in a Rat Model with Preeclamptic Features. Sci Rep. 2019;9:8579 pubmed publisher |
| Zhang C, Han F, Shi M, Sun H, Li Y, Ci Y, et al. MARVELD1 interacting with catalase regulates reactive oxygen species metabolism and mediates the sensitivity to chemotherapeutic drugs in epithelial tumors of the reproductive system. Mol Carcinog. 2019;: pubmed publisher |
| Zhang J, An H, Ni K, Chen B, Li H, Li Y, et al. Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure. Cell Death Dis. 2019;10:321 pubmed publisher |
| Zhang X, Tan H, Shi Z, Li N, Jia Y, Hao Z. Growth differentiation factor 11 is involved in isoproterenol‑induced heart failure. Mol Med Rep. 2019;19:4109-4118 pubmed publisher |
| Chen D, Zang Y, Qiu Y, Zhang F, Chen A, Wang J, et al. BCL6 Attenuates Proliferation and Oxidative Stress of Vascular Smooth Muscle Cells in Hypertension. Oxid Med Cell Longev. 2019;2019:5018410 pubmed publisher |
| Han W, Wang C, Yang Z, Mu L, Wu M, Chen N, et al. SRT1720 retards renal fibrosis via inhibition of HIF1α /GLUT1 in diabetic nephropathy. J Endocrinol. 2019;: pubmed publisher |
| Song S, Qiu D, Shi Y, Wang S, Zhou X, Chen N, et al. Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy. J Cell Physiol. 2019;: pubmed publisher |
| Zhang M, Chang Z, Zhao F, Zhang P, Hao Y, Yan L, et al. Protective Effects of 18β-Glycyrrhetinic Acid on Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats. Front Pharmacol. 2019;10:13 pubmed publisher |
| Liu B, Rong Y, Sun D, Li W, Chen H, Cao B, et al. Costunolide inhibits pulmonary fibrosis via regulating NF-kB and TGF-β1/Smad2/Nrf2-NOX4 signaling pathways. Biochem Biophys Res Commun. 2019;: pubmed publisher |
| Liu P, Zhang H, Hu K, Zhou X, Tang S. Sensory plasticity of carotid body is correlated with oxidative stress in paraventricular nucleus during chronic intermittent hypoxia. J Cell Physiol. 2019;234:13534-13543 pubmed publisher |
| Song Q, Zhang Y, Han X, Zhang Y, Zhang X, Gao Y, et al. Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro. Biomed Pharmacother. 2019;109:945-956 pubmed publisher |
| Gao W, Wang W, Liu G, Zhang J, Yang J, Deng Z. Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome. Metab Brain Dis. 2019;34:319-329 pubmed publisher |
| Hu H, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, et al. Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells. Inflammation. 2019;42:64-80 pubmed publisher |
| Choi S, Kim Y, Park Y, Yang H, Jeong P, Cha J, et al. Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis. Cell Death Differ. 2018;: pubmed publisher |
| Jiang H, Gao X, Gong J, Yang Q, Lan R, Wang T, et al. Downregulated Expression of Solute Carrier Family 26 Member 6 in NRK-52E Cells Attenuates Oxalate-Induced Intracellular Oxidative Stress. Oxid Med Cell Longev. 2018;2018:1724648 pubmed publisher |
| Fan L, Xiao Q, Zhang L, Wang X, Huang Q, Li S, et al. CAPE-pNO2 attenuates diabetic cardiomyopathy through the NOX4/NF-κB pathway in STZ-induced diabetic mice. Biomed Pharmacother. 2018;108:1640-1650 pubmed publisher |
| Li Z, Zhang X, Liu S, Zeng S, Yu L, Yang G, et al. BRG1 regulates NOX gene transcription in endothelial cells and contributes to cardiac ischemia-reperfusion injury. Biochim Biophys Acta Mol Basis Dis. 2018;1864:3477-3486 pubmed publisher |
| Takashina Y, Manabe A, Hasegawa H, Matsunaga T, Endo S, Ikari A. Sodium Citrate Increases Expression and Flux of Mg2+ Transport Carriers Mediated by Activation of MEK/ERK/c-Fos Pathway in Renal Tubular Epithelial Cells. Nutrients. 2018;10: pubmed publisher |
| Rong Y, Cao B, Liu B, Li W, Chen Y, Chen H, et al. A novel Gallic acid derivative attenuates BLM-induced pulmonary fibrosis in mice. Int Immunopharmacol. 2018;64:183-191 pubmed publisher |
| Zhang Y, Li Q, Fang M, Ma Y, Liu N, Yan X, et al. The Kidney Injury Induced by Short-Term PM2.5 Exposure and the Prophylactic Treatment of Essential Oils in BALB/c Mice. Oxid Med Cell Longev. 2018;2018:9098627 pubmed publisher |
| Yu L, Yang G, Zhang X, Wang P, Weng X, Yang Y, et al. Megakaryocytic Leukemia 1 Bridges Epigenetic Activation of NADPH Oxidase in Macrophages to Cardiac Ischemia-Reperfusion Injury. Circulation. 2018;138:2820-2836 pubmed publisher |
| Shen D, Tian L, Shen T, Sun H, Liu P. Alpha-Lipoic Acid Protects Human Aortic Endothelial Cells Against H2O2-Induced Injury and Inhibits Atherosclerosis in Ovariectomized Low Density Lipoprotein Receptor Knock-Out Mice. Cell Physiol Biochem. 2018;47:2261-2277 pubmed publisher |
| Liu L, Hong W, Li M, Ren H, Wang J, Xu H, et al. A Cross Talk Between BRG1 and Males Absent on the First Contributes to Reactive Oxygen Species Production in a Mouse Model of Nonalcoholic Steatohepatitis. Antioxid Redox Signal. 2018;: pubmed publisher |
| Liu L, Wu X, Xu H, Yu L, Zhang X, Li L, et al. Myocardin-related transcription factor A (MRTF-A) contributes to acute kidney injury by regulating macrophage ROS production. Biochim Biophys Acta Mol Basis Dis. 2018;1864:3109-3121 pubmed publisher |
| Long W, Zhang G, Dong Y, Li D. Dark tea extract mitigates hematopoietic radiation injury with antioxidative activity. J Radiat Res. 2018;59:387-394 pubmed publisher |
| Yan J, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, et al. Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway. Pharmacol Res. 2018;130:466-480 pubmed publisher |
| Almajdoob S, Hossain E, Anand Srivastava M. Resveratrol attenuates hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats: Role of ROS and ROS-mediated cell signaling. Vascul Pharmacol. 2018;101:48-56 pubmed publisher |
| Ren T, Wang J, Zhang H, Yuan P, Zhu J, Wu Y, et al. MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation. Antioxid Redox Signal. 2018;28:1120-1136 pubmed publisher |
| Ma Z, Li Y, Li W, Yan X, Yang G, Zhang J, et al. Nephroprotective Effects of Saponins from Leaves of Panax quinquefolius against Cisplatin-Induced Acute Kidney Injury. Int J Mol Sci. 2017;18: pubmed publisher |
| Zhang Q, Wang Z, Sun D, Wang Y, Xu P, Wu W, et al. Novel Therapeutic Effects of Leonurine On Ischemic Stroke: New Mechanisms of BBB Integrity. Oxid Med Cell Longev. 2017;2017:7150376 pubmed publisher |
| Lajko M, Cardona H, Taylor J, Farrow K, Fawzi A. Photoreceptor oxidative stress in hyperoxia-induced proliferative retinopathy accelerates rd8 degeneration. PLoS ONE. 2017;12:e0180384 pubmed publisher |
| Tsubouchi K, Araya J, Minagawa S, Hara H, Ichikawa A, Saito N, et al. Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4. Autophagy. 2017;13:1420-1434 pubmed publisher |
| Lu S, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, et al. The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways. Sci Rep. 2017;7:3331 pubmed publisher |
| Yao M, Gao F, Wang X, Shi Y, Liu S, Duan H. Nox4 is involved in high glucose-induced apoptosis in renal tubular epithelial cells via Notch pathway. Mol Med Rep. 2017;15:4319-4325 pubmed publisher |
| Zhang D, Liu B, Cao B, Wei F, Yu X, Li G, et al. Synergistic protection of Schizandrin B and Glycyrrhizic acid against bleomycin-induced pulmonary fibrosis by inhibiting TGF-β1/Smad2 pathways and overexpression of NOX4. Int Immunopharmacol. 2017;48:67-75 pubmed publisher |
| Zhang J, An S, Fu J, Liu P, Shao T, Li M, et al. Mixed Aqueous Extract of Salvia Miltiorrhiza Reduces Blood Pressure through Inhibition of Vascular Remodelling and Oxidative Stress in Spontaneously Hypertensive Rats. Cell Physiol Biochem. 2016;40:347-360 pubmed |
| Xiao L, Dong J, Jin S, Xue H, Guo Q, Teng X, et al. Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating BMP4/COX-2 Pathway in Rats with Hypertension. Oxid Med Cell Longev. 2016;2016:8128957 pubmed publisher |
| Chu P, Han G, Ahsan A, Sun Z, Liu S, Zhang Z, et al. Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-?B pathway. Vascul Pharmacol. 2017;91:26-35 pubmed publisher |
| Liu B, Cao B, Zhang D, Xiao N, Chen H, Li G, et al. Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2/Nox4 redox balance and TGF-?1/Smad3 signaling. Toxicol Appl Pharmacol. 2016;309:111-20 pubmed publisher |
| Li D, Tian Z, Tang W, Zhang J, Lu L, Sun Z, et al. The Protective Effects of 5-Methoxytryptamine-?-lipoic Acid on Ionizing Radiation-Induced Hematopoietic Injury. Int J Mol Sci. 2016;17: pubmed publisher |
| Xu G, Wu H, Zhang J, Li D, Wang Y, Wang Y, et al. Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice. Free Radic Biol Med. 2015;87:15-25 pubmed publisher |
| Wang J, Shao M, Liu M, Peng P, Li L, Wu W, et al. PKCα promotes generation of reactive oxygen species via DUOX2 in hepatocellular carcinoma. Biochem Biophys Res Commun. 2015;463:839-45 pubmed publisher |
| Li Y, Wang W, Xu X, Sun S, Xu X, Qu X. {2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3. Biomed Res Int. 2015;2015:491205 pubmed publisher |
| Kim H, Magesh V, Lee J, Kim S, Knaus U, Lee K. Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4. Oncotarget. 2015;6:16287-303 pubmed |
| Xue H, Zhou S, Xiao L, Guo Q, Liu S, Wu Y. Hydrogen sulfide improves the endothelial dysfunction in renovascular hypertensive rats. Physiol Res. 2015;64:663-72 pubmed |
| Fu C, Xu D, Wang C, Jin Y, Liu Q, Meng Q, et al. Alpha-Lipoic Acid Promotes Osteoblastic Formation in H2O2 -Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats. J Cell Physiol. 2015;230:2184-201 pubmed publisher |
| Jin Y, Liu K, Peng J, Wang C, Kang L, Chang N, et al. Rhizoma Dioscoreae Nipponicae polysaccharides protect HUVECs from H2O2-induced injury by regulating PPARγ factor and the NADPH oxidase/ROS-NF-κB signal pathway. Toxicol Lett. 2015;232:149-58 pubmed publisher |
