This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
SREBF1
catalog :
14088-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, bovine
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 50
Published Application/Species/Sample/DilutionReference
  • western blot; bovine; 1:500; fig 5a
Chen D, Yuan X, Liu L, Zhang M, Qu B, Zhen Z, et al. Mitochondrial ATAD3A regulates milk biosynthesis and proliferation of mammary epithelial cells from dairy cow via the mTOR pathway. Cell Biol Int. 2018;42:533-542 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1
Bai J, Wang P, Liu Y, Zhang Y, Li Y, He Z, et al. Formaldehyde alters triglyceride synthesis and very low-density lipoprotein secretion in a time-dependent manner. Environ Toxicol Pharmacol. 2017;56:15-20 pubmed publisher
Chen W, Zhang X, Xu M, Jiang L, Zhou M, Liu W, et al. Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE-/- mice. Eur J Nutr. 2020;: pubmed publisher
He Q, Wang L, Zhao R, Yan F, Sha S, Cui C, et al. Mesenchymal stem cell-derived exosomes exert ameliorative effects in type 2 diabetes by improving hepatic glucose and lipid metabolism via enhancing autophagy. Stem Cell Res Ther. 2020;11:223 pubmed publisher
Guo S, Ma B, Jiang X, Li X, Jia Y. Astragalus Polysaccharides Inhibits Tumorigenesis and Lipid Metabolism Through miR-138-5p/SIRT1/SREBP1 Pathway in Prostate Cancer. Front Pharmacol. 2020;11:598 pubmed publisher
Wang H, Cao Y, Shu L, Zhu Y, Peng Q, Ran L, et al. Long non-coding RNA (lncRNA) H19 induces hepatic steatosis through activating MLXIPL and mTORC1 networks in hepatocytes. J Cell Mol Med. 2020;24:1399-1412 pubmed publisher
Liu Y, Wang X, Zhen Z, Yu Y, Qiu Y, Xiang W. GRP78 regulates milk biosynthesis and the proliferation of bovinemammaryepithelial cells through the mTOR signaling pathway. Cell Mol Biol Lett. 2019;24:57 pubmed publisher
Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, et al. Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1. EMBO Rep. 2019;:e48115 pubmed publisher
Liu M, Huang Y, Zhang T, Tan L, Lu X, Qin J. Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota. World J Gastroenterol. 2019;25:3590-3606 pubmed publisher
Liu G, Kuang S, Cao R, Wang J, Peng Q, Sun C. Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway. FASEB J. 2019;33:10089-10103 pubmed publisher
Li X, Li P, Wang L, Zhang M, Gao X. Lysine Enhances the Stimulation of Fatty Acids on Milk Fat Synthesis via the GPRC6A-PI3K-FABP5 Signaling in Bovine Mammary Epithelial Cells. J Agric Food Chem. 2019;67:7005-7015 pubmed publisher
Chao H, Deng L, Xu F, Yu Z, Xu X, Huang J, et al. MEX3C regulates lipid metabolism to promote bladder tumorigenesis through JNK pathway. Onco Targets Ther. 2019;12:3285-3294 pubmed publisher
Xu J, Zhang L, Shu G, Wang B. microRNA-16-5p promotes 3T3-L1 adipocyte differentiation through regulating EPT1. Biochem Biophys Res Commun. 2019;: pubmed publisher
He W, Xu Y, Ren X, Xiang D, Lei K, Zhang C, et al. Vitamin E Ameliorates Lipid Metabolism in Mice with Nonalcoholic Fatty Liver Disease via Nrf2/CES1 Signaling Pathway. Dig Dis Sci. 2019;: pubmed publisher
Wu L, Wang Y, Chi G, Shen B, Tian Y, Li Z, et al. Morin reduces inflammatory responses and alleviates lipid accumulation in hepatocytes. J Cell Physiol. 2019;: pubmed publisher
Wang Y, Guo D, He J, Song L, Chen H, Zhang Z, et al. Inhibition of fatty acid synthesis arrests colorectal neoplasm growth and metastasis: Anti-cancer therapeutical effects of natural cyclopeptide RA-XII. Biochem Biophys Res Commun. 2019;512:819-824 pubmed publisher
Yuan X, Zhen Z, Zhang M, Yu Y, Gao X, Ao J. Cyclase-associated protein 1 is a key negative regulator of milk synthesis and proliferation of bovine mammary epithelial cells. Cell Biochem Funct. 2019;37:185-192 pubmed publisher
Yu Y, Zhen Z, Qi H, Yuan X, Gao X, Zhang M. U2AF65 enhances milk synthesis and growth of bovine mammary epithelial cells by positively regulating the mTOR-SREBP-1c signalling pathway. Cell Biochem Funct. 2019;37:93-101 pubmed publisher
Yuan X, Zhang M, Ao J, Zhen Z, Gao X, Li M. NUCKS1 is a novel regulator of milk synthesis in and proliferation of mammary epithelial cells via the mTOR signaling pathway. J Cell Physiol. 2019;: pubmed publisher
Ren L, Sun D, Zhou X, Yang Y, Huang X, Li Y, et al. Chronic treatment with the modified Longdan Xiegan Tang attenuates olanzapine-induced fatty liver in rats by regulating hepatic de novo lipogenesis and fatty acid beta-oxidation-associated gene expression mediated by SREBP-1c, PPAR-alpha and AMPK-alp. J Ethnopharmacol. 2019;232:176-187 pubmed publisher
Zhang N, Zhang H, Liu Y, Su P, Zhang J, Wang X, et al. SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2. Cell Death Differ. 2019;26:843-859 pubmed publisher
Wang D, Lao L, Pang X, Qiao Q, Pang L, Feng Z, et al. Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism. Int Immunopharmacol. 2018;65:256-267 pubmed publisher
Cheng Y, Zhao W, Zhang X, Sun L, Yang H, Wang Y, et al. Downregulation of microRNA-1 attenuates glucose-induced apoptosis by regulating the liver X receptor α in cardiomyocytes. Exp Ther Med. 2018;16:1814-1824 pubmed publisher
Qin D, Yang Y, Pu Z, Liu D, Yu C, Gao P, et al. NR4A1 retards adipocyte differentiation or maturation via enhancing GATA2 and p53 expression. J Cell Mol Med. 2018;22:4709-4720 pubmed publisher
Qiao X, Li Y, Mai J, Ji X, Li Q. Effect of Dibutyltin Dilaurate on Triglyceride Metabolism through the Inhibition of the mTOR Pathway in Human HL7702 Liver Cells. Molecules. 2018;23: pubmed publisher
Fong L, Yang M, Dos Santos Chaves R, Reyna S, Langness V, Woodruff G, et al. Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes. J Biol Chem. 2018;293:11341-11357 pubmed publisher
Zhang H, Zhang C, Tang H, Gao S, Sun F, Yang Y, et al. CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling. Hepatology. 2018;68:1710-1725 pubmed publisher
Yang Y, Jiang H, Xiao L, Yang X. MicroRNA-33b-5p is overexpressed and inhibits GLUT4 by targeting HMGA2 in polycystic ovarian syndrome: An in vivo and in vitro study. Oncol Rep. 2018;39:3073-3085 pubmed publisher
Tian Y, Feng H, Han L, Wu L, Lv H, Shen B, et al. Magnolol Alleviates Inflammatory Responses and Lipid Accumulation by AMP-Activated Protein Kinase-Dependent Peroxisome Proliferator-Activated Receptor α Activation. Front Immunol. 2018;9:147 pubmed publisher
Tian S, Li B, Lei P, Yang X, Zhang X, Bao Y, et al. Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways. Mol Nutr Food Res. 2018;62:e1700737 pubmed publisher
Zhang J, Zhang H, Deng X, Zhang N, Liu B, Xin S, et al. Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, inflammation and fibrosis in mice. Life Sci. 2018;192:46-54 pubmed publisher
Chen Q, Niu L, Hua C, Geng Y, Cai L, Tao S, et al. Chronic dexamethasone exposure markedly decreased the hepatic triglyceride accumulation in growing goats. Gen Comp Endocrinol. 2018;259:115-121 pubmed publisher
Chen S, Li X, Liu L, Liu C, Han X. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. FASEB J. 2018;32:1139-1153 pubmed publisher
Zhen Z, Zhang M, Yuan X, Qu B, Yu Y, Gao X, et al. DEAD-box helicase 6 (DDX6) is a new negative regulator for milk synthesis and proliferation of bovine mammary epithelial cells. In Vitro Cell Dev Biol Anim. 2018;54:52-60 pubmed publisher
Duan X, Meng Q, Wang C, Liu Z, Sun H, Huo X, et al. Effects of calycosin against high-fat diet-induced nonalcoholic fatty liver disease in mice. J Gastroenterol Hepatol. 2018;33:533-542 pubmed publisher
Zhang J, Zhao J, Zheng X, Cai K, Mao Q, Xia H. Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGK? gene knockout. Mol Med Rep. 2017;: pubmed publisher
Li L, Liu L, Qu B, Li X, Gao X, Zhang M. Twinfilin 1 enhances milk bio-synthesis and proliferation of bovine mammary epithelial cells via the mTOR signaling pathway. Biochem Biophys Res Commun. 2017;492:289-294 pubmed publisher
Zhang M, Chen D, Zhen Z, Ao J, Yuan X, Gao X. Annexin A2 positively regulates milk synthesis and proliferation of bovine mammary epithelial cells through the mTOR signaling pathway. J Cell Physiol. 2017;: pubmed publisher
Hu Y, Sun Q, Zong Y, Liu J, Idriss A, Omer N, et al. Prenatal betaine exposure alleviates corticosterone-induced inhibition of CYP27A1 expression in the liver of juvenile chickens associated with its promoter DNA methylation. Gen Comp Endocrinol. 2017;246:241-248 pubmed publisher
Luo D, Xiao H, Dong J, Li Y, Feng G, Cui M, et al. B7-H3 regulates lipid metabolism of lung cancer through SREBP1-mediated expression of FASN. Biochem Biophys Res Commun. 2017;482:1246-1251 pubmed publisher
Meng Q, Duan X, Wang C, Liu Z, Sun P, Huo X, et al. Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation. Acta Pharmacol Sin. 2017;38:69-79 pubmed publisher
Wang C, Duan X, Sun X, Liu Z, Sun P, Yang X, et al. Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholic steatohepatitis in mice. Food Funct. 2016;7:3716-23 pubmed publisher
Hu Y, Wu S, Zhao J, Ma X, Lu J, Xiu J, et al. VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet. J Lipid Res. 2016;57:1398-411 pubmed publisher
Jin M, Wu Y, Wang J, Chen J, Huang Y, Rao J, et al. MicroRNA-24 promotes 3T3-L1 adipocyte differentiation by directly targeting the MAPK7 signaling. Biochem Biophys Res Commun. 2016;474:76-82 pubmed publisher
Wang B, Fu J, Li L, Gong D, Wen X, Yu P, et al. Medium-chain fatty acid reduces lipid accumulation by regulating expression of lipid-sensing genes in human liver cells with steatosis. Int J Food Sci Nutr. 2016;67:288-97 pubmed publisher
Zhao Y, Li L, Ma J, Chen G, Bai J. LXRalpha gene downregulation by lentiviral-based RNA interference enhances liver function after fatty liver transplantation in rats. Hepatobiliary Pancreat Dis Int. 2015;14:386-93 pubmed
Chiu C, Chan I, Yang T, Liu S, Chiang M. Supplementation of chitosan alleviates high-fat diet-enhanced lipogenesis in rats via adenosine monophosphate (AMP)-activated protein kinase activation and inhibition of lipogenesis-associated genes. J Agric Food Chem. 2015;63:2979-88 pubmed publisher
Ji S, Qin Y, Shi S, Liu X, Hu H, Zhou H, et al. ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer. Cell Res. 2015;25:561-73 pubmed publisher
Cui M, Xiao Z, Wang Y, Zheng M, Song T, Cai X, et al. Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway. Cancer Res. 2015;75:846-57 pubmed publisher
Hu Y, Zhao J, Li S, Huang J, Qiu Y, Ma X, et al. RP5-833A20.1/miR-382-5p/NFIA-dependent signal transduction pathway contributes to the regulation of cholesterol homeostasis and inflammatory reaction. Arterioscler Thromb Vasc Biol. 2015;35:87-101 pubmed publisher
product information
CatalogNo :
14088-1-AP
AntigenName :
SREBF1
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
sterol regulatory element binding transcription factor 1
Immunogen :
Recombinant Protein
Species :
bovine, chicken, cow, goat, human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
bHLHd1, SREBF1, SREBP 1, SREBP1
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC063281
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Disease Related;Membrane Proteins;Metabolism;Neurology;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:50 ; IHC 1:50 ; IP 1:600 ; WB 1:1000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.