CDK6 | Proteintech Group 14052-1-AP product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Proteintech Group

product type :

antibody

product name :

CDK6

catalog :

14052-1-AP

quantity :

150UL

price :

299 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 53

Reference
Huang D, Zhu X, Wang Y, Yu H, Pu Y. Long non-coding RNA FAM133B-2 represses the radio-resistance of nasopharyngeal cancer cells by targeting miR-34a-5p/CDK6 axis. Aging (Albany NY). 2020;12:16936-16950 pubmed publisher
Yan X, Yang C, Hu W, Chen T, Wang Q, Pan F, et al. Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway. Oncol Rep. 2020;44:103-114 pubmed publisher
Zhang X, Luo Y, Li Q. TMED3 Promotes Proliferation and Migration in Breast Cancer Cells by Activating Wnt/β-Catenin Signaling. Onco Targets Ther. 2020;13:5819-5830 pubmed publisher
Lei X, Liu Y, Wang J, Cai Q, Yan M, He H, et al. SOX1 promotes differentiation of nasopharyngeal carcinoma cells by activating retinoid metabolic pathway. Cell Death Dis. 2020;11:331 pubmed publisher
Yuan Q, Fan Y, Liu Z, Wang X, Jia M, Geng Z, et al. miR-744-5p mediates lncRNA HOTTIP to regulate the proliferation and apoptosis of papillary thyroid carcinoma cells. Exp Cell Res. 2020;392:112024 pubmed publisher
Luo F, Zhao Y, Liu J. Cell adhesion molecule 4 suppresses cell growth and metastasis by inhibiting the Akt signaling pathway in non-small cell lung cancer. Int J Biochem Cell Biol. 2020;123:105750 pubmed publisher
Li H, Pan R, Lu Q, Ren C, Sun J, Wu H, et al. MicroRNA‑145‑5p inhibits osteosarcoma cell proliferation by targeting E2F transcription factor 3. Int J Mol Med. 2020;45:1317-1326 pubmed publisher
Zhao Q, Zhu H, Xie X, Mao Q, Liu Y, He X, et al. Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways. Int J Mol Sci. 2020;21: pubmed publisher
Xie H, Li J, Ying Y, Yan H, Jin K, Ma X, et al. METTL3/YTHDF2 m6 A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer. J Cell Mol Med. 2020;24:4092-4104 pubmed publisher
Mao Y, Li W, Hua B, Gu X, Pan W, Chen Q, et al. Silencing of ELK3 Induces S-M Phase Arrest and Apoptosis and Upregulates SERPINE1 Expression Reducing Migration in Prostate Cancer Cells. Biomed Res Int. 2020;2020:2406159 pubmed publisher
Feng Y, Chen X, Ding W, Ma J, Zhang B, Li X. MicroRNA-16 participates in the cell cycle alteration of HepG2 cells induced by MC-LR. Ecotoxicol Environ Saf. 2020;192:110295 pubmed publisher
Yang Y, Wei Q, Tang Y, Yuanyuan Wang -, Luo Q, Zhao H, et al. Loss of hnRNPA2B1 inhibits malignant capability and promotes apoptosis via down-regulating Lin28B expression in ovarian cancer. Cancer Lett. 2020;475:43-52 pubmed publisher
Ying Y, Li J, Xie H, Yan H, Jin K, He L, et al. CCND1, NOP14 and DNMT3B are involved in miR-502-5p-mediated inhibition of cell migration and proliferation in bladder cancer. Cell Prolif. 2020;53:e12751 pubmed publisher
Yan L, Ding B, Liu H, Zhang Y, Zeng J, Hu J, et al. Inhibition of SMYD2 suppresses tumor progression by down-regulating microRNA-125b and attenuates multi-drug resistance in renal cell carcinoma. Theranostics. 2019;9:8377-8391 pubmed publisher
Su D, Zhang D, Jin J, Ying L, Han M, Chen K, et al. Identification of predictors of drug sensitivity using patient-derived models of esophageal squamous cell carcinoma. Nat Commun. 2019;10:5076 pubmed publisher
Li S, Han J, Guo G, Sun Y, Zhang T, Zhao M, et al. Voltage-gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation. FEBS Lett. 2019;: pubmed publisher
Li T, Wang F, Dang Y, Dong J, Zhang Y, Zhang C, et al. P21 and P27 promote tumorigenesis and progression via cell cycle acceleration in seminal vesicles of TRAMP mice. Int J Biol Sci. 2019;15:2198-2210 pubmed publisher
Wei C, Zhang R, Cai Q, Gao X, Tong F, Dong J, et al. MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer. Aging (Albany NY). 2019;11:6734-6761 pubmed publisher
Wei Y, Liu P, Li Q, Du J, Chen Y, Wang Y, et al. The effect of MTHFD2 on the proliferation and migration of colorectal cancer cell lines. Onco Targets Ther. 2019;12:6361-6370 pubmed publisher
Li X, Fu Y, Xia X, Zhang X, Xiao K, Zhuang X, et al. Knockdown of SP1/Syncytin1 axis inhibits the proliferation and metastasis through the AKT and ERK1/2 signaling pathways in non-small cell lung cancer. Cancer Med. 2019;: pubmed publisher
Zhang W, Lu Y, Li X, Zhang J, Lin W, Zhang W, et al. IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation. J Exp Clin Cancer Res. 2019;38:296 pubmed publisher
Zheng M, Tian C, Fan T, Xu B. Fibronectin regulates the self-renewal of rabbit limbal epithelial stem cells by stimulating the Wnt11/Fzd7/ROCK non-canonical Wnt pathway. Exp Eye Res. 2019;185:107681 pubmed publisher
Lee Y, Lahens N, Zhang S, Bedont J, FIELD J, Sehgal A. G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment. PLoS Biol. 2019;17:e3000228 pubmed publisher
Qin F, Wang Y, Jiang X, Wang Y, Zhang N, Wen X, et al. Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma. J Enzyme Inhib Med Chem. 2019;34:909-926 pubmed publisher
Shen Z, Liao X, Shao Z, Feng M, Yuan J, Wang S, et al. Short-term stimulation with histone deacetylase inhibitor trichostatin a induces epithelial-mesenchymal transition in nasopharyngeal carcinoma cells without increasing cell invasion ability. BMC Cancer. 2019;19:262 pubmed publisher
Chen J, Yu Y, Li H, Hu Q, Chen X, He Y, et al. Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer. Mol Cancer. 2019;18:33 pubmed publisher
Jia Y, Zhao L, Bai H, Zhang C, Dai S, Lv H, et al. The tumor-suppressive function of miR-1296-5p by targeting EGFR and CDK6 in gastric cancer. Biosci Rep. 2019;39: pubmed publisher
Zhao F, Zhou L, Ge Y, Ping W, Wu X, Xu Z, et al. MicroRNA-133b suppresses bladder cancer malignancy by targeting TAGLN2-mediated cell cycle. J Cell Physiol. 2019;234:4910-4923 pubmed publisher
Li J, Ying Y, Xie H, Jin K, Yan H, Wang S, et al. Dual regulatory role of CCNA2 in modulating CDK6 and MET-mediated cell-cycle pathway and EMT progression is blocked by miR-381-3p in bladder cancer. FASEB J. 2019;33:1374-1388 pubmed publisher
Xie F, Li Y, Wang M, Huang C, Tao D, Zheng F, et al. Circular RNA BCRC-3 suppresses bladder cancer proliferation through miR-182-5p/p27 axis. Mol Cancer. 2018;17:144 pubmed publisher
Chen X, Liu C, Zhao R, Zhao P, Wu J, Zhou N, et al. Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells. Mol Pharm. 2018;15:4974-4984 pubmed publisher
Song H, Guo T, Zhao Z, Wei Y, Luo H, Weng W, et al. Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis. Biomaterials. 2018;178:23-35 pubmed publisher
Luo Y, Chen X, Luo L, Zhang Q, Gao C, Zhuang X, et al. [6]-Gingerol enhances the radiosensitivity of gastric cancer via G2/M phase arrest and apoptosis induction. Oncol Rep. 2018;39:2252-2260 pubmed publisher
Lin C, Zhang J, Lu Y, Li X, Zhang W, Zhang W, et al. NIT1 suppresses tumour proliferation by activating the TGFÎ²1-Smad2/3 signalling pathway in colorectal cancer. Cell Death Dis. 2018;9:263 pubmed publisher
Yun D, Wang Y, Meng D, Ji Y, Chen J, Chen H, et al. Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma. Oncol Rep. 2018;39:1011-1022 pubmed publisher
Xiao Y, Tian C, Huang T, Han B, Wang M, Ma H, et al. 8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo. Life Sci. 2018;192:259-269 pubmed publisher
Cui Y, Yang X, Zhang X. Shrimp miR-34 from Shrimp Stress Response to Virus Infection Suppresses Tumorigenesis of Breast Cancer. Mol Ther Nucleic Acids. 2017;9:387-398 pubmed publisher
Ruibin J, Bo J, Danying W, Chihong Z, Jianguo F, Linhui G. Therapy Effects of Wogonin on Ovarian Cancer Cells. Biomed Res Int. 2017;2017:9381513 pubmed publisher
Li Z, Xiong Q, Xu L, Duan P, Yang Q, Zhou P, et al. miR-29a regulated ER-positive breast cancer cell growth and invasion and is involved in the insulin signaling pathway. Oncotarget. 2017;8:32566-32575 pubmed publisher
Qin C, Ren L, Ji M, Lv S, Wei Y, Zhu D, et al. CDKL1 promotes tumor proliferation and invasion in colorectal cancer. Onco Targets Ther. 2017;10:1613-1624 pubmed publisher
Li P, Chen H, Chen S, Mo X, Li T, Xiao B, et al. Circular RNA 0000096 affects cell growth and migration in gastric cancer. Br J Cancer. 2017;116:626-633 pubmed publisher
Yang J, Qiao L, Zeng Z, Wang J, Zhu T, Wei J, et al. The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD. Toxicol Lett. 2017;265:131-139 pubmed publisher
Xu S, Wang H, Pan H, Shi Y, Li T, Ge S, et al. ANRIL lncRNA triggers efficient therapeutic efficacy by reprogramming the aberrant INK4-hub in melanoma. Cancer Lett. 2016;381:41-8 pubmed publisher
Xu S, Huang H, Li N, Zhang B, Jia Y, Yang Y, et al. MicroRNA-33 promotes the replicative senescence of mouse embryonic fibroblasts by suppressing CDK6. Biochem Biophys Res Commun. 2016;473:1064-1070 pubmed publisher
Fei Z, Gao Y, Qiu M, Qi X, Dai Y, Wang S, et al. Down-regulation of dihydrofolate reductase inhibits the growth of endothelial EA.hy926 cell through induction of G1 cell cycle arrest via up-regulating p53 and p21(waf1/cip1) expression. J Clin Biochem Nutr. 2016;58:105-13 pubmed publisher
Dong C, Zhao B, Long F, Liu Y, Liu Z, Li S, et al. Nogo-B receptor promotes the chemoresistance of human hepatocellular carcinoma via the ubiquitination of p53 protein. Oncotarget. 2016;7:8850-65 pubmed publisher
Yang Y, Chang S, Zhao Z, Hou N, He K, Wang X, et al. MicroRNA-214 suppresses the proliferation of human hepatocellular carcinoma cells by targeting E2F3. Oncol Lett. 2015;10:3779-3784 pubmed
Song X, Li L, Shi Q, Lehmler H, Fu J, Su C, et al. Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells. Chem Res Toxicol. 2015;28:2160-9 pubmed publisher
He K, Tong D, Zhang S, Cai D, Wang L, Yang Y, et al. miRNA-99b-3p functions as a potential tumor suppressor by targeting glycogen synthase kinase-3Î² in oral squamous cell carcinoma Tca-8113 cells. Int J Oncol. 2015;47:1528-36 pubmed publisher
Guo X, Deng K, Wang H, Xia J, Shan T, Liang Z, et al. GAS5 Inhibits Gastric Cancer Cell Proliferation Partly by Modulating CDK6. Oncol Res Treat. 2015;38:362-6 pubmed publisher
He Y, Tang D, Cai C, Chai R, Li H. LSD1 is Required for Hair Cell Regeneration in Zebrafish. Mol Neurobiol. 2016;53:2421-34 pubmed publisher
Bar J, Gorn Hondermann I, Moretto P, Perkins T, Niknejad N, Stewart D, et al. miR Profiling Identifies Cyclin-Dependent Kinase 6 Downregulation as a Potential Mechanism of Acquired Cisplatin Resistance in Non-Small-Cell Lung Carcinoma. Clin Lung Cancer. 2015;16:e121-9 pubmed publisher
Chen J, Liu G, Weng X, Liu F, Lin P, Li H, et al. Tougu Xiaotong formula induces chondrogenic differentiation in association with transforming growth factor-Î²1 and promotes proliferation in bone marrow stromal cells. Int J Mol Med. 2015;35:747-54 pubmed publisher

product information

CatalogNo :

14052-1-AP

AntigenName :

CDK6

Package :

150UL

Price :

299 USD

Exsists20ul :

20ul trial size available

FullName :

cyclin-dependent kinase 6

Immunogen :

Recombinant Protein

Species :

human, mouse, rat, zebrafish

Host :

Rabbit

IsConjugated :

Unconjugated

AntigenSpecies :

human

Application :

WB, IP, IHC, IF, ELISA

Clonlity :

Polyclonal

IsoType :

IgG

Synonyms :

CDK6, Cell division protein kinase 6, cyclin dependent kinase 6, PLSTIRE

PrimaryOrSecondary :

Primary

AntibodyBuffer :

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

GenBankNo :

BC027989

Category :

Binding Proteins;Cell Cycle;Cytoskeleton/Scaffold Proteins;Metabolism;

PurifyMethod :

Antigen affinity purification

NewAb :

False

IsSellable :

True

Feature :

siRNA

AppTiter :

IF 1:50 ; IHC 1:200 ; IP 1:1000 ; WB 1:1000 ;