This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
NPC1
catalog :
13926-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry
citations: 8
Reference
Miyamoto T, Hosoba K, Itabashi T, Iwane A, Akutsu S, Ochiai H, et al. Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome. EMBO J. 2020;39:e103499 pubmed publisher
Xiao J, Luo J, Hu A, Xiao T, Li M, Kong Z, et al. Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins. Sci China Life Sci. 2019;: pubmed publisher
Lyu J, Yang E, Head S, Ai N, Zhang B, Wu C, et al. Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking. Int J Biol Sci. 2018;14:1175-1185 pubmed publisher
Fu L, Qiu Y, Shen L, Cui C, Wang S, Wang S, et al. The delayed effects of antibiotics in type 2 diabetes, friend or foe?. J Endocrinol. 2018;238:137-149 pubmed publisher
Lyu J, Yang E, Head S, Ai N, Zhang B, Wu C, et al. Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth. Cancer Lett. 2017;409:91-103 pubmed publisher
Wei J, Zhang Y, Luo J, Wang J, Zhou Y, Miao H, et al. The GARP Complex Is Involved in Intracellular Cholesterol Transport via Targeting NPC2 to Lysosomes. Cell Rep. 2017;19:2823-2835 pubmed publisher
Hu Y, Wu S, Zhao J, Ma X, Lu J, Xiu J, et al. VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet. J Lipid Res. 2016;57:1398-411 pubmed publisher
Chu B, Liao Y, Qi W, Xie C, Du X, Wang J, et al. Cholesterol transport through lysosome-peroxisome membrane contacts. Cell. 2015;161:291-306 pubmed publisher
product information
CatalogNo :
13926-1-AP
AntigenName :
NPC1
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
Niemann-Pick disease, type C1
Immunogen :
Recombinant Protein
Species :
human, mouse
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
Niemann Pick C1 protein, Niemann Pick disease, type C1, NPC1
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC063302
Category :
Autophagy;Binding Proteins;Cytoskeleton/Scaffold Proteins;Membrane Proteins;Metabolism;Transport/Trafficking;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:50 ; IHC 1:200 ; WB 1:1000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.