This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
AEG-1/MTDH-Specific
catalog :
13860-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 19
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 1
Zou M, Zhu W, Wang L, Shi L, Gao R, Ou Y, et al. AEG-1/MTDH-activated autophagy enhances human malignant glioma susceptibility to TGF-β1-triggered epithelial-mesenchymal transition. Oncotarget. 2016;7:13122-38 pubmed publisher
Gao R, Que Q, Lin P, Pang Y, Wu H, Li X, et al. Clinical roles of miR-136-5p and its target metadherin in thyroid carcinoma. Am J Transl Res. 2019;11:6754-6774 pubmed
Qin Y, Wang J, Zhu G, Li G, Tan H, Chen C, et al. CCL18 promotes the metastasis of squamous cell carcinoma of the head and neck through MTDH-NF-κB signalling pathway. J Cell Mol Med. 2019;23:2689-2701 pubmed publisher
Yang X, Song S. Silencing of Astrocyte elevated gene-1 (AEG-1) inhibits proliferation, migration, and invasiveness, and promotes apoptosis in pancreatic cancer cells. Biochem Cell Biol. 2019;97:165-175 pubmed publisher
Yu C, Liu Y, Qin Z. Metadherin contributes to epithelial-mesenchymal transition and paclitaxel resistance induced by acidic extracellular pH in nasopharyngeal carcinoma. Oncol Lett. 2018;15:3858-3863 pubmed publisher
Zhang L, Yang G, Chen H, Huang Y, Xue W, Bo J. Depletion of astrocyte elevated gene-1 suppresses tumorigenesis through inhibition of Akt activity in bladder cancer cells. Am J Transl Res. 2017;9:5422-5431 pubmed
Miao S, Mao X, Zhao S, Song K, Xiang C, Lv Y, et al. miR-217 inhibits laryngeal cancer metastasis by repressing AEG-1 and PD-L1 expression. Oncotarget. 2017;8:62143-62153 pubmed publisher
Zhu G, Peng F, Gong W, She L, Wei M, Tan H, et al. Hypoxia promotes migration/invasion and glycolysis in head and neck squamous cell carcinoma via an HIF-1α-MTDH loop. Oncol Rep. 2017;38:2893-2900 pubmed publisher
Xue H, Yu Z, Liu Y, Yuan W, Yang T, You J, et al. Delivery of miR-375 and doxorubicin hydrochloride by lipid-coated hollow mesoporous silica nanoparticles to overcome multiple drug resistance in hepatocellular carcinoma. Int J Nanomedicine. 2017;12:5271-5287 pubmed publisher
Fan Y, Liao J, Lu Y, Tian D, Ye F, Zhao P, et al. MiR-375 and Doxorubicin Co-delivered by Liposomes for Combination Therapy of Hepatocellular Carcinoma. Mol Ther Nucleic Acids. 2017;7:181-189 pubmed publisher
Yan J, Chang Y, Zhang Y, Lin J, He X, Huang H. miR-195 inhibits cell proliferation via targeting AEG-1 in hepatocellular carcinoma. Oncol Lett. 2017;13:3118-3126 pubmed publisher
Wang J, Chen X, Tong M. Knockdown of astrocyte elevated gene-1 inhibited cell growth and induced apoptosis and suppressed invasion in ovarian cancer cells. Gene. 2017;616:8-15 pubmed publisher
Teng H, Wang P, Xue Y, Liu X, Ma J, Cai H, et al. Role of HCP5-miR-139-RUNX1 Feedback Loop in Regulating Malignant Behavior of Glioma Cells. Mol Ther. 2016;24:1806-1822 pubmed publisher
Zhang W, Zhu X, Wang Y, Mao X, Xu X, Wang Y. Upregulation of AEG-1 Involves in Schwann Cell Proliferation and Migration After Sciatic Nerve Crush. J Mol Neurosci. 2016;60:248-57 pubmed publisher
Zou M, Duan Y, Wang P, Gao R, Chen X, Ou Y, et al. DYT-40, a novel synthetic 2-styryl-5-nitroimidazole derivative, blocks malignant glioblastoma growth and invasion by inhibiting AEG-1 and NF-κB signaling pathways. Sci Rep. 2016;6:27331 pubmed publisher
Li P, Lu K, Geng L, Zhou X, Li X, Wang X. Bruton's tyrosine kinase inhibitor restrains Wnt signaling in chronic lymphocytic leukemia. Mol Med Rep. 2016;13:4934-8 pubmed publisher
Tong L, Wang C, Hu X, Pang B, Yang Z, He Z, et al. Correlated overexpression of metadherin and SND1 in glioma cells. Biol Chem. 2016;397:57-65 pubmed publisher
Yan J, Zhang Y, Liao J, Ke K, Chang Y, Li P, et al. MiR-497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG-1. Oncotarget. 2015;6:29527-42 pubmed publisher
Zhu G, Yu C, She L, Tan H, Li G, Ren S, et al. Metadherin regulation of vascular endothelial growth factor expression is dependent upon the PI3K/Akt pathway in squamous cell carcinoma of the head and neck. Medicine (Baltimore). 2015;94:e502 pubmed publisher
product information
CatalogNo :
13860-1-AP
AntigenName :
AEG-1/MTDH-Specific
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
metadherin
Immunogen :
Recombinant Protein
Species :
human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, CoIP, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
3D3, 3D3/LYRIC, AEG 1, AEG1, LYRIC, LYRIC/3D3, metadherin, Metastasis adhesion protein, MTDH, Protein LYRIC
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC045642
Category :
Autophagy;Binding Proteins;Cytoskeleton/Scaffold Proteins;Disease Related;Membrane Proteins;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:50 ; IHC 1:400 ; IP 1:1000 ; WB 1:1000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.