PFKFB3-Specific | Proteintech Group 13763-1-AP product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Proteintech Group

product type :

antibody

product name :

PFKFB3-Specific

catalog :

13763-1-AP

quantity :

150UL

price :

299 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 31

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 2g	Yu P, Wilhelm K, Dubrac A, Tung J, Alves T, Fang J, et al. FGF-dependent metabolic control of vascular development. Nature. 2017;545:224-228 pubmed publisher
western blot; human; 1:1000; loading ...; fig s1a	Li X, Song N, Liu L, Liu X, Ding X, Song X, et al. USP9X regulates centrosome duplication and promotes breast carcinogenesis. Nat Commun. 2017;8:14866 pubmed publisher
western blot; mouse; fig 2	Botchlett R, Li H, Guo X, Qi T, Zhao J, Zheng J, et al. Glucose and Palmitate Differentially Regulate PFKFB3/iPFK2 and Inflammatory Responses in Mouse Intestinal Epithelial Cells. Sci Rep. 2016;6:28963 pubmed publisher
	Chen L, Peng J, Wang Y, Jiang H, Wang W, Dai J, et al. Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway. Am J Transl Res. 2020;12:428-446 pubmed
	Prieto I, Alarcón C, Garcia Gomez R, Berdun R, Urgel T, Portero M, et al. Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential. Redox Biol. 2020;29:101396 pubmed publisher
	Wang J, Guan H, Liu H, Lei Z, Kang H, Guo Q, et al. Inhibition of PFKFB3 suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss. J Cell Mol Med. 2020;24:2294-2307 pubmed publisher
	Kong L, Wang Z, Liang X, Wang Y, Gao L, Ma C. Monocarboxylate transporter 1 promotes classical microglial activation and pro-inflammatory effect via 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3. J Neuroinflammation. 2019;16:240 pubmed publisher
	Yan S, Zhou N, Zhang D, Zhang K, Zheng W, Bao Y, et al. PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells. Int J Mol Sci. 2019;20: pubmed publisher
	Woods P, Kimmig L, Meliton A, Sun K, Tian Y, O Leary E, et al. Tissue Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation. Am J Respir Cell Mol Biol. 2019;: pubmed publisher
	Gao W, Sun J, Wang F, Lu Y, Wen C, Bian Q, et al. Deoxyelephantopin suppresses hepatic stellate cells activation associated with inhibition of aerobic glycolysis via hedgehog pathway. Biochem Biophys Res Commun. 2019;516:1222-1228 pubmed publisher
	Lypova N, Telang S, Chesney J, Imbert Fernandez Y. Increased 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 activity in response to EGFR signaling contributes to non-small cell lung cancer cell survival. J Biol Chem. 2019;294:10530-10543 pubmed publisher
	Long Q, Zou X, Song Y, Duan Z, Liu L. PFKFB3/HIF-1α feedback loop modulates sorafenib resistance in hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2019;513:642-650 pubmed publisher
	Yao H, Wu Z, Xu Y, Xu H, Lou G, Jiang Q, et al. Andrographolide attenuates imbalance of gastric vascular homeostasis induced by ethanol through glycolysis pathway. Sci Rep. 2019;9:4968 pubmed publisher
	Kovacs L, Cao Y, Han W, Meadows L, Kovacs Kasa A, Kondrikov D, et al. PFKFB3 in Smooth Muscle Promotes Vascular Remodeling in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2019;: pubmed publisher
	Tian W, Guo H, Li C, Cao W, Wang X, Mo D, et al. PFKFB3 promotes endotoxemia-induced myocardial dysfunction through inflammatory signaling and apoptotic induction. Toxicol Appl Pharmacol. 2019;368:26-36 pubmed publisher
	Zhang R, Li R, Liu Y, Li L, Tang Y. The Glycolytic Enzyme PFKFB3 Controls TNF-α-Induced Endothelial Proinflammatory Responses. Inflammation. 2019;42:146-155 pubmed publisher
	Gustafsson N, Färnegårdh K, Bonagas N, Ninou A, Groth P, Wiita E, et al. Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination. Nat Commun. 2018;9:3872 pubmed publisher
	Park Y, Woo S, Seo S, Kim H, Noh W, Lee J, et al. Ginkgetin induces cell death in breast cancer cells via downregulation of the estrogen receptor. Oncol Lett. 2017;14:5027-5033 pubmed publisher
	Liu Z, Yan S, Wang J, Xu Y, Wang Y, Zhang S, et al. Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis. Nat Commun. 2017;8:584 pubmed publisher
	Gibb A, Epstein P, Uchida S, Zheng Y, McNally L, Obal D, et al. Exercise-Induced Changes in Glucose Metabolism Promote Physiological Cardiac Growth. Circulation. 2017;136:2144-2157 pubmed publisher
	Yalcin A, Solakoglu T, Ozcan S, Guzel S, Peker S, Celikler S, et al. 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase-3 is required for transforming growth factor ?1-enhanced invasion of Panc1 cells in vitro. Biochem Biophys Res Commun. 2017;484:687-693 pubmed publisher
	Hamanaka R, Mutlu G. PFKFB3, a Direct Target of p63, Is Required for Proliferation and Inhibits Differentiation in Epidermal Keratinocytes. J Invest Dermatol. 2017;137:1267-1276 pubmed publisher
	Franklin D, He Y, Leslie P, Tikunov A, Fenger N, MacDonald J, et al. p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway. Sci Rep. 2016;6:38067 pubmed publisher
	O Neal J, Clem A, Reynolds L, Dougherty S, Imbert Fernandez Y, Telang S, et al. Inhibition of 6-phosphofructo-2-kinase (PFKFB3) suppresses glucose metabolism and the growth of HER2+ breast cancer. Breast Cancer Res Treat. 2016;160:29-40 pubmed
	Reid M, Lowman X, Pan M, Tran T, Warmoes M, Ishak Gabra M, et al. IKKÎ² promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. Genes Dev. 2016;30:1837-51 pubmed publisher
	Jiang H, Shi H, Sun M, Wang Y, Meng Q, Guo P, et al. PFKFB3-Driven Macrophage Glycolytic Metabolism Is a Crucial Component of Innate Antiviral Defense. J Immunol. 2016;197:2880-90 pubmed publisher
	Salabei J, Lorkiewicz P, Mehra P, Gibb A, Haberzettl P, Hong K, et al. Type 2 Diabetes Dysregulates Glucose Metabolism in Cardiac Progenitor Cells. J Biol Chem. 2016;291:13634-48 pubmed publisher
	Kalucka J, Missiaen R, Georgiadou M, Schoors S, Lange C, De Bock K, et al. Metabolic control of the cell cycle. Cell Cycle. 2015;14:3379-88 pubmed publisher
	Xie N, Tan Z, Banerjee S, Cui H, Ge J, Liu R, et al. Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis. Am J Respir Crit Care Med. 2015;192:1462-74 pubmed publisher
	Du J, Wang L, Wang Q, Yu L. miR-26b inhibits proliferation, migration, invasion and apoptosis induction via the downregulation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 driven glycolysis in osteosarcoma cells. Oncol Rep. 2015;33:1890-8 pubmed publisher
	Tan Z, Xie N, Banerjee S, Cui H, Fu M, Thannickal V, et al. The monocarboxylate transporter 4 is required for glycolytic reprogramming and inflammatory response in macrophages. J Biol Chem. 2015;290:46-55 pubmed publisher

product information

CatalogNo :

13763-1-AP

AntigenName :

PFKFB3-Specific

Package :

150UL

Price :

299 USD

Exsists20ul :

20ul trial size available

FullName :

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

Immunogen :

Recombinant Protein

Species :

human, mouse, rat

Host :

Rabbit

IsConjugated :

Unconjugated

AntigenSpecies :

human

Application :

WB, IP, IHC, IF, ELISA

Clonlity :

Polyclonal

IsoType :

IgG

Synonyms :

6PF 2 K/Fru 2,6 P2ase 3, IPFK2, PFK/FBPase 3, PFK2, PFKFB3

PrimaryOrSecondary :

Primary

AntibodyBuffer :

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

GenBankNo :

BC040482

Category :

Binding Proteins;Metabolism;

PurifyMethod :

Antigen affinity purification

NewAb :

False

IsSellable :

True

Feature :

siRNA

AppTiter :

IF 1:50 ; IHC 1:200 ; IP 1:1000 ; WB 1:2000 ;