This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
Caspase 8/p43/p18
catalog :
13423-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 114
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; loading ...; fig 3b
Li J, Chen K, Li S, Liu T, Wang F, Xia Y, et al. Pretreatment with Fucoidan from Fucus vesiculosus Protected against ConA-Induced Acute Liver Injury by Inhibiting Both Intrinsic and Extrinsic Apoptosis. PLoS ONE. 2016;11:e0152570 pubmed publisher
  • western blot; rat; 1:800; loading ...; fig 5a
Kong F, Wang H, Guo J, Peng M, Ji H, Yang H, et al. Hsp70 suppresses apoptosis of BRL cells by regulating the expression of Bcl-2, cytochrome C, and caspase 8/3. In Vitro Cell Dev Biol Anim. 2016;52:568-75 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6a
Zhang W, Shi H, Zhang M, Liu B, Mao S, Li L, et al. Poly C binding protein 1 represses autophagy through downregulation of LC3B to promote tumor cell apoptosis in starvation. Int J Biochem Cell Biol. 2016;73:127-136 pubmed publisher
Kang D, Zuo W, Wu Q, Zhu Q, Liu P. Inhibition of Specificity Protein 1 Is Involved in Phloretin-Induced Suppression of Prostate Cancer. Biomed Res Int. 2020;2020:1358674 pubmed publisher
Hu Z, Wang H, Fu Y, Ma K, Ma X, Wang J. Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways. Nutr Cancer. 2020;:1-12 pubmed publisher
Guo L, Liu S, Yang Q, Liu H, Xu L, Hao Y, et al. Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALB/c Mice. Biomed Res Int. 2020;2020:1594726 pubmed publisher
Liu J, Deng X, Sun X, Dong J, Huang J. Inhibition of autophagy enhances timosaponin AIII-induced lung cancer cell apoptosis and anti-tumor effect in vitro and in vivo. Life Sci. 2020;257:118040 pubmed publisher
Dong P, Fu H, Chen L, Zhang S, Zhang X, Li H, et al. PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition. J Cell Mol Med. 2020;: pubmed publisher
Guo Y, Zhu H, Weng M, Chen B, Wang C, Sun L. Baohuoside-1 targeting mTOR inducing apoptsis to inhibit hepatocellular carcinoma proliferation, invasion and migration. Biomed Pharmacother. 2020;128:110366 pubmed publisher
Yang T, Fan T, Xu B. Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells. Toxicol In Vitro. 2020;66:104868 pubmed publisher
Mao L, Kan Y, Li B, Ma S, Liu Y, Yang D, et al. Combination Therapy of Prostate Cancer by Oncolytic Adenovirus Harboring Interleukin 24 and Ionizing Radiation. Front Oncol. 2020;10:421 pubmed publisher
He S, Li A, Zhang W, Zhang L, Liu Y, Li K, et al. An integrated transcriptomics and network pharmacology approach to exploring the mechanism of adriamycin-induced kidney injury. Chem Biol Interact. 2020;325:109096 pubmed publisher
Liu X, Zhang Y, Wu S, Xu M, Shen Y, Yu M, et al. Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA. Biochem Pharmacol. 2020;175:113933 pubmed publisher
Du J, Li J, Gao M, Guan Q, Liu T, Wu Y, et al. MAY, a novel tubulin inhibitor, induces cell apoptosis in A549 and A549/Taxol cells and inhibits epithelial-mesenchymal transition in A549/Taxol cells. Chem Biol Interact. 2020;323:109074 pubmed publisher
Su W, Zhao J, Fan T. Dose- and Time-Dependent Cytotoxicity of Carteolol in Corneal Endothelial Cells and the Underlying Mechanisms. Front Pharmacol. 2020;11:202 pubmed publisher
Lin H, HAN H, Wang Y, He D, Sun W, Feng L, et al. Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo. Chin Med. 2020;15:23 pubmed publisher
Wang N, Liu H, Liu G, Li M, He X, Yin C, et al. Yeast β-D-glucan exerts antitumour activity in liver cancer through impairing autophagy and lysosomal function, promoting reactive oxygen species production and apoptosis. Redox Biol. 2020;32:101495 pubmed publisher
Gao L, Qian B, Chen H, Wang A, Li Q, Li J, et al. Hic-5 deficiency attenuates hepatic ischemia reperfusion injury through TLR4/NF-κB signaling pathways. Life Sci. 2020;249:117517 pubmed publisher
Yang B, Bai H, Sa Y, Zhu P, Liu P. Inhibiting EMT, stemness and cell cycle involved in baicalin-induced growth inhibition and apoptosis in colorectal cancer cells. J Cancer. 2020;11:2303-2317 pubmed publisher
Man S, Yang L, Xiang H, Lu G, Wang Y, Liu C, et al. Antihypertensive and renal protective effect of Shunaoxin pill combined with captopril on spontaneous hypertension rats. Biomed Pharmacother. 2020;125:109977 pubmed publisher
Liu Q, Guo X, Huang Z, He Q, Zhu D, Zhang S, et al. Anti-neuroinflammatory effects of dimethylaminomylide (DMAMCL, i.e., ACT001) are associated with attenuating the NLRP3 inflammasome in MPTP-induced Parkinson disease in mice. Behav Brain Res. 2020;383:112539 pubmed publisher
Wu K, Liu H, Wang Y, He J, Xu S, Chen Y, et al. SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States. Cell Rep. 2020;30:25-36.e6 pubmed publisher
Zhou Y, Fu X, Guan Y, Gong M, He K, Huang B. 1,3-Dicaffeoylquinic acid targeting 14-3-3 tau suppresses human breast cancer cell proliferation and metastasis through IL6/JAK2/PI3K pathway. Biochem Pharmacol. 2020;172:113752 pubmed publisher
Li Y, Wang C, Lu J, Huang K, Han Y, Chen J, et al. PPAR δ inhibition protects against palmitic acid-LPS induced lipidosis and injury in cultured hepatocyte L02 cell. Int J Med Sci. 2019;16:1593-1603 pubmed publisher
Sun Y, Gong J, Cao Y. Multi-Walled Carbon Nanotubes (MWCNTs) Activate Apoptotic Pathway Through ER Stress: Does Surface Chemistry Matter?. Int J Nanomedicine. 2019;14:9285-9294 pubmed publisher
Jiang J, Wang X, Gao G, Liu X, Chang H, Xiong R, et al. Silencing of lncRNA HOXA11-AS inhibits cell migration, invasion, proliferation, and promotes apoptosis in human glioma cells via upregulating microRNA-125a: in vitro and in vivo studies. Am J Transl Res. 2019;11:6382-6392 pubmed
Peng F, Zhang N, Wang C, Wang X, Huang W, Peng C, et al. Aconitine induces cardiomyocyte damage by mitigating BNIP3-dependent mitophagy and the TNFα-NLRP3 signalling axis. Cell Prolif. 2019;:e12701 pubmed publisher
Xin X, Zhang R, Yuan X, Liu L. Mechanisms of IFNalpha-1a-Induced Apoptosis in a Laryngeal Cancer Cell Line. Med Sci Monit. 2019;25:7100-7114 pubmed publisher
Yao Y, Zhang J, Tian P, Li L, Huang X, Nawutayi M, et al. Passive smoking induces rat testicular injury via the FAS/FASL pathway. Drug Chem Toxicol. 2019;:1-9 pubmed publisher
Zhang Q, Cao W, Wang X, Zhang M, Lu X, Chen J, et al. Genistein inhibits nasopharyngeal cancer stem cells through sonic hedgehog signaling. Phytother Res. 2019;: pubmed publisher
Wu D, Li M, Gao Y, Tian W, Li J, Zhang Q, et al. Peptide V3 Inhibits the Growth of Human Hepatocellular Carcinoma by Inhibiting the Ras/Raf/MEK/ERK Signaling Pathway. J Cancer. 2019;10:1693-1706 pubmed publisher
Xu W, Hu G, Da Costa C, Tang J, Li Q, Du L, et al. Long noncoding RNA UBE2R2-AS1 promotes glioma cell apoptosis via targeting the miR-877-3p/TLR4 axis. Onco Targets Ther. 2019;12:3467-3480 pubmed publisher
Huang Y, Ren A, Wang L, Jin L, Lin S, Li Z, et al. Casp8 hypomethylation and neural tube defects in association with polycyclic aromatic hydrocarbon exposure. Clin Epigenetics. 2019;11:72 pubmed publisher
Yang H, Qiu B, Chen S, Xun Y, Pan Y, Chen M, et al. Soluble CXCL16 promotes TNF-α-induced apoptosis in DLBCL via the AMAD10-NF-κB regulatory feedback loop. Cell Biol Int. 2019;: pubmed publisher
Li Z, Chen S, Chen S, Huang D, Ma K, Shao Z. Moderate activation of Wnt/β-catenin signaling promotes the survival of rat nucleus pulposus cells via regulating apoptosis, autophagy, and senescence. J Cell Biochem. 2019;120:12519-12533 pubmed publisher
Yan X, Zhong X, Yu S, Zhang L, Liu Y, Zhang Y, et al. p62 aggregates mediated Caspase 8 activation is responsible for progression of ovarian cancer. J Cell Mol Med. 2019;23:4030-4042 pubmed publisher
Liao Y, Hussain T, Liu C, Cui Y, Wang J, Yao J, et al. Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1β During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation. Front Immunol. 2019;10:268 pubmed publisher
Li H, Dai Y, Luo Z, Nie D. Cloning of a new testis-enriched gene C4orf22 and its role in cell cycle and apoptosis in mouse spermatogenic cells. Mol Biol Rep. 2019;: pubmed publisher
Shi J, Li J, Su W, Zhao S, Li H, Lei L. Loss of periodontal ligament fibroblasts by RIPK3-MLKL-mediated necroptosis in the progress of chronic periodontitis. Sci Rep. 2019;9:2902 pubmed publisher
Tian W, Guo H, Li C, Cao W, Wang X, Mo D, et al. PFKFB3 promotes endotoxemia-induced myocardial dysfunction through inflammatory signaling and apoptotic induction. Toxicol Appl Pharmacol. 2019;368:26-36 pubmed publisher
Li Z, Yu Y, Wang M, Xu H, Han B, Jiang P, et al. Anti-breast Cancer Activity of SPG-56 from Sweet Potato in MCF-7 Bearing Mice in Situ through Promoting Apoptosis and Inhibiting Metastasis. Sci Rep. 2019;9:146 pubmed publisher
He Y, Xia Z, Yu D, Wang J, Jin L, Huang D, et al. Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice. Int Immunopharmacol. 2019;68:171-178 pubmed publisher
Ge M, Zhang L, Cao L, Xie C, Li X, Li Y, et al. Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway. Int J Food Sci Nutr. 2019;70:570-578 pubmed publisher
Zhang D, Zhang J, Zeng J, Li Z, Zuo H, Huang C, et al. Nano-Gold Loaded with Resveratrol Enhance the Anti-Hepatoma Effect of Resveratrol In Vitro and In Vivo. J Biomed Nanotechnol. 2019;15:288-300 pubmed publisher
Li Y, Zheng Q, Sun D, Cui X, CHEN S, Bulbul A, et al. Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome. J Cell Physiol. 2019;234:7435-7447 pubmed publisher
Li S, Zhao H, Wang Y, Shao Y, Liu J, Xing M. Arsenic-induced cardiotoxicity correlates with mitochondrial damage and trace elements imbalance in broiler chickens. Poult Sci. 2019;98:734-744 pubmed publisher
Fan J, Wu M, Wang J, Ren D, Zhao J, Yang G. 1,7-Bis(4-hydroxyphenyl)-1,4-heptadien-3-one induces lung cancer cell apoptosis via the PI3K/Akt and ERK1/2 pathways. J Cell Physiol. 2019;234:6336-6349 pubmed publisher
Mao J, Yi M, Wang R, Huang Y, Chen M. Protective Effects of Costunolide Against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice. Front Pharmacol. 2018;9:1469 pubmed publisher
Hong X, Li S, Li W, Xie M, Wei Z, Guo H, et al. Disruption of protein neddylation with MLN4924 attenuates paclitaxel-induced apoptosis and microtubule polymerization in ovarian cancer cells. Biochem Biophys Res Commun. 2018;: pubmed publisher
Li L, Wang L, Cheng Y, Cao Z, Zhang X, Guo X. Discovery and Characterization of 4-Hydroxy-2-pyridone Derivative Sambutoxin as a Potent and Promising Anticancer Drug Candidate: Activity and Molecular Mechanism. Mol Pharm. 2018;15:4898-4911 pubmed publisher
Zhao W, Che C, Liu K, Zhang J, Jiang N, Yuan K, et al. Fenretinide Inhibits Neutrophil Recruitment and IL-1β Production in Aspergillus fumigatus Keratitis. Cornea. 2018;37:1579-1585 pubmed publisher
Liu Y, Fan D. Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model. Food Funct. 2018;9:5513-5527 pubmed publisher
Zhang M, Ding G, Zhou L, Shen T, Xu X, Zhao T, et al. Interferon Gamma Inhibits CXCL8-Induced Proliferation and Migration of Pancreatic Cancer BxPC-3 Cell Line via a RhoGDI2/Rac1/NF-κB Signaling Pathway. J Interferon Cytokine Res. 2018;38:413-422 pubmed publisher
Chen Y, Li Y, Wang X, Meng Y, Zhang Q, Zhu J, et al. Phenethyl isothiocyanate inhibits colorectal cancer stem cells by suppressing Wnt/β-catenin pathway. Phytother Res. 2018;32:2447-2455 pubmed publisher
Wu X, Guo Y, Min X, Pei L, Chen X. Neferine, a Bisbenzylisoquinoline Alkaloid, Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis. Am J Chin Med. 2018;46:1263-1279 pubmed publisher
You C, Zhang S, Sun Y, Zhang S, Tang G, Tang F, et al. β-catenin decreases acquired TRAIL resistance in non-small-cell lung cancer cells by regulating the redistribution of death receptors. Int J Oncol. 2018;53:2258-2268 pubmed publisher
Zheng Q, Zhou F, Cui X, Liu M, Li Y, Liu S, et al. Novel Serum Biomarkers Detected by Protein Array in Polycystic Ovary Syndrome with Low Progesterone Level. Cell Physiol Biochem. 2018;46:2297-2310 pubmed publisher
Wu D, Gao Y, Li T, Wang D, Lu D, Liu S, et al. PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways. BMC Cancer. 2018;18:499 pubmed publisher
Liu J, Zhao H, Wang Y, Shao Y, Li J, Xing M. Alterations of antioxidant indexes and inflammatory cytokine expression aggravated hepatocellular apoptosis through mitochondrial and death receptor-dependent pathways in Gallus gallus exposed to arsenic and copper. Environ Sci Pollut Res Int. 2018;25:15462-15473 pubmed publisher
Guo Y, Wu X, Wu Q, Lu Y, Shi J, Chen X. Dihydrotanshinone I, a natural product, ameliorates DSS-induced experimental ulcerative colitis in mice. Toxicol Appl Pharmacol. 2018;344:35-45 pubmed publisher
Che C, Liu J, Yang J, Ma L, Bai N, Zhang Q. Osteopontin is essential for IL-1β production and apoptosis in peri-implantitis. Clin Implant Dent Relat Res. 2018;20:384-392 pubmed publisher
Li X, Meng Y, Xie C, Zhu J, Wang X, Li Y, et al. Diallyl Trisulfide inhibits breast cancer stem cells via suppression of Wnt/β-catenin pathway. J Cell Biochem. 2018;119:4134-4141 pubmed publisher
Wang J, Tian L, Khan M, Zhang L, Chen Q, Zhao Y, et al. Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial-mesenchymal transition and stemness. Cancer Lett. 2018;415:73-85 pubmed publisher
Xiao Y, Tian C, Huang T, Han B, Wang M, Ma H, et al. 8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo. Life Sci. 2018;192:259-269 pubmed publisher
Wu J, Xing C, Zhang L, Mao H, Chen X, Liang M, et al. Autophagy promotes fibrosis and apoptosis in the peritoneum during long-term peritoneal dialysis. J Cell Mol Med. 2018;22:1190-1201 pubmed publisher
Yin S, Du W, Wang F, Han B, Cui Y, Yang D, et al. MicroRNA-326 sensitizes human glioblastoma cells to curcumin via the SHH/GLI1 signaling pathway. Cancer Biol Ther. 2018;19:260-270 pubmed publisher
Mehmood T, Maryam A, Tian X, Khan M, Ma T. Santamarine Inhibits NF-?B and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress. J Cancer. 2017;8:3707-3717 pubmed publisher
Song L, Wang Z, Wang Y, Guo D, Yang J, Chen L, et al. Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells. Molecules. 2017;22: pubmed publisher
Zheng Q, Li Y, Zhang D, Cui X, Dai K, Yang Y, et al. ANP promotes proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of PCOS rats. Cell Death Dis. 2017;8:e3145 pubmed publisher
Li S, Zhao H, Wang Y, Shao Y, Li J, Liu J, et al. The inflammatory responses in Cu-mediated elemental imbalance is associated with mitochondrial fission and intrinsic apoptosis in Gallus gallus heart. Chemosphere. 2017;189:489-497 pubmed publisher
Yuan K, Zhao G, Che C, Li C, Lin J, Zhu G, et al. Dectin-1 is essential for IL-1? production through JNK activation and apoptosis in Aspergillus fumigatus keratitis. Int Immunopharmacol. 2017;52:168-175 pubmed publisher
Wang D, Kong X, Li Y, Qian W, Ma J, Wang D, et al. Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway. Biochem Biophys Res Commun. 2017;493:521-527 pubmed publisher
Tang Q, Ji F, Wang J, Guo L, Li Y, Bao Y. Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin. Eur J Pharm Sci. 2017;109:223-232 pubmed publisher
Yan X, Li Y, Yu H, Wang W, Wu C, Yang Y, et al. Epigallocatechin-3-gallate inhibits H2O2-induced apoptosis in Mouse Vascular Smooth Muscle Cells via 67kD Laminin Receptor. Sci Rep. 2017;7:7774 pubmed publisher
Wu B, Cui J, Yang X, Liu Z, Song F, Li L, et al. Cytoplasmic fragment of CD147 generated by regulated intramembrane proteolysis contributes to HCC by promoting autophagy. Cell Death Dis. 2017;8:e2925 pubmed publisher
Zhu J, Wang S, Chen Y, Li X, Jiang Y, Yang X, et al. miR-19 targeting of GSK3β mediates sulforaphane suppression of lung cancer stem cells. J Nutr Biochem. 2017;44:80-91 pubmed publisher
Yang Y, Gong X, Huang L, Wang Z, Wan R, Zhang P, et al. Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice. Oncotarget. 2017;8:30723-30733 pubmed publisher
Xie X, Zhao N, Xu Q, Yang X, Xia W, Chen Q, et al. Relaxin attenuates aristolochic acid induced human tubular epithelial cell apoptosis in vitro by activation of the PI3K/Akt signaling pathway. Apoptosis. 2017;22:769-776 pubmed publisher
Wang X, Cao W, Zhang J, Yan M, Xu Q, Wu X, et al. A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. EMBO J. 2017;36:1243-1260 pubmed publisher
Wei H, Gao Z, Zheng L, Zhang C, Liu Z, Yang Y, et al. Protective Effects of Fucoidan on A?25-35 and d-Gal-Induced Neurotoxicity in PC12 Cells and d-Gal-Induced Cognitive Dysfunction in Mice. Mar Drugs. 2017;15: pubmed publisher
Wang H, Xu Y, Wang M, Cheng C, Bian R, Yuan H, et al. Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders. Int J Mol Med. 2017;39:819-830 pubmed publisher
Zhu J, Yang X, Chen Y, Jiang Y, Wang S, Li Y, et al. Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/?-catenin and Sonic Hedgehog Pathways. Phytother Res. 2017;31:680-688 pubmed publisher
Huang T, Xiao Y, Yi L, Li L, Wang M, Tian C, et al. Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo. Sci Rep. 2017;7:38524 pubmed publisher
Tan M, Cao X, Li P, Zhai Y, Zhou Y, Liu Y, et al. Effectively enhancing cytotoxic and apoptotic effects of alpha-momorcharin by integrating a heparin-binding peptide. Biotechnol Appl Biochem. 2017;64:918-926 pubmed publisher
Cui Y, Zhao D, Sreevatsan S, Liu C, Yang W, Song Z, et al. Mycobacterium bovis Induces Endoplasmic Reticulum Stress Mediated-Apoptosis by Activating IRF3 in a Murine Macrophage Cell Line. Front Cell Infect Microbiol. 2016;6:182 pubmed publisher
Wang X, Sun Y, Zhao C, Qu F, Zhao Y. 12-Chloracetyl-PPD, a novel dammarane derivative, shows anti-cancer activity via delay the progression of cell cycle G2/M phase and reactive oxygen species-mediate cell apoptosis. Eur J Pharmacol. 2017;798:49-56 pubmed publisher
Tang Q, Ji F, Sun W, Wang J, Guo J, Guo L, et al. Combination of baicalein and 10-hydroxy camptothecin exerts remarkable synergetic anti-cancer effects. Phytomedicine. 2016;23:1778-1786 pubmed publisher
Yuan G, Hua B, Yang Y, Xu L, Cai T, Sun N, et al. The Circadian Gene Clock Regulates Bone Formation Via PDIA3. J Bone Miner Res. 2017;32:861-871 pubmed publisher
Zhu J, Jiang Y, Yang X, Wang S, Xie C, Li X, et al. Wnt/?-catenin pathway mediates (-)-Epigallocatechin-3-gallate (EGCG) inhibition of lung cancer stem cells. Biochem Biophys Res Commun. 2017;482:15-21 pubmed publisher
Shi W, Cao C, Liu L. Interferon ? Induces the Apoptosis of Cervical Cancer HeLa Cells by Activating both the Intrinsic Mitochondrial Pathway and Endoplasmic Reticulum Stress-Induced Pathway. Int J Mol Sci. 2016;17: pubmed
Nan A, Chen L, Zhang N, Liu Z, Yang T, Wang Z, et al. A novel regulatory network among LncRpa, CircRar1, MiR-671 and apoptotic genes promotes lead-induced neuronal cell apoptosis. Arch Toxicol. 2017;91:1671-1684 pubmed publisher
Liu Z, Shi Q, Song X, Wang Y, Wang Y, Song E, et al. Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5). Chem Res Toxicol. 2016;29:1510-8 pubmed publisher
Yuan S, Wen J, Cheng J, Shen W, Zhou S, Yan W, et al. Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-κB pathway. Cell Cycle. 2016;15:2895-2905 pubmed
Li X, Zhu F, Jiang J, Sun C, Zhong Q, Shen M, et al. Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells. Autophagy. 2016;12:1521-37 pubmed publisher
Zou M, Duan Y, Wang P, Gao R, Chen X, Ou Y, et al. DYT-40, a novel synthetic 2-styryl-5-nitroimidazole derivative, blocks malignant glioblastoma growth and invasion by inhibiting AEG-1 and NF-κB signaling pathways. Sci Rep. 2016;6:27331 pubmed publisher
Lu Y, Li P, Li Y, Luo F, Guo C, Lin B, et al. Enhanced anti-tumor activity of trichosanthin after combination with a human-derived cell-penetrating peptide, and a possible mechanism of activity. Fitoterapia. 2016;112:183-90 pubmed publisher
Zhao L, Wen Q, Yang G, Huang Z, Shen T, Li H, et al. Apoptosis induction of dehydrobruceine B on two kinds of human lung cancer cell lines through mitochondrial-dependent pathway. Phytomedicine. 2016;23:114-22 pubmed publisher
Ju D, Yamaguchi F, Zhan G, Higuchi T, Asakura T, Morita A, et al. Hyperthermotherapy enhances antitumor effect of 5-aminolevulinic acid-mediated sonodynamic therapy with activation of caspase-dependent apoptotic pathway in human glioma. Tumour Biol. 2016;37:10415-26 pubmed publisher
Chen K, Dai W, Wang F, Xia Y, Li J, Li S, et al. Inhibitive effects of 15-deoxy-Δ(12),(14)-prostaglandin J2 on hepatoma-cell proliferation through reactive oxygen species-mediated apoptosis. Onco Targets Ther. 2015;8:3585-93 pubmed publisher
Nie D, Zhang D, Dai J, Zhang M, Zhao X, Xu W, et al. Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation. Biol Reprod. 2016;94:31 pubmed publisher
Wang L, Wang C, Jia Y, Liu Z, Shu X, Liu K. Resveratrol Increases Anti-Proliferative Activity of Bestatin Through Downregulating P-Glycoprotein Expression Via Inhibiting PI3K/Akt/mTOR Pathway in K562/ADR Cells. J Cell Biochem. 2016;117:1233-9 pubmed publisher
Song X, Li L, Shi Q, Lehmler H, Fu J, Su C, et al. Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells. Chem Res Toxicol. 2015;28:2160-9 pubmed publisher
Mao Y, Wang J, Yu F, Cheng J, Li H, Guo C, et al. Ghrelin reduces liver impairment in a model of concanavalin A-induced acute hepatitis in mice. Drug Des Devel Ther. 2015;9:5385-96 pubmed publisher
Aziz F, Wang X, Liu J, Yan Q. Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions. Toxicol In Vitro. 2016;31:158-66 pubmed publisher
Zhang S, Shao S, Song X, Xia C, Yang Y, Zhang P, et al. Protective effects of Forsythia suspense extract with antioxidant and anti-inflammatory properties in a model of rotenone induced neurotoxicity. Neurotoxicology. 2016;52:72-83 pubmed publisher
Zhang X, Jiang S, Shang B, Jiang H. Effects of histone deacetylase inhibitor trichostatin A combined with cisplatin on apoptosis of A549 cell line. Thorac Cancer. 2015;6:202-8 pubmed publisher
Peng X, Zhang Y, Wang J, Ji Q. Ethylacetate extract from Tetrastigma hemsleyanum induces apoptosis via the mitochondrial caspase-dependent intrinsic pathway in HepG2 cells. Tumour Biol. 2016;37:865-76 pubmed publisher
Hu L, Su C, Song X, Shi Q, Fu J, Xia X, et al. Tetrachlorobenzoquinone triggers the cleavage of Bid and promotes the cross-talk of extrinsic and intrinsic apoptotic signalings in pheochromocytoma (PC) 12 cells. Neurotoxicology. 2015;49:149-57 pubmed publisher
Khan M, Wang B, Wei J, Zhang Y, Li Q, Luan X, et al. CXCR1/2 antagonism with CXCL8/Interleukin-8 analogue CXCL8(3-72)K11R/G31P restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis. Oncotarget. 2015;6:21315-27 pubmed
Wang Y, Yan T, Ma L, Liu B. Effects of the total saponins from Dioscorea nipponica on immunoregulation in aplastic anemia mice. Am J Chin Med. 2015;43:289-303 pubmed publisher
Huang Y, Du Y, Zhang X, Bai L, Mibrahim M, Zhang J, et al. Down-regulated expression of Annexin A7 induces apoptosis in mouse hepatocarcinoma cell line by the intrinsic mitochondrial pathway. Biomed Pharmacother. 2015;70:146-50 pubmed publisher
Liu W, Ning R, Chen R, Huang X, Dai Q, Hu J, et al. Aspafilioside B induces G2/M cell cycle arrest and apoptosis by up-regulating H-Ras and N-Ras via ERK and p38 MAPK signaling pathways in human hepatoma HepG2 cells. Mol Carcinog. 2016;55:440-57 pubmed publisher
Li X, Zhu F, Jiang J, Sun C, Wang X, Shen M, et al. Synergistic antitumor activity of withaferin A combined with oxaliplatin triggers reactive oxygen species-mediated inactivation of the PI3K/AKT pathway in human pancreatic cancer cells. Cancer Lett. 2015;357:219-30 pubmed publisher
Guo L, Shen Y, Zhao X, Guo L, Yu Z, Wang D, et al. Curcumin combined with oxaliplatin effectively suppress colorectal carcinoma in vivo through inducing apoptosis. Phytother Res. 2015;29:357-65 pubmed publisher
product information
CatalogNo :
13423-1-AP
AntigenName :
Caspase 8/p43/p18
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
caspase 8, apoptosis-related cysteine peptidase
Immunogen :
Recombinant Protein
Species :
chicken, human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
Apoptotic protease Mch 5, Casp 8, CASP8, Caspase 8, Caspase 8/p18, caspase8, FADD like ICE, FLICE, ICE like apoptotic protease 5, MACH, MCH5, MORT1 associated ced 3 homolog
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC028223
Category :
Apoptosis;Binding Proteins;Cytoskeleton/Scaffold Proteins;Disease Related;Membrane Proteins;Metabolism;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:25 ; IHC 1:200 ; IP 1:500 ; WB 1:500 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.