This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
SIRT1
catalog :
13161-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 76
Reference
Zhang Y, Zhu X, Wang G, Chen L, Yang H, He F, et al. Melatonin Rescues the Ti Particle-Impaired Osteogenic Potential of Bone Marrow Mesenchymal Stem Cells via the SIRT1/SOD2 Signaling Pathway. Calcif Tissue Int. 2020;: pubmed publisher
Zhang Y, You S, Tian Y, Lu S, Cao L, Sun Y, et al. WWP2 regulates SIRT1-STAT3 acetylation and phosphorylation involved in hypertensive angiopathy. J Cell Mol Med. 2020;: pubmed publisher
Wang X, Yang J, Lu T, Zhan Z, Wei W, Lyu X, et al. The effect of swimming exercise and diet on the hypothalamic inflammation of ApoE-/- mice based on SIRT1-NF-κB-GnRH expression. Aging (Albany NY). 2020;12:11085-11099 pubmed publisher
Chao Y, Wu K, Tsai P, Tain Y, Leu S, Lee W, et al. Anomalous AMPK-regulated angiotensin AT1R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure. J Biomed Sci. 2020;27:68 pubmed publisher
Cao Y, Liu C, Wang Q, Wang W, Tao E, Wan L. Pum2 mediates Sirt1 mRNA decay and exacerbates hypoxia/reoxygenation-induced cardiomyocyte apoptosis. Exp Cell Res. 2020;393:112058 pubmed publisher
Guo S, Ma B, Jiang X, Li X, Jia Y. Astragalus Polysaccharides Inhibits Tumorigenesis and Lipid Metabolism Through miR-138-5p/SIRT1/SREBP1 Pathway in Prostate Cancer. Front Pharmacol. 2020;11:598 pubmed publisher
Jiang Y, Jiang L, Wang Y, Ma D, Li X. Quercetin Attenuates Atherosclerosis via Modulating Oxidized LDL-Induced Endothelial Cellular Senescence. Front Pharmacol. 2020;11:512 pubmed publisher
Lai H, Nie T, Zhang Y, Chen Y, Tao J, Lin T, et al. Selenium Deficiency-Induced Damage and Altered Expression of Mitochondrial Biogenesis Markers in the Kidneys of Mice. Biol Trace Elem Res. 2020;: pubmed publisher
Zhang N, Zhang Y, You S, Tian Y, Lu S, Cao L, et al. Septin4 Prevents PDGF-BB-induced HAVSMC Phenotypic Transformation, Proliferation and Migration by Promoting SIRT1-STAT3 Deacetylation and Dephosphorylation. Int J Biol Sci. 2020;16:708-718 pubmed publisher
Niu Y, Zhou W, Nie Z, Zhou D, Xu Y, Ock S, et al. Ubiquinol-10 delays postovulatory oocyte aging by improving mitochondrial renewal in pigs. Aging (Albany NY). 2020;12:1256-1271 pubmed publisher
Wang J, Li S, Wang J, Wu F, Chen Y, Zhang H, et al. Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function. Aging (Albany NY). 2020;12:650-671 pubmed publisher
Niu Y, Zhou W, Nie Z, Shin K, Cui X. Melatonin enhances mitochondrial biogenesis and protects against rotenone-induced mitochondrial deficiency in early porcine embryos. J Pineal Res. 2020;68:e12627 pubmed publisher
Zhang M, Lu Y, Chen Y, Zhang Y, Xiong B. Insufficiency of melatonin in follicular fluid is a reversible cause for advanced maternal age-related aneuploidy in oocytes. Redox Biol. 2020;28:101327 pubmed publisher
Liu X, Wu C, Han D, Liu J, Liu H, Jiang Z. Partially Hydrolyzed Guar Gum Attenuates d-Galactose-Induced Oxidative Stress and Restores Gut Microbiota in Rats. Int J Mol Sci. 2019;20: pubmed publisher
Sun X, Wang S, Li Q. Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer. Front Genet. 2019;10:879 pubmed publisher
Song S, Chu L, Liang H, Chen J, Liang J, Huang Z, et al. Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal. Front Pharmacol. 2019;10:1030 pubmed publisher
Yao B, He J, Yin X, Shi Y, Wan J, Tian Z. The protective effect of lithocholic acid on the intestinal epithelial barrier is mediated by the vitamin D receptor via a SIRT1/Nrf2 and NF-κB dependent mechanism in Caco-2 cells. Toxicol Lett. 2019;316:109-118 pubmed publisher
Zhang J, Bi R, Meng Q, Wang C, Huo X, Liu Z, et al. Catalpol Alleviates Adriamycin-Induced Nephropathy by Activating the SIRT1 Signalling Pathway In Vivo and In Vitro. Br J Pharmacol. 2019;: pubmed publisher
Liu X, Liu D, Lin G, Wu Y, Gao L, Ai C, et al. Anti-ageing and antioxidant effects of sulfate oligosaccharides from green algae Ulva lactuca and Enteromorpha prolifera in SAMP8 mice. Int J Biol Macromol. 2019;139:342-351 pubmed publisher
Liu Z, Zhang Y, Wang X, Fan X, Zhang Y, Li X, et al. SIRT1 activation attenuates cardiac fibrosis by endothelial-to-mesenchymal transition. Biomed Pharmacother. 2019;118:109227 pubmed publisher
Shen S, Liao Q, Zhang T, Pan R, Lin L. Myricanol modulates skeletal muscle-adipose crosstalk to alleviate high fat diet-induced obesity and insulin resistance. Br J Pharmacol. 2019;: pubmed publisher
Tien C, Chen C, Lin W, Liu C, Liu K, Hsiao M, et al. Ambient particulate matter attenuates Sirtuin1 and augments SREBP1-PIR axis to induce human pulmonary fibroblast inflammation: molecular mechanism of microenvironment associated with COPD. Aging (Albany NY). 2019;11:4654-4671 pubmed publisher
Xie L, Huang R, Liu S, Wu W, Su A, Li R, et al. A positive feedback loop of SIRT1 and miR17HG promotes the repair of DNA double-stranded breaks. Cell Cycle. 2019;18:2110-2123 pubmed publisher
Xu C, Liu W, Remø S, Wang B, Shi H, Zhang L, et al. Feeding restriction alleviates high carbohydrate diet-induced oxidative stress and inflammation of Megalobrama amblycephala by activating the AMPK-SIRT1 pathway. Fish Shellfish Immunol. 2019;92:637-648 pubmed publisher
Li S, Jiang X, Luo Y, Zhou B, Shi M, Liu F, et al. Sodium/calcium overload and Sirt1/Nrf2/OH-1 pathway are critical events in mercuric chloride-induced nephrotoxicity. Chemosphere. 2019;234:579-588 pubmed publisher
Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, et al. Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents. Nat Commun. 2019;10:2538 pubmed publisher
Liu Y, Li Y, Huang Z, Wang Z, Nan L, Wang F, et al. The effect of intervertebral disc degenerative change on biological characteristics of nucleus pulposus mesenchymal stem cell: an in vitro study in rats. Connect Tissue Res. 2019;60:376-388 pubmed publisher
Zhao X, Jin Y, Li L, Xu L, Tang Z, Qi Y, et al. MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1. Pharmacol Res. 2019;146:104276 pubmed publisher
Liu W, Wang Z, Yang J, Wang Y, Li K, Huang B, et al. Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice. Open Biol. 2019;9:180262 pubmed publisher
Zhong F, Hu Z, Jiang K, Lei B, Wu Z, Yuan G, et al. Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis. Cell Res. 2019;: pubmed publisher
Lin I, Wu C, Tain Y, Chen I, Hung C, Wu K. High fructose diet induces early mortality via autophagy factors accumulation in the rostral ventrolateral medulla as ameliorated by pioglitazone. J Nutr Biochem. 2019;69:87-97 pubmed publisher
Fan X, Yan K, Meng Q, Sun R, Yang X, Yuan D, et al. Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7. Int J Mol Med. 2019;44:157-171 pubmed publisher
Zhao Y, Yan J, Li A, Zhang Z, Li Z, Guo K, et al. Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling pathway in rats. Toxicol Lett. 2019;310:31-38 pubmed publisher
Li Y, Chen X, Cui Y, Wei Q, Chen S, Wang X. Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines. Oncol Lett. 2019;17:3701-3708 pubmed publisher
Zhou D, Zhuang J, Wang Y, Zhao D, Zhao L, Zhu S, et al. Propofol Alleviates DNA Damage Induced by Oxygen Glucose Deprivation and Reperfusion via FoxO1 Nuclear Translocation in H9c2 Cells. Front Physiol. 2019;10:223 pubmed publisher
Peng X, Li X, Li Y, Huang X, Luo Z. The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-κB acetylation. Int Immunopharmacol. 2019;70:520-529 pubmed publisher
Cheng Z, Zhang M, Ling C, Zhu Y, Ren H, Hong C, et al. Neuroprotective Effects of Ginsenosides against Cerebral Ischemia. Molecules. 2019;24: pubmed publisher
Xu B, Zang S, Li S, Guo J, Wang J, Wang D, et al. HMGB1-mediated differential response on hippocampal neurotransmitter disorder and neuroinflammation in adolescent male and female mice following cold exposure. Brain Behav Immun. 2019;76:223-235 pubmed publisher
Hu X, Lu Z, Yu S, Reilly J, Liu F, Jia D, et al. CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1. Autophagy. 2019;15:453-465 pubmed publisher
Pan J, Zhou H, Zhu S, Huang J, Zhao X, Ding H, et al. Nicotinamide phosphoribosyl transferase regulates cell growth via the Sirt1/P53 signaling pathway and is a prognosis marker in colorectal cancer. J Cell Physiol. 2019;234:4385-4395 pubmed publisher
Goyal R, Kapadia C, Melamed J, Riley R, Day E. Layer-by-layer assembled gold nanoshells for the intracellular delivery of miR-34a. Cell Mol Bioeng. 2018;11:383-396 pubmed publisher
Luo D, Liu L, Liang F, Yu Z, Chen R. Electroacupuncture: A Feasible Sirt1 Promoter Which Modulates Metainflammation in Diet-Induced Obesity Rats. Evid Based Complement Alternat Med. 2018;2018:5302049 pubmed publisher
Shi H, Xu C, Liu M, Wang B, Liu W, Chen D, et al. Resveratrol Improves the Energy Sensing and Glycolipid Metabolism of Blunt Snout Bream Megalobrama amblycephala Fed High-Carbohydrate Diets by Activating the AMPK-SIRT1-PGC-1α Network. Front Physiol. 2018;9:1258 pubmed publisher
Han C, Li F, Liu Y, Ma J, Yu X, Wu X, et al. Modified Si-Ni-San Decoction Ameliorates Central Fatigue by Improving Mitochondrial Biogenesis in the Rat Hippocampus. Evid Based Complement Alternat Med. 2018;2018:9452127 pubmed publisher
Ling C, Liang J, Zhang C, Li R, Mou Q, Qin J, et al. Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury. Molecules. 2018;23: pubmed publisher
Wang Z, Yuan S, Li Y, Zhang Z, Xiao W, Tang D, et al. Regulation on SIRT1-PGC-1α/Nrf2 pathway together with selective inhibition of aldose reductase makes compound hr5F a potential agent for the treatment of diabetic complications. Biochem Pharmacol. 2018;150:54-63 pubmed publisher
Li D, Wang X, Huang Q, Li S, Zhou Y, Li Z. Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-?B pathway in vivo and in vitro. Redox Biol. 2018;15:62-73 pubmed publisher
Yu C, Jiao Y, Xue J, Zhang Q, Yang H, Xing L, et al. Metformin Sensitizes Non-small Cell Lung Cancer Cells to an Epigallocatechin-3-Gallate (EGCG) Treatment by Suppressing the Nrf2/HO-1 Signaling Pathway. Int J Biol Sci. 2017;13:1560-1569 pubmed publisher
Yan P, Bai L, Lu W, Gao Y, Bi Y, Lv G. Regulation of autophagy by AMP-activated protein kinase/sirtuin 1 pathway reduces spinal cord neurons damage. Iran J Basic Med Sci. 2017;20:1029-1036 pubmed publisher
Chen R, Liu Y, Zhuang H, Yang B, Hei K, Xiao M, et al. Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation. Nucleic Acids Res. 2017;45:9947-9959 pubmed publisher
Lan K, Chao S, Wu H, Chiang C, Wang C, Liu S, et al. Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-κB and HMGB1 pathways through the upregulation of SIRT1. Sci Rep. 2017;7:12026 pubmed publisher
Wang X, Li T, Li J, Miao S, Xiao X. The Effects of Resveratrol on Inflammation and Oxidative Stress in a Rat Model of Chronic Obstructive Pulmonary Disease. Molecules. 2017;22: pubmed publisher
Ran G, Ying L, Li L, Yan Q, Yi W, Ying C, et al. Resveratrol ameliorates diet-induced dysregulation of lipid metabolism in zebrafish (Danio rerio). PLoS ONE. 2017;12:e0180865 pubmed publisher
Liu C, Sung H, Lin S, Wu C, Lee C, Lee I, et al. Resveratrol attenuates ICAM-1 expression and monocyte adhesiveness to TNF-α-treated endothelial cells: evidence for an anti-inflammatory cascade mediated by the miR-221/222/AMPK/p38/NF-κB pathway. Sci Rep. 2017;7:44689 pubmed publisher
Li Z, Guo G, Wang H, Si X, Zhou G, Xiong Y, et al. TRPC5 channel modulates endothelial cells senescence. Eur J Pharmacol. 2017;802:27-35 pubmed publisher
Zhang C, Li C, Chen S, Li Z, Ma L, Jia X, et al. Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways. Sci Rep. 2017;7:41082 pubmed publisher
Tian S, Guo X, Yu C, Sun C, Jiang J. miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1. Oncotarget. 2017;8:11071-11082 pubmed publisher
Zhang P, Li Y, Du Y, Li G, Wang L, Zhou F. Resveratrol Ameliorated Vascular Calcification by Regulating Sirt-1 and Nrf2. Transplant Proc. 2016;48:3378-3386 pubmed publisher
Jia L, Li W, Li J, Li Y, Song H, Luan Y, et al. Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity. Sci Rep. 2016;6:36209 pubmed publisher
Wang F, Zhao J, Liu D, Zhao T, Lu Z, Zhu L, et al. Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition. Cancer Biol Ther. 2016;17:1117-1125 pubmed
Chacon Cabrera A, Gea J, Barreiro E. Short- and Long-Term Hindlimb Immobilization and Reloading: Profile of Epigenetic Events in Gastrocnemius. J Cell Physiol. 2017;232:1415-1427 pubmed publisher
Rocha Rodrigues S, Rodríguez A, Gouveia A, Gonçalves I, Becerril S, Ramirez B, et al. Effects of physical exercise on myokines expression and brown adipose-like phenotype modulation in rats fed a high-fat diet. Life Sci. 2016;165:100-108 pubmed publisher
Luccarini I, Pantano D, Nardiello P, Cavone L, Lapucci A, Miceli C, et al. The Polyphenol Oleuropein Aglycone Modulates the PARP1-SIRT1 Interplay: An In Vitro and In Vivo Study. J Alzheimers Dis. 2016;54:737-50 pubmed publisher
Zhao L, Xu L, Tao X, Han X, Yin L, Qi Y, et al. Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation. Molecules. 2016;21: pubmed publisher
Tao X, Sun X, Xu L, Yin L, Han X, Qi Y, et al. Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats. Nutrients. 2016;8: pubmed publisher
Zhang W, Yin L, Tao X, Xu L, Zheng L, Han X, et al. Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation. Environ Toxicol Pharmacol. 2016;45:193-201 pubmed publisher
Chen H, Long Y, Guo L. Antiaging Effect of Inula britannica on Aging Mouse Model Induced by D-Galactose. Evid Based Complement Alternat Med. 2016;2016:6049083 pubmed publisher
Liu F, Zhang W, Yang F, Feng T, Zhou M, Yu Y, et al. Interleukin-6-stimulated progranulin expression contributes to the malignancy of hepatocellular carcinoma cells by activating mTOR signaling. Sci Rep. 2016;6:21260 pubmed publisher
Hong W, Xu X, Qiu Z, Gao J, Wei Z, Zhen L, et al. Sirt1 is involved in decreased bone formation in aged apolipoprotein E-deficient mice. Acta Pharmacol Sin. 2015;36:1487-96 pubmed publisher
Freitas M, Rodrigues A, Tomada N, Fonseca J, Magalhães A, Gouveia A, et al. Effects of Aging and Cardiovascular Disease Risk Factors on the Expression of Sirtuins in the Human Corpus Cavernosum. J Sex Med. 2015;12:2141-52 pubmed publisher
Potteti H, Rajasekaran S, Rajamohan S, Tamatam C, Reddy N, Reddy S. Sirtuin 1 Promotes Hyperoxia-Induced Lung Epithelial Cell Death Independent of NF-E2-Related Factor 2 Activation. Am J Respir Cell Mol Biol. 2016;54:697-706 pubmed publisher
Gu A, Jie Y, Sun L, Zhao S, E M, You Q. RhNRG-1β Protects the Myocardium against Irradiation-Induced Damage via the ErbB2-ERK-SIRT1 Signaling Pathway. PLoS ONE. 2015;10:e0137337 pubmed publisher
Ray Hamidie R, Yamada T, Ishizawa R, Saito Y, Masuda K. Curcumin treatment enhances the effect of exercise on mitochondrial biogenesis in skeletal muscle by increasing cAMP levels. Metabolism. 2015;64:1334-47 pubmed publisher
Pereira C, Severo M, Neves D, Ascensão A, Magalhães J, Guimarães J, et al. Natural mineral-rich water ingestion improves hepatic and fat glucocorticoid-signaling and increases sirtuin 1 in an animal model of metabolic syndrome. Horm Mol Biol Clin Investig. 2015;21:149-57 pubmed publisher
Puig Vilanova E, Martínez Llorens J, Ausin P, Roca J, Gea J, Barreiro E. Quadriceps muscle weakness and atrophy are associated with a differential epigenetic profile in advanced COPD. Clin Sci (Lond). 2015;128:905-21 pubmed publisher
Cai M, Hu Z, Liu J, Gao J, Tan M, Zhang D, et al. Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis. Oncol Rep. 2015;33:685-92 pubmed publisher
product information
CatalogNo :
13161-1-AP
AntigenName :
SIRT1
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
Immunogen :
Recombinant Protein
Species :
blunt snout bream, human, mouse, rat, swine, zebrafish
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
hSIR2, hSIRT1, SIR2 like protein 1, SIR2L1, SIRT1
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC012499
Category :
Binding Proteins;Cell Cycle;Cytoskeleton/Scaffold Proteins;Development;Membrane Proteins;Metabolism;Neurology;Senescence;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:50 ; IHC 1:50 ; IP 1:500 ; WB 1:800 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.