This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
ORAI1
catalog :
13130-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunocytochemistry
citations: 21
Reference
Angenendt A, Steiner R, Knörck A, Schwär G, Konrad M, Krause E, et al. Orai, STIM, and PMCA contribute to reduced calcium signal generation in CD8+ T cells of elderly mice. Aging (Albany NY). 2020;12:3266-3286 pubmed publisher
Pelzl L, Sahu I, Ma K, Heinzmann D, Bhuyan A, Al Maghout T, et al. Beta-Glycerophosphate-Induced ORAI1 Expression and Store Operated Ca2+ Entry in Megakaryocytes. Sci Rep. 2020;10:1728 pubmed publisher
Zhu X, Ma K, Zhou K, Voelkl J, Alesutan I, Leibrock C, et al. Reversal of phosphate-induced ORAI1 expression, store-operated Ca2+ entry and osteogenic signaling by MgCl2 in human aortic smooth muscle cells. Biochem Biophys Res Commun. 2020;523:18-24 pubmed publisher
Fang B, Zhao Q, Ling W, Zhang Y, Ou M. Hypoxia induces HT-22 neuronal cell death via Orai1/CDK5 pathway-mediated Tau hyperphosphorylation. Am J Transl Res. 2019;11:7591-7603 pubmed
Zhang B, Guo H, Yang W, Li M, Zou Y, Loor J, et al. Effects of ORAI calcium release-activated calcium modulator 1 (ORAI1) on neutrophil activity in dairy cows with subclinical hypocalcemia1. J Anim Sci. 2019;97:3326-3336 pubmed publisher
Abdelazeem K, Droppova B, Sukkar B, Al Maghout T, Pelzl L, Zacharopoulou N, et al. Upregulation of Orai1 and STIM1 expression as well as store-operated Ca2+ entry in ovary carcinoma cells by placental growth factor. Biochem Biophys Res Commun. 2019;512:467-472 pubmed publisher
Wu L, Zhang D, Zhou L, Pei Y, Zhuang Y, Cui W, et al. FUN14 domain-containing 1 promotes breast cancer proliferation and migration by activating calcium-NFATC1-BMI1 axis. EBioMedicine. 2019;41:384-394 pubmed publisher
Diercks B, Werner R, Weidemüller P, Czarniak F, Hernandez L, Lehmann C, et al. ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation. Sci Signal. 2018;11: pubmed publisher
Sukkar B, Hauser S, Pelzl L, Hosseinzadeh Z, Sahu I, Al Maghout T, et al. Inhibition of Lithium Sensitive Orai1/ STIM1 Expression and Store Operated Ca2+ Entry in Chorea-Acanthocytosis Neurons by NF-κB Inhibitor Wogonin. Cell Physiol Biochem. 2018;51:278-289 pubmed publisher
Bhattacharya A, Kumar J, Hermanson K, Sun Y, Qureshi H, Perley D, et al. The calcium channel proteins ORAI3 and STIM1 mediate TGF-? induced Snai1 expression. Oncotarget. 2018;9:29468-29483 pubmed publisher
Glosse P, Feger M, Mutig K, Chen H, Hirche F, Hasan A, et al. AMP-activated kinase is a regulator of fibroblast growth factor 23 production. Kidney Int. 2018;94:491-501 pubmed publisher
Nelson H, Leech C, Kopp R, Roe M. Interplay between ER Ca2+ Binding Proteins, STIM1 and STIM2, Is Required for Store-Operated Ca2+ Entry. Int J Mol Sci. 2018;19: pubmed publisher
Sharma A, Ramena G, Yin Y, PREMKUMAR L, Elble R. CLCA2 is a positive regulator of store-operated calcium entry and TMEM16A. PLoS ONE. 2018;13:e0196512 pubmed publisher
Zhu Z, Yu T, Liu H, Jin J, He J. SOCE induced calcium overload regulates autophagy in acute pancreatitis via calcineurin activation. Cell Death Dis. 2018;9:50 pubmed publisher
Zhang S, Al Maghout T, Bissinger R, Zeng N, Pelzl L, Salker M, et al. Epigallocatechin-3-gallate (EGCG) up-regulates miR-15b expression thus attenuating store operated calcium entry (SOCE) into murine CD4+ T cells and human leukaemic T cell lymphoblasts. Oncotarget. 2017;8:89500-89514 pubmed publisher
Inoh Y, Haneda A, Tadokoro S, Yokawa S, Furuno T. Cationic liposomes suppress intracellular calcium ion concentration increase via inhibition of PI3 kinase pathway in mast cells. Biochim Biophys Acta Biomembr. 2017;1859:2461-2466 pubmed publisher
El Najjar N, Kulkarni R, Nader N, Hodeify R, Machaca K. Effects of Hyperglycemia on Vascular Smooth Muscle Ca2+ Signaling. Biomed Res Int. 2017;2017:3691349 pubmed publisher
Sahu I, Pelzl L, Sukkar B, Fakhri H, Al Maghout T, Cao H, et al. NFAT5-sensitive Orai1 expression and store-operated Ca2+ entry in megakaryocytes. FASEB J. 2017;31:3439-3448 pubmed publisher
Huang W, Ren C, Huang G, Liu J, Liu W, Wang L, et al. Inhibition of store-operated Ca2+ entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate. Oncol Lett. 2017;13:921-929 pubmed publisher
Zhang B, Yan J, Umbach A, Fakhri H, Fajol A, Schmidt S, et al. NFκB-sensitive Orai1 expression in the regulation of FGF23 release. J Mol Med (Berl). 2016;94:557-66 pubmed publisher
MacGlashan D. Expression profiling of human basophils: modulation by cytokines and secretagogues. PLoS ONE. 2015;10:e0126435 pubmed publisher
product information
CatalogNo :
13130-1-AP
AntigenName :
ORAI1
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
ORAI calcium release-activated calcium modulator 1
Immunogen :
Recombinant Protein
Species :
human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
CRACM1, ORAI1, ORAI1 L1, ORAI1 L2, Orail L2, ORAT1, Protein orai 1, TMEM142A, Transmembrane protein 142A
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC015369
Category :
Binding Proteins;Immunology;Membrane Proteins;Transport/Trafficking;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:25 ; WB 1:800 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.