This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
PYCR1
catalog :
13108-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, western blot knockout validation
citations: 16
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; 1:1000; fig 2
  • immunohistochemistry - paraffin section; human; fig s5
Loayza Puch F, Rooijers K, Buil L, Zijlstra J, Oude Vrielink J, Lopes R, et al. Tumour-specific proline vulnerability uncovered by differential ribosome codon reading. Nature. 2016;530:490-4 pubmed publisher
  • western blot; mouse; loading ...; fig 2b
Escande Beillard N, Loh A, Saleem S, Kanata K, Hashimoto Y, Altunoglu U, et al. Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2. Neuron. 2020;107:82-94.e6 pubmed publisher
  • western blot; human; loading ...; fig 4a
Zaki M, Bhat G, Sultan T, Issa M, Jung H, Dikoglu E, et al. PYCR2 Mutations cause a lethal syndrome of microcephaly and failure to thrive. Ann Neurol. 2016;80:59-70 pubmed publisher
Liu Y, Mao C, Wang M, Liu N, Ouyang L, Liu S, et al. Cancer progression is mediated by proline catabolism in non-small cell lung cancer. Oncogene. 2020;: pubmed publisher
Ding Z, Ericksen R, Escande Beillard N, Lee Q, Loh A, Denil S, et al. Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis. J Hepatol. 2019;: pubmed publisher
Chen S, Yang X, Yu M, Wang Z, Liu B, Liu M, et al. SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism. Neoplasia. 2019;21:665-675 pubmed publisher
Hamanaka R, O Leary E, Witt L, Tian Y, Gökalp G, Meliton A, et al. Glutamine Metabolism is Required for Collagen Protein Synthesis in Lung Fibroblasts. Am J Respir Cell Mol Biol. 2019;: pubmed publisher
Guo L, Cui C, Zhang K, Wang J, Wang Y, Lu Y, et al. Kindlin-2 links mechano-environment to proline synthesis and tumor growth. Nat Commun. 2019;10:845 pubmed publisher
Huang Y, Chiang M, Ho C, Hung P, Hsu M, Lee T, et al. A Transcriptome Study of Progeroid Neurocutaneous Syndrome Reveals POSTN As a New Element in Proline Metabolic Disorder. Aging Dis. 2018;9:1043-1057 pubmed publisher
Ye Y, Wu Y, Wang J. Pyrroline-5-carboxylate reductase 1 promotes cell proliferation via inhibiting apoptosis in human malignant melanoma. Cancer Manag Res. 2018;10:6399-6407 pubmed publisher
Doğan S, Cerutti R, Benincá C, Brea Calvo G, Jacobs H, Zeviani M, et al. Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy. Cell Metab. 2018;28:764-775.e5 pubmed publisher
Hollinshead K, Munford H, Eales K, Bardella C, Li C, Escribano Gonzalez C, et al. Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis. Cell Rep. 2018;22:3107-3114 pubmed publisher
Kühl I, Miranda M, Atanassov I, Kuznetsova I, Hinze Y, Mourier A, et al. Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals. elife. 2017;6: pubmed publisher
Iyer S, Park M, Moons D, Kwan R, Liao J, Liu L, et al. Clusterin and Pycr1 alterations associate with strain and model differences in susceptibility to experimental pancreatitis. Biochem Biophys Res Commun. 2017;482:1346-1352 pubmed publisher
Jin H, Komita M, Koseki H, Aoe T. Sublethal endoplasmic reticulum stress caused by the mutation of immunoglobulin heavy chain-binding protein induces the synthesis of a mitochondrial protein, pyrroline-5-carboxylate reductase 1. Cell Stress Chaperones. 2017;22:77-85 pubmed publisher
Liu W, Hancock C, Fischer J, Harman M, Phang J. Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides. Sci Rep. 2015;5:17206 pubmed publisher
product information
CatalogNo :
13108-1-AP
AntigenName :
PYCR1
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
pyrroline-5-carboxylate reductase 1
Immunogen :
Recombinant Protein
Species :
human, mouse, rat, zebrafish
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
P5C, P5C reductase 1, P5CR, P5CR 1, PIG45, PP222, PYCR, PYCR1
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC022244
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Metabolism;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:50 ; IHC 1:200 ; IP 1:700 ; WB 1:1000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.