This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
G3BP1
catalog :
13057-2-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
citations: 46
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; rat; loading ...; fig 4f
  • immunocytochemistry; human; loading ...; fig s9a
Casci I, Krishnamurthy K, Kour S, Tripathy V, Ramesh N, Anderson E, et al. Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization. Nat Commun. 2019;10:5583 pubmed publisher
  • immunocytochemistry; mouse; 1:100; loading ...; fig e2a
Ries R, Zaccara S, Klein P, Olarerin George A, Namkoong S, Pickering B, et al. m6A enhances the phase separation potential of mRNA. Nature. 2019;571:424-428 pubmed publisher
  • immunocytochemistry; human; fig 1
  • immunocytochemistry; mouse; fig 1
Gal J, Kuang L, Barnett K, Zhu B, Shissler S, Korotkov K, et al. ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics. Acta Neuropathol. 2016;132:563-76 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 4d
Shiihashi G, Ito D, Yagi T, Nihei Y, Ebine T, Suzuki N. Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice. Brain. 2016;139:2380-94 pubmed publisher
  • immunocytochemistry; mouse; 1:500; fig 3
  • immunohistochemistry; mouse; 1:500; fig 6
  • western blot; mouse; 1:1000; fig 1
Rodriguez Ortiz C, Flores J, Valenzuela J, Rodriguez G, Zumkehr J, Tran D, et al. The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress. Am J Pathol. 2016;186:1623-34 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 1
Daigle J, Krishnamurthy K, Ramesh N, Casci I, Monaghan J, McAvoy K, et al. Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity. Acta Neuropathol. 2016;131:605-20 pubmed publisher
Rao L, Xu Y, Reineke L, Bhattacharya A, Tyryshkin A, Shin J, et al. Post-Transcriptional Regulation of Alpha One Antitrypsin by a Proteasome Inhibitor. Int J Mol Sci. 2020;21: pubmed publisher
Zhang Z, Sun W, Shi T, Lu P, Zhuang M, Liu J. Capturing RNA-protein interaction via CRUIS. Nucleic Acids Res. 2020;48:e52 pubmed publisher
Luotti S, Pasetto L, Porcu L, Torri V, Elezgarai S, Pantalone S, et al. Diagnostic and prognostic values of PBMC proteins in amyotrophic lateral sclerosis. Neurobiol Dis. 2020;139:104815 pubmed publisher
Zheng Y, Zhu G, Tang Y, Yan J, Han S, Yin J, et al. HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection. Front Microbiol. 2020;11:78 pubmed publisher
Zheng Y, Zhu G, Yan J, Tang Y, Han S, Yin J, et al. The Late Domain of Prototype Foamy Virus Gag Facilitates Autophagic Clearance of Stress Granules by Promoting Amphisome Formation. J Virol. 2020;94: pubmed publisher
Cheng J, Gao S, Zhu C, Liu S, Li J, Kang J, et al. Typical Stress Granule Proteins Interact with the 3' Untranslated Region of Enterovirus D68 To Inhibit Viral Replication. J Virol. 2020;94: pubmed publisher
Hu S, Sun H, Yin L, Li J, Mei S, Xu F, et al. PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing. Sci Signal. 2019;12: pubmed publisher
Liao Y, Fernandopulle M, Wang G, Choi H, Hao L, Drerup C, et al. RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether. Cell. 2019;179:147-164.e20 pubmed publisher
Gal J, Chen J, Na D, Tichacek L, Barnett K, Zhu H. The Acetylation of Lysine-376 of G3BP1 Regulates RNA Binding and Stress Granule Dynamics. Mol Cell Biol. 2019;39: pubmed publisher
Hicks D, Cross L, Williamson R, Rattray M. Endoplasmic Reticulum Stress Signalling Induces Casein Kinase 1-Dependent Formation of Cytosolic TDP-43 Inclusions in Motor Neuron-Like Cells. Neurochem Res. 2019;: pubmed publisher
Ukmar Godec T, Hutten S, Grieshop M, Rezaei Ghaleh N, Cima Omori M, Biernat J, et al. Lysine/RNA-interactions drive and regulate biomolecular condensation. Nat Commun. 2019;10:2909 pubmed publisher
Tischbein M, Baron D, Lin Y, Gall K, Landers J, Fallini C, et al. The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing. J Biol Chem. 2019;: pubmed publisher
Wang S, Kwon S, Su Y, Dong Z. Stress granules are formed in renal proximal tubular cells during metabolic stress and ischemic injury for cell survival. Am J Physiol Renal Physiol. 2019;317:F116-F123 pubmed publisher
Wang B, Maxwell B, Joo J, Gwon Y, Messing J, Mishra A, et al. ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97. Mol Cell. 2019;74:742-757.e8 pubmed publisher
Hoch Kraft P, Trotter J, Gonsior C. Missing in Action: Dysfunctional RNA Metabolism in Oligodendroglial Cells as a Contributor to Neurodegenerative Diseases?. Neurochem Res. 2019;: pubmed publisher
Mann J, Gleixner A, Mauna J, Gomes E, DeChellis Marks M, Needham P, et al. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. Neuron. 2019;102:321-338.e8 pubmed publisher
Baron D, Matheny T, Lin Y, Leszyk J, Kenna K, Gall K, et al. Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS. Hum Mol Genet. 2019;: pubmed publisher
Franchini D, Lanvin O, Tosolini M, Patras de Campaigno E, Cammas A, Péricart S, et al. Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells. Cell Rep. 2019;26:94-107.e7 pubmed publisher
Liu Z, Cai H, Xue W, Wang M, Xia T, Li W, et al. G3BP1 promotes DNA binding and activation of cGAS. Nat Immunol. 2019;20:18-28 pubmed publisher
Ye C, Yu Z, Xiong Y, Wang Y, Ruan Y, Guo Y, et al. STAU1 binds to IBDV genomic double-stranded RNA and promotes viral replication via attenuation of MDA5-dependent β interferon induction. FASEB J. 2019;33:286-300 pubmed publisher
Silva J, Rodrigues S, Sampaio Marques B, Gomes P, Neves Carvalho A, Dioli C, et al. Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology. Cell Death Differ. 2018;: pubmed publisher
Zhang X, Shu X, Qian S. O-GlcNAc modification of eIF4GI acts as a translational switch in heat shock response. Nat Chem Biol. 2018;14:909-916 pubmed publisher
Burgess H, Mohr I. Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS. J Virol. 2018;92: pubmed publisher
Ederle H, Funk C, Abou Ajram C, Hutten S, Funk E, Kehlenbach R, et al. Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1. Sci Rep. 2018;8:7084 pubmed publisher
Hofweber M, Hutten S, Bourgeois B, Spreitzer E, Niedner Boblenz A, Schifferer M, et al. Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation. Cell. 2018;173:706-719.e13 pubmed publisher
Ramachandran B, Stabley J, Cheng S, Behrmann A, Gay A, Li L, et al. A GTPase-activating protein-binding protein (G3BP1)/antiviral protein relay conveys arteriosclerotic Wnt signals in aortic smooth muscle cells. J Biol Chem. 2018;293:7942-7968 pubmed publisher
Herrmann A, Wittmann S, Thomas D, Shepard C, Kim B, Ferreirós N, et al. The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation. Mob DNA. 2018;9:11 pubmed publisher
Lee Y, Jonson P, Sarparanta J, Palmio J, Sarkar M, Vihola A, et al. TIA1 variant drives myodegeneration in multisystem proteinopathy with SQSTM1 mutations. J Clin Invest. 2018;128:1164-1177 pubmed publisher
Youn J, Dunham W, Hong S, Knight J, Bashkurov M, Chen G, et al. High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Mol Cell. 2018;69:517-532.e11 pubmed publisher
Mitsuhashi K, Ito D, Mashima K, Oyama M, Takahashi S, Suzuki N. De novo design of RNA-binding proteins with a prion-like domain related to ALS/FTD proteinopathies. Sci Rep. 2017;7:16871 pubmed publisher
Cifuentes Muñoz N, Branttie J, Slaughter K, Dutch R. Human Metapneumovirus Induces Formation of Inclusion Bodies for Efficient Genome Replication and Transcription. J Virol. 2017;91: pubmed publisher
Kuang L, Kamelgarn M, Arenas A, Gal J, Taylor D, Gong W, et al. Clinical and experimental studies of a novel P525R FUS mutation in amyotrophic lateral sclerosis. Neurol Genet. 2017;3:e172 pubmed publisher
Basu M, Courtney S, Brinton M. Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells. PLoS Pathog. 2017;13:e1006240 pubmed publisher
Reineke L, Tsai W, Jain A, Kaelber J, Jung S, Lloyd R. Casein Kinase 2 Is Linked to Stress Granule Dynamics through Phosphorylation of the Stress Granule Nucleating Protein G3BP1. Mol Cell Biol. 2017;37: pubmed publisher
Xia Q, Wang G, Wang H, Hu Q, Ying Z. Folliculin, a tumor suppressor associated with Birt-Hogg-Dubé (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation. Hum Mol Genet. 2016;25:83-96 pubmed publisher
Hu S, Li J, Xu F, Mei S, Le Duff Y, Yin L, et al. SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation. PLoS Genet. 2015;11:e1005367 pubmed publisher
Nielsen C, Østergaard O, Rekvig O, Sturfelt G, Jacobsen S, Heegaard N. Galectin-3 binding protein links circulating microparticles with electron dense glomerular deposits in lupus nephritis. Lupus. 2015;24:1150-60 pubmed publisher
Deng W, Yan M, Yu T, Ge H, Lin H, Li J, et al. Quantitative proteomic analysis of the metastasis-inhibitory mechanism of miR-193a-3p in non-small cell lung cancer. Cell Physiol Biochem. 2015;35:1677-88 pubmed publisher
Tao Z, Wang H, Xia Q, Li K, Li K, Jiang X, et al. Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity. Hum Mol Genet. 2015;24:2426-41 pubmed publisher
Yamakawa M, Ito D, Honda T, Kubo K, Noda M, Nakajima K, et al. Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS. Hum Mol Genet. 2015;24:1630-45 pubmed publisher
product information
CatalogNo :
13057-2-AP
AntigenName :
G3BP1
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
GTPase activating protein (SH3 domain) binding protein 1
Immunogen :
Recombinant Protein
Species :
human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, FC, CoIP, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
G3BP, G3BP 1, G3BP1, HDH VIII
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC006997
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Membrane Proteins;Metabolism;Stress Granule Marker;Transport/Trafficking;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
FC 1:1000 ; IF 1:200 ; IHC 1:200 ; IP 1:1000 ; WB 1:10000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.