This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
PDK4
catalog :
12949-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry
citations: 18
Reference
Qin Y, Lin T, Lin X, Liu Y, Zhao W, Li X, et al. Loss of PDK4 expression promotes proliferation, tumorigenicity, motility and invasion of hepatocellular carcinoma cells. J Cancer. 2020;11:4397-4405 pubmed publisher
Fukazawa A, Koike A, Karasawa T, Tsutsui M, Kondo S, Terada S. Effects of a Ketogenic Diet Containing Medium-Chain Triglycerides and Endurance Training on Metabolic Enzyme Adaptations in Rat Skeletal Muscle. Nutrients. 2020;12: pubmed publisher
Chen C, Luo F, Wu P, Huang Y, Das A, Chen S, et al. Metabolomics reveals metabolite changes of patients with pulmonary arterial hypertension in China. J Cell Mol Med. 2020;24:2484-2496 pubmed publisher
Wang L, Yu P, Zhou B, Song J, Li Z, Zhang M, et al. Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function. Nat Cell Biol. 2020;22:108-119 pubmed publisher
Jonus H, Byrnes C, Kim J, Valle M, Bartlett M, Said H, et al. Thiamine mimetics sulbutiamine and benfotiamine as a nutraceutical approach to anticancer therapy. Biomed Pharmacother. 2020;121:109648 pubmed publisher
Zhang Y, Zhou L, Zhang Z, Xu Q, Han X, Zhao Y, et al. Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5. Environ Sci Pollut Res Int. 2019;: pubmed publisher
Zhang Y, Wang S, Zhao T, Yang L, Guo S, Shi Y, et al. Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells. Ecotoxicol Environ Saf. 2019;184:109611 pubmed publisher
Liu Y, Sun L, Zheng L, Su M, Liu H, Wei Y, et al. Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction. Naunyn Schmiedebergs Arch Pharmacol. 2019;: pubmed publisher
Li Y, Pan H, Zhang X, Wang H, Liu S, Zhang H, et al. Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle. J Agric Food Chem. 2019;67:4483-4492 pubmed publisher
Fekir K, Dubois Pot Schneider H, Désert R, Daniel Y, Glaise D, Rauch C, et al. Retrodifferentiation of Human Tumor Hepatocytes to Stem Cells Leads to Metabolic Reprogramming and Chemoresistance. Cancer Res. 2019;79:1869-1883 pubmed publisher
Wang J, Qian Y, Gao M. Overexpression of PDK4 is associated with cell proliferation, drug resistance and poor prognosis in ovarian cancer. Cancer Manag Res. 2019;11:251-262 pubmed publisher
Li Y, Fan Y, Pan H, Qian H, Qi X, Wu G, et al. Effects of functional β-glucan on proliferation, differentiation, metabolism and its anti-fibrosis properties in muscle cells. Int J Biol Macromol. 2018;117:287-293 pubmed publisher
Zhang P, Song Y, Sun Y, Li X, Chen L, Yang L, et al. AMPK/GSK3β/β-catenin cascade-triggered overexpression of CEMIP promotes migration and invasion in anoikis-resistant prostate cancer cells by enhancing metabolic reprogramming. FASEB J. 2018;32:3924-3935 pubmed publisher
Liu X, Zuo R, Bao Y, Qu X, Sun K, Ying H. Down-regulation of PDK4 is Critical for the Switch of Carbohydrate Catabolism during Syncytialization of Human Placental Trophoblasts. Sci Rep. 2017;7:8474 pubmed publisher
Lin X, Qin Y, Jia J, Lin T, Lin X, Chen L, et al. MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice. PLoS Genet. 2016;12:e1006308 pubmed publisher
Li X, Liu Y, Ma H, Guan Y, Cao Y, Tian Y, et al. Enhancement of Glucose Metabolism via PGC-1? Participates in the Cardioprotection of Chronic Intermittent Hypobaric Hypoxia. Front Physiol. 2016;7:219 pubmed publisher
Jiang X, Ma H, Li C, Cao Y, Wang Y, Zhang Y, et al. Effects of neonatal dexamethasone administration on cardiac recovery ability under ischemia-reperfusion in 24-wk-old rats. Pediatr Res. 2016;80:128-35 pubmed publisher
Kemmerer M, Finkernagel F, Cavalcante M, Abdalla D, Müller R, Brüne B, et al. AMP-Activated Protein Kinase Interacts with the Peroxisome Proliferator-Activated Receptor Delta to Induce Genes Affecting Fatty Acid Oxidation in Human Macrophages. PLoS ONE. 2015;10:e0130893 pubmed publisher
product information
CatalogNo :
12949-1-AP
AntigenName :
PDK4
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
pyruvate dehydrogenase kinase, isozyme 4
Immunogen :
Recombinant Protein
Species :
human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
PDK4
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC040239
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Membrane Proteins;Metabolism;Signal transduction;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:50 ; IHC 1:200 ; WB 1:1500 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.