This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
CUL4B
catalog :
12916-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 21
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 3e
Han T, Goralski M, Gaskill N, Capota E, Kim J, Ting T, et al. Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science. 2017;356: pubmed publisher
  • western blot; human; 1:500; fig 1
Eichner R, Heider M, Fernández Sáiz V, van Bebber F, Garz A, Lemeer S, et al. Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity. Nat Med. 2016;22:735-43 pubmed publisher
Li T, Wu S, Jia L, Cao W, Yao Y, Zhao G, et al. CUL4 E3 ligase regulates the proliferation and apoptosis of lung squamous cell carcinoma and small cell lung carcinoma. Cancer Biol Med. 2020;17:357-370 pubmed publisher
Fu S, Hu M, Peng Y, Fang H, Hsiao C, Chen T, et al. CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy. Cells. 2020;9: pubmed publisher
Yu Q, Hu Z, Shen Y, Jiang Y, Pan P, Hou T, et al. Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes. Neoplasia. 2020;22:179-191 pubmed publisher
Jiang Y, Cheng W, Li L, Zhou L, Liang Y, Zhang W, et al. Effective targeting of the ubiquitin-like modifier NEDD8 for lung adenocarcinoma treatment. Cell Biol Toxicol. 2020;: pubmed publisher
Cui D, Dai X, Shu J, Ma Y, Wei D, Xiong X, et al. The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth. Cell Death Differ. 2019;: pubmed publisher
Sun S, Kelekar S, Kliewer S, Mangelsdorf D. The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation. Genes Dev. 2019;33:1083-1094 pubmed publisher
Zhou W, Ma L, Ding L, Guo Q, He Z, Yang J, et al. Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction. J Med Chem. 2019;62:5382-5403 pubmed publisher
Lai T, Hu M. Regulation of liver receptor homologue-1 by DDB2 E3 ligase activity is critical for hepatic glucose metabolism. Sci Rep. 2019;9:5304 pubmed publisher
Qi M, Hu J, Cui Y, Jiao M, Feng T, Li X, et al. CUL4B promotes prostate cancer progression by forming positive feedback loop with SOX4. Oncogenesis. 2019;8:23 pubmed publisher
Sun H, Zhang J, Xin S, Jiang M, Zhang J, Li Z, et al. Cul4-Ddb1 ubiquitin ligases facilitate DNA replication-coupled sister chromatid cohesion through regulation of cohesin acetyltransferase Esco2. PLoS Genet. 2019;15:e1007685 pubmed publisher
Nagai T, Mukoyama S, Kagiwada H, Goshima N, Mizuno K. Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation. J Cell Sci. 2018;131: pubmed publisher
Zhou W, Xu J, Tan M, Li H, Li H, Wei W, et al. UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F. Mol Cell. 2018;70:1008-1024.e6 pubmed publisher
Karim M, Yoshizawa T, Sobuz S, Sato Y, Yamagata K. Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4. Biochem Biophys Res Commun. 2017;490:423-428 pubmed publisher
Jia L, Yan F, Cao W, Chen Z, Zheng H, Li H, et al. Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer. J Biol Chem. 2017;292:2966-2978 pubmed publisher
Peng Y, Huang J, Wu H, Hsieh H, Wu C, Chen S, et al. Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90?. Sci Rep. 2016;6:32444 pubmed publisher
Yin Y, Liu L, Yang C, Lin C, Veith G, Wang C, et al. Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis. J Biol Chem. 2016;291:6923-35 pubmed publisher
Meng D, Yang S, Wan X, Zhang Y, Huang W, Zhao P, et al. A transcriptional target of androgen receptor, miR-421 regulates proliferation and metabolism of prostate cancer cells. Int J Biochem Cell Biol. 2016;73:30-40 pubmed publisher
Chen Y, Peng Y, Hu M, Huang J, Chien Y, Wu J, et al. The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels. Sci Rep. 2015;5:10667 pubmed publisher
Yamashita K, Ide M, Furukawa K, Suzuki A, Hirano H, Ohno S. Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex. Mol Biol Cell. 2015;26:2426-38 pubmed publisher
product information
CatalogNo :
12916-1-AP
AntigenName :
CUL4B
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
cullin 4B
Immunogen :
Recombinant Protein
Species :
dog, human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
CUL 4B, CUL4B, cullin 4B, KIAA0695, MRXHF2, MRXSC, SFM2
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC036216
Category :
Binding Proteins;Cell Cycle;Metabolism;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:25 ; IHC 1:100 ; IP 1:1000 ; WB 1:1000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.