| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry knockout validation; mouse; 1:150; loading ...; fig 1c
| Laclair K, Donde A, Ling J, Jeong Y, Chhabra R, Martin L, et al. Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model. Acta Neuropathol. 2016;132:859-873 pubmed |
- immunohistochemistry; human; loading ...; fig 1i
| Zhang P, Fan B, Yang P, Temirov J, Messing J, Kim H, et al. Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology. elife. 2019;8: pubmed publisher |
- western blot; human; loading ...; fig 4a
- immunohistochemistry - frozen section; mouse; loading ...; fig 7a
- western blot; mouse; loading ...; fig 4a, 4c
| Lee Y, Huang W, Lin J, Kao T, Lin H, Lee K, et al. Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology. J Biomed Sci. 2018;25:76 pubmed publisher |
- western blot; mouse; 1:2000; loading ...; fig 3a
| Maziuk B, Apicco D, Cruz A, Jiang L, Ash P, da Rocha E, et al. RNA binding proteins co-localize with small tau inclusions in tauopathy. Acta Neuropathol Commun. 2018;6:71 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 2e
| Becker L, Huang B, Bieri G, Ma R, Knowles D, Jafar Nejad P, et al. Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice. Nature. 2017;544:367-371 pubmed publisher |
- immunocytochemistry; mouse; fig 1b
- western blot; mouse; fig 1c
| Leal Lasarte M, Franco J, Labrador Garrido A, Pozo D, Roodveldt C. Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia. FASEB J. 2017;31:2797-2816 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 6g
| Boeynaems S, Bogaert E, Kovacs D, Konijnenberg A, Timmerman E, Volkov A, et al. Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics. Mol Cell. 2017;65:1044-1055.e5 pubmed publisher |
- western blot; human; 1:2500; loading ...; fig 5a
| Wobst H, Wesolowski S, Chadchankar J, Delsing L, Jacobsen S, Mukherjee J, et al. Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro. Front Mol Neurosci. 2017;10:46 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3s1
| Celona B, Dollen J, Vatsavayai S, Kashima R, Johnson J, Tang A, et al. Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106. elife. 2017;6: pubmed publisher |
- western blot; human; loading ...; fig 9f
| Suzuki H, Matsuoka M. The Lysosomal Trafficking Transmembrane Protein 106B Is Linked to Cell Death. J Biol Chem. 2016;291:21448-21460 pubmed |
- western blot; mouse; 1:1000; loading ...; fig 1b
| Shiihashi G, Ito D, Yagi T, Nihei Y, Ebine T, Suzuki N. Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice. Brain. 2016;139:2380-94 pubmed publisher |
- immunocytochemistry; mouse; 1:500; fig 3
- immunohistochemistry; mouse; 1:500; fig 6
- western blot; mouse; 1:1000; fig 1
| Rodriguez Ortiz C, Flores J, Valenzuela J, Rodriguez G, Zumkehr J, Tran D, et al. The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress. Am J Pathol. 2016;186:1623-34 pubmed publisher |
| Romano G, Klima R, Feiguin F. TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity. BMC Biol. 2020;18:82 pubmed publisher |
| Laclair K, Zhou Q, Michaelsen M, Wefers B, Brill M, Janjić A, et al. Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS. Acta Neuropathol. 2020;140:121-142 pubmed publisher |
| Pourhaghighi R, Ash P, Phanse S, Goebels F, Hu L, Chen S, et al. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Cell Syst. 2020;10:333-350.e14 pubmed publisher |
| Strah N, Romano G, Introna C, Klima R, Marzullo M, Ciapponi L, et al. TDP-43 promotes the formation of neuromuscular synapses through the regulation of Disc-large expression in Drosophila skeletal muscles. BMC Biol. 2020;18:34 pubmed publisher |
| Khosravi B, LaClair K, Riemenschneider H, Zhou Q, Frottin F, Mareljic N, et al. Cell-to-cell transmission of C9orf72 poly-(Gly-Ala) triggers key features of ALS/FTD. EMBO J. 2020;39:e102811 pubmed publisher |
| Tang F, Zhao L, Zhao Y, Sun D, Zhu X, Mei L, et al. Coupling of terminal differentiation deficit with neurodegenerative pathology in Vps35-deficient pyramidal neurons. Cell Death Differ. 2020;: pubmed publisher |
| Lanznaster D, Bourgeais J, Bruno C, Hergesheimer R, Thepault R, Vourc H P, et al. TDP-43-Mediated Toxicity in HEK293T Cells: A Fast and Reproducible Protocol To Be Employed in the Search of New Therapeutic Options against Amyotrophic Lateral Sclerosis. Cells. 2019;9: pubmed publisher |
| Yuva Aydemir Y, Almeida S, Krishnan G, Gendron T, Gao F. Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD. Nat Commun. 2019;10:5466 pubmed publisher |
| Suzuki H, Shibagaki Y, Hattori S, Matsuoka M. C9-ALS/FTD-linked proline-arginine dipeptide repeat protein associates with paraspeckle components and increases paraspeckle formation. Cell Death Dis. 2019;10:746 pubmed publisher |
| Deng Z, Lim J, Wang Q, Purtell K, Wu S, Palomo G, et al. ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway. Autophagy. 2019;:1-15 pubmed publisher |
| Donde A, Sun M, Ling J, Braunstein K, Pang B, Wen X, et al. Splicing repression is a major function of TDP-43 in motor neurons. Acta Neuropathol. 2019;: pubmed publisher |
| Sugai A, Kato T, Koyama A, Koike Y, Konno T, Ishihara T, et al. Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation. Neurobiol Dis. 2019;130:104534 pubmed publisher |
| Tsunemi T, Perez Rosello T, Ishiguro Y, Yoroisaka A, Jeon S, Hamada K, et al. Increased lysosomal exocytosis induced by lysosomal Ca2+ channel agonists protects human dopaminergic neurons from α-synuclein toxicity. J Neurosci. 2019;: pubmed publisher |
| Choi S, López González R, Krishnan G, Phillips H, Li A, Seeley W, et al. C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo. Nat Neurosci. 2019;22:851-862 pubmed publisher |
| Wang B, Maxwell B, Joo J, Gwon Y, Messing J, Mishra A, et al. ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97. Mol Cell. 2019;74:742-757.e8 pubmed publisher |
| Coudert L, Nonaka T, Bernard E, Hasegawa M, Schaeffer L, Leblanc P. Phosphorylated and aggregated TDP-43 with seeding properties are induced upon mutant Huntingtin (mHtt) polyglutamine expression in human cellular models. Cell Mol Life Sci. 2019;76:2615-2632 pubmed publisher |
| Gasset Rosa F, Lu S, Yu H, Chen C, Melamed Z, Guo L, et al. Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death. Neuron. 2019;102:339-357.e7 pubmed publisher |
| Mann J, Gleixner A, Mauna J, Gomes E, DeChellis Marks M, Needham P, et al. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. Neuron. 2019;102:321-338.e8 pubmed publisher |
| Zhang Y, Guo L, Gonzales P, Gendron T, Wu Y, Jansen West K, et al. Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity. Science. 2019;363: pubmed publisher |
| Masaki K, Sonobe Y, Ghadge G, Pytel P, Roos R. TDP-43 proteinopathy in Theiler's murine encephalomyelitis virus infection. PLoS Pathog. 2019;15:e1007574 pubmed publisher |
| Fourier A, Escal J, Bernard E, Lachman I, Perret Liaudet A, Leblanc P, et al. Development of an automated capillary nano-immunoassay-Simple Western assay-to quantify total TDP43 protein in human platelet samples. Anal Bioanal Chem. 2019;411:267-275 pubmed publisher |
| Ash P, Dhawan U, Boudeau S, Lei S, Carlomagno Y, Knobel M, et al. Heavy Metal Neurotoxicants Induce ALS-Linked TDP-43 Pathology. Toxicol Sci. 2019;167:105-115 pubmed publisher |
| Jeon G, Shim Y, Lee D, Kim J, Kang M, Ahn S, et al. Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations. Mol Neurobiol. 2019;56:2007-2021 pubmed publisher |
| Vogler T, Wheeler J, Nguyen E, Hughes M, Britson K, Lester E, et al. TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle. Nature. 2018;563:508-513 pubmed publisher |
| Liu C, Leng B, Li Y, Jiang H, Duan W, Guo Y, et al. Diallyl Trisulfide Protects Motor Neurons from the Neurotoxic Protein TDP-43 via Activating Lysosomal Degradation and the Antioxidant Response. Neurochem Res. 2018;43:2304-2312 pubmed publisher |
| Suzuki H, Shibagaki Y, Hattori S, Matsuoka M. The proline-arginine repeat protein linked to C9-ALS/FTD causes neuronal toxicity by inhibiting the DEAD-box RNA helicase-mediated ribosome biogenesis. Cell Death Dis. 2018;9:975 pubmed publisher |
| Cicardi M, Cristofani R, Rusmini P, Meroni M, Ferrari V, Vezzoli G, et al. Tdp-25 Routing to Autophagy and Proteasome Ameliorates its Aggregation in Amyotrophic Lateral Sclerosis Target Cells. Sci Rep. 2018;8:12390 pubmed publisher |
| Clemen C, Winter L, Strucksberg K, Berwanger C, Türk M, Kornblum C, et al. The heterozygous R155C VCP mutation: Toxic in humans! Harmless in mice?. Biochem Biophys Res Commun. 2018;503:2770-2777 pubmed publisher |
| Kasu Y, Alemu S, Lamari A, Loew N, Brower C. The N Termini of TAR DNA-Binding Protein 43 (TDP43) C-Terminal Fragments Influence Degradation, Aggregation Propensity, and Morphology. Mol Cell Biol. 2018;38: pubmed publisher |
| Salvatori I, Ferri A, Scaricamazza S, Giovannelli I, Serrano A, Rossi S, et al. Differential toxicity of TAR DNA-binding protein 43 isoforms depends on their submitochondrial localization in neuronal cells. J Neurochem. 2018;146:585-597 pubmed publisher |
| Wang K, Qu X, Liu S, Yang X, Bie F, Wang Y, et al. Identification of aberrantly expressed F-box proteins in squamous-cell lung carcinoma. J Cancer Res Clin Oncol. 2018;144:1509-1521 pubmed publisher |
| Maucuer A, Desforges B, Joshi V, Boca M, Kretov D, Hamon L, et al. Microtubules as platforms for probing liquid-liquid phase separation in cells - application to RNA-binding proteins. J Cell Sci. 2018;131: pubmed publisher |
| Bennett C, Dastidar S, Ling S, Malik B, Ashe T, Wadhwa M, et al. Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients. Acta Neuropathol. 2018;136:425-443 pubmed publisher |
| Mackenzie I, Nicholson A, Sarkar M, Messing J, Purice M, Pottier C, et al. TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. Neuron. 2017;95:808-816.e9 pubmed publisher |
| Prudencio M, Gonzales P, Cook C, Gendron T, Daughrity L, Song Y, et al. Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients. Hum Mol Genet. 2017;26:3421-3431 pubmed publisher |
| Osuru H, Pramoonjago P, Abhyankar M, Swanson E, Roker L, Cathro H, et al. Immunolocalization of TAR DNA-binding protein of 43?kDa (TDP-43) in mouse seminiferous epithelium. Mol Reprod Dev. 2017;84:675-685 pubmed publisher |
| Zhuang J, Wen X, Zhang Y, Shan Q, Zhang Z, Zheng G, et al. TDP-43 upregulation mediated by the NLRP3 inflammasome induces cognitive impairment in 2 2',4,4'-tetrabromodiphenyl ether (BDE-47)-treated mice. Brain Behav Immun. 2017;65:99-110 pubmed publisher |
| Wobst H, Delsing L, Brandon N, Moss S. Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant. PLoS ONE. 2017;12:e0177181 pubmed publisher |
| Ash P, Stanford E, Al Abdulatif A, Ramirez Cardenas A, Ballance H, Boudeau S, et al. Dioxins and related environmental contaminants increase TDP-43 levels. Mol Neurodegener. 2017;12:35 pubmed publisher |
| Schludi M, Becker L, Garrett L, Gendron T, Zhou Q, Schreiber F, et al. Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss. Acta Neuropathol. 2017;134:241-254 pubmed publisher |
| Ditsworth D, Maldonado M, McAlonis Downes M, Sun S, Seelman A, Drenner K, et al. Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis. Acta Neuropathol. 2017;133:907-922 pubmed publisher |
| Jeong Y, Ling J, Lin S, Donde A, Braunstein K, Majounie E, et al. Tdp-43 cryptic exons are highly variable between cell types. Mol Neurodegener. 2017;12:13 pubmed publisher |
| Manghera M, Ferguson Parry J, Douville R. TDP-43 regulates endogenous retrovirus-K viral protein accumulation. Neurobiol Dis. 2016;94:226-36 pubmed publisher |
| Wang G, Yang H, Yan S, Wang C, Liu X, Zhao B, et al. Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain. Mol Neurodegener. 2015;10:42 pubmed publisher |
| Chou C, Alexeeva O, Yamada S, Pribadi A, Zhang Y, Mo B, et al. PABPN1 suppresses TDP-43 toxicity in ALS disease models. Hum Mol Genet. 2015;24:5154-73 pubmed publisher |
| Goossens J, Vanmechelen E, Trojanowski J, Lee V, Van Broeckhoven C, van der Zee J, et al. TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies. Acta Neuropathol Commun. 2015;3:15 pubmed publisher |
| Paré B, Touzel Deschênes L, Lamontagne R, Lamarre M, Scott F, Khuong H, et al. Early detection of structural abnormalities and cytoplasmic accumulation of TDP-43 in tissue-engineered skins derived from ALS patients. Acta Neuropathol Commun. 2015;3:5 pubmed publisher |
| Raitano S, Ordovas L, De Muynck L, Guo W, Espuny Camacho I, Geraerts M, et al. Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia. Stem Cell Reports. 2015;4:16-24 pubmed publisher |
| Suzuki H, Matsuoka M. Overexpression of nuclear FUS induces neuronal cell death. Neuroscience. 2015;287:113-24 pubmed publisher |
| Han H, Wei W, Duan W, Guo Y, Li Y, Wang J, et al. Autophagy-linked FYVE protein (Alfy) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS). In Vitro Cell Dev Biol Anim. 2015;51:249-63 pubmed publisher |
| Suzuki H, Shibagaki Y, Hattori S, Matsuoka M. Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs. Hum Mol Genet. 2015;24:1513-27 pubmed publisher |
