This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
CP110
catalog :
12780-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
citations: 64
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:200; loading ...; fig 1d, 4b
  • western blot; human; 1:500; loading ...; fig 4a, s4k
Huang N, Zhang D, Li F, Chai P, Wang S, Teng J, et al. M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole. Nat Commun. 2018;9:4511 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 1b
  • western blot; human; 1:1000; loading ...; fig 1b
Li X, Song N, Liu L, Liu X, Ding X, Song X, et al. USP9X regulates centrosome duplication and promotes breast carcinogenesis. Nat Commun. 2017;8:14866 pubmed publisher
  • immunocytochemistry; human; 1:1000; loading ...; fig 1b
Wolf B, Diop F, Ferraris P, Wichit S, Busso C, Missé D, et al. Zika virus causes supernumerary foci with centriolar proteins and impaired spindle positioning. Open Biol. 2017;7: pubmed publisher
  • immunocytochemistry; human; 1:1000; loading ...; fig 3a
Fournier M, Orpinell M, Grauffel C, Scheer E, Garnier J, Ye T, et al. KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification. Nat Commun. 2016;7:13227 pubmed publisher
Yoshida S, Aoki K, Fujiwara K, Nakakura T, Kawamura A, Yamada K, et al. The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis. elife. 2020;9: pubmed publisher
Bozal Basterra L, Gonzalez Santamarta M, Muratore V, Bermejo Arteagabeitia A, Da Fonseca C, Barroso Gomila O, et al. LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome. elife. 2020;9: pubmed publisher
Kodani A, Kenny C, Lai A, Gonzalez D, Stronge E, Sejourne G, et al. Posterior Neocortex-Specific Regulation of Neuronal Migration by CEP85L Identifies Maternal Centriole-Dependent Activation of CDK5. Neuron. 2020;106:246-255.e6 pubmed publisher
Chinen T, Yamamoto S, Takeda Y, Watanabe K, Kuroki K, Hashimoto K, et al. NuMA assemblies organize microtubule asters to establish spindle bipolarity in acentrosomal human cells. EMBO J. 2020;39:e102378 pubmed publisher
Flynn M, Whitton L, Donohoe G, Morrison C, Morris D. Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function. Hum Mol Genet. 2019;: pubmed publisher
Xie S, Farmer T, Naslavsky N, Caplan S. MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium. J Cell Sci. 2019;132: pubmed publisher
Khouj E, Prosser S, Tada H, Chong W, Liao J, Sugasawa K, et al. Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair. J Cell Sci. 2019;132: pubmed publisher
Lo C, Lin I, Yang T, Huang Y, Tanos B, Chou P, et al. Phosphorylation of CEP83 by TTBK2 is necessary for cilia initiation. J Cell Biol. 2019;218:3489-3505 pubmed publisher
Li M, Xu X, Zhang J, Liu M, Wang W, Gao Y, et al. NudC-like protein 2 restrains centriole amplification by stabilizing HERC2. Cell Death Dis. 2019;10:628 pubmed publisher
Frikstad K, Molinari E, Thoresen M, Ramsbottom S, Hughes F, Letteboer S, et al. A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling. Cell Rep. 2019;28:1907-1922.e6 pubmed publisher
Wolf B, Busso C, GONCZY P. Live imaging screen reveals that TYRO3 and GAK ensure accurate spindle positioning in human cells. Nat Commun. 2019;10:2859 pubmed publisher
So C, Seres K, Steyer A, Mönnich E, Clift D, Pejkovska A, et al. A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes. Science. 2019;364: pubmed publisher
Walia V, Cuenca A, Vetter M, Insinna C, Perera S, Lu Q, et al. Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis. Dev Cell. 2019;: pubmed publisher
Yoshiba S, Tsuchiya Y, Ohta M, Gupta A, Shiratsuchi G, Nozaki Y, et al. HsSAS-6-dependent cartwheel assembly ensures stabilization of centriole intermediates. J Cell Sci. 2019;: pubmed publisher
Clijsters L, Hoencamp C, Calis J, Marzio A, Handgraaf S, Cuitino M, et al. Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs. Mol Cell. 2019;74:1264-1277.e7 pubmed publisher
Odabasi E, Gül S, Kavakli I, Firat Karalar E. Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation. EMBO Rep. 2019;20: pubmed publisher
Yamamoto S, Kitagawa D. Self-organization of Plk4 regulates symmetry breaking in centriole duplication. Nat Commun. 2019;10:1810 pubmed publisher
Tsai J, Hsu W, Liu J, Chang C, Tang T. CEP120 interacts with C2CD3 and Talpid3 and is required for centriole appendage assembly and ciliogenesis. Sci Rep. 2019;9:6037 pubmed publisher
Mao H, Tang Z, Li H, Sun B, Tan M, Fan S, et al. Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1. Protein Cell. 2019;: pubmed publisher
Watanabe K, Takao D, Ito K, Takahashi M, Kitagawa D. The Cep57-pericentrin module organizes PCM expansion and centriole engagement. Nat Commun. 2019;10:931 pubmed publisher
Insinna C, Lu Q, Teixeira I, Harned A, Semler E, Stauffer J, et al. Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport. Nat Commun. 2019;10:428 pubmed publisher
Tu H, Qin X, Liu Z, Song Z, Hu H, Zhang Y, et al. Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis. Nat Commun. 2018;9:5277 pubmed publisher
Ling H, Peng L, Wang J, Rahhal R, Seto E. Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication. Cell Rep. 2018;25:2851-2865.e3 pubmed publisher
Fong C, Ozaki K, Tsou M. PPP1R35 ensures centriole homeostasis by promoting centriole-to-centrosome conversion. Mol Biol Cell. 2018;29:2801-2808 pubmed publisher
Gavilan M, Gandolfo P, Balestra F, Arias F, Bornens M, Rios R. The dual role of the centrosome in organizing the microtubule network in interphase. EMBO Rep. 2018;19: pubmed publisher
Sydor A, Coyaud E, Rovelli C, Laurent E, Liu H, Raught B, et al. PPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTN. elife. 2018;7: pubmed publisher
Vishnoi M, Boral D, Liu H, Sprouse M, Yin W, Goswami Sewell D, et al. Targeting USP7 Identifies a Metastasis-Competent State within Bone Marrow-Resident Melanoma CTCs. Cancer Res. 2018;78:5349-5362 pubmed publisher
Weng R, Yang T, Huang C, Chang C, Wang W, Liao J. Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening. Biophys J. 2018;115:263-275 pubmed publisher
Barny I, Perrault I, Michel C, Soussan M, Goudin N, Rio M, et al. Basal exon skipping and nonsense-associated altered splicing allows bypassing complete CEP290 loss-of-function in individuals with unusually mild retinal disease. Hum Mol Genet. 2018;: pubmed publisher
Chen Z, Li Y, Wang Z, Li M, Lim H, Zhou Y, et al. Aberrant epithelial remodeling with impairment of cilia architecture in non-cystic fibrosis bronchiectasis. J Thorac Dis. 2018;10:1753-1764 pubmed publisher
Ott C, Nachmias D, Adar S, Jarnik M, Sherman S, Birnbaum R, et al. VPS4 is a dynamic component of the centrosome that regulates centrosome localization of γ-tubulin, centriolar satellite stability and ciliogenesis. Sci Rep. 2018;8:3353 pubmed publisher
Ogungbenro Y, Tena T, Gaboriau D, Lalor P, Dockery P, Philipp M, et al. Centrobin controls primary ciliogenesis in vertebrates. J Cell Biol. 2018;217:1205-1215 pubmed publisher
Bozal Basterra L, Martín Ruiz I, Pirone L, Liang Y, Sigurðsson J, Gonzalez Santamarta M, et al. Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome. Am J Hum Genet. 2018;102:249-265 pubmed publisher
Lee S, Joo K, Jung E, Hong H, Seo J, Kim J. Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1. FASEB J. 2018;32:957-968 pubmed publisher
Agbu S, Liang Y, Liu A, Anderson K. The small GTPase RSG1 controls a final step in primary cilia initiation. J Cell Biol. 2018;217:413-427 pubmed publisher
Wang J, Kong D, Hoerner C, Loncarek J, Stearns T. Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells. elife. 2017;6: pubmed publisher
Cosenza M, Cazzola A, Rossberg A, Schieber N, Konotop G, Bausch E, et al. Asymmetric Centriole Numbers at Spindle Poles Cause Chromosome Missegregation in Cancer. Cell Rep. 2017;20:1906-1920 pubmed publisher
Chen H, Wu C, Tang C, Lin Y, Wang W, Tang T. Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles. Nat Commun. 2017;8:247 pubmed publisher
Hamel V, Steib E, Hamelin R, Armand F, Borgers S, Flückiger I, et al. Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis. Curr Biol. 2017;27:2486-2498.e6 pubmed publisher
Loukil A, Tormanen K, Sütterlin C. The daughter centriole controls ciliogenesis by regulating Neurl-4 localization at the centrosome. J Cell Biol. 2017;216:1287-1300 pubmed publisher
Nechipurenko I, Olivier Mason A, Kazatskaya A, Kennedy J, McLachlan I, Heiman M, et al. A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis. Dev Cell. 2016;38:493-506 pubmed publisher
Walentek P, Quigley I, Sun D, Sajjan U, Kintner C, Harland R. Ciliary transcription factors and miRNAs precisely regulate Cp110 levels required for ciliary adhesions and ciliogenesis. elife. 2016;5: pubmed publisher
Tsuchiya Y, Yoshiba S, Gupta A, Watanabe K, Kitagawa D. Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole. Nat Commun. 2016;7:12567 pubmed publisher
Zhao X, Jin M, Wang M, Sun L, Hong X, Cao Y, et al. Fidgetin-like 1 is a ciliogenesis-inhibitory centrosome protein. Cell Cycle. 2016;15:2367-75 pubmed publisher
Lee S, Lee M, Choi T, Hong H, Seo J, Kim C, et al. MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment. Sci Rep. 2016;6:27284 pubmed publisher
Chang C, Hsu W, Tsai J, Tang C, Tang T. CEP295 interacts with microtubules and is required for centriole elongation. J Cell Sci. 2016;129:2501-13 pubmed publisher
Cortés C, McInerney Leo A, Vogel I, Rondón Galeano M, Leo P, Harris J, et al. Mutations in human C2CD3 cause skeletal dysplasia and provide new insights into phenotypic and cellular consequences of altered C2CD3 function. Sci Rep. 2016;6:24083 pubmed publisher
Hilbert M, Noga A, Frey D, Hamel V, Guichard P, Kraatz S, et al. SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture. Nat Cell Biol. 2016;18:393-403 pubmed publisher
Yadav S, Sharma N, Liu C, Dong L, Li T, Swaroop A. Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis. Development. 2016;143:1491-501 pubmed publisher
Stinchcombe J, Randzavola L, Angus K, Mantell J, Verkade P, Griffiths G. Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis. Curr Biol. 2015;25:3239-44 pubmed publisher
Srinivas V, Kitagawa M, Wong J, Liao P, Lee S. The Tumor Suppressor Cdkn3 Is Required for Maintaining the Proper Number of Centrosomes by Regulating the Centrosomal Stability of Mps1. Cell Rep. 2015;13:1569-77 pubmed publisher
Zhang Y, Wang Y, Wei Y, Li M, Yu S, Ye M, et al. MiR-129-3p promotes docetaxel resistance of breast cancer cells via CP110 inhibition. Sci Rep. 2015;5:15424 pubmed publisher
Hu S, Lu Y, Orr B, Godek K, Mustachio L, Kawakami M, et al. Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown. Mol Cancer Ther. 2015;14:2576-85 pubmed publisher
Kodani A, Yu T, Johnson J, Jayaraman D, Johnson T, Al Gazali L, et al. Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. elife. 2015;4: pubmed publisher
Ran J, Yang Y, Li D, Liu M, Zhou J. Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly. Sci Rep. 2015;5:12917 pubmed publisher
Hong H, Kim J, Kim J. Myosin heavy chain 10 (MYH10) is required for centriole migration during the biogenesis of primary cilia. Biochem Biophys Res Commun. 2015;461:180-5 pubmed publisher
Prosser S, Morrison C. Centrin2 regulates CP110 removal in primary cilium formation. J Cell Biol. 2015;208:693-701 pubmed publisher
Miyamoto T, Hosoba K, Ochiai H, Royba E, Izumi H, Sakuma T, et al. The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation. Cell Rep. 2015;10:664-673 pubmed publisher
Bangs F, Schrode N, Hadjantonakis A, Anderson K. Lineage specificity of primary cilia in the mouse embryo. Nat Cell Biol. 2015;17:113-22 pubmed publisher
Pagan J, Marzio A, Jones M, Saraf A, Jallepalli P, Florens L, et al. Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. Nat Cell Biol. 2015;17:31-43 pubmed publisher
product information
CatalogNo :
12780-1-AP
AntigenName :
CP110
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
CP110 protein
Immunogen :
Recombinant Protein
Species :
dog, human, mouse, rat, xenopus
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, FC, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
Centrosomal protein of 110 kDa, CP110, CP110 protein, KIAA0419
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC036654
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Organelle Marker;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
FC 1:0 ; IF 1:50 ; IHC 1:200 ; IP 1:1000 ; WB 1:1500 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.