SAMHD1 | Proteintech Group 12586-1-AP product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Proteintech Group

product type :

antibody

product name :

SAMHD1

catalog :

12586-1-AP

quantity :

150UL

price :

299 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, western blot knockout validation

citations: 29

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; human; 1:1000; loading ...; fig 2a immunohistochemistry; human; 1:3000; loading ...; fig 4d	Schneider C, Oellerich T, Baldauf H, Schwarz S, Thomas D, Flick R, et al. SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia. Nat Med. 2017;23:250-255 pubmed publisher
immunohistochemistry - paraffin section; human; 2000 ng/ml; loading ...; fig 2d	Herold N, Rudd S, Ljungblad L, Sanjiv K, Myrberg I, Paulin C, et al. Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies. Nat Med. 2017;23:256-263 pubmed publisher
	Li Z, Huan C, Wang H, Liu Y, Liu X, Su X, et al. TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity. EMBO Rep. 2020;21:e47528 pubmed publisher
	Bergez M, Weber J, Riess M, Erdbeer A, Seifried J, Stanke N, et al. Insights into Innate Sensing of Prototype Foamy Viruses in Myeloid Cells. Viruses. 2019;11: pubmed publisher
	Businger R, Deutschmann J, Gruska I, Milbradt J, Wiebusch L, Gramberg T, et al. Human cytomegalovirus overcomes SAMHD1 restriction in macrophages via pUL97. Nat Microbiol. 2019;4:2260-2272 pubmed publisher
	Sliva K, Martin J, von Rhein C, Herrmann T, Weyrich A, Toda M, et al. Interference with SAMHD1 Restores Late Gene Expression of Modified Vaccinia Virus Ankara in Human Dendritic Cells and Abrogates Type I Interferon Expression. J Virol. 2019;93: pubmed publisher
	Osei Kuffour E, König R, Haussinger D, Schulz W, Munk C. ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53. MBio. 2019;10: pubmed publisher
	Oellerich T, Schneider C, Thomas D, Knecht K, Buzovetsky O, Kaderali L, et al. Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML. Nat Commun. 2019;10:3475 pubmed publisher
	Shakya A, O Callaghan D, Kim S. Interferon Gamma Inhibits Varicella-Zoster Virus Replication in a Cell Line-Dependent Manner. J Virol. 2019;93: pubmed publisher
	Bejarano D, Puertas M, Börner K, Martinez Picado J, Muller B, Kräusslich H. Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human Macrophages. Viruses. 2018;10: pubmed publisher
	Rassidakis G, Herold N, Myrberg I, Tsesmetzis N, Rudd S, Henter J, et al. Low-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens. Blood Cancer J. 2018;8:98 pubmed publisher
	Knecht K, Buzovetsky O, Schneider C, Thomas D, Srikanth V, Kaderali L, et al. The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1. Proc Natl Acad Sci U S A. 2018;115:E10022-E10031 pubmed publisher
	Osei Kuffour E, Schott K, Jaguva Vasudevan A, Holler J, Schulz W, Lang P, et al. USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1. J Virol. 2018;92: pubmed publisher
	Tramentozzi E, Ferraro P, Hossain M, Stillman B, Bianchi V, Pontarin G. The dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592. Cell Cycle. 2018;17:1102-1114 pubmed publisher
	Medeiros A, Soares C, Coelho P, Vieira N, Baqui M, Teixeira F, et al. DNA damage response signaling does not trigger redistribution of SAMHD1 to nuclear foci. Biochem Biophys Res Commun. 2018;499:790-796 pubmed publisher
	Shi B, Sharifi H, DiGrigoli S, Kinnetz M, Mellon K, Hu W, et al. Inhibition of HIV early replication by the p53 and its downstream gene p21. Virol J. 2018;15:53 pubmed publisher
	Bolduan S, Koppensteiner H, Businger R, Rebensburg S, Kunze C, Brack Werner R, et al. T cells with low CD2 levels express reduced restriction factors and are preferentially infected in therapy naïve chronic HIV-1 patients. J Int AIDS Soc. 2017;20:21865 pubmed publisher
	Badia R, Pujantell M, Torres Torronteras J, MenÃ©ndez Arias L, MartÃ R, Ruzo A, et al. SAMHD1 is active in cycling cells permissive to HIV-1 infection. Antiviral Res. 2017;142:123-135 pubmed publisher
	Baldauf H, Stegmann L, Schwarz S, Ambiel I, Trotard M, Martin M, et al. Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells. Proc Natl Acad Sci U S A. 2017;114:2729-2734 pubmed publisher
	Fu W, Qiu C, Zhou M, Zhu L, Yang Y, Qiu C, et al. Immune Activation Influences SAMHD1 Expression and Vpx-mediated SAMHD1 Degradation during Chronic HIV-1 Infection. Sci Rep. 2016;6:38162 pubmed publisher
	Riess M, Fuchs N, Idica A, Hamdorf M, Flory E, Pedersen I, et al. Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a. J Biol Chem. 2017;292:264-277 pubmed publisher
	Sommer A, RiviÃ¨re L, Qu B, Schott K, Riess M, Ni Y, et al. Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle. Sci Rep. 2016;6:26616 pubmed publisher
	de Castro Amarante M, Pise Masison C, McKinnon K, Washington Parks R, Galli V, Omsland M, et al. Human T Cell Leukemia Virus Type 1 Infection of the Three Monocyte Subsets Contributes to Viral Burden in Humans. J Virol. 2015;90:2195-207 pubmed publisher
	Zhu M, Lu J, Dong X, Zheng N, Li T, Chen Z, et al. Interferon-stimulated gene factor 3 complex is required for the induction of sterile Î± motif and HD domain-containing protein 1 expression by interferon-Î± in SMMC-7721 cells. Mol Med Rep. 2015;12:7176-80 pubmed publisher
	Witkowski W, Vermeire J, Landi A, Naessens E, Vanderstraeten H, Nauwynck H, et al. Vpx-Independent Lentiviral Transduction and shRNA-Mediated Protein Knock-Down in Monocyte-Derived Dendritic Cells. PLoS ONE. 2015;10:e0133651 pubmed publisher
	Shingai M, Welbourn S, Brenchley J, Acharya P, Miyagi E, Plishka R, et al. The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells. PLoS Pathog. 2015;11:e1004928 pubmed publisher
	Schmidt S, Schenkova K, Adam T, Erikson E, Lehmann Koch J, Sertel S, et al. SAMHD1's protein expression profile in humans. J Leukoc Biol. 2015;98:5-14 pubmed publisher
	Chauveau L, Puigdomènech I, Ayinde D, Roesch F, Porrot F, Bruni D, et al. HIV-2 infects resting CD4+ T cells but not monocyte-derived dendritic cells. Retrovirology. 2015;12:2 pubmed publisher
	Kretschmer S, Wolf C, König N, Staroske W, Guck J, Hausler M, et al. SAMHD1 prevents autoimmunity by maintaining genome stability. Ann Rheum Dis. 2015;74:e17 pubmed publisher

product information

CatalogNo :

12586-1-AP

AntigenName :

SAMHD1

Package :

150UL

Price :

299 USD

Exsists20ul :

20ul trial size available

FullName :

SAM domain and HD domain 1

Immunogen :

Recombinant Protein

Species :

human, monkey, mouse, rat

Host :

Rabbit

IsConjugated :

Unconjugated

AntigenSpecies :

human

Application :

WB, IP, IHC, IF, FC, ELISA

Clonlity :

Polyclonal

IsoType :

IgG

Synonyms :

DCIP, HDDC1, Monocyte protein 5, MOP 5, MOP5, SAM domain and HD domain 1, SAMHD1, SBBI88

PrimaryOrSecondary :

Primary

AntibodyBuffer :

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

GenBankNo :

BC036450

Category :

Cytoskeleton/Scaffold Proteins;Immunology;Metabolism;

PurifyMethod :

Antigen affinity purification

NewAb :

False

IsSellable :

True

Feature :

siRNA

AppTiter :

FC 1:0 ; IF 1:50 ; IHC 1:200 ; IP 1:300 ; WB 1:1000 ;