This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
SMAD2
catalog :
12570-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 43
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 6
Chen X, Kong X, Liu D, Gao P, Zhang Y, Li P, et al. In vitro differentiation of endometrial regenerative cells into smooth muscle cells: ? potential approach for the management of pelvic organ prolapse. Int J Mol Med. 2016;38:95-104 pubmed publisher
Li Y, Yang J, Zhang X, Liu H, Guo J. KDM6A suppresses hepatocellular carcinoma cell proliferation by negatively regulating the TGF-β/SMAD signaling pathway. Exp Ther Med. 2020;20:2774-2782 pubmed publisher
Zheng S, Wan L, Ge D, Jiang F, Qian Z, Tang J, et al. LINC00266-1/miR-548c-3p/SMAD2 feedback loop stimulates the development of osteosarcoma. Cell Death Dis. 2020;11:576 pubmed publisher
Zhou X, Liu Z, Ying K, Wang H, Liu P, Ji X, et al. WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling. Oxid Med Cell Longev. 2020;2020:7950457 pubmed publisher
Su C, Wang Q, Luo H, Jiao W, Tang J, Li L, et al. Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-β1 pathway and interfering with MMP-TIMPs expression. Biomed Pharmacother. 2020;127:110132 pubmed publisher
Xu S, Mao Y, Wu J, Feng J, Li J, Wu L, et al. TGF-β/Smad and JAK/STAT pathways are involved in the anti-fibrotic effects of propylene glycol alginate sodium sulphate on hepatic fibrosis. J Cell Mol Med. 2020;24:5224-5237 pubmed publisher
Shao Q, Jiang C, Xia Y, Zhao M, Zhang Q, Jin B, et al. Dioscin ameliorates peritoneal fibrosis by inhibiting epithelial-to-mesenchymal transition of human peritoneal mesothelial cells via the TLR4/MyD88/NF-κB signaling pathway. Int J Clin Exp Pathol. 2019;12:867-875 pubmed
Tran B, Yu Y, Chang L, Tan B, Jia W, Xiong Y, et al. A Novel Liposomal S-Propargyl-Cysteine: A Sustained Release of Hydrogen Sulfide Reducing Myocardial Fibrosis via TGF-β1/Smad Pathway. Int J Nanomedicine. 2019;14:10061-10077 pubmed publisher
Zhou X, Xiong J, Lu S, Luo L, Chen Z, Yang F, et al. Inhibitory Effect of Corilagin on miR-21-Regulated Hepatic Fibrosis Signaling Pathway. Am J Chin Med. 2019;47:1541-1569 pubmed publisher
Fan P, Li Z, Zuo C, Fang M. Promotion effects of mono-2-ethyhexyl phthalate (MEHP) on migration and invasion of human melanoma cells via activation of TGF-β signals. Cell Biochem Funct. 2019;: pubmed publisher
Lei R, Li J, Liu F, Li W, Zhang S, Wang Y, et al. HIF-1α promotes the keloid development through the activation of TGF-β/Smad and TLR4/MyD88/NF-κB pathways. Cell Cycle. 2019;18:3239-3250 pubmed publisher
Jin J, Sun H, Liu D, Wang H, Liu Q, Chen H, et al. LRG1 Promotes Apoptosis and Autophagy through the TGFβ-smad1/5 Signaling Pathway to Exacerbate Ischemia/Reperfusion Injury. Neuroscience. 2019;: pubmed publisher
Yuan J, Tan L, Yin Z, Zhu W, Tao K, Wang G, et al. MIR17HG-miR-18a/19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt/β-catenin signalling. Cell Death Dis. 2019;10:454 pubmed publisher
Xue K, Zhang J, Li C, Li J, Wang C, Zhang Q, et al. The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis. J Cell Mol Med. 2019;23:4229-4243 pubmed publisher
Hu B, Mao Z, Du Q, Jiang X, Wang Z, Xiao Z, et al. miR-93-5p targets Smad7 to regulate the transforming growth factor-β1/Smad3 pathway and mediate fibrosis in drug-resistant prolactinoma. Brain Res Bull. 2019;149:21-31 pubmed publisher
Guo Y, Cui W, Pei Y, Xu D. Platelets promote invasion and induce epithelial to mesenchymal transition in ovarian cancer cells by TGF-β signaling pathway. Gynecol Oncol. 2019;153:639-650 pubmed publisher
Xie H, Su D, Zhang J, Ji D, Mao J, Hao M, et al. Raw and vinegar processed Curcuma wenyujin regulates hepatic fibrosis via bloking TGF-β/Smad signaling pathways and up-regulation of MMP-2/TIMP-1 ratio. J Ethnopharmacol. 2019;: pubmed publisher
Zhao J, Meng M, Zhang J, Li L, Zhu X, Zhang L, et al. Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction. Mol Med Rep. 2019;19:3168-3178 pubmed publisher
Lewis D, Pruitt H, Jain N, Ciccaglione M, McCaffery J, Xia Z, et al. A Feedback Loop between Hypoxia and Matrix Stress Relaxation Increases Oxygen-Axis Migration and Metastasis in Sarcoma. Cancer Res. 2019;79:1981-1995 pubmed publisher
Wang B, Xu X, Yang Z, Zhang L, Liu Y, Ma A, et al. POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1. EBioMedicine. 2019;41:320-332 pubmed publisher
He W, Liang B, Wang C, Li S, Zhao Y, Huang Q, et al. MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer. Oncogene. 2019;38:4637-4654 pubmed publisher
Yan L, You W, Sheng N, Gong J, Hu L, Tan G, et al. A CREB1/miR-433 reciprocal feedback loop modulates proliferation and metastasis in colorectal cancer. Aging (Albany NY). 2018;10:3774-3793 pubmed publisher
Ye X, He L, Ma J, Li Y, Zhang M, Yang J, et al. Downregulation of Glt25d1 aggravates carbon tetrachloride‑induced acute hepatic injury through activation of the TGF‑β1/Smad2 signaling pathway. Mol Med Rep. 2018;18:3611-3618 pubmed publisher
Hu B, Mao Z, Jiang X, He D, Wang Z, Wang X, et al. Role of TGF-β1/Smad3-mediated fibrosis in drug resistance mechanism of prolactinoma. Brain Res. 2018;1698:204-212 pubmed publisher
Lu H, Wu L, Liu L, Ruan Q, Zhang X, Hong W, et al. Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization. Biochem Pharmacol. 2018;154:203-212 pubmed publisher
Deng W, Gao M, Lei X, Lv J, Zhao H, He K, et al. Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients. Stem Cell Reports. 2018;10:1267-1281 pubmed publisher
Li J, Zou K, Yu L, Zhao W, Lu Y, Mao J, et al. MicroRNA-140 Inhibits the Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer. Mol Ther Nucleic Acids. 2018;10:426-437 pubmed publisher
Zhao B, Liu L, Mao J, Zhang Z, Wang Q, Li Q. PIM1 mediates epithelial-mesenchymal transition by targeting Smads and c-Myc in the nucleus and potentiates clear-cell renal-cell carcinoma oncogenesis. Cell Death Dis. 2018;9:307 pubmed publisher
Wang E, Fan Q, Yue Y, Xu L. Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway. Med Sci Monit. 2018;24:846-854 pubmed
Xiao Y, Ye J, Zhou Y, Huang J, Liu X, Huang B, et al. Baicalin inhibits pressure overload-induced cardiac fibrosis through regulating AMPK/TGF-?/Smads signaling pathway. Arch Biochem Biophys. 2018;640:37-46 pubmed publisher
Wang X, Li D, Fan L, Xiao Q, Zuo H, Li Z. CAPE-pNO2 ameliorated diabetic nephropathy through regulating the Akt/NF-?B/ iNOS pathway in STZ-induced diabetic mice. Oncotarget. 2017;8:114506-114525 pubmed publisher
Zhao B, Liu L, Mao J, Liu K, Fan W, Liu J, et al. Sinomenine hydrochloride attenuates the proliferation, migration, invasiveness, angiogenesis and epithelial-mesenchymal transition of clear-cell renal cell carcinoma cells via targeting Smad in vitro. Biomed Pharmacother. 2017;96:1036-1044 pubmed publisher
Cai Y, Ma W, Xiao Y, Wu B, Li X, Liu F, et al. High doses of baicalin induces kidney injury and fibrosis through regulating TGF-?/Smad signaling pathway. Toxicol Appl Pharmacol. 2017;333:1-9 pubmed publisher
Lei K, Liang X, Gao Y, Xu B, Xu Y, Li Y, et al. Lnc-ATB contributes to gastric cancer growth through a MiR-141-3p/TGF?2 feedback loop. Biochem Biophys Res Commun. 2017;484:514-521 pubmed publisher
Zhang X, Fan Q, Li Y, Yang Z, Yang L, Zong Z, et al. Transforming growth factor-beta1 suppresses hepatocellular carcinoma proliferation via activation of Hippo signaling. Oncotarget. 2017;8:29785-29794 pubmed publisher
Xiang J, Fu X, Ran W, Wang Z. Grhl2 reduces invasion and migration through inhibition of TGF?-induced EMT in gastric cancer. Oncogenesis. 2017;6:e284 pubmed publisher
Zhuang X, Lv M, Zhong Z, Zhang L, Jiang R, Chen J. Interplay between intergrin-linked kinase and ribonuclease inhibitor affects growth and metastasis of bladder cancer through signaling ILK pathways. J Exp Clin Cancer Res. 2016;35:130 pubmed publisher
Yan N, Wen L, Peng R, Li H, Liu H, Peng H, et al. Naringenin Ameliorated Kidney Injury through Let-7a/TGFBR1 Signaling in Diabetic Nephropathy. J Diabetes Res. 2016;2016:8738760 pubmed publisher
You S, Ma L, Zhao J, Zhang S, Liu T. Phenylethanol Glycosides from Cistanche tubulosa Suppress Hepatic Stellate Cell Activation and Block the Conduction of Signaling Pathways in TGF-β1/smad as Potential Anti-Hepatic Fibrosis Agents. Molecules. 2016;21:102 pubmed publisher
Zhang X, Xiao J, Li R, Qin X, Wang F, Mao Y, et al. Metformin alleviates vascular calcification induced by vitamin D3 plus nicotine in rats via the AMPK pathway. Vascul Pharmacol. 2016;81:83-90 pubmed publisher
Dong D, Yin L, Qi Y, Xu L, Peng J. Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats. Nutrients. 2015;7:4829-50 pubmed publisher
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, et al. Potent effects of dioscin against liver fibrosis. Sci Rep. 2015;5:9713 pubmed publisher
Chen M, Zhang J, Wang J, Gao L, Chen X, Xiao J. Anti-fibrotic effects of neferine on carbon tetrachloride-induced hepatic fibrosis in mice. Am J Chin Med. 2015;43:231-40 pubmed publisher
product information
CatalogNo :
12570-1-AP
AntigenName :
SMAD2
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
SMAD family member 2
Immunogen :
Recombinant Protein
Species :
c. tubulosa, human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
hMAD 2, hSMAD2, JV18, JV18 1, MAD homolog 2, Mad related protein 2, MADH2, MADR2, Mothers against DPP homolog 2, SMAD 2, SMAD family member 2, SMAD2
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC014840
Category :
Binding Proteins;Cell Cycle;Cytoskeleton/Scaffold Proteins;Development;Metabolism;Oncogene(s) and Tumor Suppressor(s);Signal transduction;Stem Cells;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:25 ; IHC 1:50 ; IP 1:1000 ; WB 1:3000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.