This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
SQLE
catalog :
12544-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, western blot knockout validation
citations: 16
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; loading ...; fig e8a
Garcia Bermudez J, Baudrier L, Bayraktar E, Shen Y, La K, Guarecuco R, et al. Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. Nature. 2019;567:118-122 pubmed publisher
  • western blot; human; loading ...; fig 7c
Pantazi A, Quintanilla A, Hari P, Tarrats N, Parasyraki E, Dix F, et al. Inhibition of the 60S ribosome biogenesis GTPase LSG1 causes endoplasmic reticular disruption and cellular senescence. Aging Cell. 2019;18:e12981 pubmed publisher
Scott N, Sharpe L, Capell Hattam I, Gullo S, Luu W, Brown A. The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6. Biochem J. 2020;477:541-555 pubmed publisher
Chua N, Scott N, Brown A. Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron. Biochem J. 2019;476:2545-2560 pubmed publisher
Werner E, Alter A, Deng Q, Dammer E, Wang Y, Yu D, et al. Ionizing Radiation induction of cholesterol biosynthesis in Lung tissue. Sci Rep. 2019;9:12546 pubmed publisher
Coates H, Chua N, Brown A. Consulting prostate cancer cohort data uncovers transcriptional control: Regulation of the MARCH6 gene. Biochim Biophys Acta Mol Cell Biol Lipids. 2019;1864:1656-1668 pubmed publisher
Zhang C, Zhang H, Zhang M, Lin C, Wang H, Yao J, et al. OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signalling pathway. Exp Cell Res. 2019;:111512 pubmed publisher
Honsho M, Dorninger F, Abe Y, Setoyama D, Ohgi R, Uchiumi T, et al. Impaired plasmalogen synthesis dysregulates liver X receptor-dependent transcription in cerebellum. J Biochem. 2019;: pubmed publisher
Pronk M, Majolee J, Loregger A, van Bezu J, Zelcer N, Hordijk P, et al. FBXW7 regulates endothelial barrier function by suppression of the cholesterol synthesis pathway and prenylation of RhoB. Mol Biol Cell. 2019;30:607-621 pubmed publisher
Volkmar N, Thezenas M, Louie S, Juszkiewicz S, Nomura D, Hegde R, et al. The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis. J Cell Sci. 2019;132: pubmed publisher
Nguyen K, Lee C, Mun S, Truong N, Park S, Hwang C. N-terminal acetylation and the N-end rule pathway control degradation of the lipid droplet protein PLIN2. J Biol Chem. 2019;294:379-388 pubmed publisher
Stefanovic Barrett S, Dickson A, Burr S, Williamson J, Lobb I, van den Boomen D, et al. MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins. EMBO Rep. 2018;19: pubmed publisher
Loregger A, Raaben M, Tan J, Scheij S, Moeton M, van den Berg M, et al. Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis. Arterioscler Thromb Vasc Biol. 2017;37:2064-2074 pubmed publisher
Haider S, McIntyre A, van Stiphout R, Winchester L, Wigfield S, Harris A, et al. Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia. Genome Biol. 2016;17:140 pubmed publisher
Loregger A, Cook E, Nelson J, Moeton M, Sharpe L, Engberg S, et al. A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes. Mol Cell Biol. 2016;36:285-94 pubmed publisher
Honsho M, Abe Y, Fujiki Y. Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis. J Biol Chem. 2015;290:28822-33 pubmed publisher
product information
CatalogNo :
12544-1-AP
AntigenName :
SQLE
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
squalene epoxidase
Immunogen :
Recombinant Protein
Species :
hamster, human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
ERG1, SE, SM, SQLE, squalene epoxidase, Squalene monooxygenase
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC017033
Category :
Cytoskeleton/Scaffold Proteins;Membrane Proteins;Metabolism;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:50 ; IHC 1:50 ; IP 1:300 ; WB 1:2000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.