This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
COX2/ Cyclooxygenase 2/ PTGS2
catalog :
12375-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry
citations: 114
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 2c, 6f
Chen L, Kong L, Wei X, Wang Y, Wang B, Zhang X, et al. β-arrestin 2 negatively regulates NOD2 signalling pathway through association with TRAF6 in microglia after cerebral ischaemia/reperfusion injury. J Cell Mol Med. 2019;23:3325-3335 pubmed publisher
Wang J, Deng B, Liu Q, Huang Y, Chen W, Li J, et al. Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload. Cell Death Dis. 2020;11:574 pubmed publisher
Fan Q, Wang J, Zhang S, Liu T, Zhao J, You S. Phenylethanol Glycosides Protect Myocardial Hypertrophy Induced by Abdominal Aortic Constriction via ECE-1 Demethylation Inhibition and PI3K/PKB/eNOS Pathway Enhancement. Evid Based Complement Alternat Med. 2020;2020:2957094 pubmed publisher
Wu Y, Wang Z, Fu X, Lin Z, Yu K. Geraniol-mediated osteoarthritis improvement by down-regulating PI3K/Akt/NF-κB and MAPK signals: In vivo and in vitro studies. Int Immunopharmacol. 2020;86:106713 pubmed publisher
Qian W, Xiao Q, Wang L, Qin T, Xiao Y, Li J, et al. Resveratrol slows the tumourigenesis of pancreatic cancer by inhibiting NFκB activation. Biomed Pharmacother. 2020;127:110116 pubmed publisher
You M, Miao Z, Sienkiewicz O, Jiang X, Zhao X, Hu F. 10-Hydroxydecanoic acid inhibits LPS-induced inflammation by targeting p53 in microglial cells. Int Immunopharmacol. 2020;84:106501 pubmed publisher
Yang H, Duan J, Liu S, Xiong J, Guan X, Zhong W, et al. A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation. Theranostics. 2020;10:4749-4761 pubmed publisher
Xie C, Ge M, Jin J, Xu H, Mao L, Geng S, et al. Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK. J Hazard Mater. 2020;394:122549 pubmed publisher
Yang F, Li S, Cheng Y, Li J, Han X. Karyopherin α 2 promotes proliferation, migration and invasion through activating NF-κB/p65 signaling pathways in melanoma cells. Life Sci. 2020;252:117611 pubmed publisher
Yu C, Cheng C, Kang Y, Chang P, Lin I, Kuo Y, et al. Hispidulin Inhibits Neuroinflammation in Lipopolysaccharide-Activated BV2 Microglia and Attenuates the Activation of Akt, NF-κB, and STAT3 Pathway. Neurotox Res. 2020;38:163-174 pubmed publisher
Lin L, Wang D, Qu S, Zhao H, Lin Y. miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition. Drug Des Devel Ther. 2020;14:1127-1141 pubmed publisher
Yang W, Chen X, Wang S, Hu H, Cheng X, Xu L, et al. 4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of Physalis peruviana L.) as a Promising Agent against Chronic Obstructive Pulmonary Disease. J Nat Prod. 2020;83:1217-1228 pubmed publisher
Lin Z, Fu C, Yan Z, Wu Y, Zhan J, Lou Z, et al. The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study. Food Funct. 2020;11:2654-2666 pubmed publisher
Yang R, Shan S, Zhang C, Shi J, Li H, Li Z. Inhibitory Effects of Bound Polyphenol from Foxtail Millet Bran on Colitis-Associated Carcinogenesis by the Restoration of Gut Microbiota in a Mice Model. J Agric Food Chem. 2020;68:3506-3517 pubmed publisher
Liu H, Zhu Y, Gao Y, Qi D, Zhao L, Zhao L, et al. NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis. Cell Death Dis. 2020;11:129 pubmed publisher
Wang M, Zhang J, Zhao H, Wan D, Jiang Z. Berberine combined with cyclosporine A alleviates acute graft-versus-host disease in murine models. Int Immunopharmacol. 2020;81:106205 pubmed publisher
Zhou R, Li S, Liu J, Wu H, Yao G, Sun Y, et al. Up-regulated FHL2 inhibits ovulation through interacting with androgen receptor and ERK1/2 in polycystic ovary syndrome. EBioMedicine. 2020;52:102635 pubmed publisher
Huang H, Cai H, Zhang L, Hua Z, Shi J, Wei Y. Oroxylin A inhibits carcinogen-induced skin tumorigenesis through inhibition of inflammation by regulating SHCBP1 in mice. Int Immunopharmacol. 2020;80:106123 pubmed publisher
Lou L, Tian M, Chang J, Li F, Zhang G. MiRNA-192-5p attenuates airway remodeling and autophagy in asthma by targeting MMP-16 and ATG7. Biomed Pharmacother. 2020;122:109692 pubmed publisher
Yan J, Du G, Qin X, Gao L. Baicalein attenuates the neuroinflammation in LPS-activated BV-2 microglial cells through suppression of pro-inflammatory cytokines, COX2/NF-κB expressions and regulation of metabolic abnormality. Int Immunopharmacol. 2020;79:106092 pubmed publisher
Wang Z, Liang M, Li H, Cai L, Yang L. Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway. Int J Mol Sci. 2019;20: pubmed publisher
Zhu J, Kang J, Li X, Wang M, Shang M, Luo Y, et al. Chronic intermittent hypoxia vs chronic continuous hypoxia: Effects on vascular endothelial function and myocardial contractility. Clin Hemorheol Microcirc. 2019;: pubmed publisher
Li H, Chen W, Chen Y, Zhou Q, Xiao P, Tang R, et al. Neferine Attenuates Acute Kidney Injury by Inhibiting NF-κB Signaling and Upregulating Klotho Expression. Front Pharmacol. 2019;10:1197 pubmed publisher
Chen P, Wang B, Mo Q, Wu P, Fang Y, Tian Y, et al. The LIV-1-GRPEL1 axis adjusts cell fate during anti-mitotic agent-damaged mitosis. EBioMedicine. 2019;49:26-39 pubmed publisher
You M, Miao Z, Pan Y, Hu F. Trans-10-hydroxy-2-decenoic acid alleviates LPS-induced blood-brain barrier dysfunction by activating the AMPK/PI3K/AKT pathway. Eur J Pharmacol. 2019;865:172736 pubmed publisher
Zhang P, He D, Song E, Jiang M, Song Y. Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and COX-2 expression. PLoS ONE. 2019;14:e0223760 pubmed publisher
Shu G, Qiu Y, Hao J, Fu Q, Deng X. γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways. Food Funct. 2019;10:6858-6872 pubmed publisher
Mo Y, Deng S, Zhang L, Huang Y, Li W, Peng Q, et al. SS-31 reduces inflammation and oxidative stress through the inhibition of Fis1 expression in lipopolysaccharide-stimulated microglia. Biochem Biophys Res Commun. 2019;520:171-178 pubmed publisher
Hu Y, Gui Z, Zhou Y, Xia L, Lin K, Xu Y. Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages. Free Radic Biol Med. 2019;145:146-160 pubmed publisher
Yang X, Zhao H, Wang Y, Liu J, Guo M, Fei D, et al. The Activation of Heat-Shock Protein After Copper(II) and/or Arsenic(III)-Induced Imbalance of Homeostasis, Inflammatory Response in Chicken Rectum. Biol Trace Elem Res. 2019;: pubmed publisher
Bao X, Huang Y, Chen F. C-Phycocyanin Alleviates Bladder Inflammation and Dysfunction in Cyclophosphamide-Induced Cystitis in a Mouse Model by Inhibiting COX-2 and EP4. Evid Based Complement Alternat Med. 2019;2019:8424872 pubmed publisher
Wu Z, Wang J. Dioscin attenuates Bleomycin-Induced acute lung injury via inhibiting the inflammatory response in mice. Exp Lung Res. 2019;:1-9 pubmed publisher
Zhao J, Cao J, Yu L, Ma H. Dehydroepiandrosterone alleviates E. Coli O157:H7-induced inflammation by preventing the activation of p38 MAPK and NF-κB pathways in mice peritoneal macrophages. Mol Immunol. 2019;114:114-122 pubmed publisher
Huang L, Zhang L, Liu Z, Zhao S, Xu D, Li L, et al. Pentamidine protects mice from cecal ligation and puncture-induced brain damage via inhibiting S100B/RAGE/NF-κB. Biochem Biophys Res Commun. 2019;517:221-226 pubmed publisher
Song X, Shang P, Sun Z, Lu M, You G, Yan S, et al. Therapeutic effect of yttrium oxide nanoparticles for the treatment of fulminant hepatic failure. Nanomedicine (Lond). 2019;: pubmed publisher
Wu Y, Lin Z, Yan Z, Wang Z, Fu X, Yu K. Sinomenine contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2/HO-1 and NF-κB signaling pathways. Int Immunopharmacol. 2019;75:105715 pubmed publisher
Wang Y, Ai L, Hai B, Cao Y, Li R, Li H, et al. Tempol alleviates chronic intermittent hypoxia-induced pancreatic injury through repressing inflammation and apoptosis. Physiol Res. 2019;68:445-455 pubmed
Zhong X, Xiao Q, Liu Z, Wang W, Lai C, Yang W, et al. TAK242 suppresses the TLR4 signaling pathway and ameliorates DCD liver IRI in rats. Mol Med Rep. 2019;20:2101-2110 pubmed publisher
Zhang Z, Huang S, Wu S, Qi J, Li W, Liu S, et al. Clearance of apoptotic cells by mesenchymal stem cells contributes to immunosuppression via PGE2. EBioMedicine. 2019;45:341-350 pubmed publisher
Zhao J, Gao W, Cai X, Xu J, Zou D, Li Z, et al. Nanozyme-mediated catalytic nanotherapy for inflammatory bowel disease. Theranostics. 2019;9:2843-2855 pubmed publisher
Lin Z, Wu D, Huang L, Jiang C, Pan T, Kang X, et al. Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice. Front Pharmacol. 2019;10:570 pubmed publisher
Ren Q, Li X, Li Q, Yang H, Wang H, Zhang H, et al. Total flavonoids from sea buckthorn ameliorates lipopolysaccharide/cigarette smoke-induced airway inflammation. Phytother Res. 2019;33:2102-2117 pubmed publisher
Wang X, Yu N, Peng H, Hu Z, Sun Y, Zhu X, et al. The profiling of bioactives in Akebia trifoliata pericarp and metabolites, bioavailability and in vivo anti-inflammatory activities in DSS-induced colitis mice. Food Funct. 2019;: pubmed publisher
Nieto Veloza A, Wang Z, Zhong Q, Krishnan H, Dia V. BG-4 from Bitter Gourd (Momordica charantia) Differentially Affects Inflammation In Vitro and In Vivo. Antioxidants (Basel). 2019;8: pubmed publisher
Wang X, Wang B, Zhan W, Kang L, Zhang S, Chen C, et al. Melatonin inhibits lung metastasis of gastric cancer in vivo. Biomed Pharmacother. 2019;117:109018 pubmed publisher
Li Z, Wang Y, Sun N, Liu X, Song E, Zhang Z, et al. Melatonin therapy protects against renal injury before and after release of bilateral ureteral obstruction in rats. Life Sci. 2019;: pubmed publisher
Yu H, Lin Y, Zeng R, Li X, Zhang T, Tasneem S, et al. Analgesic and anti-inflammatory effects and molecular mechanisms of Kadsura heteroclita stems, an anti-arthritic Chinese Tujia ethnomedicinal herb. J Ethnopharmacol. 2019;238:111902 pubmed publisher
Guo G, Tian A, Lan X, Fu C, Yan Z, Wang C. Nano hydroxyapatite induces glioma cell apoptosis by suppressing NF-κB signaling pathway. Exp Ther Med. 2019;17:4080-4088 pubmed publisher
Wu J, Miao J, Ding Y, Zhang Y, Huang X, Zhou X, et al. miR-4458 inhibits breast cancer cell growth, migration, and invasion by targeting CPSF4. Biochem Cell Biol. 2019;: pubmed publisher
Zhang C, Li C, Jia X, Wang K, Tu Y, Wang R, et al. In Vitro and In Vivo Anti-Inflammatory Effects of Polyphyllin VII through Downregulating MAPK and NF-κB Pathways. Molecules. 2019;24: pubmed publisher
Monti D, Rigano M, Monti S, Peixoto H. Role of Antioxidants in the Protection from Aging-Related Diseases. Oxid Med Cell Longev. 2019;2019:7450693 pubmed publisher
He Y, Xia Z, Yu D, Wang J, Jin L, Huang D, et al. Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice. Int Immunopharmacol. 2019;68:171-178 pubmed publisher
Liang J, Wu J, Wang F, Zhang P, Zhang X. Semaphoring 4D is required for the induction of antioxidant stress and anti-inflammatory effects of dihydromyricetin in colon cancer. Int Immunopharmacol. 2019;67:220-230 pubmed publisher
Liang C, Zhang Y, Zhuo D, Lo C, Yu L, Lau C, et al. Endothelial cell transient receptor potential channel C5 (TRPC5) is essential for endothelium-dependent contraction in mouse carotid arteries. Biochem Pharmacol. 2019;159:11-24 pubmed publisher
Li H, Wang J, Liu X, Cheng Q. MicroRNA-204-5p suppresses IL6-mediated inflammatory response and chemokine generation in HK-2 renal tubular epithelial cells by targeting IL6R. Biochem Cell Biol. 2019;97:109-117 pubmed publisher
Ma Y, Ma B, Shang Y, Yin Q, Wang D, Xu S, et al. Flavonoid-Rich Ethanol Extract from the Leaves of Diospyros kaki Attenuates D-Galactose-Induced Oxidative Stress and Neuroinflammation-Mediated Brain Aging in Mice. Oxid Med Cell Longev. 2018;2018:8938207 pubmed publisher
Sun R, Fan Y, Liang X, Gong T, Wang Q, Liu H, et al. Rapamycin and FTY720 Alleviate Atherosclerosis by Cross Talk of Macrophage Polarization and Autophagy. Biomed Res Int. 2018;2018:1010248 pubmed publisher
Wang Y, Hai B, Ai L, Cao Y, Li R, Li H, et al. Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress. Iran J Basic Med Sci. 2018;21:1238-1244 pubmed publisher
Di F, Liu J, Li S, Yao G, Hong Y, Chen Z, et al. ATF4 Contributes to Ovulation via Regulating COX2/PGE2 Expression: A Potential Role of ATF4 in PCOS. Front Endocrinol (Lausanne). 2018;9:669 pubmed publisher
Fan H, Yu X, Zou Z, Zheng W, Deng X, Guo L, et al. Metformin suppresses the esophageal carcinogenesis in rats treated with NMBzA through inhibiting AMPK/mTOR signaling pathway. Carcinogenesis. 2018;: pubmed publisher
Wang Y, Tang H, He G, Shi Y, Kang X, Lyu J, et al. High Concentration of Aspirin Induces Apoptosis in Rat Tendon Stem Cells via Inhibition of the Wnt/β-Catenin Pathway. Cell Physiol Biochem. 2018;50:2046-2059 pubmed publisher
Alduais S, Alduais Y, Wu X, Li H, Mao J. HMGB1 knock-down promoting tumor cells viability and arrest pro-apoptotic proteins via Stat3/NFκB in HepG2 cells. Biofactors. 2018;44:570-576 pubmed publisher
Liu Y, Fan D. Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model. Food Funct. 2018;9:5513-5527 pubmed publisher
Yang W, Li Y, Gao H, Wu X, Wang X, Wang X, et al. Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin-induced diabetic nephropathy in mice. J Ethnopharmacol. 2018;227:166-175 pubmed publisher
Cheng L, Chen L, Wei X, Wang Y, Ren Z, Zeng S, et al. NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease. J Neuroinflammation. 2018;15:243 pubmed publisher
Liu J, Zhao H, Wang Y, Shao Y, Zhang L, Xing M. Impacts of simultaneous exposure to arsenic (III) and copper (II) on inflammatory response, immune homeostasis, and heat shock response in chicken thymus. Int Immunopharmacol. 2018;64:60-68 pubmed publisher
Zhu X, Cheng Y, Lu Q, Du L, Yin X, Liu Y. Enhancement of glyoxalase 1, a polyfunctional defense enzyme, by quercetin in the brain in streptozotocin-induced diabetic rats. Naunyn Schmiedebergs Arch Pharmacol. 2018;391:1237-1245 pubmed publisher
Zhang L, Fan X, Xie H, He Q, Nie Y, Zhang M, et al. Anti-Inflammatory and Antioxidant Effects of Kelong-Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats. Evid Based Complement Alternat Med. 2018;2018:5290514 pubmed publisher
Wang L, Yin Y, Hou G, Kang J, Wang Q. Peroxisome Proliferator-Activated Receptor (PPARγ) Plays a Protective Role in Cigarette Smoking-Induced Inflammation via AMP-Activated Protein Kinase (AMPK) Signaling. Med Sci Monit. 2018;24:5168-5177 pubmed publisher
Xu B, Lian S, Li S, Guo J, Wang J, Wang D, et al. GABAB receptor mediate hippocampal neuroinflammation in adolescent male and female mice after cold expose. Brain Res Bull. 2018;142:163-175 pubmed publisher
Zhang D, Sun X, Ren L, Yang C, Liu X, Zhang H, et al. Proteomic profiling of human decidual immune proteins during Toxoplasma gondii infection. J Proteomics. 2018;186:28-37 pubmed publisher
He J, Lu X, Wei T, Dong Y, Cai Z, Tang L, et al. Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages. Int J Mol Sci. 2018;19: pubmed publisher
Zhao X, Yang S, Yan Y, Zhang X, Zhang L, Jiao B, et al. Identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by RNA sequencing analysis. BMC Med Genomics. 2018;11:59 pubmed publisher
Wang Y, Zhang Z, Wang J, Qian X, Cui J. HPV16 E7 increases COX-2 expression and promotes the proliferation of breast cancer. Oncol Lett. 2018;16:317-325 pubmed publisher
Lu D, Chen C, Zheng Y, Li D, Wang G, Liu J, et al. Combination Treatment of Icariin and L-DOPA Against 6-OHDA-Lesioned Dopamine Neurotoxicity. Front Mol Neurosci. 2018;11:155 pubmed publisher
Li Y, Li G, Sun L, Li L, Liu Y, Kong D, et al. Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response. Oxid Med Cell Longev. 2018;2018:7616852 pubmed publisher
Wang Y, Zhao H, Liu J, Shao Y, Li J, Luo L, et al. Copper and arsenic-induced oxidative stress and immune imbalance are associated with activation of heat shock proteins in chicken intestines. Int Immunopharmacol. 2018;60:64-75 pubmed publisher
Li Y, Fu C, Yang W, Wang X, Feng D, Wang X, et al. Investigation of constituents from Cinnamomum camphora (L.) J. Presl and evaluation of their anti-inflammatory properties in lipopolysaccharide-stimulated RAW 264.7 macrophages. J Ethnopharmacol. 2018;221:37-47 pubmed publisher
Li S, Niu H, Qiao Y, Zhu R, Sun Y, Ren Z, et al. Terpenoids isolated from Chinese liverworts Lepidozia reptans and their anti-inflammatory activity. Bioorg Med Chem. 2018;26:2392-2400 pubmed publisher
Liu J, Zhao H, Wang Y, Shao Y, Li J, Xing M. Alterations of antioxidant indexes and inflammatory cytokine expression aggravated hepatocellular apoptosis through mitochondrial and death receptor-dependent pathways in Gallus gallus exposed to arsenic and copper. Environ Sci Pollut Res Int. 2018;25:15462-15473 pubmed publisher
Shen Z, Ma Y, Ji Z, Hao Y, Yan X, Zhong Y, et al. Arachidonic acid induces macrophage cell cycle arrest through the JNK signaling pathway. Lipids Health Dis. 2018;17:26 pubmed publisher
Zhou Y, Yang Q, Yan Y, Zhu C, Zhang L, Tang J. Localized delivery of miRNAs targets cyclooxygenases and reduces flexor tendon adhesions. Acta Biomater. 2018;70:237-248 pubmed publisher
He J, Li J, Liu H, Yang Z, Zhou F, Wei T, et al. Scandoside Exerts Anti-Inflammatory Effect Via Suppressing NF-?B and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages. Int J Mol Sci. 2018;19: pubmed publisher
Qiao Y, Xu L, Tao X, Yin L, Qi Y, Xu Y, et al. Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation. Toxicol Lett. 2018;284:37-45 pubmed publisher
Lorenzi I, Oeljeklaus S, Aich A, Ronsör C, Callegari S, Dudek J, et al. The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis. Biochim Biophys Acta Mol Cell Res. 2018;1865:323-333 pubmed publisher
Zheng L, Yin L, Xu L, Qi Y, Li H, Xu Y, et al. Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo. Biomed Pharmacother. 2018;97:481-488 pubmed publisher
Zheng X, Ma W, Sun R, Yin H, Lin F, Liu Y, et al. Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity. Redox Biol. 2018;14:237-249 pubmed publisher
Xu W, Li F, Xu Z, Sun B, Cao J, Liu Y. Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells. Cell Mol Neurobiol. 2018;38:735-745 pubmed publisher
Dai C, Ciccotosto G, Cappai R, Tang S, Li D, Xie S, et al. Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis. Mol Neurobiol. 2018;55:421-434 pubmed publisher
Wang Y, Li Y, Zhang Z, Wang J, Cui J, Qian X. HPV16 E6 Promotes Breast Cancer Proliferation via Upregulation of COX-2 Expression. Biomed Res Int. 2017;2017:2948467 pubmed publisher
Wang Y, Zhao H, Shao Y, Liu J, Li J, Xing M. Copper or/and arsenic induce oxidative stress-cascaded, nuclear factor kappa B-dependent inflammation and immune imbalance, trigging heat shock response in the kidney of chicken. Oncotarget. 2017;8:98103-98116 pubmed publisher
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Huang C, Zhu L, Li H, Shi F, Wang G, Wei Y, et al. Adulthood Exposure to Lipopolysaccharide Exacerbates the Neurotoxic and Inflammatory Effects of Rotenone in the Substantia Nigra. Front Mol Neurosci. 2017;10:131 pubmed publisher
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Xu J, Xiong W, Zeng Z, Tang Y, Wang Y, Xiao M, et al. Effect of ART1 on the proliferation and migration of mouse colon carcinoma CT26 cells in vivo. Mol Med Rep. 2017;15:1222-1228 pubmed publisher
Kawakita F, Fujimoto M, Liu L, Nakano F, Nakatsuka Y, Suzuki H. Effects of Toll-Like Receptor 4 Antagonists Against Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice. Mol Neurobiol. 2017;54:6624-6633 pubmed publisher
Yan T, Yu X, Sun X, Meng D, Jia J. A new steroidal saponin, furotrilliumoside from Trillium tschonoskii inhibits lipopolysaccharide-induced inflammation in Raw264.7 cells by targeting PI3K/Akt, MARK and Nrf2/HO-1 pathways. Fitoterapia. 2016;115:37-45 pubmed publisher
Gamallat Y, Meyiah A, Kuugbee E, Hago A, Chiwala G, Awadasseid A, et al. Lactobacillus rhamnosus induced epithelial cell apoptosis, ameliorates inflammation and prevents colon cancer development in an animal model. Biomed Pharmacother. 2016;83:536-541 pubmed publisher
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Yuan L, Liu S, Bai X, Gao Y, Liu G, Wang X, et al. Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice. J Neuroinflammation. 2016;13:77 pubmed publisher
Shi S, Liang D, Chen Y, Xie Y, Wang Y, Wang L, et al. Gx-50 reduces β-amyloid-induced TNF-α, IL-1β, NO, and PGE2 expression and inhibits NF-κB signaling in a mouse model of Alzheimer's disease. Eur J Immunol. 2016;46:665-76 pubmed publisher
Zhang L, Tong Y, Zhang X, Pan M, Chen S. Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth. Drug Des Devel Ther. 2015;9:5851-62 pubmed publisher
Nagy Grócz G, Tar L, Bohár Z, Fejes Szabó A, Laborc K, Spekker E, et al. The modulatory effect of anandamide on nitroglycerin-induced sensitization in the trigeminal system of the rat. Cephalalgia. 2016;36:849-61 pubmed publisher
Wang H, Li Y, Niu Y, Zheng J, Wu J, Shi G, et al. Observing Anti-inflammatory and Anti-nociceptive Activities of Glycyrrhizin Through Regulating COX-2 and Pro-inflammatory Cytokines Expressions in Mice. Inflammation. 2015;38:2269-78 pubmed publisher
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Dong D, Yin L, Qi Y, Xu L, Peng J. Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats. Nutrients. 2015;7:4829-50 pubmed publisher
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Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, et al. Potent effects of dioscin against obesity in mice. Sci Rep. 2015;5:7973 pubmed publisher
Aziz F, Yang X, Wang X, Yan Q. Anti-LeY antibody enhances therapeutic efficacy of celecoxib against gastric cancer by downregulation of MAPKs/COX-2 signaling pathway: correlation with clinical study. J Cancer Res Clin Oncol. 2015;141:1221-35 pubmed publisher
Zhu X, Cheng Y, Du L, Li Y, Zhang F, Guo H, et al. Mangiferin attenuates renal fibrosis through down-regulation of osteopontin in diabetic rats. Phytother Res. 2015;29:295-302 pubmed publisher
Yu H, Zheng L, Xu L, Yin L, Lin Y, Li H, et al. Potent effects of the total saponins from Dioscorea nipponica Makino against streptozotocin-induced type 2 diabetes mellitus in rats. Phytother Res. 2015;29:228-40 pubmed publisher
Aras S, Bai M, Lee I, Springett R, Hüttemann M, Grossman L. MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism. Mitochondrion. 2015;20:43-51 pubmed publisher
Wang J, Yu L, Jiang C, Fu X, Liu X, Wang M, et al. Cerebral ischemia increases bone marrow CD4+CD25+FoxP3+ regulatory T cells in mice via signals from sympathetic nervous system. Brain Behav Immun. 2015;43:172-83 pubmed publisher
product information
CatalogNo :
12375-1-AP
AntigenName :
COX2/ Cyclooxygenase 2/ PTGS2
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Immunogen :
Recombinant Protein
Species :
chick, chicken, human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
COX 2, COX2, Cyclooxygenase 2, GRIPGHS, hCox 2, PGG/HS, PGH synthase 2, PGHS 2, PHS 2, PHS II, Prostaglandin G/H synthase 2, Prostaglandin H2 synthase 2, PTGS2
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC013734
Category :
Binding Proteins;Cell Cycle;Cytoskeleton/Scaffold Proteins;Disease Related;Immunology;Membrane Proteins;Metabolism;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:25 ; IHC 1:200 ; WB 1:600 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.