| Published Application/Species/Sample/Dilution | Reference |
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- western blot; human; 1:1000; loading ...; fig 5d
| Yuan S, Pardue S, Shen X, Alexander J, Orr A, Kevil C. Hydrogen sulfide metabolism regulates endothelial solute barrier function. Redox Biol. 2016;9:157-166 pubmed publisher |
| Lu F, Lu B, Zhang L, Wen J, Wang M, Zhang S, et al. Hydrogen sulphide ameliorating skeletal muscle atrophy in db/db mice via Muscle RING finger 1 S-sulfhydration. J Cell Mol Med. 2020;: pubmed publisher |
| Wang B, Xu T, Li Y, Wang W, Lyu C, Luo D, et al. Trophoblast H2S maintains early pregnancy via regulating maternal-fetal interface immune hemostasis. J Clin Endocrinol Metab. 2020;: pubmed publisher |
| Yu M, Du H, Wang B, Chen J, Lu F, Peng S, et al. Exogenous H2S Induces Hrd1 S-sulfhydration and Prevents CD36 Translocation via VAMP3 Ubiquitylation in Diabetic Hearts. Aging Dis. 2020;11:286-300 pubmed publisher |
| Saini V, Chinta K, Reddy V, Glasgow J, Stein A, Lamprecht D, et al. Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis. Nat Commun. 2020;11:557 pubmed publisher |
| Syed S, Kumar M, Ghosh A, Tomasetig F, Ali A, Whan R, et al. Endometrial Axin2+ Cells Drive Epithelial Homeostasis, Regeneration, and Cancer following Oncogenic Transformation. Cell Stem Cell. 2020;26:64-80.e13 pubmed publisher |
| Bibli S, Hu J, Leisegang M, Wittig J, Zukunft S, Kapasakalidi A, et al. Shear stress regulates cystathionine γ lyase expression to preserve endothelial redox balance and reduce membrane lipid peroxidation. Redox Biol. 2020;28:101379 pubmed publisher |
| Shi L, Liu X, Huang Z, Ma Z, Xi Y, Wang L, et al. Endogenous hydrogen sulfide and ERK1/2-STAT3 signaling pathway may participate in the association between homocysteine and hypertension. J Geriatr Cardiol. 2019;16:822-834 pubmed publisher |
| Hart J. Vasorelaxation elicited by endogenous and exogenous hydrogen sulfide in mouse mesenteric arteries. Naunyn Schmiedebergs Arch Pharmacol. 2019;: pubmed publisher |
| Han Y, Li Y, Hu Z, Wang X, Liu J, Ren X, et al. Hydrogen sulfide-mediated resistance against water avoidance stress-induced gastritis by maintenance of gastric microbial homeostasis. Microbiologyopen. 2019;:e951 pubmed publisher |
| Morales Loredo H, Barrera A, Garcia J, Pace C, Naik J, Gonzalez Bosc L, et al. Hydrogen sulfide regulation of renal and mesenteric blood flow. Am J Physiol Heart Circ Physiol. 2019;317:H1157-H1165 pubmed publisher |
| Zhu J, Berisa M, Schwörer S, Qin W, Cross J, Thompson C. Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation. Cell Metab. 2019;30:865-876.e5 pubmed publisher |
| Forsström S, Jackson C, Carroll C, Kuronen M, Pirinen E, Pradhan S, et al. Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions. Cell Metab. 2019;30:1040-1054.e7 pubmed publisher |
| Módis K, Ramanujam V, Govar A, Lopez E, Anderson K, Wang R, et al. Cystathionine-γ-lyase (CSE) deficiency increases erythropoiesis and promotes mitochondrial electron transport via the upregulation of coproporphyrinogen III oxidase and consequent stimulation of heme biosynthesis. Biochem Pharmacol. 2019;169:113604 pubmed publisher |
| Damba T, Zhang M, Buist Homan M, van Goor H, Faber K, Moshage H. Hydrogen sulfide stimulates activation of hepatic stellate cells through increased cellular bio-energetics. Nitric Oxide. 2019;92:26-33 pubmed publisher |
| Dai L, Qian Y, Zhou J, Zhu C, Jin L, Li S. Hydrogen sulfide inhibited L-type calcium channels (CaV1.2) via up-regulation of the channel sulfhydration in vascular smooth muscle cells. Eur J Pharmacol. 2019;:172455 pubmed publisher |
| Sun Y, Teng Z, Sun X, Zhang L, Chen J, Wang B, et al. Exogenous H2S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD+-SIRT3 pathway in cardiac tissues of db/db mice. Am J Physiol Endocrinol Metab. 2019;317:E284-E297 pubmed publisher |
| Yadav P, Vitvitsky V, Kim H, White A, Cho U, Banerjee R. S-3-Carboxypropyl-l-cysteine specifically inhibits cystathionine γ-lyase-dependent hydrogen sulfide synthesis. J Biol Chem. 2019;294:11011-11022 pubmed publisher |
| Chi Z, Byeon H, Seo E, Nguyen Q, Lee W, Jeong Y, et al. Histone deacetylase 6 inhibitor tubastatin A attenuates angiotensin II-induced hypertension by preventing cystathionine γ-lyase protein degradation. Pharmacol Res. 2019;146:104281 pubmed publisher |
| Qin M, Long F, Wu W, Yang D, Huang M, Xiao C, et al. Hydrogen sulfide protects against DSS-induced colitis by inhibiting NLRP3 inflammasome. Free Radic Biol Med. 2019;137:99-109 pubmed publisher |
| Sikura K, Potor L, Szerafin T, Oros M, Nagy P, Mehes G, et al. Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease. Br J Pharmacol. 2019;: pubmed publisher |
| Goren I, Köhler Y, Aglan A, Pfeilschifter J, Beck K, Frank S. Increase of cystathionine-γ-lyase (CSE) during late wound repair: Hydrogen sulfide triggers cytokeratin 10 expression in keratinocytes. Nitric Oxide. 2019;87:31-42 pubmed publisher |
| Sun X, Zhao D, Lu F, Peng S, Yu M, Liu N, et al. Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys44 to prevent cardiac structural damage in diabetic cardiomyopathy. Br J Pharmacol. 2019;: pubmed publisher |
| Abdollahi Govar A, Töro G, Szaniszlo P, Pavlidou A, Bibli S, Thanki K, et al. 3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics. Br J Pharmacol. 2019;: pubmed publisher |
| Qiu X, Liu K, Xiao L, Jin S, Dong J, Teng X, et al. Alpha-lipoic acid regulates the autophagy of vascular smooth muscle cells in diabetes by elevating hydrogen sulfide level. Biochim Biophys Acta Mol Basis Dis. 2018;1864:3723-3738 pubmed publisher |
| Bibli S, Luck B, Zukunft S, Wittig J, Chen W, Xian M, et al. A selective and sensitive method for quantification of endogenous polysulfide production in biological samples. Redox Biol. 2018;18:295-304 pubmed publisher |
| Zhang G, Lu D, Duan S, Gao Y, Liu S, Hong Y, et al. Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF-κB Signaling Pathways. Oxid Med Cell Longev. 2018;2018:9647809 pubmed publisher |
| Riggs J, Pace C, Ward H, Gonzalez Bosc L, Rios L, Barrera A, et al. Intermittent hypoxia exacerbates increased blood pressure in rats with chronic kidney disease. Am J Physiol Renal Physiol. 2018;315:F927-F941 pubmed publisher |
| Patel D, Rathinam M, Jarvis C, Mahimainathan L, Henderson G, Narasimhan M. Role for Cystathionine ? Lyase (CSE) in an Ethanol (E)-Induced Lesion in Fetal Brain GSH Homeostasis. Int J Mol Sci. 2018;19: pubmed publisher |
| Chen Y, Jin S, Teng X, Hu Z, Zhang Z, Qiu X, et al. Hydrogen Sulfide Attenuates LPS-Induced Acute Kidney Injury by Inhibiting Inflammation and Oxidative Stress. Oxid Med Cell Longev. 2018;2018:6717212 pubmed publisher |
| De Cicco P, Sanders T, Cirino G, Maloy K, Ianaro A. Hydrogen Sulfide Reduces Myeloid-Derived Suppressor Cell-Mediated Inflammatory Response in a Model of Helicobacter hepaticus-Induced Colitis. Front Immunol. 2018;9:499 pubmed publisher |
| Potor L, Mehes G, Hendrik Z, Jeney V, Pethő D, Vasas A, et al. Hydrogen Sulfide Abrogates Hemoglobin-Lipid Interaction in Atherosclerotic Lesion. Oxid Med Cell Longev. 2018;2018:3812568 pubmed publisher |
| Untereiner A, Pavlidou A, Druzhyna N, Papapetropoulos A, Hellmich M, Szabo C. Drug resistance induces the upregulation of H2S-producing enzymes in HCT116 colon cancer cells. Biochem Pharmacol. 2018;149:174-185 pubmed publisher |
| Katsouda A, Szabo C, Papapetropoulos A. Reduced adipose tissue H2S in obesity. Pharmacol Res. 2018;128:190-199 pubmed publisher |
| Hsu C, Lin Y, Lu P, Tain Y. Early Supplementation of d-Cysteine or l-Cysteine Prevents Hypertension and Kidney Damage in Spontaneously Hypertensive Rats Exposed to High-Salt Intake. Mol Nutr Food Res. 2018;62: pubmed publisher |
| Magierowski M, Magierowska K, Surmiak M, Hubalewska Mazgaj M, Kwiecien S, Wallace J, et al. The effect of hydrogen sulfide-releasing naproxen (ATB-346) versus naproxen on formation of stress-induced gastric lesions, the regulation of systemic inflammation, hypoxia and alterations in gastric microcirculation. J Physiol Pharmacol. 2017;68:749-756 pubmed |
| Jin S, Tan B, Teng X, Meng R, Jiao X, Tian D, et al. Diurnal Fluctuations in Plasma Hydrogen Sulfide of the Mice. Front Pharmacol. 2017;8:682 pubmed publisher |
| Bibli S, Szabo C, Chatzianastasiou A, Luck B, Zukunft S, Fleming I, et al. Hydrogen Sulfide Preserves Endothelial Nitric Oxide Synthase Function by Inhibiting Proline-Rich Kinase 2: Implications for Cardiomyocyte Survival and Cardioprotection. Mol Pharmacol. 2017;92:718-730 pubmed publisher |
| You J, Shi X, Liang H, Ye J, Wang L, Han H, et al. Cystathionine- ?-lyase promotes process of breast cancer in association with STAT3 signaling pathway. Oncotarget. 2017;8:65677-65686 pubmed publisher |
| Nalli A, Wang H, Bhattacharya S, Blakeney B, Murthy K. Inhibition of RhoA/Rho kinase pathway and smooth muscle contraction by hydrogen sulfide. Pharmacol Res Perspect. 2017;5: pubmed publisher |
| Phillips C, Zatarain J, Nicholls M, Porter C, Widen S, Thanki K, et al. Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis. Cancer Res. 2017;77:5741-5754 pubmed publisher |
| Peng J, Tang Z, Ren Z, He B, Zeng Y, Liu L, et al. TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H2S System. Front Pharmacol. 2017;8:486 pubmed publisher |
| Khan N, Nikkanen J, Yatsuga S, Jackson C, Wang L, Pradhan S, et al. mTORC1 Regulates Mitochondrial Integrated Stress Response and Mitochondrial Myopathy Progression. Cell Metab. 2017;26:419-428.e5 pubmed publisher |
| Zhao H, Lu S, Chai J, Zhang Y, Ma X, Chen J, et al. Hydrogen sulfide improves diabetic wound healing in ob/ob mice via attenuating inflammation. J Diabetes Complications. 2017;31:1363-1369 pubmed publisher |
| Nalli A, Bhattacharya S, Wang H, Kendig D, Grider J, Murthy K. Augmentation of cGMP/PKG pathway and colonic motility by hydrogen sulfide. Am J Physiol Gastrointest Liver Physiol. 2017;313:G330-G341 pubmed publisher |
| Merz T, Vogt J, Wachter U, Calzia E, Szabo C, Wang R, et al. Impact of hyperglycemia on cystathionine-?-lyase expression during resuscitated murine septic shock. Intensive Care Med Exp. 2017;5:30 pubmed publisher |
| Liu N, Wu J, Zhang L, Gao Z, Sun Y, Yu M, et al. Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate. J Cell Mol Med. 2017;21:3190-3203 pubmed publisher |
| Leskova A, Pardue S, Glawe J, Kevil C, Shen X. Role of thiosulfate in hydrogen sulfide-dependent redox signaling in endothelial cells. Am J Physiol Heart Circ Physiol. 2017;313:H256-H264 pubmed publisher |
| Zhang Z, Jin S, Teng X, Duan X, Chen Y, Wu Y. Hydrogen sulfide attenuates cardiac injury in takotsubo cardiomyopathy by alleviating oxidative stress. Nitric Oxide. 2017;67:10-25 pubmed publisher |
| Ahmad A, Druzhyna N, Szabo C. Cystathionine-gamma-lyase deficient mice are protected against the development of multiorgan failure and exhibit reduced inflammatory response during burn. Burns. 2017;43:1021-1033 pubmed publisher |
| Wang P, Wu L, Ju Y, Fu M, Shuang T, Qian Z, et al. Age-Dependent Allergic Asthma Development and Cystathionine Gamma-Lyase Deficiency. Antioxid Redox Signal. 2017;27:931-944 pubmed publisher |
| Sigala F, Efentakis P, Karageorgiadi D, Filis K, Zampas P, Iliodromitis E, et al. Reciprocal regulation of eNOS, H2S and CO-synthesizing enzymes in human atheroma: Correlation with plaque stability and effects of simvastatin. Redox Biol. 2017;12:70-81 pubmed publisher |
| Lu L, Kingdom J, Burton G, Cindrova Davies T. Placental Stem Villus Arterial Remodeling Associated with Reduced Hydrogen Sulfide Synthesis Contributes to Human Fetal Growth Restriction. Am J Pathol. 2017;187:908-920 pubmed publisher |
| Gonzalez Bosc L, Osmond J, Giermakowska W, Pace C, Riggs J, Jackson Weaver O, et al. NFAT regulation of cystathionine γ-lyase expression in endothelial cells is impaired in rats exposed to intermittent hypoxia. Am J Physiol Heart Circ Physiol. 2017;312:H791-H799 pubmed publisher |
| Magierowski M, Magierowska K, Hubalewska Mazgaj M, Adamski J, Bakalarz D, Sliwowski Z, et al. Interaction between endogenous carbon monoxide and hydrogen sulfide in the mechanism of gastroprotection against acute aspirin-induced gastric damage. Pharmacol Res. 2016;114:235-250 pubmed publisher |
| Ahmad A, Gero D, Olah G, Szabo C. Effect of endotoxemia in mice genetically deficient in cystathionine-?-lyase, cystathionine-?-synthase or 3-mercaptopyruvate sulfurtransferase. Int J Mol Med. 2016;38:1683-1692 pubmed publisher |
| Marino A, Martelli A, Citi V, Fu M, Wang R, Calderone V, et al. The novel H2 S donor 4-carboxy-phenyl isothiocyanate inhibits mast cell degranulation and renin release by decreasing intracellular calcium. Br J Pharmacol. 2016;173:3222-3234 pubmed publisher |
| Tain Y, Lee C, Chan J, Hsu C. Maternal melatonin or N-acetylcysteine therapy regulates hydrogen sulfide-generating pathway and renal transcriptome to prevent prenatal NG-Nitro-L-arginine-methyl ester (L-NAME)-induced fetal programming of hypertension in adult male offspring. Am J Obstet Gynecol. 2016;215:636.e1-636.e72 pubmed publisher |
| Li W, Ma F, Zhang L, Huang Y, Li X, Zhang A, et al. S-Propargyl-cysteine Exerts a Novel Protective Effect on Methionine and Choline Deficient Diet-Induced Fatty Liver via Akt/Nrf2/HO-1 Pathway. Oxid Med Cell Longev. 2016;2016:4690857 pubmed publisher |
| Sun A, Wang Y, Liu J, Yu X, Sun Y, Yang F, et al. Exogenous H2S modulates mitochondrial fusion-fission to inhibit vascular smooth muscle cell proliferation in a hyperglycemic state. Cell Biosci. 2016;6:36 pubmed publisher |
| Liu J, Wu J, Sun A, Sun Y, Yu X, Liu N, et al. Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway. Cell Biosci. 2016;6:33 pubmed publisher |
| Stenzel T, Weidgang C, Wagner K, Wagner F, Groger M, Weber S, et al. Association of Kidney Tissue Barrier Disrupture and Renal Dysfunction in Resuscitated Murine Septic Shock. Shock. 2016;46:398-404 pubmed publisher |
| Nikkanen J, Forsström S, Euro L, Paetau I, Kohnz R, Wang L, et al. Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism. Cell Metab. 2016;23:635-48 pubmed publisher |
| Bing W, Pang X, Qu Q, Bai X, Yang W, Bi Y, et al. Simvastatin improves the homing of BMSCs via the PI3K/AKT/miR-9 pathway. J Cell Mol Med. 2016;20:949-61 pubmed publisher |
| Ahmad A, Druzhyna N, Szabo C. Delayed Treatment with Sodium Hydrosulfide Improves Regional Blood Flow and Alleviates Cecal Ligation and Puncture (CLP)-Induced Septic Shock. Shock. 2016;46:183-93 pubmed publisher |
| Zhang Y, Yang J, Wang T, Wang S, Liu J, Yin C, et al. Decreased Endogenous Hydrogen Sulfide Generation in Penile Tissues of Diabetic Rats with Erectile Dysfunction. J Sex Med. 2016;13:350-60 pubmed publisher |
| Tai I, Sheen J, Lin Y, Yu H, Tiao M, Chen C, et al. Maternal N-acetylcysteine therapy regulates hydrogen sulfide-generating pathway and prevents programmed hypertension in male offspring exposed to prenatal dexamethasone and postnatal high-fat diet. Nitric Oxide. 2016;53:6-12 pubmed publisher |
| Pan Y, Zhou C, Yuan D, Zhang J, Shao C. Radiation Exposure Promotes Hepatocarcinoma Cell Invasion through Epithelial Mesenchymal Transition Mediated by H2S/CSE Pathway. Radiat Res. 2016;185:96-105 pubmed publisher |
| Liu M, Lin X, Yuan C, He J, Tan T, Wu S, et al. Hydrogen sulfide attenuates doxorubicin-induced cardiotoxicity by inhibiting the expression of peroxiredoxin III in H9c2 cells. Mol Med Rep. 2016;13:367-72 pubmed publisher |
| Kuo M, Kim D, Jandu S, Bergman Y, Tan S, Wang H, et al. MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery. Am J Physiol Heart Circ Physiol. 2016;310:H71-9 pubmed publisher |
| Chakraborty P, Xiong X, Mustafi S, Saha S, Dhanasekaran D, Mandal N, et al. Role of cystathionine beta synthase in lipid metabolism in ovarian cancer. Oncotarget. 2015;6:37367-84 pubmed publisher |
| Saha S, Chakraborty P, Xiong X, Dwivedi S, Mustafi S, Leigh N, et al. Cystathionine β-synthase regulates endothelial function via protein S-sulfhydration. FASEB J. 2016;30:441-56 pubmed publisher |
| Ju Y, Untereiner A, Wu L, Yang G. H2S-induced S-sulfhydration of pyruvate carboxylase contributes to gluconeogenesis in liver cells. Biochim Biophys Acta. 2015;1850:2293-303 pubmed publisher |
| Syhr K, Boosen M, Hohmann S, Longen S, Köhler Y, Pfeilschifter J, et al. The H2S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain. Brain Res. 2015;1624:380-9 pubmed publisher |
| Liu Y, Zhao H, Qiang Y, Qian G, Lu S, Chen J, et al. Effects of hydrogen sulfide on high glucose-induced glomerular podocyte injury in mice. Int J Clin Exp Pathol. 2015;8:6814-20 pubmed |
| Ikeda K, Marutani E, Hirai S, Wood M, Whiteman M, Ichinose F. Mitochondria-targeted hydrogen sulfide donor AP39 improves neurological outcomes after cardiac arrest in mice. Nitric Oxide. 2015;49:90-6 pubmed publisher |
| Meng X, Huang X, Zhang C, Liu D, Lu H, Kim Y, et al. Hydrogen sulfide-induced enhancement of gastric fundus smooth muscle tone is mediated by voltage-dependent potassium and calcium channels in mice. World J Gastroenterol. 2015;21:4840-51 pubmed publisher |
| Xue X, Bian J. Neuroprotective effects of hydrogen sulfide in Parkinson's disease animal models: methods and protocols. Methods Enzymol. 2015;554:169-86 pubmed publisher |
| Coletta C, Módis K, Szczesny B, Brunyánszki A, Olah G, Rios E, et al. Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by DL-α-Lipoic Acid. Mol Med. 2015;21:1-14 pubmed publisher |
| Kutz J, Greaney J, Santhanam L, Alexander L. Evidence for a functional vasodilatatory role for hydrogen sulphide in the human cutaneous microvasculature. J Physiol. 2015;593:2121-9 pubmed publisher |
| Nalli A, Rajagopal S, Mahavadi S, Grider J, Murthy K. Inhibition of RhoA-dependent pathway and contraction by endogenous hydrogen sulfide in rabbit gastric smooth muscle cells. Am J Physiol Cell Physiol. 2015;308:C485-95 pubmed publisher |
| Flannigan K, Agbor T, Motta J, Ferraz J, Wang R, Buret A, et al. Proresolution effects of hydrogen sulfide during colitis are mediated through hypoxia-inducible factor-1α. FASEB J. 2015;29:1591-602 pubmed publisher |
| Salloum F, Sturz G, Yin C, Rehman S, Hoke N, Kukreja R, et al. Beetroot juice reduces infarct size and improves cardiac function following ischemia-reperfusion injury: Possible involvement of endogenous H2S. Exp Biol Med (Maywood). 2015;240:669-81 pubmed publisher |
| Park B, Kim H, Rhyu I, Park C, Yeo S, Huh Y, et al. Hydrogen sulfide is essential for Schwann cell responses to peripheral nerve injury. J Neurochem. 2015;132:230-42 pubmed publisher |
