This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
MFN2
catalog :
12186-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 48
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:500; loading ...; fig s12a
Shen M, Wang F, Li M, Sah N, Stockton M, Tidei J, et al. Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice. Nat Neurosci. 2019;22:386-400 pubmed publisher
  • western blot; mouse; loading ...; fig 3c
Chung E, Joiner H, Skelton T, Looten K, Manczak M, Reddy P. Maternal exercise upregulates mitochondrial gene expression and increases enzyme activity of fetal mouse hearts. Physiol Rep. 2017;5: pubmed publisher
  • western blot; mouse; fig 4
Sharoar M, Shi Q, Ge Y, He W, Hu X, Perry G, et al. Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease. Mol Psychiatry. 2016;21:1263-71 pubmed publisher
Ma D, Zheng B, Liu H, Zhao Y, Liu X, Zhang X, et al. Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission. PLoS Biol. 2020;18:e3000808 pubmed publisher
Feng L, Zhao F, Liu Q, Peng J, Duan X, Yan P, et al. Role of Nrf2 in Lipopolysaccharide-Induced Acute Kidney Injury: Protection by Human Umbilical Cord Blood Mononuclear Cells. Oxid Med Cell Longev. 2020;2020:6123459 pubmed publisher
Li Y, Yu H, Chen C, Li S, Zhang Z, Xu H, et al. Proteomic Profile of Mouse Brain Aging Contributions to Mitochondrial Dysfunction, DNA Oxidative Damage, Loss of Neurotrophic Factor, and Synaptic and Ribosomal Proteins. Oxid Med Cell Longev. 2020;2020:5408452 pubmed publisher
Zhang X, Zhao D, Wu W, Ali Shah S, Lai M, Yang D, et al. Melatonin regulates mitochondrial dynamics and alleviates neuron damage in prion diseases. Aging (Albany NY). 2020;12:11139-11151 pubmed publisher
Chen K, Wang H, Jiang L, Qian Y, Yang C, Chang W, et al. Heat stress induces apoptosis through disruption of dynamic mitochondrial networks in dairy cow mammary epithelial cells. In Vitro Cell Dev Biol Anim. 2020;56:322-331 pubmed publisher
Gao Y, Li J, Li J, Hu C, Zhang L, Yan J, et al. Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1/Parkin signaling pathway. Biochem Pharmacol. 2020;177:113997 pubmed publisher
Kai J, Yang X, Wang Z, Wang F, Jia Y, Wang S, et al. Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease. Free Radic Biol Med. 2020;153:89-102 pubmed publisher
Sun Y, Lu F, Yu X, Wang B, Chen J, Lu F, et al. Exogenous H2S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice. Aging Dis. 2020;11:269-285 pubmed publisher
Hu Y, Chen H, Zhang L, Lin X, Li X, Zhuang H, et al. The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses. Autophagy. 2020;:1-15 pubmed publisher
Gao P, Yang M, Chen X, Xiong S, Liu J, Sun L. DsbA-L deficiency exacerbates mitochondrial dysfunction of tubular cells in diabetic kidney disease. Clin Sci (Lond). 2020;134:677-694 pubmed publisher
Dong L, Li P, Yang K, Liu L, Gao H, Zhou G, et al. Promotion of mitochondrial fusion protects against developmental PBDE-47 neurotoxicity by restoring mitochondrial homeostasis and suppressing excessive apoptosis. Theranostics. 2020;10:1245-1261 pubmed publisher
Kim J, Park H, Choi S, Kong M, Kang T. CDDO-Me Selectively Attenuates CA1 Neuronal Death Induced by Status Epilepticus via Facilitating Mitochondrial Fission Independent of LONP1. Cells. 2019;8: pubmed publisher
Miao X, Li W, Niu B, Li J, Sun J, Qin M, et al. Mitochondrial dysfunction in endothelial cells induced by airborne fine particulate matter (<2.5 μm). J Appl Toxicol. 2019;: pubmed publisher
Tian X, Zheng P, Zhou C, Wang X, Ma H, Ma W, et al. DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B. Autophagy. 2019;:1-14 pubmed publisher
Zeng Y, Pan Q, Wang X, Li D, Lin Y, Man F, et al. Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells. Oxid Med Cell Longev. 2019;2019:4508762 pubmed publisher
Chai N, Zhang H, Li L, Yu X, Liu Y, Lin Y, et al. Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation. Oxid Med Cell Longev. 2019;2019:5406468 pubmed publisher
Yang F, Shan Y, Tang Z, Wu X, Bi C, Zhang Y, et al. The Neuroprotective Effect of Hemin and the Related Mechanism in Sevoflurane Exposed Neonatal Rats. Front Neurosci. 2019;13:537 pubmed publisher
Gai C, Feng W, Qiang T, Ma H, Chai Y, Zhang S, et al. Da-Bu-Yin-Wan and Qian-Zheng-San Ameliorate Mitochondrial Dynamics in the Parkinson's Disease Cell Model Induced by MPP. Front Pharmacol. 2019;10:372 pubmed publisher
Yang M, Zhao L, Gao P, Zhu X, Han Y, Chen X, et al. DsbA-L ameliorates high glucose induced tubular damage through maintaining MAM integrity. EBioMedicine. 2019;: pubmed publisher
Zhao Q, Niu Q, Chen J, Xia T, Zhou G, Li P, et al. Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: mechanisms of action in vitro and associations with cognition in rats and children. Arch Toxicol. 2019;93:709-726 pubmed publisher
Zhong X, Cui P, Cai Y, Wang L, He X, Long P, et al. Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells. Cell Metab. 2019;29:979-992.e4 pubmed publisher
Lavdovskaia E, Kolander E, Steube E, Mai M, Urlaub H, Richter Dennerlein R. The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis. Nucleic Acids Res. 2018;46:8471-8482 pubmed publisher
Zheng P, Chen Q, Tian X, Qian N, Chai P, Liu B, et al. DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling. Cell Res. 2018;28:833-854 pubmed publisher
Chen J, Ren Y, Gui C, Zhao M, Wu X, Mao K, et al. Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease. Cell Death Dis. 2018;9:700 pubmed publisher
Reddy P, Yin X, Manczak M, Kumar S, Pradeepkiran J, Vijayan M, et al. Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease. Hum Mol Genet. 2018;27:2502-2516 pubmed publisher
Syu Y, Lai H, Jiang C, Tsai H, Lin C, Lee Y. GLUT10 maintains the integrity of major arteries through regulation of redox homeostasis and mitochondrial function. Hum Mol Genet. 2018;27:307-321 pubmed publisher
Lee C, Chin L, Li L. Hypertonia-linked protein Trak1 functions with mitofusins to promote mitochondrial tethering and fusion. Protein Cell. 2018;9:693-716 pubmed publisher
Ko S, Choi G, Oh J, Lee H, Kim J, Chae C, et al. Succinate promotes stem cell migration through the GPR91-dependent regulation of DRP1-mediated mitochondrial fission. Sci Rep. 2017;7:12582 pubmed publisher
Li S, Zhao H, Wang Y, Shao Y, Li J, Liu J, et al. The inflammatory responses in Cu-mediated elemental imbalance is associated with mitochondrial fission and intrinsic apoptosis in Gallus gallus heart. Chemosphere. 2017;189:489-497 pubmed publisher
Xu Z, Jin X, Pan T, Liu T, Wan N, Li S. Antagonistic effects of selenium on cadmium-induced apoptosis by restoring the mitochondrial dynamic equilibrium and energy metabolism in chicken spleens. Oncotarget. 2017;8:52629-52641 pubmed publisher
Zhou X, Han T, Chen H, Baker P, Qi H, Zhang H. Impaired mitochondrial fusion, autophagy, biogenesis and dysregulated lipid metabolism is associated with preeclampsia. Exp Cell Res. 2017;359:195-204 pubmed publisher
Liu N, Wu J, Zhang L, Gao Z, Sun Y, Yu M, et al. Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate. J Cell Mol Med. 2017;21:3190-3203 pubmed publisher
Ko A, Kang T. TRPC6-mediated ERK1/2 phosphorylation prevents dentate granule cell degeneration via inhibiting mitochondrial elongation. Neuropharmacology. 2017;121:120-129 pubmed publisher
Wang L, Zhang T, Wang L, Cai Y, Zhong X, He X, et al. Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission. EMBO J. 2017;36:1330-1347 pubmed publisher
Wang Y, Zhao W, Li G, Chen J, Guan X, Chen X, et al. Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson's Disease. PPAR Res. 2017;2017:4089214 pubmed publisher
Liu Y, Hu Y, E Q, Zuo J, Yang L, Liu W. Salvianolic acid B inhibits mitochondrial dysfunction by up-regulating mortalin. Sci Rep. 2017;7:43097 pubmed publisher
Niemann J, Johne C, Schröder S, Koch F, Ibrahim S, Schultz J, et al. An mtDNA mutation accelerates liver aging by interfering with the ROS response and mitochondrial life cycle. Free Radic Biol Med. 2017;102:174-187 pubmed publisher
Wu H, Li Z, Wang Y, Yang P, Li Z, Li H, et al. MiR-106b-mediated Mfn2 suppression is critical for PKM2 induced mitochondrial fusion. Am J Cancer Res. 2016;6:2221-2234 pubmed
Xie Q, Su J, Jiao B, Shen L, Ma L, Qu X, et al. ABT737 reverses cisplatin resistance by regulating ER-mitochondria Ca2+ signal transduction in human ovarian cancer cells. Int J Oncol. 2016;49:2507-2519 pubmed publisher
Manczak M, Kandimalla R, Fry D, Sesaki H, Reddy P. Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease. Hum Mol Genet. 2016;25:5148-5166 pubmed publisher
Sun A, Wang Y, Liu J, Yu X, Sun Y, Yang F, et al. Exogenous H2S modulates mitochondrial fusion-fission to inhibit vascular smooth muscle cell proliferation in a hyperglycemic state. Cell Biosci. 2016;6:36 pubmed publisher
Liu S, Gao Y, Zhang C, Li H, Pan S, Wang X, et al. SAMM50 Affects Mitochondrial Morphology through the Association of Drp1 in Mammalian Cells. FEBS Lett. 2016;590:1313-23 pubmed publisher
Wang Y, Wu F, Pan H, Zheng W, Feng C, Wang Y, et al. Lost region in amyloid precursor protein (APP) through TALEN-mediated genome editing alters mitochondrial morphology. Sci Rep. 2016;6:22244 pubmed publisher
Deng J, Yang M, Chen Y, Chen X, Liu J, Sun S, et al. FUS Interacts with HSP60 to Promote Mitochondrial Damage. PLoS Genet. 2015;11:e1005357 pubmed publisher
Li H, Ruan Y, Zhang K, Jian F, Hu C, Miao L, et al. Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization. Cell Death Differ. 2016;23:380-92 pubmed publisher
product information
CatalogNo :
12186-1-AP
AntigenName :
MFN2
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
mitofusin 2
Immunogen :
Recombinant Protein
Species :
chicken, cow, human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
CMT2A, CMT2A2, CPRP1, HSG, KIAA0214, MARF, MFN2, Mitofusin 2, Transmembrane GTPase MFN2
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC017061
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Development;Disease Related;Membrane Proteins;Metabolism;Neurology;Transport/Trafficking;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IHC 1:200 ; IP 1:300 ; WB 1:500 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.