This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
LC3
catalog :
12135-1-AP
quantity :
150
price :
279 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, zebrafish
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry
citations: 28
Reference
Fu Y, Liu Y, Wang J, Li C, Zhou S, Yang Y, et al. Calcium release induced by 2-pyridinecarboxaldehyde thiosemicarbazone and its copper complex contributes to tumor cell death. Oncol Rep. 2017;: pubmed publisher
La X, Zhang L, Li Z, Yang P, Wang Y. Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells.. Oncotarget. 2017;8:20909-20924 pubmed publisher
Wang E, Zou B, Shi L, Du L, Zhu Y, Jiang Y, et al. 7-O-geranylquercetin-induced autophagy contributes to apoptosis via ROS generation in human non-small cell lung cancer cells.. Life Sci. 2017;180:102-113 pubmed publisher
Liu J, Wu J, Sun A, Sun Y, Yu X, Liu N, et al. Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway. Cell Biosci. 2016;6:33 pubmed publisher
Wang Y, Wu H, Li Z, Yang P, Li Z. A Positive Feedback Loop between GRP78 and VPS34 Is Critical for GRP78-Mediated Autophagy in Cancer Cells. Exp Cell Res. 2016;: pubmed publisher
Wang T, Fu Y, Huang T, Liu Y, Wu M, Yuan Y, et al. Copper Ion Attenuated the Antiproliferative Activity of Di-2-pyridylhydrazone Dithiocarbamate Derivative; However, There Was a Lack of Correlation between ROS Generation and Antiproliferative Activity. Molecules. 2016;21: pubmed publisher
Nie Y, Wang M, Zhang P, Huan L, Liu D. Identification and characterization of an endoplasmic reticulum localization motif. Biochem Biophys Res Commun. 2016;473:249-54 pubmed publisher
Zhang S, Zhang C, Tang S, Deng S, Zhou Y, Dai C, et al. AKT/TSC2/p70S6K signaling pathway is involved in quinocetone-induced death-promoting autophagy in HepG2 cells. Toxicol Mech Methods. 2016;26:301-10 pubmed publisher
Zhou Y, Zhang S, Dai C, Tang S, Yang X, Li D, et al. Quinocetone triggered ER stress-induced autophagy via ATF6/DAPK1-modulated mAtg9a trafficking. Cell Biol Toxicol. 2016;32:141-52 pubmed publisher
Xu Y, Wu D, Fan Y, Li P, DU H, Shi J, et al. Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF-κB signaling in murine breast cancer cells. Oncol Lett. 2016;12:2632-2640 pubmed
Zhang S, Niu Q, Gao H, Ma R, Lei R, Zhang C, et al. Excessive apoptosis and defective autophagy contribute to developmental testicular toxicity induced by fluoride. Environ Pollut. 2016;212:97-104 pubmed publisher
Liu H, Tao Y, Luo P, Deng C, Gu Y, Yang L, et al. Preventive Effects of a Novel Polysaccharide from Sepia esculenta Ink on Ovarian Failure and Its Action Mechanisms in Cyclophosphamide-Treated Mice. J Agric Food Chem. 2016;64:5759-66 pubmed publisher
Tang X, Lin C, Guo D, Qian R, Li X, Shi Z, et al. CLOCK Promotes Endothelial Damage by Inducing Autophagy through Reactive Oxygen Species. Oxid Med Cell Longev. 2016;2016:9591482 pubmed publisher
Kessel D, Evans C. Promotion of Proapoptotic Signals by Lysosomal Photodamage: Mechanistic Aspects and Influence of Autophagy. Photochem Photobiol. 2016;92:620-3 pubmed publisher
Su Z, Wang K, Li R, Yin J, Hao Y, Lv X, et al. Overexpression of RBM5 induces autophagy in human lung adenocarcinoma cells. World J Surg Oncol. 2016;14:57 pubmed publisher
Sugie K, Yoshizawa H, Onoue K, Nakanishi Y, Eura N, Ogawa M, et al. Early onset of cardiomyopathy and intellectual disability in a girl with Danon disease associated with a de novo novel mutation of the LAMP2 gene. Neuropathology. 2016;36:561-565 pubmed publisher
Yang Y, Li C, Fu Y, Liu Y, Zhang Y, Zhang Y, et al. Redox cycling of a copper complex with benzaldehyde nitrogen mustard-2-pyridine carboxylic acid hydrazone contributes to its enhanced antitumor activity, but no change in the mechanism of action occurs after chelation. Oncol Rep. 2016;35:1636-44 pubmed publisher
Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, et al. Potent effects of dioscin against obesity in mice. Sci Rep. 2015;5:7973 pubmed publisher
Shen X, Zhang N, Wang Z, Bai G, Zheng Z, Gu Y, et al. Induction of autophagy improves embryo viability in cloned mouse embryos. Sci Rep. 2015;5:17829 pubmed publisher
Niso-Santano M, Malik S, Pietrocola F, Bravo-San Pedro J, Mariño G, Cianfanelli V, et al. Unsaturated fatty acids induce non-canonical autophagy. EMBO J. 2015;34:1025-41 pubmed publisher
Zheng Q, Wang Q, Wang S, Wu J, Gao Q, Liu W. Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and Microbe. Chem Biol. 2015;22:1002-7 pubmed publisher
Britto F, Begue G, Rossano B, Docquier A, Vernus B, Sar C, et al. REDD1 deletion prevents dexamethasone-induced skeletal muscle atrophy. Am J Physiol Endocrinol Metab. 2014;307:E983-93 pubmed publisher
Kessel D, Oleinick N. Initiation of autophagy by photodynamic therapy. Methods Enzymol. 2009;453:1-16 pubmed publisher
Jin Y, Chen C, Meng L, Chen J, Li M, Zhu Z, et al. A CE-LIF method to monitor autophagy by directly detecting LC3 proteins in HeLa cells. Analyst. 2012;137:5571-5 pubmed publisher
Wei D, Jia X, Liu Y, Guo F, Tang Z, Li X, et al. Cathepsin L stimulates autophagy and inhibits apoptosis of ox-LDL-induced endothelial cells: potential role in atherosclerosis. Int J Mol Med. 2013;31:400-6 pubmed publisher
Mariño G, Fernández A, Cabrera S, LUNDBERG Y, Cabanillas R, Rodriguez F, et al. Autophagy is essential for mouse sense of balance. J Clin Invest. 2010;120:2331-44 pubmed publisher
Kessel D, Arroyo A. Apoptotic and autophagic responses to Bcl-2 inhibition and photodamage. Photochem Photobiol Sci. 2007;6:1290-5 pubmed
Reiners J, Agostinis P, Berg K, Oleinick N, Kessel D. Assessing autophagy in the context of photodynamic therapy. Autophagy. 2010;6:7-18 pubmed
product information
Catalog Number :
12135-1-AP
Item Name :
LC3
Quantity / Package Size :
150
Price :
279 USD
FullName :
microtubule-associated protein 1 light chain 3 alpha
Antigen :
Recombinant Protein
Species Reactivity :
human, mouse, pig, rat, zebrafish
Host Species :
Rabbit
Conjugate :
Unconjugated
Antigen Species :
human
Applications :
ELISA, IF, IHC, WB
Type :
Polyclonal
Isotype :
IgG
Antigen Synonyms :
LC3, LC3A, LC3A/B, LC3-II, MAP1A/MAP1B LC3 A, MAP1A/MAP1B light chain 3 A, MAP1ALC3, MAP1BLC3, MAP1LC3A
Primary or Secondary? :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC015810
Category :
Apoptosis;Autophagy;Binding Proteins;Cytoskeleton/Scaffold Proteins;Membrane Proteins;Metabolism;Neurology;
Form/Purification :
Antigen affinity purification
PMID :
18046484, 19216899, 19855190, 20577052, 23057067, 25586377, 25609476, 26211364, 26643778, 26718494, 26840522, 26923134, 27005820, 27085326, 27096545, 27098396, 27145725, 27222705, 27337058, 27556432, 27703525, 28038917, 28058089, 28112358, 28157699, 28233111, 28495516
IsSellable :
1
AppTiter :
WB 1:1000 ; IF 1:50 ; IHC 1:200 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.