This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
IFITM3
catalog :
11714-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, western blot knockout validation
citations: 43
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; loading ...; fig s2a
Kühnl A, Musiol A, Heitzig N, Johnson D, Ehrhardt C, Grewal T, et al. Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus. MBio. 2018;9: pubmed publisher
  • flow cytometry; human; loading ...; fig 1b
  • immunocytochemistry; human; loading ...
Monel B, Compton A, Bruel T, Amraoui S, Burlaud Gaillard J, Roy N, et al. Zika virus induces massive cytoplasmic vacuolization and paraptosis-like death in infected cells. EMBO J. 2017;36:1653-1668 pubmed publisher
Sun Q, Lei N, Lu J, Gao R, Li Z, Liu L, et al. Interferon-induced Transmembrane Protein 3 Prevents Acute Influenza Pathogenesis in Mice. Biomed Environ Sci. 2020;33:295-305 pubmed publisher
Gobillot T, Humes D, Sharma A, Kikawa C, Overbaugh J. The Robust Restriction of Zika Virus by Type-I Interferon in A549 Cells Varies by Viral Lineage and Is Not Determined by IFITM3. Viruses. 2020;12: pubmed publisher
Wu X, Spence J, Das T, Yuan X, Chen C, Zhang Y, et al. Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase. Cell Chem Biol. 2020;27:571-585.e6 pubmed publisher
Lubow J, Virgilio M, Merlino M, Collins D, Mashiba M, Peterson B, et al. Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages. elife. 2020;9: pubmed publisher
Ali A, Syed S, Jamaluddin M, Colino Sanguino Y, Gallego Ortega D, Tanwar P. Cell Lineage Tracing Identifies Hormone-Regulated and Wnt-Responsive Vaginal Epithelial Stem Cells. Cell Rep. 2020;30:1463-1477.e7 pubmed publisher
Zani A, Zhang L, McMichael T, Kenney A, Chemudupati M, Kwiek J, et al. Interferon-Induced Transmembrane Proteins Inhibit Cell Fusion Mediated by Trophoblast Syncytins. J Biol Chem. 2019;: pubmed publisher
Hegyesi H, Sándor N, Safrany G, Lovas V, Kovacs A, Takács A, et al. Radio-detoxified LPS alters bone marrow-derived extracellular vesicles and endothelial progenitor cells. Stem Cell Res Ther. 2019;10:313 pubmed publisher
Wang Q, Su L. Vpr Enhances HIV-1 Env Processing and Virion Infectivity in Macrophages by Modulating TET2-Dependent IFITM3 Expression. MBio. 2019;10: pubmed publisher
Sharma A, McLaughlin R, Basom R, Kikawa C, OhAinle M, Yount J, et al. Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an Envelope-dependent manner. PLoS Pathog. 2019;15:e1007925 pubmed publisher
Kummer S, Avinoam O, Kräusslich H. IFITM3 Clusters on Virus Containing Endosomes and Lysosomes Early in the Influenza A Infection of Human Airway Epithelial Cells. Viruses. 2019;11: pubmed publisher
Du S, Jiang Y, Xu W, Bai J, Tian M, Wang M, et al. Construction, expression and antiviral activity analysis of recombinant adenovirus expressing human IFITM3 in vitro. Int J Biol Macromol. 2019;131:925-932 pubmed publisher
Spence J, He R, Hoffmann H, Das T, Thinon E, Rice C, et al. IFITM3 directly engages and shuttles incoming virus particles to lysosomes. Nat Chem Biol. 2019;15:259-268 pubmed publisher
Appourchaux R, Delpeuch M, Zhong L, Burlaud Gaillard J, Tartour K, Savidis G, et al. Functional Mapping of Regions Involved in the Negative Imprinting of Virion Particle Infectivity and in Target Cell Protection by Interferon-Induced Transmembrane Protein 3 against HIV-1. J Virol. 2019;93: pubmed publisher
Tammineni E, Carrillo E, Soto Acosta R, Angel Ambrocio A, Garcia M, Bautista Carbajal P, et al. The β4 subunit of Cav1.2 channels is required for an optimal interferon response in cardiac muscle cells. Sci Signal. 2018;11: pubmed publisher
Petrillo C, Thorne L, Unali G, Schiroli G, Giordano A, Piras F, et al. Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells. Cell Stem Cell. 2018;23:820-832.e9 pubmed publisher
Yu J, Liu S. The Inhibition of HIV-1 Entry Imposed by Interferon Inducible Transmembrane Proteins Is Independent of Co-Receptor Usage. Viruses. 2018;10: pubmed publisher
Xu B, Pan Q, Liang C. Role of MxB in Alpha Interferon-Mediated Inhibition of HIV-1 Infection. J Virol. 2018;92: pubmed publisher
McMichael T, Zhang Y, Kenney A, Zhang L, Zani A, Lu M, et al. IFITM3 Restricts Human Metapneumovirus Infection. J Infect Dis. 2018;218:1582-1591 pubmed publisher
Thinon E, Fernandez J, Molina H, Hang H. Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites. J Proteome Res. 2018;17:1907-1922 pubmed publisher
Roesch F, OhAinle M, Emerman M. A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery. Retrovirology. 2018;15:26 pubmed publisher
Li C, Du S, Tian M, Wang Y, Bai J, Tan P, et al. The Host Restriction Factor Interferon-Inducible Transmembrane Protein 3 Inhibits Vaccinia Virus Infection. Front Immunol. 2018;9:228 pubmed publisher
Tsai C, Chi H, Chi L, Yang H, Tsai M, Lee K, et al. Argininosuccinate synthetase 1 contributes to gastric cancer invasion and progression by modulating autophagy. FASEB J. 2018;32:2601-2614 pubmed publisher
Shan J, Zhao B, Shan Z, Nie J, Deng R, Xiong R, et al. Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation. PLoS Pathog. 2017;13:e1006773 pubmed publisher
McMichael T, Zhang L, Chemudupati M, Hach J, Kenney A, Hang H, et al. The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity. J Biol Chem. 2017;292:21517-21526 pubmed publisher
Chesarino N, Compton A, McMichael T, Kenney A, Zhang L, Soewarna V, et al. IFITM3 requires an amphipathic helix for antiviral activity. EMBO Rep. 2017;18:1740-1751 pubmed publisher
Sareila O, Hagert C, Kelkka T, Linja M, Xu B, Kihlberg J, et al. Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms. Antioxid Redox Signal. 2017;27:1473-1490 pubmed publisher
Wrensch F, Hoffmann M, Gärtner S, Nehlmeier I, Winkler M, Pohlmann S. Virion Background and Efficiency of Virion Incorporation Determine Susceptibility of Simian Immunodeficiency Virus Env-Driven Viral Entry to Inhibition by IFITM Proteins. J Virol. 2017;91: pubmed publisher
Poddar S, Hyde J, Gorman M, Farzan M, Diamond M. The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses. J Virol. 2016;90:8780-94 pubmed publisher
Gorman M, Poddar S, Farzan M, Diamond M. The Interferon-Stimulated Gene Ifitm3 Restricts West Nile Virus Infection and Pathogenesis. J Virol. 2016;90:8212-25 pubmed publisher
Wilkins J, Zheng Y, Yu J, Liang C, Liu S. Nonhuman Primate IFITM Proteins Are Potent Inhibitors of HIV and SIV. PLoS ONE. 2016;11:e0156739 pubmed publisher
Muñoz Moreno R, Cuesta Geijo M, Martínez Romero C, Barrado Gil L, Galindo I, Garcia Sastre A, et al. Antiviral Role of IFITM Proteins in African Swine Fever Virus Infection. PLoS ONE. 2016;11:e0154366 pubmed publisher
Zeng X, Wang S, Chi X, Chen S, Huang S, Lin Q, et al. Infection of goats with goatpox virus triggers host antiviral defense through activation of innate immune signaling. Res Vet Sci. 2016;104:40-9 pubmed publisher
Yu J, Li M, Wilkins J, Ding S, Swartz T, Esposito A, et al. IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein. Cell Rep. 2015;13:145-156 pubmed publisher
Koyama N, Hakura A, Toritsuka N, Sonoda J, Seki Y, Tohyama O, et al. Wif1 and Ifitm3 gene expression preferentially altered in the colon mucosa of benzo[a]pyrene pre-treated mice following exposure to dextran sulfate sodium. Chem Biol Interact. 2015;240:164-70 pubmed publisher
Chesarino N, McMichael T, Yount J. E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3. PLoS Pathog. 2015;11:e1005095 pubmed publisher
Chen Z, Luo G, Wang Q, Wang S, Chi X, Huang Y, et al. Muscovy duck reovirus infection rapidly activates host innate immune signaling and induces an effective antiviral immune response involving critical interferons. Vet Microbiol. 2015;175:232-43 pubmed publisher
Qian J, Le Duff Y, Wang Y, Pan Q, Ding S, Zheng Y, et al. Primate lentiviruses are differentially inhibited by interferon-induced transmembrane proteins. Virology. 2015;474:10-8 pubmed publisher
Yu M, Qi W, Huang Z, Zhang K, Ye J, Liu R, et al. Expression profile and histological distribution of IFITM1 and IFITM3 during H9N2 avian influenza virus infection in BALB/c mice. Med Microbiol Immunol. 2015;204:505-14 pubmed publisher
Zhang W, Zhang L, Zan Y, Du N, Yang Y, Tien P. Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins. J Gen Virol. 2015;96:170-82 pubmed publisher
Zhu X, He Z, Yuan J, Wen W, Huang X, Hu Y, et al. IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection. Cell Microbiol. 2015;17:105-18 pubmed publisher
Jia R, Xu F, Qian J, Yao Y, Miao C, Zheng Y, et al. Identification of an endocytic signal essential for the antiviral action of IFITM3. Cell Microbiol. 2014;16:1080-93 pubmed publisher
product information
CatalogNo :
11714-1-AP
AntigenName :
IFITM3
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
interferon induced transmembrane protein 3 (1-8U)
Immunogen :
Recombinant Protein
Species :
goat, human, mouse, rat, swine
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, FC, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
1 8U, Fragilis, IFITM3, IP15
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC006794
Category :
Cell Cycle;Immunology;Membrane Proteins;Stem Cells;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
FC 1:0 ; IF 1:50 ; IHC 1:200 ; IP 1:1500 ; WB 1:5000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.