This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
VPRBP
catalog :
11612-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, western blot knockout validation
citations: 15
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:2000; loading ...; fig 2c
  • immunoprecipitation; mouse; 1:200; loading ...; fig 6b
  • western blot knockout validation; human; 1:2000; loading ...; fig s5b
Guo Z, Kong Q, Liu C, Zhang S, Zou L, Yan F, et al. DCAF1 controls T-cell function via p53-dependent and -independent mechanisms. Nat Commun. 2016;7:10307 pubmed publisher
Yurkovetskiy L, Guney M, Kim K, Goh S, McCauley S, Dauphin A, et al. Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex. Nat Microbiol. 2018;3:1354-1361 pubmed publisher
Schabla N, Perry G, Palmer V, Swanson P. VprBP (DCAF1) Regulates RAG1 Expression Independently of Dicer by Mediating RAG1 Degradation. J Immunol. 2018;201:930-939 pubmed publisher
Lv L, Wang Q, Xu Y, Tsao L, Nakagawa T, Guo H, et al. Vpr Targets TET2 for Degradation by CRL4VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication. Mol Cell. 2018;70:961-970.e5 pubmed publisher
Hossain D, Ferreira Barbosa J, Cohen E, Tsang W. HIV-1 Vpr hijacks EDD-DYRK2-DDB1DCAF1 to disrupt centrosome homeostasis. J Biol Chem. 2018;293:9448-9460 pubmed publisher
Li B, Yu C, Xu Y, Liu S, Fan H, Pan W. TET1 inhibits cell proliferation by inducing RASSF5 expression. Oncotarget. 2017;8:86395-86409 pubmed publisher
Hotter D, Krabbe T, Reith E, Gawanbacht A, Rahm N, Ayouba A, et al. Primate lentiviruses use at least three alternative strategies to suppress NF-?B-mediated immune activation. PLoS Pathog. 2017;13:e1006598 pubmed publisher
Furukawa K, Yamashita K, Sakurai N, Ohno S. The Epithelial Circumferential Actin Belt Regulates YAP/TAZ through Nucleocytoplasmic Shuttling of Merlin. Cell Rep. 2017;20:1435-1447 pubmed publisher
Yu C, Ji S, Sha Q, Sun Q, Fan H. CRL4-DCAF1 ubiquitin E3 ligase directs protein phosphatase 2A degradation to control oocyte meiotic maturation. Nat Commun. 2015;6:8017 pubmed publisher
Collins D, Lubow J, Lukic Z, Mashiba M, Collins K. Vpr Promotes Macrophage-Dependent HIV-1 Infection of CD4+ T Lymphocytes. PLoS Pathog. 2015;11:e1005054 pubmed publisher
Yamashita K, Ide M, Furukawa K, Suzuki A, Hirano H, Ohno S. Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex. Mol Biol Cell. 2015;26:2426-38 pubmed publisher
Li J, Xu F, Hu S, Zhou J, Mei S, Zhao X, et al. Characterization of the interactions between SIVrcm Vpx and red-capped mangabey SAMHD1. Biochem J. 2015;468:303-13 pubmed publisher
Jáuregui P, Logue E, Schultz M, Fung S, Landau N. Degradation of SAMHD1 by Vpx Is Independent of Uncoating. J Virol. 2015;89:5701-13 pubmed publisher
Nakagawa T, Lv L, Nakagawa M, Yu Y, Yu C, D Alessio A, et al. CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases. Mol Cell. 2015;57:247-260 pubmed publisher
Kyei G, Cheng X, Ramani R, Ratner L. Cyclin L2 is a critical HIV dependency factor in macrophages that controls SAMHD1 abundance. Cell Host Microbe. 2015;17:98-106 pubmed publisher
product information
CatalogNo :
11612-1-AP
AntigenName :
VPRBP
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
Vpr (HIV-1) binding protein
Immunogen :
Recombinant Protein
Species :
dog, human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, FC, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
DCAF1, HIV 1 Vpr binding protein, KIAA0800, Protein VPRBP, RIP, Vpr (HIV 1) binding protein, Vpr interacting protein, VPRBP
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC022792
Category :
Binding Proteins;Metabolism;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
FC 1:0 ; IF 1:50 ; IHC 1:200 ; IP 1:1000 ; WB 1:4000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.