This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
SIX2
catalog :
11562-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, western blot knockout validation
citations: 113
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; loading ...; fig 4e, e4d, e9c
Liu Z, Mar K, Hanners N, Perelman S, Kanchwala M, Xing C, et al. A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB. Nature. 2019;: pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 3d
Calandrini C, Schutgens F, Oka R, Margaritis T, Candelli T, Mathijsen L, et al. An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity. Nat Commun. 2020;11:1310 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1b
Low J, Li P, Chew E, Zhou B, Suzuki K, Zhang T, et al. Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network. Cell Stem Cell. 2019;25:373-387.e9 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 1f
Lawlor K, Zappia L, Lefevre J, Park J, Hamilton N, Oshlack A, et al. Nephron progenitor commitment is a stochastic process influenced by cell migration. elife. 2019;8: pubmed publisher
  • immunocytochemistry; human; 1:200; fig 4a
  • western blot; human; 1:600; fig s2
Hsieh W, Ramadesikan S, FEKETE D, Aguilar R. Kidney-differentiated cells derived from Lowe Syndrome patient's iPSCs show ciliogenesis defects and Six2 retention at the Golgi complex. PLoS ONE. 2018;13:e0192635 pubmed publisher
  • immunohistochemistry; mouse; 1:300; fig 2
Reginensi A, Enderle L, Gregorieff A, Johnson R, Wrana J, McNeill H. A critical role for NF2 and the Hippo pathway in branching morphogenesis. Nat Commun. 2016;7:12309 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 4d
  • western blot; mouse; loading ...; fig 2i
Xu J, Liu H, Chai O, Lan Y, Jiang R. Osr1 Interacts Synergistically with Wt1 to Regulate Kidney Organogenesis. PLoS ONE. 2016;11:e0159597 pubmed publisher
  • immunocytochemistry; mouse; 1:200; fig 8a
Dauleh S, Santeramo I, Fielding C, Ward K, Herrmann A, Murray P, et al. Characterisation of Cultured Mesothelial Cells Derived from the Murine Adult Omentum. PLoS ONE. 2016;11:e0158997 pubmed publisher
  • immunohistochemistry; rat; 1:500; fig s13
Kirita Y, Kami D, Ishida R, Adachi T, Tamagaki K, Matoba S, et al. Preserved Nephrogenesis Following Partial Nephrectomy in Early Neonates. Sci Rep. 2016;6:26792 pubmed publisher
Drake K, Chaney C, Das A, Roy P, Kwartler C, Rakheja D, et al. Stromal beta-catenin activation impacts nephron progenitor differentiation in the developing kidney and may contribute to Wilms tumor. Development. 2020;: pubmed publisher
Velazco Cruz L, Goedegebuure M, Maxwell K, Augsornworawat P, Hogrebe N, Millman J. SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro. Cell Rep. 2020;31:107687 pubmed publisher
Murphy A, Chen X, Pinto E, Williams J, Clay M, Pounds S, et al. Forty-five patient-derived xenografts capture the clinical and biological heterogeneity of Wilms tumor. Nat Commun. 2019;10:5806 pubmed publisher
Barry D, McMillan E, Kunar B, Lis R, Zhang T, Lu T, et al. Molecular determinants of nephron vascular specialization in the kidney. Nat Commun. 2019;10:5705 pubmed publisher
Sweat Y, Sweat M, Mansaray M, Cao H, Eliason S, Adeyemo W, et al. Six2 regulates Pax9 expression, palatogenesis and craniofacial bone formation. Dev Biol. 2019;: pubmed publisher
Rutledge E, Lindström N, Michos O, McMahon A. Genetic manipulation of ureteric bud tip progenitors in the mammalian kidney through an Adamts18 enhancer driven tet-on inducible system. Dev Biol. 2019;: pubmed publisher
Wan Z, Ma Y, Jiang T, Lin Y, Shi Y, Tan Y, et al. Six2 is negatively correlated with prognosis and facilitates epithelial-mesenchymal transition via TGF-β/Smad signal pathway in hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int. 2019;18:525-531 pubmed publisher
Faraj R, Irizarry Alfonzo A, Puri P. Molecular characterization of nephron progenitors and their early epithelial derivative structures in the nephrogenic zone of the canine fetal kidney. Eur J Histochem. 2019;63: pubmed publisher
Benedetti V, Lavecchia A, Locatelli M, Brizi V, Corna D, Todeschini M, et al. Alteration of thyroid hormone signaling triggers the diabetes-induced pathological growth, remodeling, and dedifferentiation of podocytes. JCI Insight. 2019;4: pubmed publisher
O Hara R, Arsenault M, Esparza Gonzalez B, Patriquen A, Hartwig S. Three Optimized Methods for In Situ Quantification of Progenitor Cell Proliferation in Embryonic Kidneys Using BrdU, EdU, and PCNA. Can J Kidney Health Dis. 2019;6:2054358119871936 pubmed publisher
Cerqueira D, Hemker S, Bodnar A, Ortiz D, Oladipupo F, Mukherjee E, et al. In utero exposure to maternal diabetes impairs nephron progenitor differentiation. Am J Physiol Renal Physiol. 2019;317:F1318-F1330 pubmed publisher
Cheng N, Li H, Han Y, Sun S. Transcription factor Six2 induces a stem cell like phenotype in renal cell carcinoma cells. FEBS Open Bio. 2019;: pubmed publisher
Rutledge E, Parvez R, Short K, Smyth I, McMahon A. Morphogenesis of the kidney and lung requires branch-tip directed activity of the Adamts18 metalloprotease. Dev Biol. 2019;454:156-169 pubmed publisher
Watanabe M, Nakano K, Uchikura A, Matsunari H, Yashima S, Umeyama K, et al. Anephrogenic phenotype induced by SALL1 gene knockout in pigs. Sci Rep. 2019;9:8016 pubmed publisher
Cargill K, Hemker S, Clugston A, Murali A, Mukherjee E, Liu J, et al. Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation. J Am Soc Nephrol. 2019;: pubmed publisher
Combes A, Phipson B, Lawlor K, Dorison A, Patrick R, Zappia L, et al. Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk. Development. 2019;146: pubmed publisher
Wu Y, Song T, Liu M, He Q, Chen L, Liu Y, et al. PPARG Negatively Modulates Six2 in Tumor Formation of Clear Cell Renal Cell Carcinoma. DNA Cell Biol. 2019;: pubmed publisher
Fujimoto T, Yamanaka S, Tajiri S, Takamura T, Saito Y, Matsumoto K, et al. In vivo regeneration of interspecies chimeric kidneys using a nephron progenitor cell replacement system. Sci Rep. 2019;9:6965 pubmed publisher
Liu Y, Kanyomse Q, Xie Y. Tumor-suppressive activity of Hnf1β in Wilms' tumor. Biosci Biotechnol Biochem. 2019;:1-8 pubmed publisher
Yosypiv I, Sequeira Lopez M, Song R, De Goes Martini A. Stromal prorenin receptor is critical for normal kidney development. Am J Physiol Regul Integr Comp Physiol. 2019;316:R640-R650 pubmed publisher
Liu Z, Li C, Xu J, Lan Y, Liu H, Li X, et al. Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development. J Dent Res. 2019;98:572-579 pubmed publisher
Zhang H, Bagherie Lachidan M, Badouel C, Enderle L, Peidis P, Bremner R, et al. FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling. Dev Cell. 2019;: pubmed publisher
Phua Y, Chen K, Hemker S, Marrone A, Bodnar A, Liu X, et al. Loss of miR-17~92 results in dysregulation of Cftr in nephron progenitors. Am J Physiol Renal Physiol. 2019;316:F993-F1005 pubmed publisher
Hochane M, van den Berg P, Fan X, Bérenger Currias N, Adegeest E, Bialecka M, et al. Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney development. PLoS Biol. 2019;17:e3000152 pubmed publisher
Garreta E, Prado P, Tarantino C, Oria R, Fanlo L, Marti E, et al. Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells. Nat Mater. 2019;18:397-405 pubmed publisher
Goto T, Hara H, Sanbo M, Masaki H, Sato H, Yamaguchi T, et al. Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats. Nat Commun. 2019;10:451 pubmed publisher
Murakami Y, Naganuma H, Tanigawa S, Fujimori T, Eto M, Nishinakamura R. Reconstitution of the embryonic kidney identifies a donor cell contribution to the renal vasculature upon transplantation. Sci Rep. 2019;9:1172 pubmed publisher
Yermalovich A, Osborne J, Sousa P, Han A, Kinney M, Chen M, et al. Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis. Nat Commun. 2019;10:168 pubmed publisher
Wang J, Liu M, Zhao L, Li Y, Zhang M, Jin Y, et al. Disabling of nephrogenesis in porcine embryos via CRISPR/Cas9-mediated SIX1 and SIX4 gene targeting. Xenotransplantation. 2019;26:e12484 pubmed publisher
Jo N, Sogabe Y, Yamada Y, Ukai T, Kagawa H, Mitsunaga K, et al. Platforms of in vivo genome editing with inducible Cas9 for advanced cancer modeling. Cancer Sci. 2019;110:926-938 pubmed publisher
Wanner N, Vornweg J, Combes A, Wilson S, Plappert J, Rafflenbeul G, et al. DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation. J Am Soc Nephrol. 2019;30:63-78 pubmed publisher
Reilly M, Stokman M, Magry V, Jeanpierre C, Alves M, Paydar M, et al. Loss-of-function mutations in KIF14 cause severe microcephaly and kidney development defects in humans and zebrafish. Hum Mol Genet. 2019;28:778-795 pubmed publisher
O Brien L, Combes A, Short K, Lindström N, Whitney P, Cullen McEwen L, et al. Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment. elife. 2018;7: pubmed publisher
He Q, Chen L, Liu Y, Wu Y, Ni D, Liu J, et al. Gulo regulates the proliferation, apoptosis and mesenchymal-to-epithelial transformation of metanephric mesenchyme cells via inhibiting Six2. Biochem Biophys Res Commun. 2018;504:885-891 pubmed publisher
Rabadi M, Abdulmahdi W, Nesi L, Jules E, Marghani Y, Sheinin E, et al. Maternal malnourishment induced upregulation of fetuin-B blunts nephrogenesis in the low birth weight neonate. Dev Biol. 2018;443:78-91 pubmed publisher
Short K, Combes A, Lisnyak V, Lefevre J, Jones L, Little M, et al. Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration. elife. 2018;7: pubmed publisher
Held M, Santeramo I, Wilm B, Murray P, Levy R. Ex vivo live cell tracking in kidney organoids using light sheet fluorescence microscopy. PLoS ONE. 2018;13:e0199918 pubmed publisher
Rowan C, Li W, Martirosyan H, Erwood S, Hu D, Kim Y, et al. Hedgehog-GLI signaling in Foxd1-positive stromal cells promotes murine nephrogenesis via TGF? signaling. Development. 2018;145: pubmed publisher
Zhang L, Ettou S, Khalid M, Taglienti M, Jain D, Jung Y, et al. EED, a member of the polycomb group, is required for nephron differentiation and the maintenance of nephron progenitor cells. Development. 2018;145: pubmed publisher
Dionne L, Shim K, Hoshi M, Cheng T, Wang J, Marthiens V, et al. Centrosome amplification disrupts renal development and causes cystogenesis. J Cell Biol. 2018;217:2485-2501 pubmed publisher
Nishikawa M, Kimura H, Yanagawa N, Hamon M, Hauser P, Zhao L, et al. An optimal serum-free defined condition for in vitro culture of kidney organoids. Biochem Biophys Res Commun. 2018;501:996-1002 pubmed publisher
Li J, Huang C, Li J, Yuan J, Chen Q, Zhang W, et al. Six2 is negatively correlated with good prognosis and decreases 5-FU sensitivity via suppressing E-cadherin expression in hepatocellular carcinoma cells. Biomed Pharmacother. 2018;104:204-210 pubmed publisher
Liu H, Chen S, Yao X, Li Y, Chen C, Liu J, et al. Histone deacetylases 1 and 2 regulate the transcriptional programs of nephron progenitors and renal vesicles. Development. 2018;145: pubmed publisher
Magella B, Mahoney R, Adam M, Potter S. Reduced Abd-B Hox function during kidney development results in lineage infidelity. Dev Biol. 2018;438:84-93 pubmed publisher
Fukunaga S, Yamanaka S, Fujimoto T, Tajiri S, Uchiyama T, Matsumoto K, et al. Optimal route of diphtheria toxin administration to eliminate native nephron progenitor cells in vivo for kidney regeneration. Biochem Biophys Res Commun. 2018;496:1176-1182 pubmed publisher
O Brien L, Guo Q, Bahrami Samani E, Park J, Hasso S, Lee Y, et al. Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies. PLoS Genet. 2018;14:e1007181 pubmed publisher
Combes A, Wilson S, Phipson B, Binnie B, Ju A, Lawlor K, et al. Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number. Kidney Int. 2018;93:589-598 pubmed publisher
Puri P, Schaefer C, Bushnell D, Taglienti M, Kreidberg J, Yoder B, et al. Ectopic Phosphorylated Creb Marks Dedifferentiated Proximal Tubules in Cystic Kidney Disease. Am J Pathol. 2018;188:84-94 pubmed publisher
Liao H, Hatanaka F, Araoka T, Reddy P, Wu M, Sui Y, et al. In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation. Cell. 2017;171:1495-1507.e15 pubmed publisher
Okello D, Iyyanar P, Kulyk W, Smith T, Lozanoff S, Ji S, et al. Six2 Plays an Intrinsic Role in Regulating Proliferation of Mesenchymal Cells in the Developing Palate. Front Physiol. 2017;8:955 pubmed publisher
Yamanaka S, Tajiri S, Fujimoto T, Matsumoto K, Fukunaga S, Kim B, et al. Generation of interspecies limited chimeric nephrons using a conditional nephron progenitor cell replacement system. Nat Commun. 2017;8:1719 pubmed publisher
Taguchi A, Nishinakamura R. Higher-Order Kidney Organogenesis from Pluripotent Stem Cells. Cell Stem Cell. 2017;21:730-746.e6 pubmed publisher
De Tomasi L, David P, Humbert C, Silbermann F, Arrondel C, Tores F, et al. Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice. Am J Hum Genet. 2017;101:803-814 pubmed publisher
Bohndorf M, Ncube A, Spitzhorn L, Enczmann J, Wruck W, Adjaye J. Derivation and characterization of integration-free iPSC line ISRM-UM51 derived from SIX2-positive renal cells isolated from urine of an African male expressing the CYP2D6 *4/*17 variant which confers intermediate drug metabolizing activity. Stem Cell Res. 2017;25:18-21 pubmed publisher
Pan X, Karner C, Carroll T. Myc cooperates with β-catenin to drive gene expression in nephron progenitor cells. Development. 2017;144:4173-4182 pubmed publisher
Munro D, Hohenstein P, Coate T, Davies J. Refuting the hypothesis that semaphorin-3f/neuropilin-2 exclude blood vessels from the cap mesenchyme in the developing kidney. Dev Dyn. 2017;246:1047-1056 pubmed publisher
Yucer N, Holzapfel M, Jenkins Vogel T, Lenaeus L, Ornelas L, Laury A, et al. Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium. Sci Rep. 2017;7:10741 pubmed publisher
Awazu M, Nagata M, Hida M. BMP7 dose-dependently stimulates proliferation and cadherin-11 expression via ERK and p38 in a murine metanephric mesenchymal cell line. Physiol Rep. 2017;5: pubmed publisher
Sparrow A, Sweetman D, Welham S. LIM kinase function and renal growth: Potential role for LIM kinases in fetal programming of kidney development. Life Sci. 2017;186:17-24 pubmed publisher
Munro D, Hohenstein P, Davies J. Cycles of vascular plexus formation within the nephrogenic zone of the developing mouse kidney. Sci Rep. 2017;7:3273 pubmed publisher
Monti M, Imberti B, Bianchi N, Pezzotta A, Morigi M, Del Fante C, et al. A Novel Method for Isolation of Pluripotent Stem Cells from Human Umbilical Cord Blood. Stem Cells Dev. 2017;26:1258-1269 pubmed publisher
Pode Shakked N, Gershon R, Tam G, Omer D, Gnatek Y, Kanter I, et al. Evidence of In Vitro Preservation of Human Nephrogenesis at the Single-Cell Level. Stem Cell Reports. 2017;9:279-291 pubmed publisher
Naiman N, Fujioka K, Fujino M, Valerius M, Potter S, McMahon A, et al. Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell. 2017;41:349-365.e3 pubmed publisher
Cerqueira D, Bodnar A, Phua Y, Freer R, Hemker S, Walensky L, et al. Bim gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney development. FASEB J. 2017;31:3540-3554 pubmed publisher
Mao Z, Lyu Z, Huang L, Zhou Q, Weng Y. T?RII Regulates the Proliferation of Metanephric Mesenchyme Cells through Six2 In Vitro. Int J Mol Sci. 2017;18: pubmed publisher
Belle M, Godefroy D, Couly G, Malone S, Collier F, Giacobini P, et al. Tridimensional Visualization and Analysis of Early Human Development. Cell. 2017;169:161-173.e12 pubmed publisher
Sambi M, Chow T, Whiteley J, Li M, Chua S, Raileanu V, et al. Acellular Mouse Kidney ECM can be Used as a Three-Dimensional Substrate to Test the Differentiation Potential of Embryonic Stem Cell Derived Renal Progenitors. Stem Cell Rev. 2017;13:513-531 pubmed publisher
Saarela U, Akram S, Desgrange A, Rak Raszewska A, Shan J, Cereghini S, et al. Novel fixed z-direction (FiZD) kidney primordia and an organoid culture system for time-lapse confocal imaging. Development. 2017;144:1113-1117 pubmed publisher
Liu S, Song N, He J, Yu X, Guo J, Jiao X, et al. Effect of Hypoxia on the Differentiation and the Self-Renewal of Metanephrogenic Mesenchymal Stem Cells. Stem Cells Int. 2017;2017:7168687 pubmed publisher
Lefevre J, Chiu H, Combes A, Vanslambrouck J, Ju A, Hamilton N, et al. Self-organisation after embryonic kidney dissociation is driven via selective adhesion of ureteric epithelial cells. Development. 2017;144:1087-1096 pubmed publisher
Tögel F, Valerius M, Freedman B, Iatrino R, Grinstein M, Bonventre J. Repair after nephron ablation reveals limitations of neonatal neonephrogenesis. JCI Insight. 2017;2:e88848 pubmed publisher
Zhou Z, Wang J, Guo C, Chang W, Zhuang J, Zhu P, et al. Temporally Distinct Six2-Positive Second Heart Field Progenitors Regulate Mammalian Heart Development and Disease. Cell Rep. 2017;18:1019-1032 pubmed publisher
Yuri S, Nishikawa M, Yanagawa N, Jo O, Yanagawa N. In Vitro Propagation and Branching Morphogenesis from Single Ureteric Bud Cells. Stem Cell Reports. 2017;8:401-416 pubmed publisher
Morizane R, Bonventre J. Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells. Nat Protoc. 2017;12:195-207 pubmed publisher
McNeill H, Reginensi A. Lats1/2 Regulate Yap/Taz to Control Nephron Progenitor Epithelialization and Inhibit Myofibroblast Formation. J Am Soc Nephrol. 2017;28:852-861 pubmed publisher
Chung E, Deacon P, Marable S, Shin J, Park J. Notch signaling promotes nephrogenesis by downregulating Six2. Development. 2016;143:3907-3913 pubmed
Liu J, Ju P, Zhou Y, Zhao Y, Xie Y, Long Y, et al. Six2 Is a Coordinator of LiCl-Induced Cell Proliferation and Apoptosis. Int J Mol Sci. 2016;17: pubmed publisher
Gu Y, Zhao Y, Zhou Y, Xie Y, Ju P, Long Y, et al. Zeb1 Is a Potential Regulator of Six2 in the Proliferation, Apoptosis and Migration of Metanephric Mesenchyme Cells. Int J Mol Sci. 2016;17: pubmed publisher
Combes A, Lefevre J, Wilson S, Hamilton N, Little M. Cap mesenchyme cell swarming during kidney development is influenced by attraction, repulsion, and adhesion to the ureteric tip. Dev Biol. 2016;418:297-306 pubmed publisher
Tanigawa S, Taguchi A, Sharma N, Perantoni A, Nishinakamura R. Selective In Vitro Propagation of Nephron Progenitors Derived from Embryos and Pluripotent Stem Cells. Cell Rep. 2016;15:801-813 pubmed publisher
Camarata T, Howard A, Elsey R, Raza S, O Connor A, Beatty B, et al. Postembryonic Nephrogenesis and Persistence of Six2-Expressing Nephron Progenitor Cells in the Reptilian Kidney. PLoS ONE. 2016;11:e0153422 pubmed publisher
Arda H, Li L, Tsai J, Torre E, Rosli Y, Peiris H, et al. Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human ? Cell Function. Cell Metab. 2016;23:909-20 pubmed publisher
Huang L, Mokkapati S, Hu Q, Ruteshouser E, Hicks M, Huff V. Nephron Progenitor But Not Stromal Progenitor Cells Give Rise to Wilms Tumors in Mouse Models with β-Catenin Activation or Wt1 Ablation and Igf2 Upregulation. Neoplasia. 2016;18:71-81 pubmed publisher
Song R, Preston G, Kidd L, Bushnell D, Sims Lucas S, Bates C, et al. Prorenin receptor is critical for nephron progenitors. Dev Biol. 2016;409:382-91 pubmed publisher
Batchelder C, Martinez M, Tarantal A. Natural Scaffolds for Renal Differentiation of Human Embryonic Stem Cells for Kidney Tissue Engineering. PLoS ONE. 2015;10:e0143849 pubmed publisher
Muthukrishnan S, Yang X, Friesel R, Oxburgh L. Concurrent BMP7 and FGF9 signalling governs AP-1 function to promote self-renewal of nephron progenitor cells. Nat Commun. 2015;6:10027 pubmed publisher
Blake J, Hu D, Cain J, Rosenblum N. Urogenital development in Pallister-Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor. Hum Mol Genet. 2016;25:437-47 pubmed publisher
Ohmori T, Tanigawa S, Kaku Y, Fujimura S, Nishinakamura R. Sall1 in renal stromal progenitors non-cell autonomously restricts the excessive expansion of nephron progenitors. Sci Rep. 2015;5:15676 pubmed publisher
Elias B, Das A, Parekh D, Mernaugh G, Adams R, Yang Z, et al. Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development. J Cell Sci. 2015;128:4293-305 pubmed publisher
Chen S, Brunskill E, Potter S, Dexheimer P, Salomonis N, Aronow B, et al. Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan. Dev Cell. 2015;35:49-62 pubmed publisher
Takasato M, Er P, Chiu H, Maier B, Baillie G, Ferguson C, et al. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature. 2015;526:564-8 pubmed publisher
Phua Y, Chu J, Marrone A, Bodnar A, Sims Lucas S, Ho J. Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival. Physiol Rep. 2015;3: pubmed publisher
Brown A, Muthukrishnan S, Oxburgh L. A synthetic niche for nephron progenitor cells. Dev Cell. 2015;34:229-41 pubmed publisher
Raines A, Magella B, Adam M, Potter S. Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development. BMC Dev Biol. 2015;15:28 pubmed publisher
Mao Y, Francis West P, Irvine K. Fat4/Dchs1 signaling between stromal and cap mesenchyme cells influences nephrogenesis and ureteric bud branching. Development. 2015;142:2574-85 pubmed publisher
Bagherie Lachidan M, Reginensi A, Pan Q, Zaveri H, Scott D, Blencowe B, et al. Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool. Development. 2015;142:2564-73 pubmed publisher
Webb C, Ratliff M, Powell R, Wirsig Wiechmann C, Lakiza O, Obara T. A developmentally plastic adult mouse kidney cell line spontaneously generates multiple adult kidney structures. Biochem Biophys Res Commun. 2015;463:1334-1340 pubmed publisher
Yuri S, Nishikawa M, Yanagawa N, Jo O, Yanagawa N. Maintenance of Mouse Nephron Progenitor Cells in Aggregates with Gamma-Secretase Inhibitor. PLoS ONE. 2015;10:e0129242 pubmed publisher
Pan X, Schnell U, Karner C, Small E, Carroll T. A Cre-inducible fluorescent reporter for observing apical membrane dynamics. Genesis. 2015;53:285-93 pubmed publisher
Kann M, Bae E, Lenz M, Li L, Trannguyen B, Schumacher V, et al. WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals. Development. 2015;142:1254-66 pubmed publisher
Boivin F, Sarin S, Lim J, Javidan A, Svajger B, Khalili H, et al. Stromally expressed β-catenin modulates Wnt9b signaling in the ureteric epithelium. PLoS ONE. 2015;10:e0120347 pubmed publisher
Imberti B, Tomasoni S, Ciampi O, Pezzotta A, Derosas M, Xinaris C, et al. Renal progenitors derived from human iPSCs engraft and restore function in a mouse model of acute kidney injury. Sci Rep. 2015;5:8826 pubmed publisher
Di Giovanni V, Walker K, Bushnell D, Schaefer C, Sims Lucas S, Puri P, et al. Fibroblast growth factor receptor-Frs2α signaling is critical for nephron progenitors. Dev Biol. 2015;400:82-93 pubmed publisher
Recuenco M, Ohmori T, Tanigawa S, Taguchi A, Fujimura S, Conti M, et al. Nonmuscle Myosin II Regulates the Morphogenesis of Metanephric Mesenchyme-Derived Immature Nephrons. J Am Soc Nephrol. 2015;26:1081-91 pubmed publisher
product information
CatalogNo :
11562-1-AP
AntigenName :
SIX2
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
SIX homeobox 2
Immunogen :
Recombinant Protein
Species :
american alligator, dog, human, mouse, pig, rat, swine
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, pull-down, IP, chIP, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
Homeobox protein SIX2, Sine oculis homeobox homolog 2, SIX homeobox 2, SIX2
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC024033
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Development;Metabolism;Stem Cells;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IP 1:500 ; WB 1:1500 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.