| Published Application/Species/Sample/Dilution | Reference |
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- immunohistochemistry - paraffin section; human; loading ...; fig 8l
| Li X, Wu Y, Zhao J, Wang H, Tan J, Yang M, et al. Distinct cardiac energy metabolism and oxidative stress adaptations between obese and non-obese type 2 diabetes mellitus. Theranostics. 2020;10:2675-2695 pubmed publisher |
| Sun B, Wang X, Liu X, Wang L, Ren F, Wang X, et al. Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease. Antioxidants (Basel). 2020;9: pubmed publisher |
| Wang T, Jian Z, Baskys A, Yang J, Li J, Guo H, et al. MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system. Biomaterials. 2020;257:120264 pubmed publisher |
| Lu Y, Sun Y, Liu Z, Lu Y, Zhu X, Lan B, et al. Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease. Sci Transl Med. 2020;12: pubmed publisher |
| Zhang H, Chen Y, Chen Y, Ji S, Jia P, Li Y, et al. Comparison of the protective effects of resveratrol and pterostilbene against intestinal damage and redox imbalance in weanling piglets. J Anim Sci Biotechnol. 2020;11:52 pubmed publisher |
| Huang K, Zhao X. USP9X prevents AGEs-induced upregulation of FN and TGF-β1 through activating Nrf2-ARE pathway in rat glomerular mesangial cells. Exp Cell Res. 2020;393:112100 pubmed publisher |
| Chen X, Qi J, Wu Q, Jiang H, Wang J, Chen W, et al. High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression. Acta Biochim Biophys Sin (Shanghai). 2020;52:506-516 pubmed publisher |
| Zhang L, Zhang J, Yan E, He J, Zhong X, Zhang L, et al. Dietary Supplemented Curcumin Improves Meat Quality and Antioxidant Status of Intrauterine Growth Retardation Growing Pigs via Nrf2 Signal Pathway. Animals (Basel). 2020;10: pubmed publisher |
| Wang S, Cheng H, Wang L, Zhao R, Guan D. Overexpression of NRF1-742 or NRF1-772 Reduces Arsenic-Induced Cytotoxicity and Apoptosis in Human HaCaT Keratinocytes. Int J Mol Sci. 2020;21: pubmed publisher |
| Choi I, Zhang Y, Seegobin S, Pruvost M, Wang Q, Purtell K, et al. Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration. Nat Commun. 2020;11:1386 pubmed publisher |
| Wang Z, Cai L, Li H, Liang M, Zhang Y, Wu Q, et al. Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats. J Food Biochem. 2020;44:e13180 pubmed publisher |
| Liu H, Zhu Y, Gao Y, Qi D, Zhao L, Zhao L, et al. NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis. Cell Death Dis. 2020;11:129 pubmed publisher |
| Qi L, Jiang J, Zhang J, Zhang L, Wang T. Curcumin Protects Human Trophoblast HTR8/SVneo Cells from H2O2-Induced Oxidative Stress by Activating Nrf2 Signaling Pathway. Antioxidants (Basel). 2020;9: pubmed publisher |
| Kang L, Liu S, Li J, Tian Y, Xue Y, Liu X. The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance. Cell Prolif. 2020;53:e12779 pubmed publisher |
| Xu Q, Shi W, Lv P, Meng W, Mao G, Gong C, et al. Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy. Cell Death Dis. 2020;11:6 pubmed publisher |
| Kang L, Liu S, Li J, Tian Y, Xue Y, Liu X. Parkin and Nrf2 prevent oxidative stress-induced apoptosis in intervertebral endplate chondrocytes via inducing mitophagy and anti-oxidant defenses. Life Sci. 2020;243:117244 pubmed publisher |
| Zhu M, Liu H, Sun K, Liu J, Mou Y, Qi D, et al. Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss. Biomed Pharmacother. 2020;123:109769 pubmed publisher |
| Zhang P, Yin Y, Wang T, Li W, Li C, Zeng X, et al. Maresin 1 mitigates concanavalin A-induced acute liver injury in mice by inhibiting ROS-mediated activation of NF-κB signaling. Free Radic Biol Med. 2020;147:23-36 pubmed publisher |
| Gao X, Jiang S, Du Z, Ke A, Liang Q, Li X. KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo. Oxid Med Cell Longev. 2019;2019:8564681 pubmed publisher |
| Wang Y, Jiang F, Cheng H, Tan X, Liu Y, Wei C, et al. Astragaloside IV Protects Against Oxidative Stress in Calf Small Intestine Epithelial Cells via NFE2L2-Antioxidant Response Element Signaling. Int J Mol Sci. 2019;20: pubmed publisher |
| Lazzara P, David B, Ankireddy A, Richardson B, Dye K, Ratia K, et al. Isoquinoline Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-like 2 (KEAP1-NRF2) Inhibitors with High Metabolic Stability. J Med Chem. 2019;: pubmed publisher |
| Bersuker K, Hendricks J, Li Z, Magtanong L, Ford B, Tang P, et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. 2019;575:688-692 pubmed publisher |
| Shu G, Qiu Y, Hao J, Fu Q, Deng X. γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways. Food Funct. 2019;10:6858-6872 pubmed publisher |
| Lin F, Yang D, Huang Y, Zhao Y, Ye J, Xiao M. The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice. Mar Drugs. 2019;17: pubmed publisher |
| Deng Z, Lim J, Wang Q, Purtell K, Wu S, Palomo G, et al. ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway. Autophagy. 2019;:1-15 pubmed publisher |
| Lu Q, Tan S, Gu W, Li F, Hua W, Zhang S, et al. Phytochemical composition, isolation and hepatoprotective activity of active fraction from Veronica ciliata against acetaminophen-induced acute liver injury via p62-Keap1-Nrf2 signaling pathway. J Ethnopharmacol. 2019;243:112089 pubmed publisher |
| Betharia S, Rondόn Ortiz A, Brown D. Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells. Neurochem Res. 2019;: pubmed publisher |
| Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, et al. Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents. Nat Commun. 2019;10:2538 pubmed publisher |
| Li A, Shen T, Wang T, Zhou M, Wang B, Song J, et al. Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis. Free Radic Biol Med. 2019;141:21-33 pubmed publisher |
| Zhou W, Ma L, Ding L, Guo Q, He Z, Yang J, et al. Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction. J Med Chem. 2019;62:5382-5403 pubmed publisher |
| Sparaneo A, Fabrizio F, la Torre A, Graziano P, Di Maio M, Fontana A, et al. Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors. Int J Mol Sci. 2019;20: pubmed publisher |
| Zhao X, Jin Y, Li L, Xu L, Tang Z, Qi Y, et al. MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1. Pharmacol Res. 2019;146:104276 pubmed publisher |
| Ren L, Zhan P, Wang Q, Wang C, Liu Y, Yu Z, et al. Curcumin upregulates the Nrf2 system by repressing inflammatory signaling-mediated Keap1 expression in insulin-resistant conditions. Biochem Biophys Res Commun. 2019;: pubmed publisher |
| Yan J, Pang Y, Zhuang J, Lin H, Zhang Q, Han L, et al. Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1-Nrf2-ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo. ACS Chem Neurosci. 2019;: pubmed publisher |
| Jia Y, Peng Y, Zhao Y, Cheng X, Zhou Y, Chai C, et al. Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs. J Agric Food Chem. 2019;: pubmed publisher |
| Wang Z, Liang M, Li H, Cai L, He H, Wu Q, et al. l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats. J Sci Food Agric. 2019;99:4849-4862 pubmed publisher |
| Qi Y, Li R, Xu L, Yin L, Xu Y, Han X, et al. Neuroprotective Effect of Dioscin on the Aging Brain. Molecules. 2019;24: pubmed publisher |
| Li W, Zhou H, Chen Y, Cai X, Tang H, Ren J, et al. NAD(P)H: Quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein. Cancer Lett. 2019;451:156-167 pubmed publisher |
| Liu H, Dong Y, Gao Y, Zhao L, Cai C, Qi D, et al. Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss. J Cell Physiol. 2019;234:11009-11022 pubmed publisher |
| Huang J, Lu Y, Zhang B, Yang S, Zhang Q, Cui H, et al. Antagonistic effect of epigallocatechin-3-gallate on neurotoxicity induced by formaldehyde. Toxicology. 2019;412:29-36 pubmed publisher |
| Li Y, Chen Y, Qiu C, Ma X, Lei K, Cai G, et al. 17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death. J Cell Biochem. 2018;: pubmed publisher |
| Yi T, Li X, Wang E, Zhang Y, Fu Y, Li J, et al. Activation of the Nuclear Erythroid 2-Related Factor 2 Antioxidant Responsive Element (Nrf2-ARE) Signaling Pathway Alleviates Acute Graft-Versus-Host Disease by Reducing Oxidative Stress and Inhibiting Infiltration of Inflammatory Cells in an Allogen. Med Sci Monit. 2018;24:5973-5979 pubmed publisher |
| Wang K, Lv Q, Miao Y, Qiao S, Dai Y, Wei Z. Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. Biochem Pharmacol. 2018;155:494-509 pubmed publisher |
| Zhang L, Fan X, Xie H, He Q, Nie Y, Zhang M, et al. Anti-Inflammatory and Antioxidant Effects of Kelong-Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats. Evid Based Complement Alternat Med. 2018;2018:5290514 pubmed publisher |
| Ning C, Gao X, Wang C, Kong Y, Liu Z, Sun H, et al. Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro. Regul Toxicol Pharmacol. 2018;98:58-68 pubmed publisher |
| Endo H, Owada S, Inagaki Y, Shida Y, Tatemichi M. Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells. Sci Rep. 2018;8:10122 pubmed publisher |
| Li Y, Qian W, Wang D, Meng Y, Wang X, Chen Y, et al. Resveratrol relieves particulate matter (mean diameter < 2.5 ?m)-induced oxidative injury of lung cells through attenuation of autophagy deregulation. J Appl Toxicol. 2018;38:1251-1261 pubmed publisher |
| Pu D, Zhao Y, Chen J, Sun Y, Lv A, Zhu S, et al. Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity. Neuroscience. 2018;381:35-45 pubmed publisher |
| Liang M, Wang Z, Li H, Cai L, Pan J, He H, et al. l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway. Food Chem Toxicol. 2018;115:315-328 pubmed publisher |
| Dong W, Yang B, Wang L, Li B, Guo X, Zhang M, et al. Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signaling. Toxicol Appl Pharmacol. 2018;346:28-36 pubmed publisher |
| Tang X, Liu B, Wang X, Yu Q, Fang R. Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect IPEC-J2 Cells from Lipopolysaccharides-Induced Apoptosis. Int J Mol Sci. 2018;19: pubmed publisher |
| Zhang J, Tucker L, DongYan -, Lu Y, Yang L, Wu C, et al. Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats. Neurochem Int. 2018;116:1-12 pubmed publisher |
| Zhao L, Tao X, Qi Y, Xu L, Yin L, Peng J. Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress. Redox Biol. 2018;16:189-198 pubmed publisher |
| Jia Y, Lu H, Peng Y, Zhang B, Gong X, Su J, et al. Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice. Int Immunopharmacol. 2018;56:105-112 pubmed publisher |
| Huang Y, Mao Y, Li H, Shen G, Nan G. Knockdown of Nrf2 inhibits angiogenesis by downregulating VEGF expression through PI3K/Akt signaling pathway in cerebral microvascular endothelial cells under hypoxic conditions. Biochem Cell Biol. 2018;96:475-482 pubmed publisher |
| Shi A, Shi H, Wang Y, Liu X, Cheng Y, Li H, et al. Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury. Int Immunopharmacol. 2018;54:125-130 pubmed publisher |
| Zheng L, Yin L, Xu L, Qi Y, Li H, Xu Y, et al. Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo. Biomed Pharmacother. 2018;97:481-488 pubmed publisher |
| Zhu Y, Li J, Wu Z, Lu Y, You H, Li R, et al. Acute exposure of ozone induced pulmonary injury and the protective role of vitamin E through the Nrf2 pathway in Balb/c mice. Toxicol Res (Camb). 2016;5:268-277 pubmed publisher |
| Sang L, Wang X, Xu D, Sang L, Han Y, Jiang L. Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model. World J Gastroenterol. 2017;23:8334-8344 pubmed publisher |
| Wu C, Yang L, Tucker D, Dong Y, Zhu L, Duan R, et al. Beneficial Effects of Exercise Pretreatment in a Sporadic Alzheimer's Rat Model. Med Sci Sports Exerc. 2017;: pubmed publisher |
| Wang W, Chen R, Wang J. Procyanidin B2 ameliorates carrageenan-induced chronic nonbacterial prostatitis in rats via anti-inflammatory and activation of the Nrf2 pathway. Biochem Biophys Res Commun. 2017;493:794-799 pubmed publisher |
| Niu L, Shao M, Liu Y, Hu J, Li R, Xie H, et al. Reduction of oxidative damages induced by titanium dioxide nanoparticles correlates with induction of the Nrf2 pathway by GSPE supplementation in mice. Chem Biol Interact. 2017;275:133-144 pubmed publisher |
| Su C, Liu Z, Wang Y, Wang Y, Song E, Song Y. The electrophilic character of quinones is essential for the suppression of Bach1. Toxicology. 2017;387:17-26 pubmed publisher |
| Wu H, Zhang G, Huang L, Pang H, Zhang N, Chen Y, et al. Hepatoprotective Effect of Polyphenol-Enriched Fraction from Folium Microcos on Oxidative Stress and Apoptosis in Acetaminophen-Induced Liver Injury in Mice. Oxid Med Cell Longev. 2017;2017:3631565 pubmed publisher |
| Zhang Y, Liu B, Chen X, Zhang N, Li G, Zhang L, et al. Naringenin Ameliorates Behavioral Dysfunction and Neurological Deficits in a d-Galactose-Induced Aging Mouse Model Through Activation of PI3K/Akt/Nrf2 Pathway. Rejuvenation Res. 2017;20:462-472 pubmed publisher |
| Sang Y, Zhang F, Wang H, Yao J, Chen R, Zhou Z, et al. Apigenin exhibits protective effects in a mouse model of d-galactose-induced aging via activating the Nrf2 pathway. Food Funct. 2017;8:2331-2340 pubmed publisher |
| Yuan X, Huang H, Huang Y, Wang J, Yan J, Ding L, et al. Nuclear factor E2-related factor 2 knockdown enhances glucose uptake and alters glucose metabolism in AML12 hepatocytes. Exp Biol Med (Maywood). 2017;242:930-938 pubmed publisher |
| Hu Y, Ma H, Zou Z, He K, Xiao Y, Wang Y, et al. Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress. Biomed Pharmacother. 2017;85:313-322 pubmed publisher |
| Shen S, Li J, You H, Wu Z, Wu Y, Zhao Y, et al. Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin. Food Chem Toxicol. 2017;99:60-69 pubmed publisher |
| Tan R, Chartoumpekis D, Rush B, Zhou D, Fu H, Kensler T, et al. Keap1 hypomorphism protects against ischemic and obstructive kidney disease. Sci Rep. 2016;6:36185 pubmed publisher |
| Zhang Q, Li Z, Wu S, Li X, Sang Y, Li J, et al. Myricetin alleviates cuprizone-induced behavioral dysfunction and demyelination in mice by Nrf2 pathway. Food Funct. 2016;7:4332-4342 pubmed |
| Wang P, Hung Y, Li W, Yeh C, Pan T. Systematic revelation of the protective effect and mechanism of Cordycep sinensis on diethylnitrosamine-induced rat hepatocellular carcinoma with proteomics. Oncotarget. 2016;7:60270-60289 pubmed publisher |
| Su C, Shi Q, Song X, Fu J, Liu Z, Wang Y, et al. Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling. Toxicology. 2016;363-364:48-57 pubmed publisher |
| Zhang W, Yin L, Tao X, Xu L, Zheng L, Han X, et al. Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation. Environ Toxicol Pharmacol. 2016;45:193-201 pubmed publisher |
| Zheng Z, Xu H, Suo S, Xu X, Ni M, Gu L, et al. The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer. Sci Rep. 2016;6:26093 pubmed publisher |
| Zhou Z, Ren L, Zhan P, Yang H, Chai D, Yu Z. Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling. Acta Pharmacol Sin. 2016;37:1063-75 pubmed publisher |
| Li H, He H, Wang Z, Cai J, Sun B, Wu Q, et al. Rice protein suppresses ROS generation and stimulates antioxidant gene expression via Nrf2 activation in adult rats. Gene. 2016;585:256-64 pubmed publisher |
| Ni S, Wang D, Qiu X, Pang L, Song Z, Guo K. Bone marrow mesenchymal stem cells protect against bleomycin-induced pulmonary fibrosis in rat by activating Nrf2 signaling. Int J Clin Exp Pathol. 2015;8:7752-61 pubmed |
| Shi Z, Niu Y, Wang Q, Shi L, Guo H, Liu Y, et al. Reduction of DNA damage induced by titanium dioxide nanoparticles through Nrf2 in vitro and in vivo. J Hazard Mater. 2015;298:310-9 pubmed publisher |
| Su C, Xia X, Shi Q, Song X, Fu J, Xiao C, et al. Neohesperidin Dihydrochalcone versus CClâ‚„-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation. J Agric Food Chem. 2015;63:5468-75 pubmed publisher |
| Su C, Zhang P, Song X, Shi Q, Fu J, Xia X, et al. Tetrachlorobenzoquinone activates Nrf2 signaling by Keap1 cross-linking and ubiquitin translocation but not Keap1-Cullin3 complex dissociation. Chem Res Toxicol. 2015;28:765-74 pubmed publisher |
