This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
OCT4
catalog :
11263-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunoprecipitation
citations: 74
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 1e
Liu X, Huang J, Xie Y, Zhou Y, Wang R, Lou J. Napabucasin Attenuates Resistance of Breast Cancer Cells to Tamoxifen by Reducing Stem Cell-Like Properties. Med Sci Monit. 2019;25:8905-8912 pubmed publisher
  • western blot; human; loading ...; fig 1c
Li E, Zhang T, Sun X, Li Y, Geng H, Yu D, et al. Sonic hedgehog pathway mediates genistein inhibition of renal cancer stem cells. Oncol Lett. 2019;18:3081-3091 pubmed publisher
  • immunoprecipitation; mouse; fig s2
Borkent M, Bennett B, Lackford B, Bar Nur O, Brumbaugh J, Wang L, et al. A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2. Stem Cell Reports. 2016;6:704-716 pubmed publisher
Sun H, Zhang T, Liu R, Cao W, Zhang Z, Liu Z, et al. Resveratrol Inhibition of Renal Cancer Stem Cell Characteristics and Modulation of the Sonic Hedgehog Pathway. Nutr Cancer. 2020;:1-11 pubmed publisher
Shi D, Shi X, Xing K, Zhou H, Lu L, Wu W. miR-296-5p suppresses stem cell potency of hepatocellular carcinoma cells via regulating Brg1/Sall4 axis. Cell Signal. 2020;72:109650 pubmed publisher
Deng K, Liu L, Tan X, Zhang Z, Li J, Ou Y, et al. WIP1 promotes cancer stem cell properties by inhibiting p38 MAPK in NSCLC. Signal Transduct Target Ther. 2020;5:36 pubmed publisher
Yang B, Bai H, Sa Y, Zhu P, Liu P. Inhibiting EMT, stemness and cell cycle involved in baicalin-induced growth inhibition and apoptosis in colorectal cancer cells. J Cancer. 2020;11:2303-2317 pubmed publisher
Liu X, Yang X, Li Y, Wang X, Ma J, Jiang W, et al. Generation of patient-specific pluripotent induced stem cell line SDUBMSI002-A from a patient with X-linked mental retardation syndrome. Stem Cell Res. 2020;43:101724 pubmed publisher
Xiaojing W, Yanyan M, Ruonan D, Xiaolin L, Haiyan Z, Jian M, et al. Generation of a human induced pluripotent stem cell line (SDUBMSi001-A) from a hereditary spastic paraplegia patient carrying kif1a c.773C>T missense mutation. Stem Cell Res. 2020;43:101727 pubmed publisher
Chen Y, Shao Z, Jiang E, Zhou X, Wang L, Wang H, et al. CCL21/CCR7 interaction promotes EMT and enhances the stemness of OSCC via a JAK2/STAT3 signaling pathway. J Cell Physiol. 2020;235:5995-6009 pubmed publisher
Mei Y, Cai D, Dai X. Modulating cancer stemness provides luminal a breast cancer cells with HER2 positive-like features. J Cancer. 2020;11:1162-1169 pubmed publisher
Guo Y, Yuan X, Li K, Dai M, Zhang L, Wu Y, et al. GABPA is a master regulator of luminal identity and restrains aggressive diseases in bladder cancer. Cell Death Differ. 2019;: pubmed publisher
Wang S, Hu H, Zhong B, Shi D, Qing X, Cheng C, et al. Bruceine D inhibits tumor growth and stem cell-like traits of osteosarcoma through inhibition of STAT3 signaling pathway. Cancer Med. 2019;8:7345-7358 pubmed publisher
Li C, Zheng H, Hou W, Bao H, Xiong J, Che W, et al. Long non-coding RNA linc00645 promotes TGF-β-induced epithelial-mesenchymal transition by regulating miR-205-3p-ZEB1 axis in glioma. Cell Death Dis. 2019;10:717 pubmed publisher
Guo Y, Wang P, Ma J, Cui Z, Yu Q, Liu S, et al. Modeling Retinitis Pigmentosa: Retinal Organoids Generated From the iPSCs of a Patient With the USH2A Mutation Show Early Developmental Abnormalities. Front Cell Neurosci. 2019;13:361 pubmed publisher
Zhang Q, Cao W, Wang X, Zhang M, Lu X, Chen J, et al. Genistein inhibits nasopharyngeal cancer stem cells through sonic hedgehog signaling. Phytother Res. 2019;: pubmed publisher
Liu X, Fu Y, Huang J, Wu M, Zhang Z, Xu R, et al. ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation. J Exp Clin Cancer Res. 2019;38:315 pubmed publisher
Zhang H, Chen F, He S, Liang Y, Wang Z, Wang L, et al. In vivo tracking on longer retention of transplanted myocardin gene-modified adipose-derived stem cells to improve erectile dysfunction in diabetic rats. Stem Cell Res Ther. 2019;10:208 pubmed publisher
Duan C, Xie H, Zhao X, Xu W, Zhang M. Limbal niche cells can reduce the angiogenic potential of cultivated oral mucosal epithelial cells. Cell Mol Biol Lett. 2019;24:3 pubmed publisher
Ai L, Mu S, Sun C, Fan F, Yan H, Qin Y, et al. Myeloid-derived suppressor cells endow stem-like qualities to multiple myeloma cells by inducing piRNA-823 expression and DNMT3B activation. Mol Cancer. 2019;18:88 pubmed publisher
He W, Liang B, Wang C, Li S, Zhao Y, Huang Q, et al. MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer. Oncogene. 2019;38:4637-4654 pubmed publisher
Kampo S, Ahmmed B, Zhou T, Owusu L, Anabah T, Doudou N, et al. Scorpion Venom Analgesic Peptide, BmK AGAP Inhibits Stemness, and Epithelial-Mesenchymal Transition by Down-Regulating PTX3 in Breast Cancer. Front Oncol. 2019;9:21 pubmed publisher
Ge M, Zhang L, Cao L, Xie C, Li X, Li Y, et al. Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway. Int J Food Sci Nutr. 2019;70:570-578 pubmed publisher
Schuster S, Saravanakumar S, Schols L, Hauser S. Generation of a homozygous CRISPR/Cas9-mediated knockout human iPSC line for the STUB1 locus. Stem Cell Res. 2019;34:101378 pubmed publisher
Liu Y, Wang S, Xu Q, Yuan H, Guo Y, Wang Q, et al. Acetyl-11-keto-β-boswellic acid suppresses docetaxel-resistant prostate cancer cells in vitro and in vivo by blocking Akt and Stat3 signaling, thus suppressing chemoresistant stem cell-like properties. Acta Pharmacol Sin. 2019;40:689-698 pubmed publisher
Qin T, Li B, Feng X, Fan S, Liu L, Liu D, et al. Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity. J Exp Clin Cancer Res. 2018;37:287 pubmed publisher
Peng X, Kang Q, Wan R, Wang Z. miR-26a/HOXC9 Dysregulation Promotes Metastasis and Stem Cell-Like Phenotype of Gastric Cancer. Cell Physiol Biochem. 2018;49:1659-1676 pubmed publisher
Chen Y, Li Y, Wang X, Meng Y, Zhang Q, Zhu J, et al. Phenethyl isothiocyanate inhibits colorectal cancer stem cells by suppressing Wnt/β-catenin pathway. Phytother Res. 2018;32:2447-2455 pubmed publisher
Li H, Pei H, Nie J, Qu M, Fan Z, Jia Y, et al. Integration-free reprogramming of human umbilical arterial endothelial cells into induced pluripotent stem cells IHSTMi001-A. Stem Cell Res. 2018;31:231-234 pubmed publisher
Ren J, Ding L, Zhang D, Shi G, Xu Q, Shen S, et al. Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19. Theranostics. 2018;8:3932-3948 pubmed publisher
Ye J, Liu S, Shang Y, Chen H, Wang R. R-spondin1/Wnt-enhanced Ascl2 autoregulation controls the self-renewal of colorectal cancer progenitor cells. Cell Cycle. 2018;17:1014-1025 pubmed publisher
Song L, Chen X, Wang P, Gao S, Qu C, Liu L. Effects of baicalein on pancreatic cancer stem cells via modulation of sonic Hedgehog pathway. Acta Biochim Biophys Sin (Shanghai). 2018;50:586-596 pubmed publisher
Jin N, Zhu X, Cheng F, Zhang L. Disulfiram/copper targets stem cell-like ALDH+ population of multiple myeloma by inhibition of ALDH1A1 and Hedgehog pathway. J Cell Biochem. 2018;119:6882-6893 pubmed publisher
Li C, Fan Q, Quan H, Nie M, Luo Y, Wang L. The three branches of the unfolded protein response exhibit differential significance in breast cancer growth and stemness. Exp Cell Res. 2018;367:170-185 pubmed publisher
Zhang Q, Li X, Chen Y, Chen J, Zhu J, Meng Y, et al. Wnt/β-catenin signaling mediates the suppressive effects of diallyl trisulfide on colorectal cancer stem cells. Cancer Chemother Pharmacol. 2018;81:969-977 pubmed publisher
Jia W, Jiang X, Liu W, Wang L, Zhu B, Zhu H, et al. Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells. Int J Oncol. 2018;52:1787-1800 pubmed publisher
Xu R, Zhu X, Chen F, Huang C, Ai K, Wu H, et al. LncRNA XIST/miR-200c regulates the stemness properties and tumourigenicity of human bladder cancer stem cell-like cells. Cancer Cell Int. 2018;18:41 pubmed publisher
Qian W, Kong X, Zhang T, Wang D, Song J, Li Y, et al. Cigarette smoke stimulates the stemness of renal cancer stem cells via Sonic Hedgehog pathway. Oncogenesis. 2018;7:24 pubmed publisher
Wang W, Chen D, Zhu K. SOX2OT variant 7 contributes to the synergistic interaction between EGCG and Doxorubicin to kill osteosarcoma via autophagy and stemness inhibition. J Exp Clin Cancer Res. 2018;37:37 pubmed publisher
Li X, Meng Y, Xie C, Zhu J, Wang X, Li Y, et al. Diallyl Trisulfide inhibits breast cancer stem cells via suppression of Wnt/β-catenin pathway. J Cell Biochem. 2018;119:4134-4141 pubmed publisher
Wang J, Tian L, Khan M, Zhang L, Chen Q, Zhao Y, et al. Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial-mesenchymal transition and stemness. Cancer Lett. 2018;415:73-85 pubmed publisher
Wei X, Ye J, Shang Y, Chen H, Liu S, Liu L, et al. Ascl2 activation by YAP1/KLF5 ensures the self-renewability of colon cancer progenitor cells. Oncotarget. 2017;8:109301-109318 pubmed publisher
Yu X, Zhang F, Mao J, Lu Y, Li J, Ma W, et al. Protein tyrosine phosphatase receptor-type ? acts as a negative regulator suppressing breast cancer. Oncotarget. 2017;8:98798-98811 pubmed publisher
Liu T, Wu C, Weng G, Zhao Z, He X, Fu C, et al. Bufalin Inhibits Cellular Proliferation and Cancer Stem Cell-Like Phenotypes via Upregulation of MiR-203 in Glioma. Cell Physiol Biochem. 2017;44:671-681 pubmed publisher
Wu X, Yang B, Hu Y, Sun R, Wang H, Fu J, et al. NRF2 Is a Potential Modulator of Hyperresistance to Arsenic Toxicity in Stem-Like Keratinocytes. Oxid Med Cell Longev. 2017;2017:7417694 pubmed publisher
Zhang L, Yan Y, Jiang Y, Qian J, Jiang L, Hu G, et al. Knockdown of SALL4 expression using RNA interference induces cell cycle arrest, enhances early apoptosis, inhibits invasion and increases chemosensitivity to temozolomide in U251 glioma cells. Oncol Lett. 2017;14:4263-4269 pubmed publisher
Wang D, Kong X, Li Y, Qian W, Ma J, Wang D, et al. Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway. Biochem Biophys Res Commun. 2017;493:521-527 pubmed publisher
Liu J, Shang D, Xiao Y, Zhong P, Cheng H, Zhou R. Isolation and characterization of string-forming female germline stem cells from ovaries of neonatal mice. J Biol Chem. 2017;292:16003-16013 pubmed publisher
Yang H, Yu M, Jin H, Yao J, Lu Z, Yabasin I, et al. Fentanyl Promotes Breast Cancer Cell Stemness and Epithelial-Mesenchymal Transition by Upregulating ?1, 6-Fucosylation via Wnt/?-Catenin Signaling Pathway. Front Physiol. 2017;8:510 pubmed publisher
Sun J, Xu K, Qiu Y, Gao H, Xu J, Tang Q, et al. Bufalin reverses acquired drug resistance by inhibiting stemness in colorectal cancer cells. Oncol Rep. 2017;38:1420-1430 pubmed publisher
Gao Y, Zhang Z, Li K, Gong L, Yang Q, Huang X, et al. Linc-DYNC2H1-4 promotes EMT and CSC phenotypes by acting as a sponge of miR-145 in pancreatic cancer cells. Cell Death Dis. 2017;8:e2924 pubmed publisher
Chen Y, Wang X, Zhang Q, Zhu J, Li Y, Xie C, et al. (-)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt/β-Catenin Pathway. Nutrients. 2017;9: pubmed publisher
Liu G, Zhou S, Ding X, Fang C, Mi S, Gao X, et al. Soluble expression of recomb inant cMyc, Klf4, Oct4, and Sox2 proteins in bacteria and transduction into living cells. Int J Ophthalmol. 2017;10:560-566 pubmed publisher
Zhu J, Wang S, Chen Y, Li X, Jiang Y, Yang X, et al. miR-19 targeting of GSK3β mediates sulforaphane suppression of lung cancer stem cells. J Nutr Biochem. 2017;44:80-91 pubmed publisher
Gao Z, Cai L, Lu J, Wang C, Li Q, Chen J, et al. Expression of Stem Cell Markers and Dopamine D2 Receptors in Human and Rat Prolactinomas. Med Sci Monit. 2017;23:1827-1833 pubmed
Freitag D, McLean A, Simon M, Koch A, Grube S, Walter J, et al. NANOG overexpression and its correlation with stem cell and differentiation markers in meningiomas of different WHO grades. Mol Carcinog. 2017;56:1953-1964 pubmed publisher
Xiao W, Gao Z, Duan Y, Yuan W, Ke Y. Notch signaling plays a crucial role in cancer stem-like cells maintaining stemness and mediating chemotaxis in renal cell carcinoma. J Exp Clin Cancer Res. 2017;36:41 pubmed publisher
Wu T, Chen L, Bu L, Gao J, Zhang W, Jia J. CD44+ cancer cell-induced metastasis: A feasible neck metastasis model. Eur J Pharm Sci. 2017;101:243-250 pubmed publisher
Zhu J, Yang X, Chen Y, Jiang Y, Wang S, Li Y, et al. Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/?-catenin and Sonic Hedgehog Pathways. Phytother Res. 2017;31:680-688 pubmed publisher
Chen S, Sun Y, Zhang Z, Li Y, Xu Z, Fu W. Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3β-involved Wnt/β-catenin pathway. Oncotarget. 2017;8:14708-14718 pubmed publisher
Hsieh C, Hsiung S, Yeh C, Yen C, Chou Y, Lei W, et al. Differential expression of CD44 and CD24 markers discriminates the epitheliod from the fibroblastoid subset in a sarcomatoid renal carcinoma cell line: evidence suggesting the existence of cancer stem cells in both subsets as studied with sorted cell. Oncotarget. 2017;8:15593-15609 pubmed publisher
Zhu J, Jiang Y, Yang X, Wang S, Xie C, Li X, et al. Wnt/?-catenin pathway mediates (-)-Epigallocatechin-3-gallate (EGCG) inhibition of lung cancer stem cells. Biochem Biophys Res Commun. 2017;482:15-21 pubmed publisher
Liu Y, Liu D, Dong L, Wen D, Shi D, Zhou J, et al. miR-612 suppresses stem cell-like property of hepatocellular carcinoma cells by modulating Sp1/Nanog signaling. Cell Death Dis. 2016;7:e2377 pubmed publisher
Wang B, Sun J, Shi J, Guo Q, Tong X, Zhang J, et al. Small-Activating RNA Can Change Nucleosome Positioning in Human Fibroblasts. J Biomol Screen. 2016;21:634-42 pubmed publisher
Umazume T, Thomas W, Campbell S, Aluri H, Thotakura S, Zoukhri D, et al. Lacrimal Gland Inflammation Deregulates Extracellular Matrix Remodeling and Alters Molecular Signature of Epithelial Stem/Progenitor Cells. Invest Ophthalmol Vis Sci. 2015;56:8392-402 pubmed publisher
Pan Z, Sun M, Li J, Zhou F, Liang X, Huang J, et al. The Expression of Markers Related to Ovarian Germline Stem Cells in the Mouse Ovarian Surface Epithelium and the Correlation with Notch Signaling Pathway. Cell Physiol Biochem. 2015;37:2311-22 pubmed publisher
Wu Y, Shu J, He C, Li M, Wang Y, Ou W, et al. ROCK inhibitor Y27632 promotes proliferation and diminishes apoptosis of marmoset induced pluripotent stem cells by suppressing expression and activity of caspase 3. Theriogenology. 2016;85:302-14 pubmed publisher
Maragkoudaki M, Vaiopoulou A, Theodoropoulos G, Legaki E, Sechi L, Karamanolis G, et al. Specific detection of OCT4 isoforms in inflammatory bowel disease. Gut Pathog. 2015;7:25 pubmed publisher
Yang G, Jia Y, Li C, Cheng Q, Yue W, Pei X. Hyperglycemic Stress Impairs the Stemness Capacity of Kidney Stem Cells in Rats. PLoS ONE. 2015;10:e0139607 pubmed publisher
Lin C, Lin Y, Adebayo B, Wu A, Chen J, Peng Y, et al. Silencing JARID1B suppresses oncogenicity, stemness and increases radiation sensitivity in human oral carcinoma. Cancer Lett. 2015;368:36-45 pubmed publisher
Lin Y, Liu A, Fan C, Zheng H, Li Y, Zhang C, et al. MicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1. Sci Rep. 2015;5:9995 pubmed publisher
Kissing S, Hermsen C, Repnik U, Nesset C, von Bargen K, Griffiths G, et al. Vacuolar ATPase in phagosome-lysosome fusion. J Biol Chem. 2015;290:14166-80 pubmed publisher
Ma S, Wang W, Huang C, Zhang W, Sun Z. Anterior gradient protein 2 expression in high grade head and neck squamous cell carcinoma correlated with cancer stem cell and epithelial mesenchymal transition. Oncotarget. 2015;6:8807-21 pubmed
Zheng Y, Zou F, Wang J, Yin G, Le V, Fei Z, et al. Photodynamic therapy-mediated cancer vaccination enhances stem-like phenotype and immune escape, which can be blocked by thrombospondin-1 signaling through CD47 receptor protein. J Biol Chem. 2015;290:8975-86 pubmed publisher
product information
CatalogNo :
11263-1-AP
AntigenName :
OCT4
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
POU class 5 homeobox 1
Immunogen :
Recombinant Protein
Species :
human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
Oct 3, Oct 4, OCT3, OCT3/4, OCT4, Octamer binding protein 3, Octamer binding protein 4, OTF 3, OTF3, OTF4, POU class 5 homeobox 1, POU5F1
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC020712
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Development;Disease Related;Metabolism;Stem Cells;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
WB 1:1000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.