This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
SETDB1
catalog :
11231-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, western blot knockout validation
citations: 24
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; 1:1000; loading ...; fig 2h
  • chromatin immunoprecipitation; human; loading ...; fig 3f
Zhu Y, Wang G, Cingoz O, Goff S. NP220 mediates silencing of unintegrated retroviral DNA. Nature. 2018;564:278-282 pubmed publisher
  • western blot; human; loading ...; fig 3h
Guo J, Dai X, Laurent B, Zheng N, Gan W, Zhang J, et al. AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions. Nat Cell Biol. 2019;21:226-237 pubmed publisher
Cao N, Yu Y, Zhu H, Chen M, Chen P, Zhuo M, et al. SETDB1 promotes the progression of colorectal cancer via epigenetically silencing p21 expression. Cell Death Dis. 2020;11:351 pubmed publisher
He Z, Jing S, Yang T, Chen J, Huang F, Zhang W, et al. PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat. J Virol. 2020;94: pubmed publisher
Price A, Manjegowda M, Kain J, Anandh S, Bochkis I. Hdac3, Setdb1, and Kap1 mark H3K9me3/H3K14ac bivalent regions in young and aged liver. Aging Cell. 2020;19:e13092 pubmed publisher
Yang W, Su Y, Hou C, Chen L, Zhou D, Ren K, et al. SETDB1 induces epithelial‑mesenchymal transition in breast carcinoma by directly binding with Snail promoter. Oncol Rep. 2019;41:1284-1292 pubmed publisher
Zhang Y, Wang C, Liu X, Yang Q, Ji H, Yang M, et al. AFF3-DNA methylation interplay in maintaining the mono-allelic expression pattern of XIST in terminally differentiated cells. J Mol Cell Biol. 2018;: pubmed publisher
Mochizuki K, Tando Y, Sekinaka T, Otsuka K, Hayashi Y, Kobayashi H, et al. SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling. Development. 2018;145: pubmed publisher
Cossec J, Theurillat I, Chica C, Búa Aguín S, Gaume X, Andrieux A, et al. SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States. Cell Stem Cell. 2018;23:742-757.e8 pubmed publisher
Hirota T, Blakeley P, Sangrithi M, Mahadevaiah S, Encheva V, Snijders A, et al. SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice. Dev Cell. 2018;47:645-659.e6 pubmed publisher
Yurkovetskiy L, Guney M, Kim K, Goh S, McCauley S, Dauphin A, et al. Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex. Nat Microbiol. 2018;3:1354-1361 pubmed publisher
Lv Y, Zhang P, Guo J, Zhu Z, Li X, Xu D, et al. Melatonin protects mouse spermatogonial stem cells against hexavalent chromium-induced apoptosis and epigenetic histone modification. Toxicol Appl Pharmacol. 2018;340:30-38 pubmed publisher
Chen K, Zhang F, Ding J, Liang Y, Zhan Z, Zhan Y, et al. Histone Methyltransferase SETDB1 Promotes the Progression of Colorectal Cancer by Inhibiting the Expression of TP53. J Cancer. 2017;8:3318-3330 pubmed publisher
Liu T, Chen X, Li T, Li X, Lyu Y, Fan X, et al. Histone methyltransferase SETDB1 maintains survival of mouse spermatogonial stem/progenitor cells via PTEN/AKT/FOXO1 pathway. Biochim Biophys Acta Gene Regul Mech. 2017;1860:1094-1102 pubmed publisher
Tchasovnikarova I, Timms R, Douse C, Roberts R, Dougan G, Kingston R, et al. Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2. Nat Genet. 2017;49:1035-1044 pubmed publisher
Timms R, Tchasovnikarova I, Antrobus R, Dougan G, Lehner P. ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex. Cell Rep. 2016;17:653-659 pubmed publisher
Takikita S, Muro R, Takai T, Otsubo T, Kawamura Y, Dohi T, et al. A Histone Methyltransferase ESET Is Critical for T Cell Development. J Immunol. 2016;197:2269-79 pubmed publisher
Sharif J, Endo T, Nakayama M, Karimi M, Shimada M, Katsuyama K, et al. Activation of Endogenous Retroviruses in Dnmt1(-/-) ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA. Cell Stem Cell. 2016;19:81-94 pubmed publisher
Daxinger L, Oey H, Isbel L, Whitelaw N, Youngson N, Spurling A, et al. Hypomethylation of ERVs in the sperm of mice haploinsufficient for the histone methyltransferase Setdb1 correlates with a paternal effect on phenotype. Sci Rep. 2016;6:25004 pubmed publisher
Collins P, Kyle K, Egawa T, Shinkai Y, Oltz E. The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes. Proc Natl Acad Sci U S A. 2015;112:8367-72 pubmed publisher
Tchasovnikarova I, Timms R, Matheson N, Wals K, Antrobus R, Göttgens B, et al. GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells. Science. 2015;348:1481-1485 pubmed publisher
Song Y, Choi J, Lee H. Setdb1 is required for myogenic differentiation of C2C12 myoblast cells via maintenance of MyoD expression. Mol Cells. 2015;38:362-72 pubmed publisher
Martin F, Xu Y, Lohmann F, Ciccone D, Nicholson T, Loureiro J, et al. KMT1E-mediated chromatin modifications at the FcγRIIb promoter regulate thymocyte development. Genes Immun. 2015;16:162-9 pubmed publisher
Sun Q, Ding L, Xiao J, Chien W, Lim S, Hattori N, et al. SETDB1 accelerates tumourigenesis by regulating the WNT signalling pathway. J Pathol. 2015;235:559-70 pubmed publisher
product information
CatalogNo :
11231-1-AP
AntigenName :
SETDB1
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
SET domain, bifurcated 1
Immunogen :
Recombinant Protein
Species :
human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, chIP, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
ESET, H3 K9 HMTase 4, H3 K9 HMTase4, KG1T, KIAA0067, KMT1E, Lysine N methyltransferase 1E, SET domain bifurcated 1, SET domain, bifurcated 1, SETDB1
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC009362
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Membrane Proteins;Metabolism;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IHC 1:50 ; IP 1:1000 ; WB 1:1000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.