This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
SOX2
catalog :
11064-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section
citations: 70
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 5c
Zhan Y, Li R, Feng C, Li X, Huang S, Wang L, et al. Chlorogenic acid inhibits esophageal squamous cell carcinoma growth in vitro and in vivo by downregulating the expression of BMI1 and SOX2. Biomed Pharmacother. 2020;121:109602 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 2a
Liu Y, Jiang Q, Liu X, Lin X, Tang Z, Liu C, et al. Cinobufotalin powerfully reversed EBV-miR-BART22-induced cisplatin resistance via stimulating MAP2K4 to antagonize non-muscle myosin heavy chain IIA/glycogen synthase 3β/β-catenin signaling pathway. EBioMedicine. 2019;48:386-404 pubmed publisher
  • western blot; human; loading ...; fig 3e
Xie C, Zhu J, Jiang Y, Chen J, Wang X, Geng S, et al. Sulforaphane Inhibits the Acquisition of Tobacco Smoke-Induced Lung Cancer Stem Cell-Like Properties via the IL-6/ΔNp63α/Notch Axis. Theranostics. 2019;9:4827-4840 pubmed publisher
  • immunohistochemistry - frozen section; mouse; tbl 1
PACKARD A, Lin B, Schwob J. Sox2 and Pax6 Play Counteracting Roles in Regulating Neurogenesis within the Murine Olfactory Epithelium. PLoS ONE. 2016;11:e0155167 pubmed publisher
  • immunocytochemistry; human; fig s3a
Vicidomini C, Ponzoni L, Lim D, Schmeisser M, Reim D, Morello N, et al. Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice. Mol Psychiatry. 2017;22:689-702 pubmed publisher
Chen Y, Niu J, Li L, Li Z, Jiang J, Zhu M, et al. Polydatin executes anticancer effects against glioblastoma multiforme by inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail signaling pathway. Life Sci. 2020;258:118158 pubmed publisher
Liu H, Chen C, Ma D, Li Y, Yin Q, Li Q, et al. Inhibition of PIM1 attenuates the stem cell-like traits of breast cancer cells by promoting RUNX3 nuclear retention. J Cell Mol Med. 2020;24:6308-6323 pubmed publisher
Liu H, Liu Z, Gao M, Hu X, Sun R, Shen X, et al. The Effects of Daxx Knockout on Pluripotency and Differentiation of Mouse Induced Pluripotent Stem Cells. Cell Reprogram. 2020;22:90-98 pubmed publisher
Yang B, Bai H, Sa Y, Zhu P, Liu P. Inhibiting EMT, stemness and cell cycle involved in baicalin-induced growth inhibition and apoptosis in colorectal cancer cells. J Cancer. 2020;11:2303-2317 pubmed publisher
Mei Y, Cai D, Dai X. Modulating cancer stemness provides luminal a breast cancer cells with HER2 positive-like features. J Cancer. 2020;11:1162-1169 pubmed publisher
Apaya M, Hsiao P, Yang Y, Shyur L. Deregulating the CYP2C19/Epoxy-Eicosatrienoic Acid-Associated FABP4/FABP5 Signaling Network as a Therapeutic Approach for Metastatic Triple-Negative Breast Cancer. Cancers (Basel). 2020;12: pubmed publisher
Xiang R, Han X, Ding K, Wu Z. CMIP promotes Herceptin resistance of HER2 positive gastric cancer cells. Pathol Res Pract. 2020;216:152776 pubmed publisher
Guo Y, Li B, Yan X, Shen X, Ma J, Liu S, et al. Bisphenol A and polychlorinated biphenyls enhance the cancer stem cell properties of human ovarian cancer cells by activating the WNT signaling pathway. Chemosphere. 2019;246:125775 pubmed publisher
Chen Q, Luo J, Wu C, Lu H, Cai S, Bao C, et al. The miRNA-149-5p/MyD88 axis is responsible for ursolic acid-mediated attenuation of the stemness and chemoresistance of non-small cell lung cancer cells. Environ Toxicol. 2019;: pubmed publisher
Tang Y, Lu Y, Chen Y, Luo L, Cai L, Peng B, et al. Pre-metastatic niche triggers SDF-1/CXCR4 axis and promotes organ colonisation by hepatocellular circulating tumour cells via downregulation of Prrx1. J Exp Clin Cancer Res. 2019;38:473 pubmed publisher
Zhou H, Xiong Y, Peng L, Wang R, Zhang H, Fu Z. LncRNA-cCSC1 modulates cancer stem cell properties in colorectal cancer via activation of the Hedgehog signaling pathway. J Cell Biochem. 2019;: pubmed publisher
Sun D, Yang L, Cao H, Shen Z, Song H. Study of the protective effect on damaged intestinal epithelial cells of rat multilineage-differentiating stress-enduring (Muse) cells. Cell Biol Int. 2019;: pubmed publisher
Wang S, Hu H, Zhong B, Shi D, Qing X, Cheng C, et al. Bruceine D inhibits tumor growth and stem cell-like traits of osteosarcoma through inhibition of STAT3 signaling pathway. Cancer Med. 2019;8:7345-7358 pubmed publisher
Li C, Zheng H, Hou W, Bao H, Xiong J, Che W, et al. Long non-coding RNA linc00645 promotes TGF-β-induced epithelial-mesenchymal transition by regulating miR-205-3p-ZEB1 axis in glioma. Cell Death Dis. 2019;10:717 pubmed publisher
Zhao H, Wu S, Li H, Duan Q, Zhang Z, Shen Q, et al. ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer. Mol Ther Oncolytics. 2019;14:299-312 pubmed publisher
Guo Y, Wang P, Ma J, Cui Z, Yu Q, Liu S, et al. Modeling Retinitis Pigmentosa: Retinal Organoids Generated From the iPSCs of a Patient With the USH2A Mutation Show Early Developmental Abnormalities. Front Cell Neurosci. 2019;13:361 pubmed publisher
Liu Q, Guan Y, Li Z, Wang Y, Liu Y, Cui R, et al. miR-504 suppresses mesenchymal phenotype of glioblastoma by directly targeting the FZD7-mediated Wnt-β-catenin pathway. J Exp Clin Cancer Res. 2019;38:358 pubmed publisher
Chen K, Wei H, Pan J, Chen Z, Pan D, Gao T, et al. Six1 is negatively correlated with poor prognosis and reduces 5-fluorouracil sensitivity via attenuating the stemness of hepatocellular carcinoma cells. Eur J Pharmacol. 2019;861:172599 pubmed publisher
Xiong G, Zhao L, Yan M, Wang X, Zhou Z, Chang X. N-acetylcysteine alleviated paraquat-induced mitochondrial fragmentation and autophagy in primary murine neural progenitor cells. J Appl Toxicol. 2019;: pubmed publisher
Zhang H, Chen F, He S, Liang Y, Wang Z, Wang L, et al. In vivo tracking on longer retention of transplanted myocardin gene-modified adipose-derived stem cells to improve erectile dysfunction in diabetic rats. Stem Cell Res Ther. 2019;10:208 pubmed publisher
Wen Y, Yang H, Wu J, Wang A, Chen X, Hu S, et al. COL4A2 in the tissue-specific extracellular matrix plays important role on osteogenic differentiation of periodontal ligament stem cells. Theranostics. 2019;9:4265-4286 pubmed publisher
Zhu R, Gires O, Zhu L, Liu J, Li J, Yang H, et al. TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling. Nat Commun. 2019;10:2863 pubmed publisher
Hartheimer J, Park S, Rao S, Kim Y. Targeting Hyaluronan Interactions for Glioblastoma Stem Cell Therapy. Cancer Microenviron. 2019;12:47-56 pubmed publisher
Duan C, Xie H, Zhao X, Xu W, Zhang M. Limbal niche cells can reduce the angiogenic potential of cultivated oral mucosal epithelial cells. Cell Mol Biol Lett. 2019;24:3 pubmed publisher
Ai L, Mu S, Sun C, Fan F, Yan H, Qin Y, et al. Myeloid-derived suppressor cells endow stem-like qualities to multiple myeloma cells by inducing piRNA-823 expression and DNMT3B activation. Mol Cancer. 2019;18:88 pubmed publisher
Zeng X, Wang Q, Tan X, Jia L, Li Y, Hu M, et al. Mild thermotherapy and hyperbaric oxygen enhance sensitivity of TMZ/PSi nanoparticles via decreasing the stemness in glioma. J Nanobiotechnology. 2019;17:47 pubmed publisher
Li Z, Chen Y, An T, Liu P, Zhu J, Yang H, et al. Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway. J Exp Clin Cancer Res. 2019;38:139 pubmed publisher
Chen Y, Liu P, Sun P, Jiang J, Zhu Y, Dong T, et al. Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme. Theranostics. 2019;9:1453-1473 pubmed publisher
Wang D, Li W, Zhao R, Chen L, Liu N, Tian Y, et al. Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells In Vivo. Cancer Res. 2019;79:1769-1783 pubmed publisher
Zhong J, Ge H, Zhang C, Chen J, Li H, Fang X, et al. G protein-coupled estrogen receptor 1 negatively regulates the proliferation of mouse-derived neural stem/progenitor cells via extracellular signal-regulated kinase pathway. Brain Res. 2019;1714:158-165 pubmed publisher
Kampo S, Ahmmed B, Zhou T, Owusu L, Anabah T, Doudou N, et al. Scorpion Venom Analgesic Peptide, BmK AGAP Inhibits Stemness, and Epithelial-Mesenchymal Transition by Down-Regulating PTX3 in Breast Cancer. Front Oncol. 2019;9:21 pubmed publisher
Zhong J, Lan C, Zhang C, Yang Y, Chen W, Zhang K, et al. Chondroitin sulfate proteoglycan represses neural stem/progenitor cells migration via PTPσ/α-actinin4 signaling pathway. J Cell Biochem. 2019;: pubmed publisher
Li B, Cao Y, Meng G, Qian L, Xu T, Yan C, et al. Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway. EBioMedicine. 2019;39:239-254 pubmed publisher
Yuan W, Ji J, Shu Y, Chen J, Liu S, Wu L, et al. Downregulation of DAPK1 promotes the stemness of cancer stem cells and EMT process by activating ZEB1 in colorectal cancer. J Mol Med (Berl). 2019;97:89-102 pubmed publisher
Liu Y, Cao W, Kong X, Li J, Chen X, Ge Y, et al. Protective effects of α‑2‑macroglobulin on human bone marrow mesenchymal stem cells in radiation injury. Mol Med Rep. 2018;18:4219-4228 pubmed publisher
Sun Z, Zhu M, Lv P, Cheng L, Wang Q, Tian P, et al. The Long Noncoding RNA Lncenc1 Maintains Naive States of Mouse ESCs by Promoting the Glycolysis Pathway. Stem Cell Reports. 2018;11:741-755 pubmed publisher
Grifone R, Saquet A, Xu Z, Shi D. Expression patterns of Rbm24 in lens, nasal epithelium, and inner ear during mouse embryonic development. Dev Dyn. 2018;247:1160-1169 pubmed publisher
Ren J, Ding L, Zhang D, Shi G, Xu Q, Shen S, et al. Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19. Theranostics. 2018;8:3932-3948 pubmed publisher
Kong L, Li J, Liu Y, Sun Z, Zhou S, Tang J, et al. Neuralized1a regulates asymmetric division in mouse Lewis lung carcinoma cells. Life Sci. 2018;206:70-76 pubmed publisher
Fan L, Liu C, Chen X, Zou Y, Zhou Z, Lin C, et al. Directing Induced Pluripotent Stem Cell Derived Neural Stem Cell Fate with a Three-Dimensional Biomimetic Hydrogel for Spinal Cord Injury Repair. ACS Appl Mater Interfaces. 2018;10:17742-17755 pubmed publisher
Song L, Chen X, Wang P, Gao S, Qu C, Liu L. Effects of baicalein on pancreatic cancer stem cells via modulation of sonic Hedgehog pathway. Acta Biochim Biophys Sin (Shanghai). 2018;50:586-596 pubmed publisher
Guo Y, Zeng Q, Liu S, Yu Q, Wang P, Ma H, et al. Generation of an iPS cell line via a non-integrative method using urine-derived cells from a patient with USH2A-associated retinitis pigmentosa. Stem Cell Res. 2018;29:139-142 pubmed publisher
Tang L, Wang D, Gu D. Knockdown of Sox2 Inhibits OS Cells Invasion and Migration via Modulating Wnt/β-Catenin Signaling Pathway. Pathol Oncol Res. 2018;24:907-913 pubmed publisher
Li C, Fan Q, Quan H, Nie M, Luo Y, Wang L. The three branches of the unfolded protein response exhibit differential significance in breast cancer growth and stemness. Exp Cell Res. 2018;367:170-185 pubmed publisher
Jia W, Jiang X, Liu W, Wang L, Zhu B, Zhu H, et al. Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells. Int J Oncol. 2018;52:1787-1800 pubmed publisher
Li H, Wang Y, Yang J, Liu X, Shi J. [Impact of Cystic Fibrosis Transmembrane Conductance Regulator on Malignant
 Properties of KRAS Mutant Lung Adenocarcinoma A549 Cells]. Zhongguo Fei Ai Za Zhi. 2018;21:89-98 pubmed publisher
Park J, Weldon B, Hong S, Workman T, Griffith W, Park J, et al. Characterization of 3D embryonic C57BL/6 and A/J mouse midbrain micromass in vitro culture systems for developmental neurotoxicity testing. Toxicol In Vitro. 2018;48:33-44 pubmed publisher
Wang J, Tian L, Khan M, Zhang L, Chen Q, Zhao Y, et al. Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial-mesenchymal transition and stemness. Cancer Lett. 2018;415:73-85 pubmed publisher
Chen C, Hsu P, Wang T, Miao Z, Lin R, Juo S. TRPV4 Activation Contributes Functional Recovery from Ischemic Stroke via Angiogenesis and Neurogenesis. Mol Neurobiol. 2018;55:4127-4135 pubmed publisher
Zhang Q, Zhuang J, Deng Y, Yang L, Cao W, Chen W, et al. miR34a/GOLPH3 Axis abrogates Urothelial Bladder Cancer Chemoresistance via Reduced Cancer Stemness. Theranostics. 2017;7:4777-4790 pubmed publisher
Lin B, Coleman J, Peterson J, Zunitch M, Jang W, Herrick D, et al. Injury Induces Endogenous Reprogramming and Dedifferentiation of Neuronal Progenitors to Multipotency. Cell Stem Cell. 2017;21:761-774.e5 pubmed publisher
Yang H, Yu M, Jin H, Yao J, Lu Z, Yabasin I, et al. Fentanyl Promotes Breast Cancer Cell Stemness and Epithelial-Mesenchymal Transition by Upregulating ?1, 6-Fucosylation via Wnt/?-Catenin Signaling Pathway. Front Physiol. 2017;8:510 pubmed publisher
Sun J, Xu K, Qiu Y, Gao H, Xu J, Tang Q, et al. Bufalin reverses acquired drug resistance by inhibiting stemness in colorectal cancer cells. Oncol Rep. 2017;38:1420-1430 pubmed publisher
Song N, Cao C, Tang Y, Bi L, Jiang Y, Zhou Y, et al. The ubiquitin ligase SCFFBXW7? promotes GATA3 degradation. J Cell Physiol. 2017;: pubmed publisher
Montani C, Ramos Brossier M, Ponzoni L, Gritti L, Cwetsch A, Braida D, et al. The X-Linked Intellectual Disability Protein IL1RAPL1 Regulates Dendrite Complexity. J Neurosci. 2017;37:6606-6627 pubmed publisher
Liu G, Zhou S, Ding X, Fang C, Mi S, Gao X, et al. Soluble expression of recomb inant cMyc, Klf4, Oct4, and Sox2 proteins in bacteria and transduction into living cells. Int J Ophthalmol. 2017;10:560-566 pubmed publisher
Gao Z, Cai L, Lu J, Wang C, Li Q, Chen J, et al. Expression of Stem Cell Markers and Dopamine D2 Receptors in Human and Rat Prolactinomas. Med Sci Monit. 2017;23:1827-1833 pubmed
Chen S, Sun Y, Zhang Z, Li Y, Xu Z, Fu W. Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3β-involved Wnt/β-catenin pathway. Oncotarget. 2017;8:14708-14718 pubmed publisher
Liu Y, Liu D, Dong L, Wen D, Shi D, Zhou J, et al. miR-612 suppresses stem cell-like property of hepatocellular carcinoma cells by modulating Sp1/Nanog signaling. Cell Death Dis. 2016;7:e2377 pubmed publisher
Tabata T, Petitt M, Fang Hoover J, Zydek M, Pereira L. Persistent Cytomegalovirus Infection in Amniotic Membranes of the Human Placenta. Am J Pathol. 2016;186:2970-2986 pubmed publisher
Kim H, Wegner S, Van Ness K, Park J, Pacheco S, Workman T, et al. Differential epigenetic effects of chlorpyrifos and arsenic in proliferating and differentiating human neural progenitor cells. Reprod Toxicol. 2016;65:212-223 pubmed publisher
Song Y, Tian K, Mi W, Han P, Ding Z, Qiu Y, et al. Combinatorial enzymatic digestion with thermolysin and collagenase type I improved the isolation and culture effects of hair cell progenitors from rat cochleae. In Vitro Cell Dev Biol Anim. 2016;52:537-44 pubmed publisher
Wu Y, Shu J, He C, Li M, Wang Y, Ou W, et al. ROCK inhibitor Y27632 promotes proliferation and diminishes apoptosis of marmoset induced pluripotent stem cells by suppressing expression and activity of caspase 3. Theriogenology. 2016;85:302-14 pubmed publisher
Yang G, Jia Y, Li C, Cheng Q, Yue W, Pei X. Hyperglycemic Stress Impairs the Stemness Capacity of Kidney Stem Cells in Rats. PLoS ONE. 2015;10:e0139607 pubmed publisher
Wang Y, He L, Du Y, Zhu P, Huang G, Luo J, et al. The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling. Cell Stem Cell. 2015;16:413-25 pubmed publisher
product information
CatalogNo :
11064-1-AP
AntigenName :
SOX2
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
SRY (sex determining region Y)-box 2
Immunogen :
Recombinant Protein
Species :
goat, human, mouse, rat, zebrafish
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IHC, IF, FC, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
ANOP3, MCOPS3, SOX2, Transcription factor SOX 2
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC013923
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Disease Related;Metabolism;Neurology;Stem Cells;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:50 ; IHC 1:200 ; WB 1:600 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.